Most cells communicate with their immediate neighbors through the exchange of cytosolic molecules such as ions, second messengers and small metabolites. This activity is made possible by clusters of intercellular channels called gap junctions, which connect adjacent cells. In terms of molecular architecture, intercellular channels consist of two channels, called connexons, which interact to span the plasma membranes of two adjacent cells and directly join the cytoplasm of one cell to another. Connexons are made of structural proteins named connexins, which (...) compose a multigene family. Connexin channels participate in the regulation of signaling between developing and differentiated cell types, and recently there have been some unexpected findings. First, unique ionic‐ and size‐selectivities are determined by each connexin; second, the establishment of intercellular communication is defined by the expression of compatible connexins; third, the discovery of connexin mutations associated with human diseases and the study of knockout mice have illustrated the vital role of cell‐cell communication in a diverse array of tissue functions. (shrink)

According to a leading view, emotions such as admiration, contempt, pride, and shame are important vehicles of agential development. Through admiration and contempt, we establish models and countermodels against which to shape our character; through pride and shame, we get a sense of how we measure up to them. Critics of this view object that these emotions always deliver uncompromising evaluations: admiration casts people in a completely positive light, while contempt casts aspersion on them. Therefore, insofar as they lack the (...) capacity for nuance, these emotions are systematically unfitting and misleading. This paper discusses this objection as originally formulated by John Doris as well as Macalester Bell’s response. Drawing from research on emotional intentionality, it will be argued that Doris’ and Bell’s accounts are respectively misguided criticisms and inadequate defences of these emotions. Their mistake lies in an invalid transition from the claim that these emotions are intentionally directed towards persons to the claim that they deliver global evaluations of those towards whom they are directed. By rejecting this inference, it will be shown that these emotions can deliver nuanced and fitting evaluations in a way Doris’ objection overlooks and Bell’s response precludes us from articulating. (shrink)

Roberto Esposito is one of the most prolific and important exponents of contemporary Italian political theory.

This book by Roberto Esposito - a leading Italian political philosopher - is a highly original exploration of the relationship between human bodies and societies. The original function of law, even before it was codified, was to preserve peaceful cohabitation between people who were exposed to the risk of destructive conflict. Just as the human body's immune system protects the organism from deadly incursions by viruses and other threats, law also ensures the survival of the community in a life-threatening (...) situation. It protects and prolongs life. But the function of law as a form of immunization points to a more disturbing consideration. Like the individual body, the collective body can be immunized from the perceived danger only by allowing a little of what threatens it to enter its protective boundaries. This means that in order to escape the clutches of death, life is forced to incorporate within itself the lethal principle. Starting from this reflection on the nature of immunization, Esposito offers a wide-ranging analysis of contemporary biopolitics. Never more than at present has the demand for immunization come to characterize all aspects of our existence. The more we feel at risk of being infiltrated and infected by foreign elements, the more the life of the individual and society closes off within its protective boundaries, forcing us to choose between a self-destructive outcome and a more radical alternative based on a new conception of community. (shrink)

Improvements in deep sequencing, together with methods to rapidly deplete essential transcription factors (TFs) and chromatin remodelers, have recently led to a more detailed picture of promoter nucleosome architecture in yeast and its relationship to transcriptional regulation. These studies revealed that ∼40% of all budding yeast protein‐coding genes possess a unique promoter structure, where we propose that an unusually unstable nucleosome forms immediately upstream of the transcription start site (TSS). This “fragile” nucleosome (FN) promoter architecture relies on the combined action (...) of the essential RSC (Remodels Structure of Chromatin) nucleosome remodeler and pioneer transcription factors (PTFs). FNs are associated with genes whose expression is high, coupled to cell growth, and characterized by low cell‐to‐cell variability (noise), suggesting that they may promote these features. Recent studies in metazoans suggest that the presence of dynamic nucleosomes upstream of the TSS at highly expressed genes may be conserved throughout evolution. (shrink)

