It was initially believed that G‐protein‐coupled receptors, such as metabotropic glutamate receptors, could simply be described as individual proteins that are associated with intracellular signal cascades via G‐proteins. This view is no longer tenable. Today we know that metabotropic glutamate receptors (mGluRs) can dimerize and bind to a variety of proteins in addition to trimeric G‐proteins. These newly identified protein interactions led to the discovery of new regulatory mechanisms that are independent of and sometimes synergistic with the classical G‐protein‐coupled second (...) messenger pathways. Notably, several of these mechanisms connect mGluR‐mediated signaling to other receptor classes, thereby creating a network of different receptor types and associated signal cascades. The intracellular C‐termini of mGluRs play a key role in the regulation of these networks, and various new protein interactions of these domains were described recently. Because mGluRs are involved in a variety of physiological and pathophysiological processes, some of the proteins interacting with this receptor class have potential as valuable pharmaceutical targets. This review will give a comprehensive overview of proteins interacting with mGluR C‐termini, highlight new evolving regulatory mechanisms for glutamatergic signal transduction and discuss possibilities for future drug development. BioEssays 29: 60–73, 2007. © 2006 Wiley Periodicals, Inc. (shrink)

ABSTRACTOne prestudy based on a corpus analysis and four experiments in which participants had to invent novel names for persons or objects investigated how the valence of a face or an object affects the phonological characteristics of the respective novel name. Based on the articulatory feedback hypothesis, we predicted that /i:/ is included more frequently in fictional names for faces or objects with a positive valence than for those with a negative valence. For /o:/, the pattern should reverse. An analysis (...) of the Berlin Affective Word List – Reloaded yielded a higher number of occurrences of /o:/ in German words with negative valence than in words with positive valence; with /i:/ the situation is less clear. In Experiments 1 and 2, participants named persons showing a positive or a negative facial expression. Names for smiling persons included more /i:/s and fewer /o:/s than names for persons with a negative facial expression. In Experiments 3 and 4, participant... (shrink)

Inductive Metaphysics combines an anti-aprioristic emphasis on an empirical and scientific basis for metaphysics with an insistence on a specifically philosophical abductive theory-building. Since the latter specifically philosophical work is not empirical itself, it may in a liberal sense be called apriori. This paper highlights this apriori dimension within IM by a case study on Structuralism, the view that fundamental reality consists of a network of relations, which a number of philosophers consider to be suggested by modern physics. Focussing on (...) Dasgupta’s algebraic Generalism, the author argues that Structuralism suffers from a severe entailment problem, because the relations-spanning apparatus must stand for metaphysically fundamental forms. Schaffer’s contention that there are no entailment problems is rejected. Advocates of IM are well advised to take seriously their own insistence on metaphysical abduction and not to one-sidedly emphasise the empirical input: the elaboration of exact metaphysical theories and the apriori evaluation of their inherent tenability is a constituent of IM no less important than the consideration of scientific input. More traditional ways of metaphysical reasoning inevitably survive as an essential dimension within IM. (shrink)

Strong dispositional monism, the position that all fundamental physical properties consist in dispositional relations to other properties, is naturally construed as property structuralism. J. Lowe’s circularity/regress objection constitutes a serious challenge to SDM that questions the possibility of a purely relational determination of all property essences. The supervenience thesis of A. Bird’s graph-theoretic asymmetry reply to CRO can be rigorously proved. Yet the reply fails metaphysically, because it reveals neither a metaphysical determination of identities on a purely relational basis nor (...) a determination specifically of identities in the sense of essences. Asymmetry is thus not by itself sufficient for a solution to CRO. But it cannot even help to answer CRO when a model for the determination of essences is taken as a basis. Nor is asymmetry necessary for a reply, as property structures may well be symmetric. A metaphysics of dispositional properties as grounded in a purely relational structure faces serious obstacles, and the properties would not be fundamental. Since essence and grounding are notions of metaphysical priority, there can be no essentially dispositional metaphysically fundamental properties, and the prospects of a “coherentist” metaphysics of basic properties are dim. A modal retreat that refrains from a post-modal conception of essence and simply claims that fundamental properties play dispositional roles by metaphysical necessity is unsatisfactory. (shrink)

This ground-breaking book brings together researchers from a wide range of disciplines to discuss the control and coordination of processes involved in perceptually guided actions. The research area of motor control has become an increasingly multidisciplinary undertaking. Understanding the acquisition and performance of voluntary movements in biological and artificial systems requires the integration of knowledge from a variety of disciplines from neurophysiology to biomechanics.

First published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.

