One way to address such questions about artifact kinds is to look for clues in the available literature on parallel questions that have been posed with respect to kinds in the natural domain. Philosophers have long been concerned with the ...

We propose for the first time to divide histone proteolysis into “histone degradation” and the epigenetically connoted “histone clipping”. Our initial observation is that these two different classes are very hard to distinguish both experimentally and biologically, because they can both be mediated by the same enzymes. Since the first report decades ago, proteolysis has been found in a broad spectrum of eukaryotic organisms. However, the authors often not clearly distinguish or determine whether degradation or clipping was studied. Given the (...) importance of histone modifications in epigenetic regulation we further elaborate on the different ways in which histone proteolysis could play a role in epigenetics. Finally, unanticipated histone proteolysis has probably left a mark on many studies of histones in the past. In conclusion, we emphasize the significance of reviving the study of histone proteolysis both from a biological and an experimental perspective.Also watch the Video Abstract. (shrink)

Humans are always interested in distinguishing natural and artificial entities although there is no sharp demarcation between the two categories. Surprisingly, things do not improve when the second type of entities is restricted to the arguably more constrained realm of physical technical artifacts. This paper helps to clarify the relationship between natural entities and technical artifacts by developing a conceptual landscape within which to analyze these notions. The framework is developed by studying three definitions of technical artifact which arise from (...) different perspectives. All these perspectives share two intuitions: that technical artifacts are physical objects that exist by human intervention; and that technical artifacts are entities to be contrasted to natural entities. Yet the perspectives are different in the way they spell out these intuitions: the relevant human intervention may range from intentional selection to intentional production; and the contrast between technical artifacts and natural entities may be introduced by a constitution relation or by defining properties that set technical artifacts apart. The three perspectives are compared and their similarities and dissimilarities are explored with the help of ontological analysis. (shrink)

This collection of essays delineates the history of the rather disparate intellectual tradition usually labeled as "Platonic" or "Neoplatonic". In chronological order, the book covers the most eminent philosophic schools of thought within that tradition. The most important terms of the Platonic tradition are studied together with a discussion of their semantic implications, the philosophical and theological claims associated with the terms, the sources that furnish the terms, and the intellectual traditions aligned with or opposed to them. The contributors thereby (...) provide a vivid intellectual map of the Middle Ages and the Early Modern period. Contributions are written in English or German. (shrink)

The commentary of the Italian physician and philosopher Pietro d'Abano on Bartholomew of Messina's Latin translation of Pseudo-Aristotle's 'Problemata Physica', published in 1310, constitutes an important historical source. In a section of the corpus Aristotelicum that was not part of the standard curriculum at the medieval university, the commentary of Pietro d'Abano investigates the complex relationship between text, translation, and commentary. The eight articles in this volume provide valuable insights into the manner in which Pietro d'Abano deals with the problems (...) of a translated text. They emphasize the idiosyncrasy of his approach in comparison to his contemporaries and successors, the particularities of his commentary in light of the habitual exegetical practices applied in the teaching of curricular texts, as well as the influence of philosophical traditions outside the strict framework of the medieval arts faculty. (shrink)

This volume features 16 essays on the philosophy of technology that discuss its identity, its position in philosophy in general, and the role of empirical studies in philosophical analyses of engineering ethics and engineering practices. This volume is published about fifteen years after Peter Kroes and Anthonie Meijers published a collection of papers under the title The empirical turn in the philosophy of technology, in which they called for a reorientation toward the practice of engineering, and sketched the likely benefits (...) for philosophy of technology of pursuing its major questions in an empirically informed way. The essays in this volume fall apart in two different kinds. One kind follows up on The empirical turn discussion about what the philosophy of technology is all about. It continues the search for the identity of the philosophy of technology by asking what comes after the empirical turn. The other kind of essays follows the call for an empirical turn in the philosophy of technology by showing how it may be realized with regard to particular topics. Together these essays offer the reader an overview of the state of the art of an empirically informed philosophy of technology and of various views on the empirical turn as a stepping stone into the future of the philosophy of technology. (shrink)

Over the last twenty years, in all of these neighbouring fields, modal systems have been developed that we call multi-dimensional. (Our definition of multi ...

