Many philosophical theories of causation are egalitarian, rejecting a distinction between causes and mere causal conditions. We sought to determine the extent to which people's causal judgments discriminate, selecting as causes counternormal events—those that violate norms of some kind—while rejecting non-violators. We found significant selectivity of this sort. Moreover, priming that encouraged more egalitarian judgments had little effect on subjects. We also found that omissions are as likely as actions to be judged as causes, and that counternormative selectivity appears to (...) apply equally to actions and omissions. (shrink)

In Free Will and Luck, Mele presents a case of an agent Ernie, whose zygote was intentionally designed so that Ernie A-s in 30 years, bringing about a certain event E. Mele uses this case of original design to outline the zygote argument against compatibilism. In this paper I criticize the zygote argument. Unlike other compatibilists who have responded to the zygote argument, I contend that it is open to the compatibilist to accept premise one, that Ernie does not act (...) freely and is not morally responsible for anything he does. I argue that compatibilists should deny premise two. Diana’s effective intention to create Ernie’s zygote such that Ernie A-s in 30 years and her intervention to bring about his A-ing mark a significant difference between Ernie and normal agents in a deterministic universe with regard to how their zygotes were created that affects whether those agents act freely and are morally responsible for so acting. (shrink)

The use of brain scanning now dominates the cognitive sciences, but important questions remain to be answered about what, exactly, scanning can tell us. One corner of cognitive science that has been transformed by the use of neuroimaging, and that a scanning enthusiast might point to as proof of scanning's importance, is the study of face perception. Against this view, we argue that the use of scanning has, in fact, told us rather little about the information processing underlying face perception (...) and that it is not likely to tell us much more. (shrink)

Psychopathy refers to a range of complex behaviors and personality traits, including callousness and antisocial behavior, typically studied in criminal populations. Recent studies have used self-reports to examine psychopathic traits among noncriminal samples. The goal of the current study was to examine the underlying factor structure of the Self-Report of Psychopathy Scale–Short Form (SRP-SF) across complementary samples and examine the impact of gender on factor structure. We examined the structure of the SRP-SF among 2,554 young adults from three undergraduate samples (...) and a high-risk young adult sample. Using confirmatory factor analysis, a four-correlated factor model and a four-bifactor model showed good fit to the data. Evidence of weak invariance was found for both models across gender. These findings highlight that the SRP-SF is a useful measure of low-level psychopathic traits in noncriminal samples, although the underlying factor structure may not fully translate across men and women. (shrink)

Recognising and responding appropriately to emotions is critical to adaptive psychological functioning. Psychopathic traits (e.g. callous, manipulative, impulsive, antisocial) are related to differences in recognition and response when emotion is conveyed through facial expressions and language. Use of emotional music stimuli represents a promising approach to improve our understanding of the specific emotion processing difficulties underlying psychopathic traits because it decouples recognition of emotion from cues directly conveyed by other people (e.g. facial signals). In Experiment 1, participants listened to clips (...) of emotional music and identified the emotional content (Sample 1, N = 196) or reported on their feelings elicited by the music (Sample 2, N = 197). Participants accurately recognised (t(195) = 32.78, p <.001, d = 4.69) and reported feelings consistent with (t(196) = 7.84, p <.001, d = 1.12) the emotion conveyed in the music. However, psychopathic traits were associated with reduced emotion recognition accuracy (F(1, 191) = 19.39, p <.001) and reduced likelihood of feeling the emotion (F(1, 193) = 35.45, p <.001), particularly for fearful music. In Experiment 2, we replicated findings for broad difficulties with emotion recognition (Sample 3, N = 179) and emotional resonance (Sample 4, N = 199) associated with psychopathic traits. Results offer new insight into emotion recognition and response difficulties that are associated with psychopathic traits. (shrink)

Proteins are targeted to plastids by N‐terminal transit peptides, which are recognized by protein import complexes in the organelle membranes. Historically, transit peptide properties have been defined from vascular plant sequences, but recent large‐scale genome sequencing from the many plastid‐containing lineages across the tree of life has provided a much broader representation of targeted proteins. This includes the three lineages containing primary plastids (plants and green algae, rhodophytes and glaucophytes) and also the seven major lineages that contain secondary plastids, “secondhand” (...) plastids derived through eukaryotic endosymbiosis. Despite this extensive spread of plastids throughout Eukaryota, an N‐terminal transit peptide has been maintained as an essential plastid‐targeting motif. This article provides the first global comparison of transit peptide composition and summarizes conservation of some features, the loss of an ancestral motif from the green lineages including plants, and modifications to transit peptides that have occurred in secondary and even tertiary plastids. BioEssays 29:1048–1058, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The aim of this paper is to challenge libertarian accounts of free will. It is argued that there is an irreconcilable tension between the way in which philosophers motivate the incompatibilist ability to do otherwise and the way in which they formally express it. Potential incompatibilist responses in the face of this tension are canvassed, and it is argued that each response is problematic. It is not claimed that incompatibilist accounts in general are incoherent, but rather that any incompatibilist account (...) that requires that an agent have alternative possibilities at the point of a free action fails. (shrink)

In this paper we make the case for the emergence of novel kind of bias with the use of algorithmic decision-making systems. We argue that the distinctive generative process of feature creation, characteristic of machine learning (ML), contorts feature parameters in ways that can lead to emerging feature spaces that encode novel algorithmic bias involving already marginalized groups. We term this bias _assembled bias._ Moreover, assembled biases are distinct from the much-discussed algorithmic bias, both in source (training data versus feature (...) creation) and in content (mimics of extant societal bias versus reconfigured categories). As such, this problem is distinct from issues arising from bias-encoding training feature sets or proxy features. Assembled bias is not epistemically transparent in source or content. Hence, when these ML models are used as a basis for decision-making in social contexts, algorithmic fairness concerns are compounded. (shrink)

