Athlete after athlete in this book found discipline, hope, and inspiration on the playing field, rising above their circumstances. Filled with first-hand accounts from stars who exemplify the idea of enduring at all costs, Rising Above will serve as a must-read source of inspiration for kids and sports fans of all ages.

The Modern Synthesis has dominated biology for 80 years. It was formulated in 1942, a decade before the major achievements of molecular biology, including the Double Helix and the Central Dogma. When first formulated in the 1950s these discoveries and concepts seemed initially to completely justify the central genetic assumptions of the Modern Synthesis. The Double Helix provided the basis for highly accurate DNA replication, while the Central Dogma was viewed as supporting the Weismann Barrier, so excluding the inheritance of (...) acquired characteristics. This article examines the language of the Modern Synthesis and reveals that it is based on four important misinterpretations of what molecular biology had shown, so forming the basis of the four Illusions: 1. Natural Selection; 2. The Weismann Barrier; 3. The Rejection of Darwin’s Gemmules; 4. The Central Dogma. A multi-level organisation view of biology avoids these illusions through the principle of biological relativity. Molecular biology does not therefore confirm the assumptions of the Modern Synthesis. (shrink)

What is Life? To answer this question, Denis Noble argues that we must look beyond the gene's eye view. For modern 'systems biology' considers life on a variety of levels, as an intricate web of feedback between gene, cell, organ, body, and environment. He shows how it is both a biologically rigorous and richly rewarding way of understanding life.

This paper seeks to highlight the importance of spatial cognition in Bergson’s Données immédiates by engaging with Robert Watt’s reconstruction of Bergson’s argument that every idea of number involves the idea of space. We focus on the second stage of Watt’s reconstruction, where Bergson argues that only space can provide the distinction required for our counting of otherwise identical items. Watt bases his reconstruction on a premise regarding the possibility that identical objects, in the absence of spatial distinction, might remain (...) identical across different “temporal locations”. Our paper raises the prospect that Bergson is committed to a stronger thesis, namely one implying that identical objects would necessarily remain indistinguishable without the intervention of space. The paper thus concludes by emphasizing the indispensability of space for knowledge according to Bergson. (shrink)

The extensive range and depth of the twenty commentaries on my target article confirms that something has gone deeply wrong in biology. A wide range of biologists has more than met my invitation for “others to pitch in and develop or counter my arguments.” The commentaries greatly develop those arguments. Also remarkably, none raise issues I would seriously disagree with. I will focus first on the more critical comments, summarise the other comments, and then point the way forward on what (...) I view as a necessary and long-overdue transition in the foundations of biology. (shrink)

In this paper, we argue that Plotinus denies deliberative forethought about the physical cosmos to the demiurge on the basis of certain basic and widely shared Platonic and Aristotelian assumptions about the character of divine thought. We then discuss how Plotinus can nonetheless maintain that the cosmos is «providentially» ordered.

In the last book of The Consolation of Philosophy, Boethius develops his solution to the problem of divine foreknowledge and free choice. Interpreters standardly hold that this problem and his solution to it presuppose causal indeterminism. In this paper, I argue that Boethius, following a Neoplatonist view found in Proclus, is a causal determinist and compatibilist and maintains that God’s providential knowledge ensures the occurrence of all the events he knows. This alternative interpretation offers a better fit with Boethius’s text (...) and its historical antecedents and provides resources to address the main criticisms of his solution. (shrink)

This article discusses the function, development and maintenance of meaning and the importance of meaning-making from different perspectives, as it is based on a collaboration between professionals from health science and psychology. The aim is to discuss how meaning-making processes can be employed in the health context to enhance individuals’ well-being. Starting point is a description of the common basis of the understanding of meaning-making. Afterwards brief examples from the different professional areas will show how meaning-making can improve health care (...) practice. We will focus on the processual nature of meaning-making, its existential layers, as well as the ways in which meaning-making is at play in everyday activities and limit situations, such as illness or suicidality. (shrink)