This unique textbook states and proves all the major theorems of many-valued propositional logic and provides the reader with the most recent developments and trends, including applications to adaptive error-correcting binary search. The book is suitable for self-study, making the basic tools of many-valued logic accessible to students and scientists with a basic mathematical knowledge who are interested in the mathematical treatment of uncertain information. Stressing the interplay between algebra and logic, the book contains material never before published, such as (...) a simple proof of the completeness theorem and of the equivalence between Chang's MV algebras and Abelian lattice-ordered groups with unit - a necessary prerequisite for the incorporation of a genuine addition operation into fuzzy logic. Readers interested in fuzzy control are provided with a rich deductive system in which one can define fuzzy partitions, just as Boolean partitions can be defined and computed in classical logic. Detailed bibliographic remarks at the end of each chapter and an extensive bibliography lead the reader on to further specialised topics. (shrink)

The aim of education is a key question; in a certain sense it is a traditional question — viewed by some as a given. Indeed, perhaps because it appears to be self-evident, it has long since ceased to be a focus, with a number of undesirable consequences. Education invariably remains an action that is explicitly or implicitly imbued with intentionality, but if it loses sight of its goals (or, worse still, does not acknowledge them expressively), it risks becoming ethically and (...) politically ambiguous, if not downright corrupted or distorted. (shrink)

Se intentan poner de manifiesto isomorfismos estructurales en las teorías de Heidegger y Husserl sobre tiempo e historia. En relación con Ser y tiempo, la atención está puesta en la tesis compartida de que la historiografía está arraigada en la historicidad y esta en la temporeidad. Con referencia al curso de 1934 se pone de relieve la convergencia heideggeriana de misión, encargo y trabajo, que remiten al futuro, al pasado y al presente. Se muestran nociones equivalentes en los niveles que (...) Husserl distingue en la historia: protohistoria, historia efectiva e historia racional. Finalmente, en lo que atañe al viraje, se trazan paralelos entre el Ereignis y el presente viviente como instancias últimas de una indagación restrospectiva, entre la temporeidad del Dasein y al tiempo inmanente como resonancias de una dimensión profunda, y en torno de una conexión mutua en el análisis de la historia en términos de desviación, reposición, incorporación y superación, esto es, los momentos que componen la noción de Gewind. (shrink)

The experience of illness raises profound issues concerning the sense or non-sense of human existence as a whole: does life have meaning when it is marked by suffering? And what meaning would it bear, in this case? These questions are asked by both caregivers and recipients of care when they come into contact with limits, pain, and death. In this regard, the existential condition of homo patiens is ambiguous: it can lead either to nihilism and despair or to a higher (...) level of awareness and responsibility. Studies on resilience, post-traumatic growth, and meaning-making processes seem to suggest that in difficult situations the search for meaning comes most clearly to the fore, so that the possibility of finding meaning in life can be a protective factor and a key therapeutic resource, while meaninglessness increases weakness and vulnerability. But what is meant by “meaning” in the illness experience and how may it be integrated into one’s personal life story? This question is answered here in terms of narrative methods that can enhance healthcare practitioners’ capacity to approach their patients with sensitivity and deep understanding and guide them to find meaning in their lives, despite all. (shrink)

Despite a growing literature on environmental inaction, it remains poorly understood. This article examines much of this literature including environmental ethics, policy studies, disaster theory, and psychology. Among the many existing explanations, we examine shifting values, rational incentives, and psychological barriers to action. Ultimately, we show how most of these explanations rely on simplistic assumptions about subjectivity. To address this, we apply the phenomenology of Maurice Merleau-Ponty to show how an understanding of habit informed by Merleau-Ponty’s phenomenology reveals the deeper (...) conditions of both action and inaction. (shrink)

The prominence of the island city of Corcyra in Thucydides’ history of the Peloponnesian War presents a puzzle. It appears in the opening of the work in a conflict with its mother city Corinth, after which representatives of both Corinth and Corcyra deliver speeches at Athens. Further conflict between the two cities follows, with Athens supporting Corcyra. Later on, Thucydides depicts two unusually graphic episodes ofstasisat Corcyra. This prominence is surprising, given that the historian himself explicitly states that the initial (...) set of events involving the island does not in fact represent the beginning of the war, and that the Corcyreanstasisis not the first in the war, and that, as has been often observed, it is not even particularly remarkable or influential in it. In what follows, I seek to clarify Thucydides’ use of the island first by exploring ancient views of Corcyra's ‘predecessor’, Homer's Phaeacia, and by arguing that perceptions of the mythical place mirror and reinforce beliefs about its successor Corcyra. An interpretation of Phaeacia as a representative of excess luxury, weakness and friendlessness requires an aggressive reading of Homer. As Rose and others have made clear, however, this position is defensible even if not all readers may choose to accede to it. A significant strand of ancient opinion seems to have adopted a similar attitude as well, perhaps projecting a fifth-century prejudice identified by Rusten back onto Corcyra's Homeric forerunner. In the second part of this paper, I argue that this background influences Thucydides’ presentation of Corcyra, and that the historian emphasizes the story of the island in order to illustrate a pattern of extravagant wealth followed by civic collapse that would have been readily recognizable to an ancient audience. The fact that Thucydides’ Corcyra-story traces all the stages of this process, from a nod to Homeric opulence through pre-war selfishness to wartime collapse, effectively explains his conspicuous use of the city. (shrink)

