Ovid completes his narrative of the origin of Croton with the following lines :talia constabat certa primordia famaesse loci positaeque Italis in finibus urbis.It was agreed by sure fame that such were the beginningsof the place and of the city established within Italian borders.

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

This article proposes and interprets a previously undiscussed connection between Horace'sCarmen2.15 and the description of the Corycian gardener at Virgil'sGeorgics4.125–48. It argues that this allusion to Virgil sharpens the moral pessimism of Horace's ode. It first considers the circumstantial, general and formal elements connecting these two poems; it then considers how the model of the Corycian gardener brings further point and nuance to the moralizing message ofCarmen2.15 and the way in which this allusion is meaningfully echoed atCarmen3.16.

Journal Name: Philologus Issue: Ahead of print.