In Ennead 3.6, Plotinus maintains that the soul is unaffectable. This thesis is widely taken to imply that his soul is exempt from change and free from emotional ‘affections’. Yet these claims are difficult to reconcile with evidence that Plotinian souls acquire dispositional states, such as virtues, and are subjects of emotional ‘affections’, such as anger. This paper offers an alternative account that aims to address these difficulties. In denying affections to soul, Plotinus is offering a distinction between the soul’s (...) self-actuated motions (or "activities") and the passive motions (or "affections") of bodies. But this distinction does not imply the soul’s changelessness, since Plotinus regards psychic motions that culminate in the soul’s acquisition of new dispositional states as changes. As for emotional ‘affections’, these (as activities) are merely homonymous with the affections denied to soul, and so do not violate the ban on the soul’s affectability. (shrink)

This article examines the issues that are at stake in the current resurgence of interest in the subject of habit. We focus on the role that habit has played in conceptions of the relations between body and society, and the respects in which such conceptions have been implicated in processes of governance. We argue that habit has typically constituted a point of leverage for regulatory practices that seek to effect some realignment of the relations between different components of personhood – (...) will, character, memory and instinct, for example – in order to bring about a specific end. In reviewing its functioning in this regard across a range of modern disciplines – philosophy, psychology, sociology – we explore the tensions between its use and interpretation in different lineages: in particular, the Cartesian–Kantian/ravaisson–bergson–deleuze lineages. The article then identifies how these questions are addressed across the contributions collected in this special issue. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life that pretends to (...) do completely without the distinction, while using agent-centred concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

In this paper, we demonstrate (1) how harnessing stochasticity can be the basis of creative agency; (2) that such harnessing can resolve the apparent conflict between reductionist (micro-level) accounts of behaviour and behaviour as the outcome of rational and value-driven (macro-level) decisions; (3) how neurophysiological processes can instantiate such behaviour; (4) The processes involved depend on three features of living organisms: (a) they are necessarily open systems; (b) micro-level systems therefore nest within higher-level systems; (c) causal interactions must occur across (...) all the boundaries between the levels of organization. The higher levels constrain the dynamics of lower levels. The experimental evidence and theoretical arguments are shown to be consistent with previous research on the neuronal mechanisms of conscious choice, and with the interconnected multi-level processes by which organisms harness stochasticity, whether conscious or unconscious. (shrink)

Many later thinkers in the Islamic world pick up on, and further expand, the idea of intuition (ḥads) as they react to Avicenna (Ibn Sīnā). Focusing on figures from the twelfth–thirteenth century, in this paper we will focus especially on the following points of debate: (1) Avicenna’s idea that intuition is distingiushed from normal (discursive) thought by lacking ‘motion’, (2) The question of how and why different individuals differ in the extent of their intuition, (3) The role of intuitive thought (...) in grounding knowledge: is intuition needed every time a certain item of knowledge is grasped for the first time, and hence without a teacher; and further, is intuition needed as an ultimate justification for all non-intuitive knowledge? (shrink)

For the mature Leibniz, a living being is a created substance composed of an infinitely complex organic body and a simple, immaterial soul. Soul and body do not interact directly, but rather their states correspond according to a harmony preestablished by God. I show that Leibniz’s theory faces challenges with respect to the question of whether substances need to possess knowledge of how they bring about their effects, and I argue that, to address these challenges, Leibniz turns to a concept (...) of “divine preformation” that he attributes to both soul and body. Insofar as divine preformation provides Leibniz with an explanation for how soul and body can both act without possessing explicit knowledge of what they are doing, it serves as a key tool for justifying the theory of preestablished harmony. (shrink)

