With the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), global researchers were confronted with major challenges. The German National Pandemic Cohort Network (NAPKON) was launched in fall 2020 to effectively leverage resources and bundle research activities in the fight against the coronavirus disease 2019 (COVID-19) pandemic. We analyzed the setup phase of NAPKON as an example for multicenter studies in Germany, highlighting challenges and optimization potential in connecting 59 university and nonuniversity study sites. We examined the ethics application (...) process of 121 ethics submissions considering durations, annotations, and outcomes. Study site activation and recruitment processes were investigated and related to the incidence of SARS-CoV-2 infections. For all initial ethics applications, the median time to a positive ethics vote was less than two weeks and 30 of these study sites (65%) joined NAPKON within less than three weeks each. Electronic instead of postal ethics submission (9.5 days (Q1: 5.75, Q3: 17) vs. 14 days (Q1: 11, Q3: 26), p value = 0.01) and adoption of the primary ethics vote significantly accelerated the ethics application process. Each study center enrolled a median of 37 patients during the 14-month observation period, with large differences depending on the health sector. We found a positive correlation between recruitment performance and COVID-19 incidence as well as hospitalization incidence. Our analysis highlighted the challenges and opportunities of the federated system in Germany. Digital ethics application tools, adoption of a primary ethics vote and standardized formal requirements lead to harmonized and thus faster study initiation processes during a pandemic. (shrink)

We have evolved to become who we are, at least in part, due to our general drive to create new things and ideas. When seeking to improve our creations, ideas, or situations, we systematically overlook opportunities to perform subtractive changes. For example, when tasked with giving feedback on an academic paper, reviewers will tend to suggest additional explanations and analyses rather than delete existing ones. Here, we show that this addition bias is systematically reflected in English language statistics along several (...) distinct dimensions. First, we show that words associated with an increase in quantity or number (e.g., add, addition, more, most) are more frequent than words associated with a decrease in quantity or number (e.g., subtract, subtraction, less, least). Second, we show that in binomial expressions, addition-related words are mentioned first, that is, add and subtract rather than subtract and add. Third, we show that the distributional semantics of verbs of change, such as to improve and to transform, overlap more with the distributional semantics of add/increase than subtract/decrease, which suggests that change verbs are implicitly biased toward addition. Fourth, addition-related words have more positive connotations than subtraction-related words. Fifth, we demonstrate that state-of-the-art large language models, such as the Generative Pre-trained Transformer (GPT-3), are also biased toward addition. We discuss the implications of our results for research on cognitive biases and decision-making. (shrink)

While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)

Die sozial- und kulturwissenschaftliche Erforschung auditiver Phänomene ist stets mit spezifischen Wissensformen konfrontiert. Die Rolle, die Musik und andere Klänge in verschiedenen sozialen und kulturellen Kontexten spielen, hängt mit dem Wissen zusammen, welches in bestimmter Weise (re)produziert und vermittelt wird. Wir können etwas über Klänge wissen, oder etwas durch Klänge wissen. Wir können Wissen über die spezifische Erzeugung von Klängen erwerben und weitergeben, oder aber Nachrichten – etwa eine Warnung – klanglich übermitteln. Diese vielfältigen Formen von Klangwissen können auf sehr (...) unterschiedliche Weisen zum Gegenstand wissenschaftlicher Untersuchungen gemacht werden. Der vorliegende Band zu auditiven Wissenskulturen ist ein Versuch, jene üblicherweise in verschiedenen Disziplinen wie Soziologie und Anthropologie, in Geschichte, Psychologie, Ethnologie und Philosophie der Musik oder in Medienwissenschaften verorteten Zugänge zu auditivem Wissen in ein produktives interdisziplinäres Gespräch zu bringen. (shrink)

