Whipple disease is a rare, infectious, disease first described from a single case by Whipple in 1907. As well as characterising the clinical and pathological features of the condition, Whipple made two suggestions regarding its aetiology. These were either than the disease was caused by an infectious agent, or that it was of metabolic origin. As the disease is now thought to be caused by infection with the bacterium Tropheryma whipplei, historical reviews of the history of the disease typically mention (...) only the first of these suggestions. In this paper, we therefore revisit Whipple’s other theory. We argue that a diverse and often successful research programme was developed around this mechanism of disease causation which gave rise to many useful findings on the condition. In the later parts of this article, we then turn to discuss the surprising neglect of this period of Whipple disease research in the current literature, and conclude by offering a brief reconstruction of this early history suitable for use in a technical context. (shrink)

Dorian Gray pays a hefty price for years of sin and vice in this completely unabridged edition of The Picture of Dorian Gray.

I argue that a standard formulation of hinge epistemology is host to epistemic relativism and show that two leading hinge approaches (Coliva’s acceptance account and Pritchard’s nondoxastic account) are vulnerable to a form of incommensurability that leads to relativism. Building on both accounts, I introduce a new, minimally epistemic conception of hinges that avoids epistemic relativism and rationally resolves hinge disagreements. According to my proposed account, putative cases of epistemic incommensurability are rationally resolvable: hinges are propositions that are the objects (...) of our belief-like attitudes and are rationally revisable in virtue of our overarching commitment to avoid systematic deception in our epistemic practices. (shrink)

Considering the case of Juan de Vilanova y Piera, often celebrated as the first scientist to accept the prehistoric antiquity of palaeolithic paintings, we explore some of the problems related to the concept of ‘precursor’ in the field of the history of science. In the first section, we propose a brief history of this notion focusing on those authors who have reflected critically on the meaning of predecessors. In the second section, the example of Vilanova illustrates the ways in which (...) historians of science have created precursors. From the vantage of modern science, precursors have traditionally been defined as those who first indicated or announced ideas or theories later accepted by the scientific community. As a result, they have been represented as ‘heroes’ struggling hard to defeat the ignorance of their time. As the case of Juan de Vilanova illustrates, this traditional view is unsatisfactory in many ways. For this reason we consider in the third section a number of methodological strategies to promote a more adequate approach to pioneers. In particular, we suggest that the best way to surmount hagiographical approaches to past scientists is to put them in their own intellectual and historical contexts. (shrink)

I argue against the Standard View of ignorance, according to which ignorance is defined as equivalent to lack of knowledge, that cases of environmental epistemic luck, though entailing lack of knowledge, do not necessarily entail ignorance. In support of my argument, I contend that in cases of environmental luck an agent retains what I call epistemic access to the relevant fact by successfully exercising her epistemic agency and that ignorance and non-ignorance, contrary to what the Standard View predicts, are not (...) modal in the sense that knowledge is. After responding to objections, I conclude by sketching an alternative account of ignorance centered on the notions of epistemic access and epistemic agency. (shrink)

In attempting to debunk moral realism through an appeal to evolutionary facts, debunkers face a series of problems, which we label the problems of scope, corrosiveness, and post‐hoc justification. To overcome these problems, debunkers must assume certain metaphysical or epistemological positions, or otherwise pre‐establish them. In doing so, they must assume or pre‐establish the very conclusion they seek in advancing the argument. This means that such debunking arguments either beg the question against the moral realist or are undermined as standalone (...) metaethical arguments. (shrink)

This book presents an original thesis about the notion of sensory experience and of the mind’s architecture, which is grounded in current trends in cognitive science and philosophy of mind. Presented in the form of a dialogue, the book explores some of the psychological and philosophical consequences that the author derives from his proposal.

An individual's health, genetic, or environmental-exposure data, placed in an online repository, creates a valuable shared resource that can accelerate biomedical research and even open opportunities for crowd-sourcing discoveries by members of the public. But these data become “immortalized” in ways that may create lasting risk as well as benefit. Once shared on the Internet, the data are difficult or impossible to redact, and identities may be revealed by a process called data linkage, in which online data sets are matched (...) to each other. Reidentification, the process of associating an individual's name with data that were considered deidentified, poses risks such as insurance or employment discrimination, social stigma, and breach of the promises often made in informed-consent documents. At the same time, re-ID poses risks to researchers and indeed to the future of science, should re-ID end up undermining the trust and participation of potential research participants. The ethical challenges of online data sharing are heightened as so-called big data becomes an increasingly important research tool and driver of new research structures. Big data is shifting research to include large numbers of researchers and institutions as well as large numbers of participants providing diverse types of data, so the participants’ consent relationship is no longer with a person or even a research institution. In addition, consent is further transformed because big data analysis often begins with descriptive inquiry and generation of a hypothesis, and the research questions cannot be clearly defined at the outset and may be unforeseeable over the long term. In this article, we consider how expanded data sharing poses new challenges, illustrated by genomics and the transition to new models of consent. We draw on the experiences of participants in an open data platform—the Personal Genome Project—to allow study participants to contribute their voices to inform ethical consent practices and protocol reviews for big-data research. (shrink)