The young Spinoza and the mature Leibniz both characterize the soul as a self-moving spiritual automaton. Though it is unclear if Leibniz’s use of the term was suggested to him from his reading of Spinoza, Leibniz was aware of its presence in Spinoza’s Treatise on the Emendation of the Intellect. Considering Leibniz’s staunch opposition to Spinozism, the question arises as to why he was willing to adopt this term. I propose an answer to this question by comparing the spiritual automaton (...) in both philosophers. For Spinoza, the soul acts as a spiritual automaton when it overcomes imaginative ideas and produces true ideas. For Leibniz, the soul acts as a spiritual automaton when it spontaneously produces its perceptions according to the universal harmony preestablished by God. Thus, for Leibniz contra Spinoza, the spiritual automaton is a means to render intelligible a providential order in which everything happens for the best. (shrink)

In this paper, I investigate the foundations of Plotinus’ innovative theory that prime matter is unaffectable. I begin by showing that Plotinus’ main arguments for this thesis (in Ennead 3.6) all rely upon the controversial assumption that the properties prime matter underlies are not properties of prime matter itself. It is then argued that prime matter’s privation of sensible qualities has its conceptual basis in an idiosyncratic understanding of form-matter composition generally, and its primary doctrinal basis in Aristotle’s critical reports (...) on the Platonists’ substratum in Physics 1.9. While Plotinus finds Platonic authority for unaffectible matter in the Receptacle passage of the Timaeus, it is Aristotle’s testimony that provides the crucial impetus for reading that text in this way. On this basis, Plotinus develops a Platonist conception of form’s inherence in matter with distinctively non-Aristotelian features. (shrink)

This article reports on a survey of DNA-related practices and procedures within District Attorneys' offices to obtain preliminary information about actual prosecutorial practices. The data obtained is preliminary but supportive of further study of areas targeted by the survey.

Plotinus maintains that there is a single first principle, the One (or the Good), from which all other things derive. He is usually thought to hold this view on the grounds that any other thing’s existence depends on its participation in a paradigm of unity. This paper argues that Plotinus has a further, independent argument for adopting a single first principle, according to which principle pluralism is committed (unacceptably) to attributing good cosmic states of affairs to chance. This argument exhibits (...) similarities to ancient design arguments, but is used to draw the more radical conclusion that there is only one non-derivative existent. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life that pretends to (...) do completely without the distinction, while using agent-centred concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life that pretends to (...) do completely without the distinction, while using agent-centered concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

In this paper we challenge the notion of ‘normativity’ used by some enactive approaches to cognition. We define some varieties of enactivism and their assumptions and make explicit the reasoning behind the co-emergence of individuality and normativity. Then we argue that appealing to dispositions for explaining some living processes can be more illuminating than claiming that all such processes are normative. For this purpose, we will present some considerations, inspired by Wittgenstein, regarding norm-establishing and norm-following and show that attributions of (...) normativity to non-social agents are deeply paradoxical. The main conclusions of our discussion are: (1) circular and internal explanations centred on the stability of living systems are insufficient to account for processes where the environment plays an important role, such as adaptation. Enactivism is not an explanatory alternative to evolutionary biology but needs it as a complement to accounts focused on the internal self-assembly of organisms; (2) though we share enactivism’s anti-representational spirit, we argue that ecological psychology can offer a better account of perception. (shrink)

This article presents results from an empirical investigation of the role and importance of ethics in the daily work of Danish oncologyphysicians and Danish molecular biologists. The study is based on 12 semi-structured interviews with three groups of respondents: a group of oncology physicians working in a clinic at a public hospital and two groups of molecular biologists conducting basic research, one group employed at a public university and the other in a private biopharmaceutical company.We found that oncology physicians consider (...) ethical evaluation as part of their daily work. They discuss how to treat patients in groups and they have interdisciplinary seminars. In contrast, molecular biologists employed at the university do not think that basic research causes significant ethical problems, they do not talk about ethics in their daily work and they do not want to prioritise seminars on ethics. Molecular biologists employed in a private biopharmaceutical company do not think that basic research causes significant ethical problems, but the private company prioritises ethical evaluation. If the company behaves unethical, they will be punished by the consumers and by the investors in the last end. In general, oncology physicians working in the clinic experience a closer relationship between their daily work and ethical problems concerning human beings than molecular biologists conducting basic research. (shrink)