Roberto Esposito is one of leading figures in a new generation of Italian philosophers. This book criticizes the notion of the person and develops an original account of the concept of the impersonal - what he calls the third person.

This paper is concerned with certain ontological issues in the foundations of geographic representation. It sets out what these basic issues are, describes the tools needed to deal with them, and draws some implications for a general theory of spatial representation. Our approach has ramifications in the domains of mereology, topology, and the theory of location, and the question of the interaction of these three domains within a unified spatial representation theory is addressed. In the final part we also consider (...) the idea of non-standard geographies, which may be associated with geography under a classical conception in the same sense in which non-standard logics are associated with classical logic. (shrink)

"A pleasure to read. Gracefully written by a scholar well grounded in the relevant philosophical, historical, and technical background.... a helpfully clarifying review and analysis of some issues of importance to recent philosophy of science and a source of some illuminating insights."—Burke Townsend, Philosophy of Science.

A wide family of many-valued logics—for instance, those based on the weak Kleene algebra—includes a non-classical truth-value that is ‘contaminating’ in the sense that whenever the value is assigned to a formula φ⁠, any complex formula in which φ appears is assigned that value as well. In such systems, the contaminating value enjoys a wide range of interpretations, suggesting scenarios in which more than one of these interpretations are called for. This calls for an evaluation of systems with multiple contaminating (...) values. In this paper, we consider the countably infinite family of multiple-conclusion consequence relations in which classical logic is enriched with one or more contaminating values whose behavior is determined by a linear ordering between them. We consider some motivations and applications for such systems and provide general characterizations for all consequence relations in this family. Finally, we provide sequent calculi for a pair of four-valued logics including two linearly ordered contaminating values before defining two-sided sequent calculi corresponding to each of the infinite family of many-valued logics studied in this paper. (shrink)

Volume 19, Issue 9, September 2019, Page 37-39.

This article addresses some useful coordinates for the analysis of the relationship between philosophy and taxation. My argument aims to show the relevance of a philosophy of taxation and thus draw attention to civic education required to shape a democratic public reason, truthful, critical and attentive. I emphasize the character of “donation” that is the rule of law within a democratic constitutional regime, which depends on tax payments for the purposes proposed, and particularly those of a social distributive justice. I (...) distinguish between charity and justice and political obligation to maintain that by implementing an effective "rule of law" citizens “donate” ourselves mechanisms and procedures for advancing a system of justice as fairness. This grant does not pertain to the field of natural duties, charity or sacrifice of supererogatory acts, but is expressed in institutional programs whose implementation and maintenance required from us pay taxes, but always based on personal commitment. Thus, close to John Rawls I emphasize the value of freedom. (shrink)

This study documents how people who inject drugs in rural Puerto Rico perceive payments for participating in HIV epidemiological studies. In-depth interviews were conducted among a subset of active PWID older than 18 years of age who had been previously enrolled in a much larger study. Findings suggest that financial compensation was the main motivation for initially enrolling in the parent study. Then, as trust in the researchers developed, participants came to perceive compensation as part of a reciprocal exchange in (...) which they assisted researchers by providing a trustful account of their experiences and researchers reciprocated with financial support. (shrink)

