Exercise may influence components of executive functioning, specifically cognitive control and action monitoring. We aimed to determine whether high level exercise improves the efficacy of cognitive control in response to differing levels of conflict. Fitter individuals were expected to demonstrate enhanced action monitoring and optimal levels of cognitive control in response to changing task demands. Participants were divided into the highly active or low-active group based on self-reported activity using the International Physical Activity Questionnaire. A modified flanker task was then (...) performed, in which the level of conflict was modulated by distance of distractors from the target and congruency of arrows. Electroencephalography was collected during 800 trials; trials were 80% congruent, 20% incongruent, 50% close, and 50% far. The error-related negativity and error positivity were extracted from the difference wave of correct and incorrect response locked epochs, the N2 from the difference wave of congruent and incongruent stimulus locked epochs and the P3 from stimulus locked epochs. The HA group showed a larger Pe amplitude compared to the low-active group. Close trials elicited a larger N2 amplitude than far trials in the HA group, but not the low-active group, the HA group also made fewer errors on far trials than on close trials. Finally, the P3 was smaller in the lowest conflict condition in the HA, but not the low-active group. These findings suggest that habitual, high levels of exercise may influence the endogenous processing involved in pre-response conflict detection and the post-error response. (shrink)

ABSTRACT:Suicide is a worldwide public health issue, and suicide ideation and behavior among adolescents, females in particular, have been increasing. Focusing on the risk factors that are unique to adolescents and adolescent females can help tailor and inform prevention strategies. There are unique biological, psychological, social, and societal factors that contribute to suicide ideation and behavior among adolescent females. Some of these include hormonal fluctuations and sensitivity, developing brain systems, impacts of social media, maladaptive coping, and peer influence. These changes (...) do not occur in a vacuum and have recently been impacted by the COVID-19 pandemic, which has been associated with increased social isolation and decreased mental health. By identifying how these factors coalesce and interact to drive suicide ideation and behavior, we can derive potential solutions to this problem. Given the variability in individuals, families, and communities, and the interacting and reinforcing nature of these risk factors, a multi-pronged approach that incorporates multiple interventions and involves families, schools, and communities is needed. (shrink)

The 2017–2018 basic income pilot in the Canadian province of Ontario attempted to alleviate poverty in a precarious economy. With three communities participating, we examine how the pilot was framed by local media, permitting a look at the narratives that were dominant in the participating communities. In essence, were recipients framed as “deserving?” How the media addresses this question can set the foundation for whether policymakers can proceed with basic income. Given that media coverage of poverty alleviation in the United (...) States generally follows an episodic frame, which puts focus on individuals and their particular circumstances (i.e. lifestyle choices), while major Canadian media generally shows a mix of frames, results of a media content analysis at the local level shows basic-income pilot was covered mainly through thematic frames, which emphasizes systemic factors and more general social conditions, which support state action on basic income. (shrink)

Are the commands and exhortations of the Lord Jesus directed to his disciples only or are they directed to all mankind? The question arises from an examination of traditional Jewish teaching, around the time of Jesus's life in Palestine, that Jewish Law applies only to Jews. Seeing that there is no way of knowing what God requires of humans unless he reveals his requirements, and seeing that God's revealing of any requirements he has made has been carried out by Jesus (...) the Christ and, further, that the best evidence for his teachings are the accounts of his teaching in the New Testament, this article examines it and concludes that his Law applies only to his disciples. (shrink)

Metaphors used to describe new technologies mediate public understanding of the innovations. Analyzing the linguistic, rhetorical, and affective aspects of these metaphors opens the range of issues available for bioethical scrutiny and increases public accountability. This article shows how such a multidisciplinary approach can be useful by looking at a set of texts about one issue, the use of a newly developed technique for genetic modification, CRISPRcas9.