The mechanics of claims focusses predominantly on the claim to life. The claim to life is rooted in the autonomy principle, just like other specific claims. Still, the mechanics of claims does not have a systematic place for the fundamental negation of the status as an autonomous being as such. It is, however, the proctiction of the status as such, which is at the center of the protection of human dignity in German constitutional law. Looked at it from this perspective, (...) the protection of human dignity as the protection of the status of an autonomous human being, appears to be a blind spot of the mechanics of claims. The comment attempts to show, how this blindspot leads to inconsistencies in the mechanics of claims, and how they might be ameliorated if human dignity is considered as an absolute right independent of the claims to life. (shrink)

Dissipative systems are described by a Hamiltonian, combined with a “dynamical matrix” which generalizes the simplectic form of the equations of motion. Criteria for dissipation are given and the examples of a particle with friction and of the Lotka-Volterra model are presented. Quantization is first introduced by translating generalized Poisson brackets into commutators and anticommutators. Then a generalized Schrödinger equation expressed by a dynamical matrix is constructed and discussed.

Simulation – imagining future events – plays a role in decision-making. In Conviction Narrative Theory, people's emotional responses to their simulations inform their choices. Yet imagining one possible future also increases its plausibility and accessibility relative to other futures. We propose that the act of simulation, in addition to affective evaluation, drives people to choose in accordance with their simulations.

Inhalt Einfuhrung - Staat im Wandel. Rudiger Voigt zum 65. Geburtstag I. Konzeptualisierung und Systematisierung von Staatswandel Ralf Walkenhaus: Entwicklungslinien moderner Staatlichkeit.

Der Staat hat die politische Moderne wie keine andere Institution und Ordnungsidee gepragt. Als eine Herrschaftsformation, die sich standig an die Umweltbedingungen anpasst, ist ihm die Funktionalitat des Wandels quasi institutionell in die Wiege gelegt. Dennoch ist der Nationalstaat im Prozess der Globalisierung und Europaisierung als Entgrenzung von Herrschaftsraumen der groae Verlierer geworden: Legitimations-, Souveranitats- und Steuerungsprobleme sind die Folge. Der Band erfasst den Staatswandel auf politik- und verwaltungswissenschaftlicher, geschichtswissenschaftlicher, soziologischer und offentlich-rechtlicher Ebene. Dabei behandeln die Beitrage exemplarisch Politikfelder wie (...) Soziales, Wirtschaft, Umwelt, Bildung, Wissenschaft und Verwaltung und bieten so ein breites Forum interdisziplinarer Staatsforschung. Inhalt Einfuehrung - Staat im Wandel. Ruediger Voigt zum 65. Geburtstag I. Konzeptualisierung und Systematisierung von Staatswandel Ralf Walkenhaus: Entwicklungslinien moderner Staatlichkeit. Konzeptualisierungsprobleme des Staatswandels Peter Nahamowitz: Themenkonjunkturen der Politikwissenschaft als Indikatoren fuer nachhaltige Veranderungen der Staatlichkeit in Deutschland? Zugleich ein Nachruf auf die okonomische Globalisierung II. Staatliche Steuerung in einzelnen Politikfeldern Nicolai Dose: Der informierende Staat: Information als Instrument staatlicher Steuerung Lutz R. Reuter: Zum Wandel des staatlichen Handelns im Bildungswesen Helmuth Schulze-Fielitz: Staatliche Wissenschaftssteuerung als organisations- und verfahrensrechtliche Aufgabe Dietrich Fuerst: Der Beitrag der Regionalplanung zur nachhaltigen Entwicklung. Eine steuerungstheoretische Perspektive Erhard Treutner: Staat und nachhaltige Entwicklung. Zur Bedeutung staatlicher Steuerung fuer Prozesse nachhaltiger Entwicklung III. Einzelaspekte Emanual Richter: Zur Rekonstruktion der Kategorie aNachhaltigkeito Stefan Machura: Der Einfluss der Parteien auf die dritte Gewalt Axel Gorlitz / Oliver Sigrist: Des Staates neue Kleider. Demokratie- und Rechtsstaatsdefizite der Verwaltungsreformkonzepte Peter Nitschke: Die Reterritorialisierung Europas auf subnationaler Identitatsebene. Uberlegungen zu einer Rekonstruktion der Theorie des apolitischen Raumeso Klaus A. Ziegert: Weltgesellschaft und Nationalstaat im 21. Jahrhundert. Eine rechtssoziologische Analyse Michael Staack: Multilateralismus, Unilateralismus und das Volkerrecht. Deutschland und die aBush-Revolutiono IV. Historische Bezuege Otwin Massing: Der (europaische) Praambelgott. Fetisch, sakralisierende Uberhohung oder Skandalon? Uber den Atavismus politischer Symbolsprache in amoderneno Staaten Rainer S. Elkar: Die Meister des Staates. Vom Scheitern und von der Aktualitat des Korporatismus Walter Demel: Verwaltung in China und Japan aus der Sicht des fruehneuzeitlichen Europa Georg-Christoph von Unruh: Widerstandsrecht und Widerstandspflicht Verzeichnis der Publikationen von Ruediger Voigt Verzeichnis der Doktoranden und Habilitanden von Ruediger Voigt Verzeichnis der Autoren. (shrink)