Não é pensando que criamos mundos. É compreendendo o mundo que aprendemos a pensar. Cosmovisão é um termo que deve significar um conjunto de fundamentos dos quais emerge uma compreensão sistêmica do Universo, seus componentes como a vida, o mundo em que vivemos, a natureza, o fenômeno humano e suas relações. Trata-se, portanto, de um campo da filosofia analítica alimentado pelas ciências, cujo objetivo é esse conhecimento agregado e epistemologicamente sustentável sobre tudo o que somos e contemos, que nos cerca (...) e que nos relaciona de alguma forma. É algo tão antigo quanto o pensamento humano e, além de utilizar elementos da cosmologia científica, engloba tudo na filosofia e na ciência que se refere ao universo e à vida. Uma cosmovisão não é um conjunto de ideias, hipóteses e suposições, mas um sistema baseado em observação, análise, evidência e demonstração. Nenhuma cosmovisão pretende definir, estabelecer, propor, mas apenas compreender, analisar e interpretar. Cada um de nós constrói e transporta sua cosmovisão ao longo da vida, sem estabelecer formas, como pano de fundo para nosso pensamento e comportamento. Linguisticamente, o termo “cosmovisão” derivaria do alemão, equivalente ao conceito de “ Weltanschauung”, usado por vários filósofos. No entanto, essa relação linguística não é aplicável porque contraria o que propomos como cosmovisão. Esta palavra alemã refere-se a uma visão pré-lógica ou proto-experimental da realidade, com um contexto intuitivo e longe de um conhecimento crítico ainda inexistente no momento da sua formulação. Sem dúvida, as cosmovisões , no sentido em que as entendemos, abrigam e utilizam esses elementos protoexperimentais ou pré-lógicos que incluem a história, o inconsciente coletivo e todos os arquétipos que carregamos. No entanto, no conceito que aqui aplicamos, a cosmovisão vai muito além desse conteúdo, primeiro por submetê-lo constantemente ao pensamento crítico presente e, finalmente, por tornar a experiência analítica (e não o próprio pensamento ou intuição) seu universo real. António Lopes expõe a amplitude deste conteúdo: -/- “Cosmovisões não são o produto do pensamento. Não nascem do simples desejo de saber. A apreensão da realidade é um momento importante em sua configuração, mas, no entanto, é apenas um. Vem da conduta vital, da experiência da vida, da estrutura de nossa totalidade psíquica. A elevação da vida à consciência no conhecimento da realidade, na valorização da vida e na realidade volitiva é o trabalho lento e árduo que a humanidade tem feito no desenvolvimento das concepções de vida. (W. Dilthey, 1992 [1911]: 120)” Neste trabalho, buscamos traçar uma cosmovisão baseada nas realidades que a ciência oferece hoje. Não nos propomos, em nenhum momento, a fazer ciência ou teorizar a filosofia, mas sempre buscaremos ser apoiados por elas ou, pelo menos, protegidos por elas das distorções cognitivas que costumamos carregar. (shrink)