To assess the effectiveness of Visual Thinking Strategies in medical education curricula, a pretest–posttest experimental study design was used to evaluate the impact of participating in VTS workshops on first-year medical students. A total of forty-one intervention and sixty comparative students completed the study which included the analysis of clinical images followed by a measurement of word count, length of time analyzing images, and quality of written observations of clinical images. VTS training increased the total number of words used to (...) describe clinical images, the time spent analyzing the images, and the number of clinically relevant observations. (shrink)

Although critical reception of discourse markers (DMs) such as like and you know has often been noted, surprisingly little research has actually investigated this attitudinal perspective on usage. Moreover, a recent, rapidly expanding body of research on non-L1 speakers’ use of discourse markers in English has suggested that their more or less frequent use of specific markers may be due to familiarity with these markers and positive or negative marker perceptions. The present study presents the results of a survey measuring (...) British English L1 speakers’, English as Foreign Language (EFL) learners’, and English as a Lingua Franca (ELF) speakers’ perceptions of the discourse markers so, like, well and you know and their reactions to either abundance or lack of DMs. The survey measured speaker attitudes by asking participants to evaluate the usage of other DMs. We found that L1, EFL, and ELF have varying attitudes about certain markers, and these markers are perceived differently for traits like politeness and friendliness. Generally speaking, L1 speakers were more positively disposed towards markers than either of the other groups, who in their turn rated the propositional functions of the markers as more acceptable than interactional functions. (shrink)

Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of movement disorders including Parkinson's Disease. Despite its therapeutic benefits, STN-DBS has been associated with adverse effects on mood and cognition. Specifically, apathy, which is defined as a loss of motivation, has been reported to emerge or to worsen following STN-DBS. However, it is often challenging to disentangle the effects of STN-DBSper sefrom concurrent reduction of dopamine replacement therapy, from underlying PD pathology or from disease (...) progression. To this end, pre-clinical models allow for the dissociation of each of these factors, and to establish neural substrates underlying the emergence of motivational symptoms following STN-DBS. Here, we performed a systematic analysis of rodent studies assessing the effects of STN-DBS on reward seeking, reward motivation and reward consumption across a variety of behavioral paradigms. We find that STN-DBS decreases reward seeking in the majority of experiments, and we outline how design of the behavioral task and DBS parameters can influence experimental outcomes. While an early hypothesis posited that DBS acts as a “functional lesion,” an analysis of lesions and inhibition of the STN revealed no consistent pattern on reward-related behavior. Thus, we discuss alternative mechanisms that could contribute to the amotivational effects of STN-DBS. We also argue that optogenetic-assisted circuit dissection could yield important insight into the effects of the STN on motivated behavior in health and disease. Understanding the mechanisms underlying the effects of STN-DBS on motivated behavior-will be critical for optimizing the clinical application of STN-DBS. (shrink)

The discipline of affective neuroscience is concerned with the underlying neural substrates of emotion and mood. This review presents an historical overview of the pioneering work in affective neuroscience of James and Lange, Cannon and Bard, and Hess, Papez, and MacLean before summarizing the current state of research on the brain regions identified by these seminal researchers. We also discuss the more recent strides made in the field of affective neuroscience. A final section considers different hypothetical organizations of affective neuroanatomy (...) and highlights future directions for the discipline. (shrink)

Alexithymia, psychological distress, and posttraumatic stress disorder (PTSD) are highly related constructs. The ongoing debate about the nature and relationship between these constructs is perpetuated by an overreliance on cross-sectional research. We examined the longitudinal interactive relationship between alexithymia, psychological distress, and PTSD. We hypothesised that there is an interactive relationship between the three constructs. Military personnel (N = 1871) completed the Toronto Alexithymia Scale, the Kessler 10 and a PTSD Checklist (PCL-C) at pre-deployment, post-deployment, and at 3–4 years following (...) the post-deployment assessment. We initially tested whether psychological distress is either a moderator or mediator in the relationship between alexithymia and PTSD across the time points. General psychological distress was a partial mediator of total PTSD severity and hyperarousal symptomology at all three time points. Psychological distress fully mediated re-experiencing and avoidance symptomology at all three time points. Our results suggest that those with alexithymia are at longitudinal risk of developing more severe PTSD symptomology and experiencing hyperarousal irrespective of temporal proximity to traumatic exposure. Further, vulnerability to the emergence of re-experiencing and avoidance symptomology for those with alexithymia is increased when one experiences greater distress. Our results show that alexithymia is a persistent risk factor for PTSD symptomology. (shrink)

New techniques have made genome modification cheaper, easier, and faster than before, leading to a boom in research—both “basic” research and research applied to many species, and to germlines as well as somatic cells, with especially strong interest in biomedical uses. Given the scope and potential power of this work, it is vital that people be provided with accurate information about what is being done or proposed, and why. Such information is crucial to their making good decisions both in their (...) private roles as patients and in their public roles as citizens. Communicating this information, however, is not easy.Metaphors can be useful in explaining these kinds of complex biological processes. They present the... (shrink)