Relationalism maintains that perceptual experience involves, as part of its nature, a distinctive kind of conscious perceptual relation between a subject of experience and an object of experience. Together with the claim that perceptual experience is presentational, relationalism is widely believed to be a core aspect of the naive realist outlook on perception. This is a mistake. I argue that naive realism about perception can be upheld without a commitment to relationalism.

The debate on the conventionality of simultaneity and the debate on the dimensionality of the world have been central in the philosophy of special relativity. The link between both debates however has rarely been explored. The purpose of this paper is to gauge what implications the former debate has for the latter. I show the situation to be much more subtle than was previously argued, and explain how the ontic versus epistemic distinction in the former debate impacts the latter. Despite (...) claims to the contrary, I conclude that special relativity leaves the debate on the dimensionality of the world underdetermined. (shrink)

John Hyman insists that Frege-style cases for depiction show that any sound theory of depiction must distinguish between the ‘sense’ and the ‘reference’ of a picture. I argue that this rests on a mistake. Making sense of the cases does not require the distinction.

The aim of this doctoral dissertation is to closely explore the nature of Einstein’s block universe and to tease out its implications for the nature of time and human freedom. Four questions, in particular, are central to this dissertation, and set out the four dimensions of this philosophical investigation: (1) Does the block universe view of time follow inevitably from the theory of special relativity? (2) Is there room for the passage of time in the block universe? (3) Can we (...) distinguish past from future in the block universe? (4) Is there room for human freedom in the block universe? Although the answer of most philosophers would be yes, triple no, my own answer, controversially, is no, triple yes. -/- I thereby challenge the status quo with respect to each of these metaphysical questions, and argue that none of these questions can be answered from looking at physics alone. Physics may constrain our metaphysics, but it certainly does not settle it. What is needed in order to answer these questions, are additional metaphysical assumptions that fall outside the scope of modern physics. My primary goal in this dissertation, therefore, is not to settle the debates on the nature of time and human freedom, but to clarify them by expliciting the metaphysical assumptions that are otherwise left implicit. (shrink)

This volume explores the different aspects of the thinking of Marsilius of Inghen . It is devoted to the background of his philosophy and theology, to the significance of his many writings, and to the impact of his thought.

The revised edition contains a new chapter which provides an elegant description of the semantics. The various classes of lambda calculus models are described in a uniform manner. Some didactical improvements have been made to this edition. An example of a simple model is given and then the general theory (of categorical models) is developed. Indications are given of those parts of the book which can be used to form a coherent course.

To this day, a hundred and fifty years after Mendeleev's discovery, the overal structure of the periodic system remains unaccounted for in quantum-mechanical terms. Given this dire situation, a handful of scientists in the 1970s embarked on a quest for the symmetries that lie hidden in the periodic table. Their goal was to explain the table's structure in group-theoretical terms. We argue that this symmetry program required an important paradigm shift in the understanding of the nature of chemical elements. The (...) idea, in essence, consisted of treating the chemical elements, not as particles, but as states of a superparticle. We show that the inspiration for this came from elementary particle physics, and in particular from Heisenberg's suggestion to treat the proton and neutron as different states of the nucleon. We provide a careful study of Heisenberg's last paper on the nature of elementary particles, and explain why the Democritean picture of matter no longer applied in modern physics and a Platonic symmetry-based picture was called for instead. We show how Heisenberg's Platonic philosophy came to dominate the field of elementary particle physics, and how it found its culmination point in Gell-Mann's classification of the hadrons in the eightfold way. We argue that it was the success of Heisenberg's approach in elementary particle physics that sparked the group-theoretical approach to the periodic table. We explain how it was applied to the set of chemical elements via a critical examination of the work of the Russian mathematician Abram Ilyich Fet the Turkish-American physicist Asim Orhan Barut, before giving some final reflections. (shrink)

Human freedom is in tension with nomological determinism and with statistical determinism. The goal of this paper is to answer both challenges. Four contributions are made to the free-will debate. First, we propose a classification of scientific theories based on how much freedom they allow. We take into account that indeterminism comes in different degrees and that both the laws and the auxiliary conditions can place constraints. A scientific worldview pulls towards one end of this classification, while libertarianism pulls towards (...) the other end of the spectrum. Second, inspired by Hoefer, we argue that an interval of auxiliary conditions corresponds to a region in phase space, and to a bundle of possible block universes. We thus make room for a form of non-nomological indeterminism. Third, we combine crucial elements from the works of Hoefer and List; we attempt to give a libertarian reading of this combination. On our proposal, throughout spacetime, there is a certain amount of freedom that can be interpreted as the result of agential choices. Fourth, we focus on the principle of alternative possibilities throughout and propose three ways of strengthening it. (shrink)