Ce n'est pas en pensant que nous créons des mondes. C'est en comprenant le monde que nous apprenons à penser. La cosmovision est un terme qui devrait désigner un ensemble de fondements d'où émerge une compréhension systémique de l'Univers, de ses composantes comme la vie, le monde dans lequel nous vivons, la nature, le phénomène humain et leurs relations. C'est donc un champ de la philosophie analytique nourri par les sciences, dont l'objectif est cette connaissance agrégée et épistémologiquement soutenable de (...) tout ce que nous sommes et contenons, qui nous entoure, et qui nous concerne de quelques manières que ce soit. C'est quelque chose d'aussi vieux que la pensée humaine et, en plus d'utiliser des éléments de la cosmologie scientifique, il englobe tout ce qui, dans la philosophie et la science, se réfère à l'univers et à la vie. Une cosmovision n'est pas un ensemble d'idées, d'hypothèses et de suppositions, mais un système établi sur l'observation, l'analyse, la preuve et la démonstration. Aucune cosmovision n'entend définir, établir ou proposer, mais seulement comprendre, analyser et interpréter. Chacun de nous construit et transporte sa cosmovision tout au long de sa vie, sans établir de forme, comme toile de fond de nos pensées et de nos comportements. Linguistiquement, le terme « cosmovision » dériverait de l'allemand, équivalent au concept de « Weltanschauung », tel qu'il a été utilisé par plusieurs philosophes. Cependant, cette relation linguistique n'est pas applicable, car elle contredit ce que nous proposons comme cosmovision. Ce mot allemand fait référence à une vision prélogique ou proto-expérimentale de la réalité, avec un contexte intuitif et loin des connaissances critiques encore inexistantes au moment de sa formulation. Sans aucun doute, les cosmovisions, au sens où nous les entendons, abritent et utilisent ces éléments proto-expérimentaux ou prélogiques qui incluent l'histoire, l'inconscient collectif et tous les archétypes que nous portons. Or, dans le concept que nous appliquons ici, la cosmovision va bien au-delà de ce contenu, d'abord en le soumettant constamment à la pensée critique actuelle et enfin en faisant de l'expérience analytique (et non de la pensée elle-même ou de l'intuition) son univers réel. António Lopes expose l'étendue de ce contenu : [ ] « Les cosmovisions ne sont pas le produit de la pensée. Ils ne naissent pas du simple désir de savoir. L'appréhension de la réalité est un moment important dans sa configuration, mais, néanmoins, ce n'en est qu'un. Elle vient de la conduite vitale, de l'expérience de la vie, de la structure de notre totalité psychique. L'élévation de la vie à la conscience dans la connaissance de la réalité, dans l'évaluation de la vie et dans la réalité volitive est le travail lent et ardu que l'humanité a fait dans le développement des conceptions de la vie. (W.Dilthey, 1992 [1911] : 120). Dans cet ouvrage, nous cherchons à esquisser une cosmovision fondée sur les réalités que la science offre aujourd'hui. Nous ne proposons, à aucun moment, de faire de la science ; ou théoriser la philosophie, mais nous chercherons toujours à être soutenus par eux ou, du moins, protégés par eux des distorsions cognitives que nous portons habituellement. -/- . (shrink)

Nicht durch das Denken erschaffen wir Welten. Indem wir die Welt verstehen, lernen wir zu denken. Kosmovision ist ein Begriff, der eine Reihe von Grundlagen bedeuten sollte, aus denen ein systemisches Verständnis des Universums, seiner Bestandteile als Leben, der Welt, in der wir leben, der Natur, des menschlichen Phänomens und ihrer Beziehungen hervorgehen sollte. Es handelt sich also um ein von den Wissenschaften gespeistes Feld der analytischen Philosophie, deren Ziel dieses aggregierte und erkenntnistheoretisch nachhaltige Wissen über alles ist, was wir (...) sind und beinhalten, was uns umgibt und was uns in einer Weise betrifft. Sie ist so alt wie das menschliche Denken und umfasst neben der Verwendung von Elementen der wissenschaftlichen Kosmologie alles in Philosophie und Wissenschaft, was sich auf das Universum und das Leben bezieht. Eine Kosmovision ist keine Sammlung von Ideen, Hypothesen und Annahmen, sondern ein System, das auf Beobachtung, Analyse, Beweisen und Demonstrationen basiert. Keine Kosmovision will definieren, etablieren oder vorschlagen, sondern nur verstehen, analysieren und interpretieren. Jeder von uns baut und transportiert sein ganzes Leben lang seine Kosmovision, ohne Formen zu etablieren, als Hintergrund für unser Denken und Handeln. In dieser Arbeit versuchen wir, eine Kosmovision zu skizzieren, die auf den Realitäten basiert, die die Wissenschaft heute bietet. Wir schlagen zu keinem Zeitpunkt vor, Wissenschaft zu betreiben; oder Philosophie zu theoretisieren, aber wir werden immer versuchen, von ihnen unterstützt oder zumindest vor den kognitiven Verzerrungen geschützt zu werden, die wir normalerweise mit uns herumtragen. (shrink)

