There is limited knowledge about cancer patients' experiences of uncertainty while waiting for genome sequencing results, and whether prolonged uncertainty contributes to psychological factors in this context. To investigate uncertainty in patients with a cancer of likely hereditary origin while waiting for genome sequencing results, we collected questionnaire and interview data at baseline, and at three and 12 months follow up. Participants had negative attitudes towards uncertainty at baseline, and low levels of uncertainty at three and 12 months. Uncertainty about (...) genome sequencing did not change significantly over time [t = 0.660, p = 0.510]. Greater perceived susceptibility for cancer [r = 0.14, p < 0.01], fear of cancer recurrence [r = 0.19, p < 0.01], perceived importance of genome sequencing [r = 0.24, p < 0.01], intention to change behavior if a gene variant indicating risk is found [r = 0.29, p < 0.01], perceived ability to cope with results [r = 0.36, p < 0.01], and satisfaction with decision to have genome sequencing [r = 0.52, p < 0.01] were significantly correlated with negative attitudes towards uncertainty at baseline. Multiple primary cancer diagnoses [B = −2.364 [−4.238, −0.491], p = 0.014], lower perceived ability to cope with results [B = −0.1.881 [−3.403, −0.359], p = 0.016] at baseline, greater anxiety about genome sequencing [B = 0.347 [0.148, 0.546], p = 0.0012] at 3 months, and greater perceived uncertainty about genome sequencing [B = 0.494 [0.267, 0.721] p = 0.000] at 3 months significantly predicted greater perceived uncertainty about genome sequencing at 12 months. Greater perceived uncertainty about genome sequencing at 3 months significantly predicted greater anxiety about genome sequencing at 12 months [B = 0.291 [0.072, 0.509], p = 0.009]. Semi-structured interviews revealed that while participants were motivated to pursue genome sequencing as a strategy to reduce their illness and risk uncertainty, genome sequencing generated additional practical, scientific and personal uncertainties. Some uncertainties were consistently discussed over the 12 months, while others emerged over time. Similarly, some uncertainty coping strategies were consistent over time, while others emerged while patients waited for their genome sequencing results. This study demonstrates the complexity of uncertainty generated by genome sequencing for cancer patients and provides further support for the inter-relationship between uncertainty and anxiety. Helping patients manage their uncertainty may ameliorate psychological morbidity. (shrink)

Since at least as far back as the infamous Derek Bentley case of the 1950s in which an unarmed 19-year-old was convicted and executed for murder based on his alleged uttering of the words _let him have it_ to his gun-wielding accomplice, the issue of incitement has been positioned firmly as an object of interest for forensic linguists. An example of a language crime—i.e. an unlawful speech act (as reported by Shuy in Language crimes: The use and abuse of language (...) evidence in the courtroom, Wiley Blackwell, Hoboken, 1993) the features of incitement—formalized as _intentionally encouraging or assisting others to commit an offence_ in the law of England & Wales under section 44 of the Serious Crime Act 2007 (https://www.legislation.gov.uk/ukpga/2007/27/contents)—have been widely debated by linguists and legal scholars alike. This paper draws on two webinars hosted by The Hunting Office in August 2020, which were subsequently leaked by the Hunt Saboteurs Association. Featuring senior figures from the hunting community addressing a nationwide audience of hunt masters, the webinars led to a police investigation and subsequent prosecution and conviction of one of the main speakers, Mark Hankinson, for _encouraging or assisting others to commit an offence under the Hunting Act 2004_. In this paper I explore what, linguistically, is meant by _encouraging or assisting_. Through corpus-assisted pragmatic and discourse analyses I interrogate the webinars to address the question of how precisely Hankinson implied his encouragement of illegal hunting with dogs. The phenomena of collocation and semantic prosody are crucial for understanding how such meanings came to be attached to the contributions Hankinson makes to the webinars. Moreover the paper will examine the contributions of other speakers and demonstrate that the same incriminating linguistic patterns in Hankinson’s talk are also evident in that of those who were not prosecuted. (shrink)

_Quantum Theory and the Schism in Physics_ is one of the three volumes of Karl Popper’s _Postscript to the Logic of scientific Discovery_. The_ Postscript_ is the culmination of Popper’s work in the philosophy of physics and a new famous attack on subjectivist approaches to philosophy of science. Quantum Theory and the Schism in Physics is the third volume of the _Postscript_. It may be read independently, but it also forms part of Popper’s interconnected argument in the _Postscript_. It presents (...) Popper’s classic statement on quantum physics and offers important insights into his thinking on problems of method within science and physics as a whole. (shrink)