Bourdieu’s thought is disturbing. Provocative. Scandalous even, at least for those who do not easily tolerate the unmitigated truth about the social. Nonetheless his ideas, among the most important and innovative of our time, are here to stay. This thought has taken form in the course of a career and through works on diverse subjects that have constructed a far-reaching analytical model of social life, which the author calls more readily an anthropology rather than a sociology. In their totality, they (...) constitute today an original and powerful proposal to explain human practices. In the face of criticisms commonly leveled at Bourdieu’s thought (notably the charge that it reduces everything to a single schematic model), it is important to identify the spirit of his enterprise. Early on, it is true, his thought drew on a few fundamental concepts—the trilogy habitus, field (champ), practice (pratique)—to which it constantly returned, and followed a clearly defined trajectory. At the same time, however, he continually reformulated, adapted, and refined his analytical model, depending on the operations to which he subjected new objects of inquiry. The regenerative and transformative force of his thought was supported by two convictions. First, that there being nothing more vain than theory for theory’s sake, it is preferable that theoretical production originate in the study of concrete and occasionally very specific cases. Second, that in order to escape stereotypical classifications, boundaries separating disciplines are best transgressed, thereby favoring new constructions of the object of inquiry. (shrink)

Studies have shown that during social interaction a shared system underlies inferring one’s own mental state, and the mental states of others – processes often referred to as mentalization. However, no validated assessment has been developed to measure second order mentalization, or whether this capacity plays a significant role in social interaction. The current work presents a interactive mentalization theory, which divides these directional and second order aspects of mentalization, and investigates whether these constructs are measurable, stable, and meaningful in (...) social interactions. We developed a 20-item, self-report interactive mentalization questionnaire in order to assess the different sub-components of mentalization: self–self, self–other, and other–self mentalization. We then tested this scale on a large, online sample, and report convergent and discriminant validity in the form of correlations with other measures, as well as correlations with social deception behaviors in real online interaction with Mturk studies. These results validate the IMQ, and support the idea that these three factors can predict mentalization in social interaction. (shrink)

A review of Meaghan Morris, Siu Leung and Stephen Chan Ching-kiu,_ Hong Kong Connections: Transnational Imagination in Action Cinema _.

It is pictures rather than propositions, metaphors rather than statements, which determine most of our philosophical convictions. Bioethics has been particularly attentive to the role of metaphors in the discourse on moral issues in medicine. In The Physician’s Covenant, William May discusses how the various metaphors of the physician influence the manner in which we analyze problems in clinical ethics. Meaghan O’Keefe and colleagues have argued that particular metaphors dominate and in turn mediate the representation of genetic modification to (...) the public’. Craig Klugman has analyzed the power of various metaphors used in the discussion of... (shrink)

The book includes contributions by Sarah-Jayne Blakemore, George F. R. Ellis, Christopher D. Frith, Mark Hallett, David Hodgson, Owen D. Jones, Alicia Juarrero, J. A. Scott Kelso, Christof Koch, Hans Küng, Hakwan C. Lau, Dean Mobbs,...

The American poet Alice Notley has described one of her goals as being to take up ‘as much literary space as any male poet’ (Notley, 2005: 6), a phrase that questions the nature of ‘literary space’, and its relationship to material and political spaces. In Disobedience (2001), as in her earlier book The Descent of Alette (1992), the city is imagined in relation to what lies beneath it. Both of these extended poem sequences set up urban underground geographies, Alette – (...) a mythical underground of caves and ghostly trains, and Disobedience – a largely subterranean Paris that shifts between the ‘real’ metro and a series of filmic dreamscapes. In challenging the scope and scale of canonical epics with feminist reconfigurations of form, her work engages with the public space of the city. This article will explore the connection between the extended poetic forms she uses in these two books, and ways in which her work conceptualizes the gendering of city space through relationships between the body and language. Through reference to readings of Michel de Certeau by Meaghan Morris and Doreen Massey, I will show how Notley's approach to problems of language and form, and their potential solutions, are not only enmeshed in certain spatial concepts but also able to offer a critique of them. (shrink)