Resumen: Este artículo tiene como propósito interpretar los pensamientos de Karl Jaspers y Martin Heidegger con los parámetros amalgama y sinergia de Cristóbal Holzapfel, y a partir de estos derivar proyecciones hacia la ontoepistemología de las ciencias sociales y humanas. Para esto se lleva a cabo un análisis comparativo entre las principales estructuras existenciales del esclarecimiento existencial presente en "Filosofía II" de Jaspers y la analítica existencial presente en "Ser y tiempo" de Heidegger. A partir de las amalgamas evidenciadas (...) entre ambas analíticas se deducen determinados existenciales que son analizados en su sinergia epistémica y proyectados hacia el esbozo de una posible ontoepistemología con base en las estructuras: concepto de ser humano, relación sujeto-objeto y relación investigador-investigado. Se obtuvo una concepción situada y proyectiva de ser humano, una relación sujeto-objeto como escisión compleja y una relación investigador-investigado fundada en una comunicación existencial enmarcada en la tradición discursiva de su respectiva comunidad semiótica.: This article intends to interpret the thoughts of Karl Jaspers and Martin Heidegger with the parameters amalgam and synergy of Cristóbal Holzapfel in order to propose an ontoepistemology of the social and human sciences. For this objective, a comparative analysis is carried out between the main existential structures of the existential enlightenment present in "Philosophy II" of Jaspers and the existential analytic present in "Being and time" of Heidegger. From the amalgams evidenced between the two analytics, certain existential are deduced that are analyzed in their epistemic synergy and projected towards the outline of a possible ontoepistemology based on the structures: concept of human being, subject-object relationship and researcher-researched relationship. It was obtained a situated and projective conception of the human being, a subject-object relationship as a complex cleavage and a researcher-researched relationship founded on an existential communication framed in the discursive tradition of their respective semiotic community. (shrink)

Introduction Perhaps more than any other member of the Frankfurt School, Herbert Marcuse articulated a hope for a radically transfigured world. He imagined a world characterized by receptive, generous relationships rather than domination and violence. Yet Marcuse's philosophy of liberation has been placed on trial within various critical circles. Michel Foucault's rejection of the “repressive hypothesis” and his concomitant analysis of power as generative is typically interpreted as an indirect response to Marcuse's tendency to treat the social order as a (...) primarily repressive force vis-à-vis our instincts and desires.1 Martin Jay has expressed concerns about the…. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Three Odes HORACE (Translated by Charles Martin) To Marcus Vipsanius Agrippa No fears, Agrippa: your exploits will be Saluted by a bard who will eclipse Homer in singing your command of ships, Your winning use of cavalry. It won’t be us. Gifts far surpassing mine Are to be found in Varius, who sings Achilles’ spleen, Ulysses’ wanderings At sea, or Pelops’ nasty line. Of loftiness, we have (...) a deficit, And so our Muse forbids us to pursue Praising your glory and our Caesar’s too, Lest, overwrought, we lessen it. Varius is fit to sing of Mars arrayed In armor, of Meriones in dust, Or of those gods that Diomedes thrust His lance through, with Athena’s aid. Ours, the wine bar and the local fray, The bachelorettes whose nails leave livid traces We later notice on their boyfriends’ faces And lightly sing of, in our way. (Odes i.6) arion 28.3 winter 2021 74 threee odes To Leuconoe Stop seeking what the gods prohibit us from apprehending, Leuconoe—the date on which it all comes to an ending. Better to toss the Dream Book and accept whatever comes, Whether Jove sends more winters, or the last we’ll know now drums The Tuscan Sea into submission on opposing cliffs. Be wise—decant this evening’s wine, curtail your hopeful ifs: Live in the moment: as we speak, now is becoming then; And insofar as possible, ignore tomorrow’s, “When….” (Odes i.11) To Iccius Iccius, are you hot for Arabian Loot now, devising tactics to subjugate The previously undefeated Kings of Sabaea? Forging new fetters For the ferocious Medes while previsioning Your oriental sex-slave, unguarded by The boyfriend whom you’ve slain in battle? What perfumed page from some royal palace, Whose father taught him Sinoform archery, Will be your Ganymede? Oh, deny falling Rivers the right to scale steep mountains, Tell us the Tiber can’t flow back upstream, When you—who were once so very promising, Rush to exchange your Works of Panaetius AND those Platonic scrolls you scoured bookstalls in search of—for Spanish armor! (Odes i.29)... (shrink)

This volume reconstructs Martin Heidegger's lecture course at the University of Marburg in the winter semester of 1924-25, which was devoted to an interpretation of Plato and Aristotle.

The Journal of Aesthetics and Art Criticism, Volume 78, Issue 1, Page 101-105, Winter 2020.

Introduction to Phenomenological Research, volume 17 of Martin Heidegger’s Gesamtausgabe, contains his first lectures given at Marburg in the winter semester of 1923–1924. In these lectures, Heidegger introduces the notion of phenomenology by tracing it back to Aristotle’s treatments of phainomenon and logos. This extensive commentary on Aristotle is an important addition to Heidegger’s ongoing interpretations which accompany his thinking during the period leading up to Being and Time. Additionally, these lectures develop critical differences between Heidegger’s phenomenology and (...) that of Descartes and Husserl and elaborate questions of facticity, everydayness, and flight from existence that are central in his later work. Here, Heidegger dismantles the history of ontology and charts a new course for phenomenology by defining and distinguishing his own methods. (shrink)

