In humans, there are two skeletal muscle α‐actinins, encoded by ACTN2 and ACTN3, and the ACTN3 genotype is associated with human athletic performance. Remarkably, approximately 1 billion people worldwide are deficient in α‐actinin‐3 due to the common ACTN3 R577X polymorphism. The α‐actinins are an ancient family of actin‐binding proteins with structural, signalling and metabolic functions. The skeletal muscle α‐actinins diverged ∼250–300 million years ago, and ACTN3 has since developed restricted expression in fast muscle fibres. Despite ACTN2 and ACTN3 retaining considerable (...) sequence similarity, it is likely that following duplication there was a divergence in function explaining why α‐actinin‐2 cannot completely compensate for the absence of α‐actinin‐3. This paper focuses on the role of skeletal muscle α‐actinins, and how possible changes in functions between these duplicates fit in the context of gene duplication paradigms. (shrink)

ABSTRACTThis article describes our experience using art and theatre to engage rural communities in western Cambodia to understand malaria and support malaria control and elimination. The project was a pilot science–arts initiative to supplement existing engagement activities conducted by local authorities. In 2016, the project was conducted in 20 villages, involved 300 community members and was attended by more than 8000 people. Key health messages were to use insecticide-treated bed-nets and repellents, febrile people should attend village malaria workers, and to (...) raise awareness about the risk of forest-acquired malaria. Building on the experience and lessons learnt in the year prior, the 2017 project which was conducted in 15 villages involved 600 community members and attracted more than 12,000 people. In addition to the malaria theme, upon discussion with local health authorities, secondary theme was added to the 2017 project. We learnt the following lessons from our experience in... (shrink)

Joanna Tokarska-Bakir puts into analysis the main ideas of Eugen Drewermann expressed in his book Kleriker: Psychogramm eines ideals. She sets forth the sense of “total institution” – the main category used by Drewermann to characterize the essence of catholic church. According to Drewermann, catholic priests have been involved in struggling for political power rather than satisfying deep religious needs.

Artykuł podejmuje się pytania o trwałość granic ludzkiego ciała i jego związki z otaczającą rzeczywistością. W odniesieniu do pogłebiającego się w wyniku zmian klimatycznych i zwiększającej się toksyczności środowiska lęku przed tym, co wnika z zewnątrz do naszego ciała, przywołuję koncepcje takich myślicielek, jak Stacy Alaimo, Donna Haraway i Karen Barad, by zastanowić się, w jaki sposób przemyśleć nasze relacje ze środowiskiem. Problem ten poruszam poprzez lekturę dwóch powieści eko-grozy, „Wilder Girls” Rory Power (2019) oraz „Unicestwienia” Jeffa VanderMeera (2014). Najważniejsze (...) tematy analizy to relacja między wnętrzem i zewnętrzem ciała, powiązania między ludźmi a środowiskiem, przemiany ciał wynikajace z zakażenia oraz znaczenie języka. Odwołując się do artykułu Bethany Doane „Sublime Annihilation and Planetary Ecohorror” (2020), zastanawiam się nad etycznym wymiarem podobnych opowieści i ich znaczeniem w obliczu katastrofy klimatycznej. (shrink)

Idioms -- Rituals -- Values -- The land of Israel -- Authors and methods.

Maʼamarim she-hevi ha-Ḥo. ha-l. be-shem aḥerim -- Maʼamarim she-katav ha-Ḥo. ha-l. be-ʻatsmo.