This paper analyzes Leibniz’s use of analogies in both natural philosophical and metaphysical contexts. Through an examination of Leibniz’s notes on scientific methodology, I show that Leibniz explicitly recognizes the utility of analogies as heuristic tools that aid us in conceiving unfamiliar theoretical domains. I further argue that Leibniz uses the notion of a self-moving machine or automaton to help capture the activities of the immaterial soul. My account helps resist the conventional image of Leibniz as an arch-rationalist unconcerned with (...) methods of empirical discovery and contributes to ongoing discussions on the nature of immaterial substance and mind in Leibniz. (shrink)

Recent theorizing has emphasized the concept of "difference" and how its normative deployment orders our knowledge of the world. This ethical determination of how we know, however, is only half of a loop as difference has epistemological roots. It is precisely the concept '.s inherent connection to the epistemological demand that we must be certain of what we know that underprops it as a contemporary problematic. This demand is basic to philosophy since ancient times. We find it, for example, in (...) the late Platonic dialogues Theaetetus and Sophist as Plato endeavors to define and account for knowledge and true belief We also find this in Aristotle '.s Categories, which not only underpins his other philosophical works, but also founds the categorialism still current in philosophical thinking. We can think of categorial thinking as defining and structuring what we can know. And insofar as our knowledge guides our practice, categorial thinking also defines and structures our reality. In this essay, I perform a simple content analysis of the Categories. The aim is to look for difference and its variants, to count how many times they appear, to identify the general and specific contexts of their appearance, to find related terms and concepts in the specific context of the sentences that they appear in. The essay's analyses try to find explanations as to what Aristotle's concept of difference is, as to what Aristotle think of it as it appears in various contexts in the Categories, as to how it reflects the structure of our knowledge of the world, and as to how it likewise reflects the manner by which we attempt to structure or order our world. (shrink)

A clean energy future is both plausible and in the best interests of the country. The Upper Midwest, acting in concert with appropriate policy changes at the national level, could play a pivotal role in helping the nation move in that direction. As the past century’s embrace of centralized power is beginning to weaken, a variety of policy drivers, including concerns about energy system capacity and reliability, the improvement of public health by reducing pollution, the enhancement of national security by (...) decreased reliance on nuclear power, and the need to curtail greenhouse gas emissions, are beginning to make clear the outlines of this energy transition. The proposals offered by the Environmental Lawand Policy Center and Minnesotans for an Energy-Efficient Economy rely on proven, economical, and environmentally sustainable technology options. An aggressive development plan featuring efficiency, wind, and other renewable resources will be a significant first step in solving the climate change problem. (shrink)

During Advent we prayerfully consider how Jesus was born to save us from death through his incarnation, death, and resurrection. Remembering this in light of your own death can change your life. Mememto mori or "remember your death" is a phrase long associated with the practice of remembering the unpredictable and inevitable end of one's life. This book is the latest in a series of books by Sr. Theresa Alethia Noble, FSP, that explores the traditional Christian practice of meditation (...) on death in light of Christ. This book will help you to connsider the four Last Things: death, judgment, hell, and heaven in the context of Advent. -- Adapted from back cover. (shrink)

Systems Biology is the study of the interactions between the elements (genes, proteins and other molecules) of living systems. Genes do not act in isolation either from each other or from the environment, and so I replace the metaphor of the selfish gene with metaphors that emphasise the processes involved rather than the molecular biological components. This may seem a simple shift of viewpoint. In fact it is revolutionary. Nothing remains the same. There is no 'book of life', nor are (...) there 'genetic programs'. The consequences for the study of the brain and the nature of the self are profound. They lead naturally to the concept of anātman, no-self, and to a better understanding of the relation between the microscopic and macroscopic views of the world. Organisms are viewed as variable open systems, rather than as determinate closed systems. (shrink)