This book is about how to understand quantum mechanics by means of a modal interpretation. Modal interpretations provide a general framework within which quantum mechanics can be considered as a theory that describes reality in terms of physical systems possessing definite properties. Quantum mechanics is standardly understood to be a theory about probabilities with which measurements have outcomes. Modal interpretations are relatively new attempts to present quantum mechanics as a theory which, like other physical theories, describes an observer-independent reality. In (...) this book, Pieter Vermaas summarises the results of this work. The book will be of great value to undergraduates, graduate students and researchers in philosophy of science, and physics departments with an interest in learning about modal interpretations of quantum mechanics. (shrink)

According to Leininger, presentists and growing blockers cannot explain why past and present regularities persist in the future. In order to do so, they would have to appeal to enforcers, such as causation, laws or dispositions. But in a world with no future, these enforcers are powerless and cannot guarantee future regularity. I disagree and argue that Leininger’s coordination problem can be met by distinguishing type- from token-level necessitation. Whereas token-level necessitation is cross-temporal and subject to Leininger’s coordination problem, type-level (...) necessitation is atemporal and immune to the coordination problem. For this solution to work, though, type-level necessitation must be ontologically prior to token-level necessitation. This forces us to adopt a Platonist position according to which universals are transcendent, and not immanent. (shrink)

What is wrong with ad hoc hypotheses? Ever since Popper’s falsificationist account of adhocness, there has been a lively philosophical discussion about what constitutes adhocness in scientific explanation, and what, if anything, distinguishes legitimate auxiliary hypotheses from illicit ad hoc ones. This paper draws upon distinct examples from pseudoscience to provide us with a clearer view as to what is troubling about ad hoc hypotheses. In contrast with other philosophical proposals, our approach retains the colloquial, derogative meaning of adhocness, and (...) calls attention to the way in which the context of a theoretical move bears on the charge of adhocness. We also discuss the role of motivations implicit in the concept of adhocness, and the way ad hoc moves draw on theory-internal rationalizations. (shrink)

Abstractabstract:Most of Charles Darwin's ideas have withstood the test of time, but some of them turned out to be dead ends. This article focuses on one such dead end: Darwin's ideas about the connection between piloerection and mental illness. Piloerection is a medical umbrella term to refer to a number of phenomena in which our hair tends to stand on end. Darwin was one of the first scientists to study it systematically. In The Expression of the Emotions in Man and (...) Animals (1872), he discusses piloerection in the context of his analysis of the expressions involved in fear and anger, relying heavily on the evidence provided by one of his correspondents, the British psychiatrist James Crichton Browne. This essay reveals how Darwin's initial doubts about the similarity between piloerection in animals and psychiatric patients were eased when studying photographic portraits of female psychiatric patients sent to him by Crichton Browne. It considers arguments against Darwin's reading of these portraits and the apparent contrast between this reading and his own skepticism, in later years, about the value of documentary photography. The article concludes with some notes regarding the reception of Darwin's ideas about psychopathology. (shrink)

This book presents and exemplifies the theory of grammar called Semantic Syntax. The grammar, which offers a syntactic theory closely connected with semantic analyses, is a direct continuation of Generative Semantics; it will re-ignite interest in that framework which flourished and promised so much in the 1960s and 1970s.

The block universe theory of time is commonly said to be incompatible with temporal becoming. This confuses Maudlin who upholds both eternalism and passage. The aim of this paper is to answer Maudlin’s plea for clarification by distinguishing four degrees of temporal becoming. After discussing their respective compatibility with the block universe, I show that Maudlin asks much less from temporal becoming than most philosophers of time. Consequently, his form of becoming is compatible with the block universe, whereas the stronger (...) forms of becoming are not. (shrink)

Many people assume that fictional entities are encapsulated in the world of fiction. I show that this cannot be right. Some works of fiction tell us about pieces of poetry, music, or theatre written by fictional characters. Such creations are fictional creations, as I will call them. Their authors do not exist. But that does not take away that we can perform, recite, or otherwise generate actual instances of such works. This means we can bring such individuals actually into existence, (...) as the works they are. I conclude that the assumption about encapsulation is untenable, unless an exception is made for types. (shrink)