Insofar as development implies economic growth, the term 'sustainable development' appears to some as a contradiction in terms. However, such conclusions still lack a thorough examination of the conceptual structure of the two terms between which there is a purported contradiction. In order to address this issue, the present paper scrutinises some of the assumptions which underwrite the ideologies of sustainability and of development. It is argued that there are key assumptions which both ideas have in common, and that sustainable (...) development is thus perfectly coherent on a conceptual level. It is alternatives which retain either term (such as 'sustainable degrowth') that are embroiled in paradox. The paper then examines two concepts for criticising the ideology of economic growth in other terms: dépense and conviviality. It is argued that the latter is preferable to the former for the purpose of developing post-sustainable critiques of growth. (shrink)

Reconstruction is a central notion in Dewey’s account of inquiry and in his metaphilosophical commitments. In his work, Dewey made a call for reconstruction of philosophy, in the reconstruction of central notions of the discipline, like knowledge, logic, truth, the good, reason, and experience. Inquiry itself is reconstructive, according to Dewey, involving the transformation of an indeterminate situation into one which is determinate and understood. Dewey’s philosophical views should therefore be of interest to those taking part in the recent turn (...) towards revisionary philosophical methodologies, like conceptual engineering, explication, and amelioration. In light of the recent developments in revisionary methodologies, I aim to explore Dewey’s conception of concepts in relation to the conceptual engineering literature, suggesting that it provides a useful conception of concepts for conceptual engineering, and to suggest a Deweyan model of philosophical inquiry where concepts are the objects of inquiry. In both cases, I hope to show a productive interaction between Dewey’s ideas and contemporary discussions of conceptual engineering. (shrink)

Rousseau avait tout lieu, dans la controverse qui oppose au xviii e siècle partisans et pourfendeurs des voyages d’éducation, de prendre position contre ces voyages, suivant en cela les déclarations de Béat de Muralt, qu’il approuvait dans une large mesure. Nous constatons pourtant qu’en abordant « la question des voyages », l’auteur de l’Émile se voit obligé, tout en condamnant cette « mode », à la manière de Muralt, d’opérer un glissement théorique et de conférer à l’expérience du voyage, comme (...) expérience critique de la pluralité et de la liberté, une place essentielle dans son système, place rendue nécessaire par sa théorie des affects politiques. (shrink)

The basis for ‘sound’ medical opinion has moved from clinical opinion to evidence based research. This article will comment on the basis on which evidence in clinical medicine is collected and, indeed, what actually constitutes evidence. It is suggested that the definition of guidelines arising from evidence-based medicine may lead to false conclusion and, as noted by Sir Douglas Black, whilst ‘guidelines can of course be helpful in clear-cut situations; [but] these are the minority in actual practice’.

Placing the question -- Patristic Precedents -- Moltmann's perichoretic spaces for God and creation -- No place for the spirit? Jean-Luc Marion's placial refusal -- Notes toward a Trinitarian theology of Place.

O princípio de intersubstituição dos idênticos salva veritate, que constitui uma peça de importância central para a teoria leibniziana da demostração, para não falar de suas implicações ontológicas, recebeu a crítica de que encerra uma confusão entre uso e menção. Em contraste com essa crítica, o presente trabalho defende a tese de que o princípio não está suscetível a essa pretensa confusão, utilizando, para tanto, a distinção leibniziana entre “a consideração do modo de conceber” e a “consideração da coisa mesma”. (...) A introdução dessa distinção, porém, vem acompanhada com a necessidade de estabelecer restrições à aplicação do mencionado princípio. (shrink)

Carta sobre el platonismo, enviada por G.W. Leibniz a M.G. Hansch el 25 de julio de 1707.