The paper aims to put certain basic mathematical elements and operations into an empirical perspective, evaluate the empirical status of various analytic operations widely used within psychology and suggest alternatives to procedures criticized as inadequate. Experimentation shows the "manyness" of items to be a perceptual quality for both young children and animals and that natural operations are performed by naive children analogous to those performed by persons tutored in arithmetic. Number, counting, arithmetic operations therefore can make distinctions that are not (...) inevitably arbitrary, and conceptual operations can obviously have a status as natural events with psychology. If the elements and conceptual operations involved in mathematical systems were not inherent in physiological process, various primitive discriminations could not be possible. Also, since some calculi have a natural status in a given empirical circumstance, the axioms of others can not be satisfied. Therefore the psychologist when acting as an empirical scientist seeks a calculus having a structure whose elements are isomorphic with natural units of stimulus and response and whose operations are isomorphic with whatever natural processes are involved. Measurement poses a special problem for the empirical scientist. It concerns but a single class of natural qualities and this only in a limited way. The concept of quantity has a natural counterpart but quantity and measurement are not wholly analogous. Measurement is defined, as H. S. Leonard suggests, as a theoretical activity. Measurement theory has a formal structure but empirical end. Measurement hypothesizes about the position of a particular quality within a definite range of qualities. It therefore is beholden to definite empirical restrictions. Some hypotheses-making systems use terms and relations per se as the context and starting point for dealing with discriminable events. Such procedures are 'transcendent." In empirical science, questions are part of problem-solving activity and their reference is naturally restricted. In providing description and explanation, psychological researchers frequently use calculi in a transcendent way. This results in theories that are only quasi-empirical and "half" true. The roles measurement plays in psychology are discussed. Of particular concern are those cases in which the results of measuring or a theory of measurement are used to define the "real" units, or the "real" relations involved in problematic psychological events, and thence to describe and explain behaviors of interest. Metaphysical or ontological usages of measurement sometimes occur. The implication of these arguments with regard to a view of empirical science is discussed. (shrink)

The Alaska National Interest Lands Conservation Act of 1980 requires federal agencies to provide a meaningful role for rural subsistence harvesters in management of fish and wildlife in Alaska. We constructed an interpretive analysis of qualitative interviews with residents of the Yukon-Kuskokwim Delta. Stakeholders' perceptions of their roles and motivations to participate in collaborative management are linked to unseen and often ignored cultural features and differing worldviews that influence outcomes of collaboration. Agencies need to better understand Yup'ik preferences for working (...) together and change their formats and methods of public engagement. More frequent and higher quality interactions among stakeholders in rural communities will create awareness of cultural differences. Improved awareness will allow managers to design and implement a process that is culturally appropriate and increase the meaningfulness of collaborative management. (shrink)

Systems of private regulation based on certification have recently emerged to address environmental issues in the forest products industry and labor issues in the apparel industry. To explain why the same regulatory form has emerged across these fields, the author uses a historical and comparative case study approach, closely examining early moments and paying attention to “roads not taken.” Two types of factors led to the initial emergence of private certification: social movement campaigns targeting companies and a neo-liberal institutional context. (...) The analysis shows specific ways in which these factors led states, nongovernmental organizations, and companies to build or support certification associations. (shrink)

This work opens with a development of the notion of Unfathomed Knowledge, which Bartley makes clear by using it to explain such recent scientific advances as the development of drugs for the treatment of AIDS, and by showing its implications for such far-flung fields as the Marxist theory of alienation, the sociology of knowledge, patent law, and morality.

C.J. Bartley places Ramunuja in his intellectual context. This study is particularly concerned with Ramanuja's engagement with opposing schools of thought and practice, rendering it a valuable contribution to the history of Indian thought.

The implementation of transnational standards — in codes of conduct, certification, and monitoring initiatives — necessarily intertwines with domestic law and other types of rules. Yet much of the existing literature overlooks or obscures this fundamental point. Indeed, scholars often err either by treating private regulatory standards as transcendent or by viewing implementation as fundamentally a technical problem. This Article argues that understanding the operation of transnational private regulation requires attention to the layering of multiple rules in a given location. (...) It develops a framework for examining this layering and illustrates it by briefly looking at two major issues—community rights in sustainable forestry standards and freedom of association in fair labor standards — and their implementation in Indonesia. In various ways, these domains illustrate how conflict and complementarity between public and private standards structure the practice of private regulation. (shrink)