Review of the following books (in German): -/- Michael Ruoff: Foucault-Lexikon, München 2007. Fink/UTB. -/- Clemens Kammler, Rolf Parr und Ulrich Johannes Schneider (Hrsg.): Foucault-Handbuch. Leben – Werk – Wirkung, Stuttgart 2008. Metzler. -/- Paul Veyne: Foucault. Der Philosoph als Samurai, Stuttgart 2009. Reclam. -/- Thomas Lemke: Gouvernementalität und Biopolitik, Wiesbaden 2007. VS Verlag. -/- Patricia Purtschert, Katrin Meyer und Yves Winter (Hrsg.): Gouvernementalität und Sicherheit. Zeitdiagnostische Beiträge im Anschluss an Foucault, Bielefeld 2008. Transcript. -/- Daniel Hechler und Axel (...) Philipps (Hrsg.): Widerstand denken. Michel Foucault und die Grenzen der Macht, Bielefeld 2008. Transcript. -/- Jeffrey T. Nealon: Foucault Beyond Foucault: Power and its Intensifi cations since 1984, Stanford 2008. Stanford University Press. -/- Amy Allen: The Politics of Our Selves: Power, Autonomy, and Gender in Contemporary Critical Theory, New York 2008. Columbia University Press. -/- Wendy Brown: Regulating Aversion: Tolerance in the Age of Identity and Empire, Princeton 2006. Princeton University Press. -/- Giorgio Agamben: Was ist ein Dispositiv?, Zürich-Berlin 2008. Diaphanes. -/- Philipp Sarasin: Darwin und Foucault. Genealogie und Geschichte im Zeitalter der Biologie, Frankfurt/M. 2008. Suhrkamp. (shrink)

Review of the following books: -/- Michael Ruoff: Foucault-Lexikon, München 2007. Fink/UTB. -/- Clemens Kammler, Rolf Parr und Ulrich Johannes Schneider (Hrsg.): Foucault-Handbuch. Leben – Werk – Wirkung, Stuttgart 2008. Metzler. -/- Paul Veyne: Foucault. Der Philosoph als Samurai, Stuttgart 2009. Reclam. -/- Thomas Lemke: Gouvernementalität und Biopolitik, Wiesbaden 2007. VS Verlag. -/- Patricia Purtschert, Katrin Meyer und Yves Winter (Hrsg.): Gouvernementalität und Sicherheit. Zeitdiagnostische Beiträge im Anschluss an Foucault, Bielefeld 2008. Transcript. -/- Daniel Hechler und Axel Philipps (Hrsg.): (...) Widerstand denken. Michel Foucault und die Grenzen der Macht, Bielefeld 2008. Transcript. -/- Jeffrey T. Nealon: Foucault Beyond Foucault: Power and its Intensifi cations since 1984, Stanford 2008. Stanford University Press. -/- Amy Allen: The Politics of Our Selves: Power, Autonomy, and Gender in Contemporary Critical Theory, New York 2008. Columbia University Press. -/- Wendy Brown: Regulating Aversion: Tolerance in the Age of Identity and Empire, Princeton 2006. Princeton University Press. -/- Giorgio Agamben: Was ist ein Dispositiv?, Zürich-Berlin 2008. Diaphanes. -/- Philipp Sarasin: Darwin und Foucault. Genealogie und Geschichte im Zeitalter der Biologie, Frankfurt/M. 2008. Suhrkamp. (shrink)

Volume 27 of Heidegger's Complete Works offers a translation of the lecture course Einleitung in die Philosophie, which Martin Heidegger delivered in the winter semester of 1928-29 at the University of Freiburg. This course represents an important bridge between the last course Heidegger offered at Marburg in summer semester 1928, The Metaphysical Foundations of Logic, and the seminal winter semester 1929-30 course The Fundamental Concepts of Metaphysics. The two major themes treated in the course are the relation (...) between philosophy and science and that between philosophy and Weltanschauung. It will come as no surprise to those familiar with Heidegger's work and teaching that the course is anything but a schematic introduction to an academic discipline labeled Philosophy. It is designed instead as a veritable initiation into philosophical thinking, with the stated aim of "getting philosophizing underway.". (shrink)

