Entry into mitosis is driven by the activity of kinases, which phosphorylate over 7000 proteins on multiple sites. For cells to exit mitosis and segregate their genome correctly, these phosphorylations must be removed in a specific temporal order. This raises a critical and important question: how are specific phosphorylation sites on an individual protein removed? Traditionally, the temporal order of dephosphorylation was attributed to decreasing kinase activity. However, recent evidence in human cells has identified unique patterns of dephosphorylation during mammalian (...) mitotic exit that cannot be fully explained by the loss of kinase activity. This suggests that specificity is determined in part by phosphatases. In this review, we explore how the physicochemical properties of an individual phosphosite and its surrounding amino acids can affect interactions with a phosphatase. These positive and negative interactions in turn help determine the specific pattern of dephosphorylation required for correct mitotic exit. (shrink)

Winner of the Wolf Prize for his contribution to our understanding of the universe, Penrose takes on the question of whether artificial intelligence will ever ...

The Taming of the True poses a broad challenge to realist views of meaning and truth that have been prominent in recent philosophy. Neil Tennant argues compellingly that every truth is knowable, and that an effective logical system can be based on this principle. He lays the foundations for global semantic anti-realism and extends its consequences from the philosophy of mathematics and logic to the theory of meaning, metaphysics, and epistemology.

This paper argues for two theses: that degrees of belief are context sensitive; that outright belief is belief to degree 1. The latter thesis is rejected quickly in most discussions of the relationship between credence and belief, but the former thesis undermines the usual reasons for doing so. Furthermore, identifying belief with credence 1 allows nice solutions to a number of problems for the most widely-held view of the relationship between credence and belief, the threshold view. I provide a sketch (...) of a formal framework on which both theses are true. This is a modified Bayesian framework; I argue that despite making credences context-sensitive, the framework lets Bayesians hold on to their signature explanatory successes. The sort of context-sensitivity claimed for credences here mirrors the sort of context-sensitivity I have elsewhere claimed for outright belief: one's credences depend, in part, on the space of alternative possibilities one takes seriously in a context. (shrink)

This is the first comprehensive biography of John Locke to be published in nearly a half century. Setting Locke's life within exciting historical and intellectual contexts, which included the English Civil War, religious persecution, and the Glorious Revolution of 1688, Roger Woolhouse interweaves an account of Locke's life with a summary and development of his ideas in theory of knowledge, philosophy of science, medicine, economics, philosophy of religion, and political philosophy. Systematic and encyclopedic in its coverage, Woolhouse's biography offers (...) both an account and explanation of Locke's ideas, while treating seriously his emotional relationship with Elinor Parry. Based on broad research and many years of study of Locke's philosophy, this volume is an authoritative biography on one of the most significant early modern philosophers. (shrink)

For many decades, the proponents of `artificial intelligence' have maintained that computers will soon be able to do everything that a human can do. In his bestselling work of popular science, Sir Roger Penrose takes us on a fascinating roller-coaster ride through the basic principles of physics, cosmology, mathematics, and philosophy to show that human thinking can never be emulated by a machine.

The author comments on the article “The Neurobiology of Addiction: Implications for Voluntary Control of Behavior,‘ by S. E. Hyman. Hyman’s article suggests that addicted individuals have impairments in cognitive control of behavior. The author agrees with Hyman’s view that addiction weakens the addict’s ability to align his actions with his judgments. The author states that neuroethics may focus on brains and highlight key aspects of behavior but we still risk missing explanatory elements. Accession Number: 24077912; Authors: Levy, Neil (...) 1,2; Email Address: [email protected]; Affiliations: 1: University of Melbourne, Parkville 3010, Australia; 2: University of Oxford; Subject: ADDICTIONS; Subject: ALCOHOLISM; Subject: COGNITION; Subject: BEHAVIOR; Subject: JUDGMENT; Subject: HYMAN, S. E.; Subject: NEUROBIOLOGY; Number of Pages: 2p. (shrink)

Roger Montague; VI—Happiness, Proceedings of the Aristotelian Society, Volume 67, Issue 1, 1 June 1967, Pages 87–102, https://doi.org/10.1093/aristotelian/67.1.