While Wallace disagreed with Darwin that domesticates provided a great deal of useful information on wild populations,71 Darwin continued to draw on his domesticated animals and plants to inform him on the workings of his theory. Unlike Wallace, his exposure to natural populations was extremely limited after his return from the Beagle voyage. By the 1850s, he had settled into a life at Down House and was becoming more and more withdrawn from London scientific circles. He turned to his network (...) of informants, visits from colleagues such as Hooker and T. H. Huxley, subscriptions to various journals, and his own experimental studies at Down.This work on domesticates was clearly related to other natural history studies conducted by Darwin and others during the same period. For example, during the 1850s when Darwin worked on domesticates, he was also engaged in questions of geographic distribution. To study the dispersal and subsequent viability of introduced seeds, he soaked various seeds in a tub filled with seawater and counted which of the seeds floated after a given period; later he planted the seeds in the yard at Down to look for potential viability. There was no attempt at controlled, replicated experiments in these studies, or in his work with domesticates, nor should there have been. To Darwin the results of one experiment represented a potential truth of nature, and he was quick to seize upon these results as supporting evidence for his theory.I have suggested in this paper that his work on domesticates was not simply meant to provide an analogy for natural selection but rather became a research program to investigate other aspects of his natural selection theory, especially inheritance and variability; these subjects were integral parts of his theory of natural selection, but by 1859 he had not found a mechanism to account for them. The experiments brought home the difficult problems of inheritance, and Darwin specifically formulated pangenesis to account for these problems. Pangenesis was not an afterthought but an integration of several decades of thinking on inheritance. It was a unified theory to explain the complicated results he witnessed in his own experiments.Much of the Darwin scholarship has focused on Darwin's path toward the discovery of natural selection. Natural selection per se was a major interest, but not the only area of interest to Darwin. Inheritance was an area of serious concern for him both before and after he had formulated natural selection. His experimentation with domesticates was an attempt to look beyond natural selection and to concentrate on the difficult subject of inheritance. He found inheritance especially troublesome, requiring a “provisional hypothesis” to account for it. To see domesticates, as they are described in the Origin, as merely an analogy for natural selection, does not account for the importance Darwin placed on them. For him they were not man's monstrous productions, but worthy experimental subjects providing him with crucial information on inheritance. (shrink)

This paper explores a case example of qualitative research that applied productive hermeneutics and the central concept, fusion of horizons. Interpretation of meaning is a fusing of the researchers’ and subjects’ perspectives and serves to expand understanding. The purpose is to illustrate an exemplar of qualitative research without establishing a rigid recipe of methodology. The illustration is based on in-depth observational and textual data from an applied anthropological study conducted in western Alaska with Yup’ik hunters and fishers and government agency (...) employees as they worked towards collaborative management. The metaphor of the hermeneutical circle is showcased to help the reader understand the philosophical underpinnings and the analytical processes used to realize a meaningful interpretation. A series of organizing systems for the interpretation is described, culminating in a final organizing system to communicate a fully realized understanding of collaborative management at the time. (shrink)

I argue that good communication is vital to philosophy’s project of understanding truth. I consider what good communication would involve, especially with regards to the needs of a popular philosophy magazine such as Philosophy Now. What makes a good or bad article? And how can one edit oneself for clarity? Finally I consider the difference the internet makes. and some of its implications for future philosophers.

This alphabetical handbook defines and explains key concepts in classical Indian philosophy, identifies controversial issues, describes major traditions of thought, and locates influential thinkers in their intellectual and religious contexts. Extensive cross-referencing provides users with an overview of systematic doctrines and disagreements. While many entries deal with fundamentals, others explain technicalities usually overlooked in Western writings about Indian thought, making Indian Philosophy A-Z a unique resource for both beginners and specialists in the fields of Indian religions and philosophies.Features* The only (...) handbook of its kind* Written in non-technical language* Extensive cross-referencing. (shrink)

The significance of the de Broglie/Bohm hidden-particle position in the relativistic regime is addressed, seeking connection to the single-particle Newton–Wigner position. The effect of non-positive excursions of the ensemble density for extreme cases of positive-energy waves is easily computed using an integral of the equations of motion developed here for free spin-0 particles in 1 + 1 dimensions and is interpreted in terms of virtual-like pair creation and annihilation beneath the Compton wavelength. A Bohm-theoretic description of the acausal explosion of (...) a specific Newton–Wigner-localized state is presented in detail. The presence of virtual pairs found is interpreted as the Bohm picture of the spatial extension beyond single point particles proposed in the 1960s as to why space-like hyperplane dependence of the Newton–Wigner wavefunctions may be needed to achieve Lorentz covariance. For spin-1/2 particles the convective current is speculatively utilized for achieving parity with the spin-0 theory. The spin-0 improper quantum potential is generalized to an improper stress tensor for spin-1/2 particles. (shrink)