This paper argues that there are instances in which tobacco control litigation is strengthening the justiciability of the right to health and health-related rights. This is happening in different parts of the world, but in particular in Latin America. In part this is because, to a certain extent, tobacco control litigation based on fundamental rights overcomes the traditional arguments against economic, social and cultural rights adjudication: the anti-democratic argument, the lack of technical competency argument, the problem of the misallocation of (...) scarce public resources and the problem of the implementation of judicial decisions. As we analyzed in this paper, tobacco control cases based on fundamental rights are allowing courts to elaborate on broader standards of judicial adjudication of social rights, e.g., expand notions of standing, progressive realization, and state obligations enshrined in the right to health. Key to this judicial trend is the Framework Convention on Tobacco Control, which provides a legal standard — supported by scientific evidence — defining concrete measures states should take to address the tobacco epidemic, and thus giving content to the right to health as it relates to tobacco control. (shrink)

There is perhaps no area of law that so effectively protects human health and thereby advances the right to the highest attainable standard of health, as tobacco control. Globally, tobacco is responsible for 1 in 10 adult deaths, and is on track to kill 10 million people per year, mostly in developing countries, representing a US$200 billion drain on the global economy. Yet experience in recent decades has shown that a range of tobacco control measures, such as comprehensive bans on (...) smoking in public places, tobacco taxes, and limits on tobacco advertising, can greatly reduce smoking prevalence. These measures have slowly curtailed the epidemic, despite strong opposition from various sectors led by the tobacco industry. It is fitting that tobacco control is the focus of a recent, widely ratified global treaty and of increasing national litigation, often directly linked to countries’ human rights commitments. (shrink)

This paper discusses the meaning of an image rarely used within the religious and philosophical corpus of ancient India in order to describe the ultimate nature of God and the human being: a wall or canvas (Sanskrit, bhitti). The usage of such a peculiar image belongs to Abhinavagupta, the great exegete of the Tantric tradition who lived in Kashmir between the tenth and eleventh centuries A.D. After presenting some antecedents, the paper focuses on key passages taken fromAbhinavagupta’s work and shows (...) how, far from being secondary, the image of a wall possesses a remarkable consistency and expressive power in accordance withAbhinavagupta’s doctrinal presuppositions, in particular his commitment to a dynamic and ultimately paradoxical view of the divine realm, the universe and salvation. (shrink)

Philosophical intervention in the dialogue between science and theology: an analysis of the concept of consonance In the last decades, a strong debate on the relationship between science and theology has taken place. In the early 1980, Ernan McMullin introduced the notion of “consonance”, defined as the spontaneous convergence of the conclusions presented by the natural sciences and theology on certain features or properties of the universe. In this paper, I shall try, first and foremost, to carefully look into the (...) meaning that has been attributed to this relationship. Thus, I shall examine the possible implications derived from specific cases of consonance; I shall consider the connection between consonance and truth ; I shall expand on the proposal for a dialogue based on different attitudes regarding consonance ; I shall evaluate the thesis that understands consonance as a cultural construction or an a priori accepted in certain contexts; finally, I shall mention certain variations of this concept, such as strong and weak consonance, or hypothetical consonance. Then, I shall explain the assumptions on which the idea of consonance rests: the unity and intelligibility of reality, the diversity of formal objects and the realism of knowledge. All these assumptions are comprehensive proof of the indispensable intervention of philosophy, as wisdom, in any kind of exchange that occurs between science and theology. And it is only from them that criticism regarding this issue is vested authority. Finally, I suggest a series of critical proposals on the notion of consonance. I shall stress, on the positive side, the opportunity that it offers to move towards a greater disciplinary integration and foster, at the same time, the ordering mission of philosophical wisdom. On the negative side, I shall point out the confusion between religion and theology, the tendency towards a kind of epistemic naturalism of theology, the uncertain creation of the idea of scientific realism and the aspiration to an excessive interference among disciplines. (shrink)

Este artículo busca saber en qué medida la iglesia de Saint Denis corresponde a las observaciones heideggerianas acerca del construir y del habitar, evidenciando el vínculo de Suger con las doctrinas de Dionisio, el pseudo-Areopagita, y Juan Escoto Eriúgena desde una perspectiva anagógica de la naturaleza y del mundo.

Este trabajo tiene por objeto demostrar la importancia de la Ética en las Constituciones políticas y Tratados internacionales desde la teoría de la virtud aristotélica. Dicho objeto es imprescindible debido al aumento de la frivolidad, decadencia institucional y corrupción política en diversos gobiernos y administraciones públicas contemporáneas.

A diferencia de las disciplinas en las que la reflexión sobre sí mismas no forma parte de ellas, en la filosofía, como lo testimonia la obra de filósofos pertenecientes a distintas épocas y tradiciones, desde Platón y Aristóteles hasta Wittgenstein o Husserl, esa reflexión ocupa una posición central. Dado que no existe un modo canónico de entender y practicar la filosofía, al menos uno que exceda el ámbito de una particular escuela o tradición, la reflexión sobre la propia disciplina resulta (...) ser más imperiosa que en otros ámbitos. Y lo es sobre todo en tiempos de crisis y de transformaciones, por lo que no es sorprendente que el siglo que acaba de finalizar, caracterizado justamente por una acumulación de cambios radicales o «giros», haya sido una época especialmente rica en producción metafilosófica. En el ámbito de la filosofía iberoamericana la filosofía de la filosofía ha tenido históricamente cierto número de manifestaciones, sobre todo en México a partir de la influencia de José Gaos. Actualmente, el cultivo de la problemática metafilosófica, signo de la madurez de una comunidad filosófica, está despertando un interés creciente entre filósofos iberoamericanos de distintas orientaciones. Con este volumen, cuyo objetivo es proporcionar una muestra variada y plural de la reflexión metafilosófica actual en español, se pretende asimismo estimular el desarrollo ulterior de este campo. (shrink)