In an influential recent paper, Hawthorne, Rothschild, and Spectre (“HRS”) argue that belief is weak. More precisely: they argue that the referent of believe in ordinary language is much weaker than epistemologists usually suppose; that one needs very little evidence to be entitled to believe a proposition in this sense; and that the referent of believe in ordinary language just is the ordinary concept of belief. I argue here to the contrary. HRS identify two alleged tests of weakness – the (...) neg-raising and weak upper bounds tests, as I call them – which they claim believe and think pass. But I identify several other expressions in ordinary English for attributing belief, all of which fail both tests. Therefore, even if HRS are correct that believe and think refer to a weak attitude, it does not follow that the ordinary concept of belief is weak. I conclude by raising some problems for the accounts of belief as guessing, building on HRS's arguments, due to Kevin Dorst, Matt Mandelkern, and Ben Holguín. (shrink)

The preface paradox does not show that it can be rational to have inconsistent beliefs, because preface writers do not have inconsistent beliefs. I argue, first, that a fully satisfactory solution to the preface paradox would have it that the preface writer's beliefs are consistent. The case here is on basic intuitive grounds, not the consequence of a theory of rationality or of belief. Second, I point out that there is an independently motivated theory of belief – sensitivism – which (...) allows such a solution. I sketch a sensitivist account of the preface writer's doxastic state. (shrink)

Roger Montague; VI—Happiness, Proceedings of the Aristotelian Society, Volume 67, Issue 1, 1 June 1967, Pages 87–102, https://doi.org/10.1093/aristotelian/67.1.

Roger White; X*—Wittgenstein on Identity, Proceedings of the Aristotelian Society, Volume 78, Issue 1, 1 June 1978, Pages 157–174, https://doi.org/10.1093/arist.

Roger Marples; Is Religious Education Possible?, Journal of Philosophy of Education, Volume 12, Issue 1, 30 May 2006, Pages 81–91, https://doi.org/10.1111/j.146.

Roger White; X*—Wittgenstein on Identity, Proceedings of the Aristotelian Society, Volume 78, Issue 1, 1 June 1978, Pages 157–174, https://doi.org/10.1093/arist.

In this wide-ranging study of subjectivity and intersubjectivity, Roger Frie develops a critical account of recent conceptions of the subject in philosophy and pdychoanalytic theory. Using a line of analysis strongly grounded in the European tradition, Frie examines the complex relationship between the theories of subjectivity, intersubjectivity, language and love in the work of a diverse body of philosophers and psychoanalyists. He provides lucid interpretations of the work of Sartre, Binswanger, Lacan, Habermas, Heidegger, Freud and others. Because it integrates (...) perspectives from continental philosophy, analytical philosophy, and psychoanalytic theory, this book will appeal to a wide audience in the areas of philosophy, history of philosophy, psychoanalysis, and social theory. (shrink)

The main question explored by the book is: How can cross-border access to human genetic resources, such as blood or DNA samples, be governed in such a way as to achieve equity for vulnerable populations in developing countries? The book situates the field of genomic and genetic research within global health and research frameworks, describing the concerns that have been raised about the potential unfairness in exchanges during recent decades. Access to and sharing in the benefits of human biological resources (...) are aspects not regulated by any international legal framework such as the Convention on Biological Diversity, which applies only to the exchange of plants, animals and microorganisms, as well as to associated traditional knowledge. Examples of genetic research perceived as exploitative are provided in order to illustrate the legal vacuum concerning the global governance of human genetic resources. The main conclusions drawn from the legal and ethical analysis are: - Benefit sharing is crucial in order to avoid the exploitation of developing countries in human genetic research. - With functioning research ethics committees, undue inducement is less of a concern in genetic research than in other areas of medical research (e.g. clinical trials). - Concerns remain over research involving indigenous populations; accordingly, recommendations are provided. In drawing these conclusions, the book addresses in detail a highly pressing topic in global bioethics and international law. In this regard, it combines bioethical arguments with jurisprudence, in particular with reference to the law of equity and the legal concepts of duress (coercion), unconscionable dealing, and undue inducement. (shrink)

I argue that Frank Jackson's knowledge argument cannot succeed in showing that qualia are epiphenomenal. The reason for this is that there is, given the structure of the argument, an irreconcilable tension between his support for the claim that qualia are non-physical and his conclusion that they are epiphenomenal. The source of the tension is that his argument for the non-physical character of qualia is plausible only on the assumption that they have causal efficacy, while his argument for the epiphenomenal (...) character of qualia is plausible only on the assumption that they are non-physical. Since these two arguments cannot be combined coherently, the most Jackson's argument can establish is that qualia are non-physical. (shrink)

The historiography of the ‘dark age’ of biochemistry between 1910–1930 is examined. The biochemistry of the period is located within a larger contemporary debate on the interrelationship between structure and function on a submicroscopic level. It is suggested that biocolloid science was an understandable part of the historical development of biochemistry, representing a conceptual bridge between the cell biology of the late nineteenth century, and the era of structural macromolecular studies of proteins that began after 1930.