Philosophers and psychologists often assume that mirror reflections are optical illusions. According to many authors, what we see in a mirror appears to be behind it. I discuss two strategies to resist this piece of dogma. As I will show, the conviction that mirror reflections are illusions is rooted in a confused conception of the relations between location, direction, and visibility. This conception is unacceptable to those who take seriously the way in which mirrors contribute to our experience of the (...) world. My argument may be read as an advertisement of the neglected field of philosophical catoptrics, the philosophical study of the optical properties of mirrors. It enables us to recast familiar issues in the philosophy of perception. (shrink)

Many people have a fascination with ‘senseless violence’ and are concerned about its rise in our society. In the real world, however, violence is rarely senseless. It is not random and haphazard but driven by rational motives and justifications and governed by its own internal logic. The myth of ‘senseless violence’ taps into certain moral intuitions, but it has little or nothing to do with reality. If we want to prevent violent acts, we need to understand the motivations of the (...) perpetrators rather than portraying their violence as random, mysterious, devoid of reason. I apply these insights to the extreme atrocities committed by the group known as the Islamic State and show how the myth of senseless violence has led many policymakers and commentators astray. (shrink)

In this paper I attempt to show how the African philosopher - Kwasi Wiredu - constructs an ethnic perspectival model of ethics from the structure of kinship relations found among the Akans of Ghana. The specifics of this structure generate a notion of particularity in morals, which is carried from its origins in civic society, through a process of contested dialogue, into civil society where it is validated as norm-setter in an actual public forum of debate. The dynamics of this (...) forum ensures that the renewal of tradition remains an ongoing process and that a participatory ethos remains ascendant. I hope that my interpretation and reconstruction of Wiredu is correct. I have not attempted to cover the entire picture of Akan ethics, but only that part of it which deals with members of Akan society, and not strangers. (shrink)

Name der Zeitschrift: Das Mittelalter Jahrgang: 21 Heft: 2 Seiten: 419-447.

Part of the distinction between artefacts, objects made by humans for particular purposes, and natural objects is that artefacts are subject to normative judgements. A drill, say, can be a good drill or a poor drill, it can function well or correctly or it can malfunction. In this paper I investigate how such judgements fit into the domain of the normative in general and what the grounds for their normativity are. Taking as a starting point a general characterization of normativity (...) proposed by Dancy, I argue how statements such as ‘this is a good drill’ or ‘this drill is malfunctioning’ can be seen to express normative facts, or the content of normative statements. What they say is that a user who has a desire to achieve a particular relevant outcome has a reason to use, or not to use, the artefact in question. Next this analysis is extended to show that not just statements that say that an artefact performs its function well or poorly, but all statements that ascribe a function to an artefact can be seen as expressing a normative fact. On this approach the normativity of artefacts is analyzed in terms of reasons on grounds of practical, and to a lesser extent theoretical, rationality. I close by investigating briefly to what extent reasons on moral grounds are, in the analysis adopted here, involved in the normativity of artefacts.Keywords: Artefact; Normativity; Instrumental reason; Practical rationality; Function; Use. (shrink)

One of the older questions in the debate about Corporate Social Responsibility (CSR) is whether it is worthwhile for organizations to pay attention to societal demands. This debate was emotionally, normatively, and ideologically loaded. Up to the present, this question has been an important trigger for empirical research in CSR. However, the answer to the question has apparently not been found yet, at least that is what many researchers state. This apparent ambivalence in CSR consequences invites a literature study that (...) can clarify the debate and allow for the drawing of conclusions. The results of the literature study performed here reveal that there is indeed clear empirical evidence for a positive correlation between corporate social and financial performance. Voices that state the opposite refer to out-dated material. Since the beginnings of the CSR debate, societies have changed. We can therefore clearly state that, for the present Western society, “Good Ethics is Good Business.”. (shrink)