In spite of the considerable literature nowadays existing on the issue of the moral exclusion of nonhuman animals, there is still work to be done concerning the characterization of the conceptual framework with which this question can be appraised. This paper intends to tackle this task. It starts by defining speciesism as the unjustified disadvantageous consideration or treatment of those who are not classified as belonging to a certain species. It then clarifies some common misunderstandings concerning what this means. Next, (...) it rejects the idea that there are different kinds of speciesism. Such an idea may result from confusion because there are (1) different ways in which speciesism can be defended; and (2) different speciesist positions, that is, different positions that assume speciesism among their premises. Depending on whether or not these views assume other criteria for moral consideration apart from speciesism, they can be combined or simple speciesist positions. But speciesism remains in all cases the same idea. Finally, the paper examines the concept of anthropocentrism, the disadvantageous treatment or consideration of those who are not members of the human species. This notion must be conceptually distinguished from speciesism and from misothery (aversion to nonhuman animals). Anthropocentrism is shown to be refuted because it either commits a petitio principia fallacy or it falls prey to two arguments: the argument from species overlap (widely but misleadingly known as “argument from marginal cases”) and the argument from relevance. This rebuttal identifies anthropocentrism as a speciesist view. (shrink)

Many people think we should refrain from intervening in nature as much as possible. One of the main reasons for thinking this way is that the existence of nature is a net positive. However, population dynamics teaches us that most sentient animals who come into existence in nature die shortly thereafter, mostly in painful ways. Those who survive often suffer greatly due to natural causes. If sentient beings matter, this gives us reasons to intervene to prevent such harms. This counterintuitive (...) conclusion can be opposed by arguing that we should not care about nonhuman animals; that other values, such as the existence of certain ecosystemic relations or of untouched wild areas, count for more than the interests of sentient beings; or that intervention in nature cannot succeed. There are, however, strong reasons to reject these claims and to support significant intervention in nature for the sake of animals, despite our deep-rooted intuitions to the contrary. (shrink)

ABSTRACTColin Hay's constructivist institutionalism and Vivien A. Schmidt's discursive institutionalism are two recent attempts to theorize ideas as potential explanations of institutional change. This new attention to the causal role of ideas is welcome, but Hay and Schmidt do not take into consideration the constitutive and structural aspects of ideas. Instead they reduce ideas to properties of individual conscious minds, scanting the respects in which ideas are intersubjectively baked into the practices shared by individuals. This aspect of ideas—arguably, the institutional (...) side of ideas—is developed in post-structuralist thought, which therefore demands a place in ideational research. (shrink)

El Espacio Europeo de Educación Superior (EEES) establece que el aprendizaje debe estar centrado en el estudiante. Partiendo de este enunciado, el artículo explica cómo la gamificación puede ser una técnica pedagógica que propicie el ansiado cambio en la docencia universitaria hacia donde marca el EEES. Este trabajo presenta el diseño de una metodología de gamificación sencilla y fácil de implementar en un Grado de Ingeniería utilizando Kahoot! como herramienta y su evolución a lo largo de tres cursos académicos. Los (...) resultados indican que los alumnos ven más atractiva la asignatura, aumenta el seguimiento y mejoran sus resultados académicos. (shrink)

El presente artículo pretende dar a conocer de manera general pero completa el pensamiento del filósofo y crítico italiano Giorgio Colli acerca del origen de la filosofía griega. Poniendo especial atención al paradigma nietzscheano de lo apolíneo, Colli considera el origendel logos racional en los sabios de la época arcaica a partir de la interpretación del oráculo de Apolo que seresenta a los hombres como un enigma. De este origen nacerán las dos características básicas del pensar arcaico que después se (...) plasmarán en la filosofía:su carácter polémico y su carácter destructivo. (shrink)

In this essay I argue that some aspects of aesthetic philosophy of music education are compatible with multicultural proposals. To show this I first distinguish between two different aspects of multicultural advocacy: one related to sociopolitical goals and one related to the inclusion of different musical traditions and practices in our music programs. These two conceptions of multiculturalism are complementary but can be distinguished for purposes of clarifying the relationship between aesthetic and multicultural assumptions about the value of multicultural music (...) education. I then consider how the multicultural interest for the appreciation of extramusical values can coexist with aesthetic education’s concerns .. (shrink)