Neuroscientists have located brain activity that prepares or encodes action plans before agents are aware of intending to act. On the basis of these findings and broader agency research, activity in these regions has been proposed as the neural realizers of practical intention. My aim in this paper is to evaluate the case for taking these neural states to be neural representations of intention. I draw on work in philosophy of action on the role and nature of practical intentions to (...) construct a framework of the functional profile of intentions fit for empirical investigation. With this framework, I turn to the broader empirical neuroscience literature on agency to assess these proposed neural representations of intention. I argue that while these neural states in some respects satisfy the functions of intention in planning agency prospective of action, their fit with the role of intention in action execution is not well supported. I close by offering a sketch of which experimental task features could aid in the search for the neural realizer of intention in action. (shrink)

It has recently emerged that malarial, toxoplasmodial and related parasites contain a vestigial plastid (the organelle in which photosynthesis occurs in plants and algae). The function of the plastid in these obligate intracellular parasites has not been established. It seems likely that modern apicomplexans derive from photosynthetic predecessors, which perhaps formed associations with protists and invertebrates and abandoned autotrophy in favour of parasitism. Recognition of a third genetic compartment in these parasites proffers alternative strategies for combating a host of important (...) human and animal diseases. It also poses some fascinating questions about the evolutionary biology of this important group of pathogens. (shrink)

The aim of this dissertation is to respond to a collection of conceptual and scientific threats to compatibilist accounts of free will, particularly reasons-responsive views. Compatibilists hold that free will is compatible with the truth of determinism. Some compatibilists also claim that some actual agent at least sometimes acts freely, where it is true that she acts freely in virtue of her satisfying a specific set of control and epistemic conditions. These conditions often include the possession of certain capacities, such (...) as the capacity to recognize reasons for acting and to act on the basis of those reasons. First, I address two pressing philosophical objections to the adequacy of compatibilist accounts of free will: Are reasons-responsive accounts of free will too permissive in their class of free agents? Must reasons-responsive theorists - and compatibilists more generally - concede that some agents who are manipulated or intentionally designed by others are none the less acting freely and morally responsible for their actions? I then survey a widely proposed scientific threat to compatibilist accounts of free will - and to any account of free will that requires the same basic capacities as compatibilists do: Even if the compatibilist account accurately captures the basic capacities that an agent requires to act freely, does neuroscientific work on practical decision-making and action production limit - or worse, speak against -- our actual exercise of free will, as compatibilists conceive of it? I argue that the compatibilist need not yield to these philosophical challenges to the adequacy of their accounts of free will and to their claim that some actual agents act freely, sketching plausible compatibilist-friendly reasons to doubt the potency of each challenge. Finally, I argue that the extant incompatibilist accounts of free will suffer from a previously undiagnosed, serious problem: that there is an irreconcilable tension between the way in which philosophers motivate the incompatibilist ability to do otherwise and the way in which they formally express it. I conclude by offering a diagnosis for the future of the free will debate given the arguments advanced. (shrink)

Mitochondrial genomes represent relict bacterial genomes derived from a progenitor α‐proteobacterium that gave rise to all mitochondria through an ancient endosymbiosis. Evolution has massively reduced these genomes, yet despite relative simplicity their organization and expression has developed considerable novelty throughout eukaryotic evolution. Few organisms have reengineered their mitochondrial genomes as thoroughly as the protist lineage of dinoflagellates. Recent work reveals dinoflagellate mitochondrial genomes as likely the most gene‐impoverished of any free‐living eukaryote, encoding only two to three proteins. The organization and (...) expression of these genomes, however, is far from the simplicity their gene content would suggest. Gene duplication, fragmentation, and scrambling have resulted in an inflated and complex genome organization. Extensive RNA editing then recodes gene transcripts, and trans‐splicing is required to assemble full‐length transcripts for at least one fragmented gene. Even after these processes, messenger RNAs (mRNAs) lack canonical start codons and most transcripts have abandoned stop codons altogether. (shrink)

In Responsibility and Control: A Theory of Moral Responsibility John Martin Fischer and Mark Ravizza propose an account of moral responsibility according to which an agent is morally responsible for an action just when that action is the product of her own moderately reasons-responsive mechanism, where reasons-responsiveness is explained in terms of the mechanism’s regular reasons-receptivity and weak reasons-reactivity. In a review of Fischer and Ravizza’s book Mele contends that their weakly reasons-reactivity condition is inadequate, constructing a case in which, (...) according to their theory, an extreme agoraphobic is morally responsible for his staying in his home. In this paper I modify Fischer and Ravizza’s account of moral responsibility in light of Mele’s problematic example, suggesting a refinement of their weakly reasons-reactivity requirement via a distinction between weakly sufficient reasons and strongly sufficient reasons. (shrink)

This chapter examines the control capacities of individuals with certain mental disorders and how, specifically, their reasons-responsiveness improves with treatment. Successful talk therapy, in particular, can bring individuals with disorders of agency closer to full-blown agency. The discussion focuses, first, on Agoraphobia and Exposure Therapy and, second, on Borderline Personality Disorder and Dialectical Behavior Therapy. We can see effective techniques of talk therapy, such as gradual exposure or radical acceptance exercises, as operating on the ability of patients to respond appropriately (...) to reasons. In this way, reasons-responsiveness is a lens through which both to better appreciate the flourishing of patients, via improved control in both moral and nonmoral contexts. The chapter bridges philosophical concepts of reasons-responsiveness with key psychiatric constructs, such as distress tolerance and experiential avoidance. (shrink)