Roger Squires; Discussions: Dream Time, Proceedings of the Aristotelian Society, Volume 95, Issue 1, 1 June 1995, Pages 83–92, https://doi.org/10.1093/aristotel.

I argue that the explanatory gap is generated by factors consistent with the view that qualia are physical properties. I begin by considering the most plausible current approach to this issue based on recent work by Valerie Hardcastle and Clyde Hardin. Although their account of the source of the explanatory gap and our potential to close it is attractive, I argue that it is too speculative and philosophically problematic. I then argue that the explanatory gap should not concern physicalists because (...) it makes excessive demands on physical theory. (shrink)

Examines the aims and tools of science for creating theories and explanations of phenomena, with an eye to answering the question of whether or not science ...

Disputes over territory are a major contributing factor to the disruption of international relations. We believe that a cumulative, integrated, and continuously updated resource providing information about such disputes in an easily accessible form would be of benefit to intelligence analysts, military strategists, political scientists, and also to historians and others concerned with international disputes. We propose an ontology-based strategy for creating such a resource. The resource will contain information about territorial disputes, arguments for and against claims pertaining to sovereignty, (...) proffered evidence for such claims, political and military motives (overt or hidden), and associated conflicts. Our approach is designed to address several issues surrounding the representation of geopolitical conflict, including the tracking and individuation of disputes and the validation of disseminated information. (shrink)

I propose a new form of epiphenomenalism, 'explanatory epiphenomenalism', the view that the identification of A's mental properties does not provide a causal explanation of A's behaviour. I arrive at this view by showing that although anomalous monism does not entail type epiphenomenalism (despite what many of Davidson's critics have suggested), it does (when coupled with some additional claims) lead to the conclusion that the identification of A's reasons does not causally explain A's behaviour. I then formalize this view and (...) show that it is an attractive position, because it captures the insights of existing forms of epiphenomenalism without their onerous metaphysical commitments. (shrink)

Roger Gibson; Logic as a Core Curriculum Subject: its case as an alternative to mathematics, Journal of Philosophy of Education, Volume 20, Issue 1, 30 May 2006.

Roger Gibson; Logic as a Core Curriculum Subject: its case as an alternative to mathematics, Journal of Philosophy of Education, Volume 20, Issue 1, 30 May 2006.

Roger Gibson; On the Use of the Name ‘Logic’, Journal of Philosophy of Education, Volume 18, Issue 2, 30 May 2006, Pages 199–211, https://doi.org/10.1111/j.1467.

Roger Gibson; On the Use of the Name ‘Logic’, Journal of Philosophy of Education, Volume 18, Issue 2, 30 May 2006, Pages 199–211, https://doi.org/10.1111/j.1467.

Roger Squires; Discussions: Dream Time, Proceedings of the Aristotelian Society, Volume 95, Issue 1, 1 June 1995, Pages 83–92, https://doi.org/10.1093/aristotel.

For many philosophers working in the area of Population Ethics, it seems that either they have to confront the Repugnant Conclusion , or they have to confront the Non-Identity Problem . To them it seems there is no escape, they either have to face one problem or the other. However, there is a way around this, allowing us to escape the Repugnant Conclusion, by using what I will call Negative Average Preference Utilitarianism – which though similar to anti-frustrationism, has some (...) important differences in practice. Current “positive” forms of utilitarianism have struggled to deal with the Repugnant Conclusion, as their theory actually entails this conclusion; however, it seems that a form of Negative Average Preference Utilitarianism easily escapes this dilemma. (shrink)

En utilisant le cadre théorique développé par Jaegwon Kim, soit l’opposition entre le réalisme explicatif et l’irréalisme explicatif, ainsi que quelques observations sur la métaphysique et l’épistémologie de l’explication, je réexamine le désaccord opposant Robert Kane à Richard Double au sujet du principe de l’explication rationnelle. Je défends la position de Kane sur la double rationalité et je soutiens que le principe proposé par Double possède un champ d’application plus limité qu’il le prétend. Je montre aussi que, contrairement à ce (...) que suppose Double, la façon dont Kane entend expliquer l’action ne se transforme pas en une forme d’irréalisme explicatif. (shrink)