This is the first English translation of the seminar Martin Heidegger gave during the Winter of 1934-35, which dealt with Hegel's Philosophy of Right. This remarkable text is the only one in which Heidegger interprets Hegel's masterpiece in the tradition of Continental political philosophy while offering a glimpse into Heidegger's own political thought following his engagement with Nazism. It also confronts the ideas of Carl Schmitt, allowing readers to reconstruct the relation between politics and ontology. The book is (...) enriched by a collection of interpretations of the seminar, written by select European and North American political thinkers and philosophers. Their essays aim to make the seminar accessible to students of political theory and philosophy, as well as to open new directions for debating the relation between the two disciplines. A unique contribution, this volume makes available key lectures by Heidegger that will interest a wide readership of students and scholars. (shrink)

Der erste Teilband des umfangreichen Seminarbandes 84 der Gesamtausgabe gehort in den grossen Kontext von Martin Heideggers Auseinandersetzung mit Immanuel Kant und Gottfried Wilhelm Leibniz. Leibniz ist fur Heidegger von herausragender Bedeutung fur die Geschichte der neuzeitlichen Metaphysik zwischen Descartes und Kant. Im Band 84.1 kommen drei Seminare zu Kant und ein Seminar zu Leibniz erstmals zur Veroffentlichung. Die drei Kant-Seminare befassen sich mit Kants Preisschrift uber die aFortschritte der Metaphysik (Sommer 1931), mit Kants aTranszendentaler Dialektik aus der Kritik (...) der reinen Vernunft im Hinblick und Vorgriff auf Kants praktische Philosophie (Winter 1931/32) und nochmals mit aHauptstucken aus der Kritik der reinen Vernunft (Sommer 1934). Das Leibniz-Seminar (Winter 1935/36) gibt erstmals eine grundlegende und wegweisende Gesamtinterpretation der aMonadologie. (shrink)

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

In this study, we investigate the conceptual structure of the metaphor “SIMILARITY IS PROXIMITY.” The results of four experiments suggest a tight mental link between similarity and proximity. Two experiments revealed that people judge entities to be more similar to each other when they are placed closely in space, while two other experiments showed that entities are judged to be closer to each other when they are thought to be more similar. We discuss this bidirectional metaphor transfer effect in light (...) of approaches to metaphor understanding, including the long-standing view that metaphorical mappings are assumed to be asymmetrical. We also consider the implications of this bi-directional mapping for high level cognition. (shrink)

Micheline Sauvage of the French National Scientific Research Centre traces for us the story of this great Athenian and great philosopher, as seen both by his contemporaries and by the European philosophers who followed after him.

A study of Philo and Paul and the first-century sophistic movement.

Martin Wrights original ground-breaking and influential analysis of the defects of the adversarial system of justice, plus the arguments in favour of a more ...

In November 1953 after giving his lecture “The Question Concerning Technology” at the Bavarian Academy of Fine Arts, Martin Heidegger wrote in a letter to his wife: “Yet the decisive thing is…the fact that a horizon is opening up amongst the young people, one which announces itself from within technology while going beyond it.” The genesis of Heidegger’s now famous essay occurred 4 years earlier, however, during a series of four lectures delivered on the evening of December 1st, 1949 (...) to a semi-private group of wealthy ship brokers, businessmen, and industry leaders at the Club zu Bremen. The December 1949 lecture would mark Heidegger’s first public speaking engagement since being made an Emeritus Professor at Freiburg University and the institution of a teaching ban as a result of his affiliation with the Nazi party, which, although lifted in 1949, would prevent him from teaching again until the winter semester of 1950–1951. It was at this prestigious Bremen club, in front of an audien .. (shrink)

Heidegger in America explores the surprising legacy of his life and thought in the United States of America. As a critic of modern life, Heidegger often lamented the growing global influence of all things American. However, it was precisely in America where his thought inspired the work of generations of thinkers – not only philosophers but also theologians, architects, novelists, and even pundits. As a result, the reception and dissemination of Heidegger's philosophical writings transformed the intellectual and cultural history of (...) the United States at a time when American influence was itself transforming the world. A case study in the complex and sometimes contradictory process of transnational exchange, Heidegger in America recasts the scope and methods of contemporary intellectual and cultural history in the age of globalization, challenging what we think we know about Heidegger and American ideas simultaneously. (shrink)

In this lively collection ten philosophers tackle the notoriously elusive issues raised by religious discourse in a series of linked debates. The debates focus on reason and faith; the logic of mysticism; the meaning of the word 'God'; language, biblical interpretation and worship; and religion and ethics. Through contemporary philosophical analysis it is possible to shed new light on teh status and language of religion, and in many ways the contributors to Religion and Philosophy break new ground in this perennially (...) controversial field. The collection is addressed to philosophers, theologians and anyone with a general intellectual interest in religion. Certainly it will be a valuable addition to the reading list of all teachers or students of the philosophy of religion. (shrink)