It is shown in ZF that if $\delta < \delta^+ < \Omega$ are such that $\delta$ and $\delta^+$ are either both weakly compact or singular cardinals and $\Omega$ is large enough for putting the core model apparatus into action then there is an inner model with a Woodin cardinal.

This paper distinguishes bruteness from fundamentality by developing a theory of stochastic grounding that makes room for non-fundamental bruteness. Stochastic grounding relations, which only underwrite incomplete explanations, arise when the fundamental level underdetermines derivative levels. The framework is applied to fission cases, showing how one can break symmetries and mitigate bruteness whilst avoiding arbitrariness and hypersensitivity.

Resemblance Nominalism About Perfect Naturalness is the view that perfect naturalness of classes is best defined by a conceptual primitive of resemblance between particulars. The adequacy of RNPN is defended by outlining nominalism as the strictly anti-constitutive view that the particulars’ being the fundamental ways they are is not constituted by anything further, supplying a doubly plural contrastive and graded resemblance predicate that allows for a definition of perfect naturalness on an actualist basis, and proving a representation and a uniqueness (...) theorem on the basis of a formal constraint on resemblance called “the Principle”, thereby revealing that bodies of nominalist resemblance facts are guaranteed to behave as if they were grounded in patterns of universals distributed over particulars. (shrink)

ABSTRACTThis paper addresses the problem of opaque sweetening and argues that one should use stochastic dominance in comparing lotteries even when dealing with incomplete orderings that allow for non-comparable outcomes.

The current paper proves the results announced in [5]. We isolate a new large cardinal concept, "remarkability." Consistencywise, remarkable cardinals are between ineffable and $\omega$-Erdos cardinals. They are characterized by the existence of "O$^#$-like" embeddings; however, they relativize down to L. It turns out that the existence of a remarkable cardinal is equiconsistent with L absoluteness for proper forcings. In particular, said absoluteness does not imply $\Pi^1_1$ determinacy.

Contemporary research on Neuroimaging seems to provide various techniques toread a personÏs mind and her individual thoughts. In this essay I examine someethical and metaphysical aspects of mind reading with a focus on how techniques ofmind-reading might concern the idea of human dignity.

Recently, metaphysical coherentism has been propounded as an alternative to metaphysical foundationalism and infinitism. The view replaces the picture of reality as a hierarchy of levels with that of a network of objects or facts standing in symmetric or, more generally, cyclic relations of metaphysical dependence. This paper defends the orthodox picture of a well-founded hierarchy against the claimed superiority of coherentism. First, it will be argued that alleged theoretical advantages of coherentism do not hold up to scrutiny. Secondly, examples (...) that are claimed to support coherentism are either misdescribed as involving metaphysical interdependence, or foundationalist treatments fare at least as good and often better than coherentist interpretations. Thirdly, a similar diagnosis applies to a recently proposed coherentist interpretation of quantum entanglement. The more general diagnosis is that claims of metaphysical dependence are convincing only if there is a detailed account of how one item metaphysically explains another. While foundationalists can resort to various specific explanatory relations, coherentism seems to be incapable of providing detailed explanations. (shrink)

With catastrophic events of «nature» like global warming, arguments emerge that insinuate an equivalence of vulnerability, responsibility or being affected by these catastrophes. Such an alleged equivalence when facing climate catastrophe is already visible, for example, in the notion of the «Anthropocene» itself, which obscures both causes and various vulnerabilities in a homogenized as well as universalized concept of humanity (anthropos). Taking such narratives as a starting point, the paper explores questions about the connection between catastrophe, temporality, and history, following (...) mainly Walter Benjamin, Dipesh Chakrabarty and Jean-Luc Nancy with the goal to provide (1) a critique of the concept «Anthropocene» on the basis of nonequivalence while retaining its key features to still grasp the catastrophic present, (2) an analysis of anthropocenic time and the chronical structure of catastrophe, (3) philosophical considerations on the intersection of catastrophe and history. (shrink)