Космовидение - термин, под которым следует понимать совокупность оснований, из которых возникает системное понимание Вселенной, таких ее составляющих, как жизнь, мир, в котором мы живем, природа, феномен человека, и их взаимосвязей. таким образом, это область аналитической философии, питаемая науками, целью которой является совокупное и эпистемологически устойчивое знание обо всем, чем мы являемся и что в нас содержится, что нас окружает и что так или иначе с нами связано. это старое, как человеческая мысль, понятие, которое не только использует элементы научной космологии, (...) но и охватывает все, что относится к вселенной и жизни в философии и науке. Космовидение — это не набор идей, гипотез и предположений, а система, основанная на наблюдениях, анализе, доказательствах и демонстрациях. Космовидение не ставит своей целью определить, установить или предложить, а лишь понять, проанализировать и интерпретировать. Каждый из нас строит и переносит свое космовидение в течение жизни, не устанавливая форм, как фон для нашего мышления и поведения. С лингвистической точки зрения термин "космовидение" происходит от немецкого, эквивалентного понятию "Weltanschauung", используемому рядом философов. Однако эта лингвистическая связь неприменима, поскольку противоречит тому, что мы предлагаем в качестве космовидения. Это немецкое слово обозначает дологическое или протоэкспериментальное видение реальности, имеющее интуитивный контекст и далекое от критического знания, еще не существовавшего на момент его формулировки. Несомненно, космовидения в том смысле, как мы их понимаем, содержат и используют эти протоэкспериментальные или дологические элементы, включающие историю, коллективное бессознательное и все архетипы, которые мы носим в себе. Однако в той концепции, которую мы здесь применяем, космовидение выходит далеко за пределы этого содержания, во-первых, постоянно подчиняя его современному критическому мышлению и, наконец, делая аналитический опыт (а не саму мысль или интуицию) своей актуальной вселенной. Антониу Лопес раскрывает широту этого содержания: -/- "Космовидения не являются продуктом мысли. Они не возникают из простого желания знать. Постижение реальности - важный момент в ее конфигурации, но, тем не менее, только один. Оно исходит из жизненного поведения, из жизненного опыта, из структуры нашей психической совокупности. Возвышение жизни до сознания в познании реальности, в оценке жизни и в волевой реальности — это медленная и тяжелая работа, которую проделало человечество в развитии представлений о жизни". (В. Дильтей, 1992 [1911]: 120)". . В данной работе мы стремимся изложить космовидение, основанное на тех реалиях, которые сегодня предлагает наука. Мы ни в коем случае не собираемся заниматься наукой или теоретизировать философию, но всегда будем стремиться опираться на них или, по крайней мере, защищаться ими от тех когнитивных искажений, которые мы обычно несем. (shrink)

What is the relationship between persons and things? And how does the body transform this relationship? In this highly original new book, Roberto Esposito - one of Italy’s leading political philosophers - considers these questions and shows that starting from the body, rather than from the thing or the person, can help us to reconsider the status of both. Ever since its beginnings, our civilization has been based on a strict, unequivocal distinction between persons and things, founded on the (...) instrumental domination of persons over things. This opposition arose out of ancient Roman law and persisted throughout modernity, to take its place in our current global market, where it continues to generate growing contradictions. Although the distinction seems to appear clear and necessary to us, what we are continually witnessing in legal, economic, and technological practice is a reversal of perspectives: some categories of persons are becoming assimilated with things, while some types of things are taking on a personal profile. With his customary rigour, Roberto Esposito argues that there exists an escape route out of this paradox, constituted by a new point of view founded in the body. Neither a person nor a thing, the human body becomes the decisive element in rethinking the concepts and values that govern our philosophical, legal, and political lexicons. (shrink)

That emotions are especially valuable for our well-being has become a widely agreed upon claim. In this article, we argue that many of the ways in which the emotions are commonly considered to be prudentially valuable – hedonically, experientially, and adaptively – are not specific to the emotions: they are in fact shared by other affective reactions such as drives and sensory affects. This may suggest that emotions are not prudentially valuable in any distinctive manner. We challenge this suggestion by (...) arguing that, unlike other affective reactions, emotions provide unique contexts in which to refine our general sensibility to a wide variety of evaluative properties – and that in this sense they are prudentially valuable in a distinctive way. (shrink)

Roberto Schwarz’s 1966 reading reveals the social content of a famously elusive text by Franz Kafka, and hints at its hidden affinities with both the historical moment of Schwarz’s reading and with our own present.

Nonhuman animals are the most prominent alterity with which humans have engaged in interaction and in comparative self-definition. The reference point of nonhuman alterity is central both to the development of humanism and of posthumanism. In the complex and nonlinear interfaces with nonhumans, humans are extensively hybridized in a process that defines their very humanity. Understanding humans as open and interactive animals rather than as closed and autarchic entities is indispensable to the dismantling of humanism and the development of posthuman (...) thought. Nonhuman and human animals host and are hosted by one another in dynamic and emergent relations. (shrink)