The present study examined whether individuals with full-blown memories of highly implausible events are prone to commit source monitoring errors. Participants reporting previous-life memories and those without such memories completed a false fame task. This task provides an index of source monitoring errors . Participants with previous-life memories had a greater tendency to judge the names of previously presented non-famous people as famous than control participants. The two groups did not differ in terms of correct recognition of new non-famous names (...) and famous names. Although dissociation, cognitive failures, sleep-related experiences, depressive symptoms, and signs of psychological distress were all significantly higher in participants with previous-life memories than in controls, these variables did not predict the false fame illusion. (shrink)

For a long time, philosophers of science have expressed little interest in the so-called demarcation project that occupied the pioneers of their field, and most now concur that terms like “pseudoscience” cannot be defined in any meaningful way. However, recent years have witnessed a revival of philosophical interest in demarcation. In this paper, I argue that, though the demarcation problem of old leads to a dead-end, the concept of pseudoscience is not going away anytime soon, and deserves a fresh look. (...) My approach proposes to naturalize and down-size the concept, anchoring it in real-life doctrines and fields of inquiry. First, I argue against the definite article “the” in “the demarcation problem”, distinguishing between territorial and normative demarcation, and between different failures and shortcomings in science apart from pseudoscience. Next, I argue that pseudosciences can be fruitfully regarded as simulacra of science, doctrines that are not epistemically warranted but whose proponents try to create the impression that they are. In this element of imitation or mimicry, I argue, lies the clue to their common identity. Despite the huge variety of doctrines and beliefs gathered under the rubric of “pseudoscience”, and the wide range of defects from which they suffer, pseudosciences all engage in similar strategies to create an impression of epistemic warrant. The indirect, symptomatic approach defended here leads to a general characterization of pseudosciences in all domains of inquiry, and to a useful diagnostic tool. (shrink)

This chapter gives an overview of the evolution of the position of the rare-earth elements in the periodic system, from Mendeleev’s time to the present. Three fundamentally different accommodation methodologies have been proposed over the years. Mendeleev considered the rare-earth elements as homologues of the other elements. Other chemists looked upon the rare earths as forming a special intraperiodic group and therefore clustered the rare-earth elements in one of the groups of the periodic table. Still others adhered to the intergroup (...) accommodation of the rare earths, according to which the rare-earth elements do not show any relationship with the other elements, so that they had to be placed within the periodic table as a separate family of elements. The intergroup accommodation became the preferred one in the twentieth century. The advantages and disadvantages of the different representations of the modern periodic table are discussed. (shrink)

In various publications over the past years, Floridi has developed a theory of semantic information as well-formed, meaningful, and truthful data. This theory is more or less orthogonal to the standard entropy-based notions of information known from physics, information theory, and computer science that all define the amount of information in a certain system as a scalar value without any direct semantic implication. In this context the question rises what the exact relation between these various conceptions of information is and (...) whether there is a real need to enrich these mathematically more or less rigid definitions with a less formal notion of semantic information. I investigate various philosophical aspects of the more formal definitions of information in the light of Floridi’s theory. The position I defend is that the formal treatment of the notion of information as a general theory of entropy is one of the fundamental achievements of modern science that in itself is a rich source for new philosophical reflection. This makes information theory a competitor of classical epistemology rather than a servant. In this light Floridi’s philosophy of information is more a reprise of classical epistemology that only pays lip service to information theory but fails to address the important central questions of philosophy of information. Specifically, I will defend the view that notions that are associated with truth, knowledge, and meaning all can adequately be reconstructed in the context of modern information theory and that consequently there is no need to introduce a concept of semantic information. (shrink)

n various publications over the past years, Floridi has developed a theory of semantic information as well-formed, meaningful, and truthful data. This theory is more or less orthogonal to the standard entropy-based notions of information known from physics, information theory, and computer science that all define the amount of information in a certain system as a scalar value without any direct semantic implication. In this context the question rises what the exact relation between these various conceptions of information is and (...) whether there is a real need to enrich these mathematically more or less rigid definitions with a less formal notion of semantic information. I investigate various philosophical aspects of the more formal definitions of information in the light of Floridi’s theory. The position I defend is that the formal treatment of the notion of information as a general theory of entropy is one of the fundamental achievements of modern science that in itself is a rich source for new philosophical reflection. This makes information theory a competitor of classical epistemology rather than a servant. In this light Floridi’s philosophy of information is more a reprise of classical epistemology that only pays lip service to information theory but fails to address the important central questions of philosophy of information. Specifically, I will defend the view that notions that are associated with truth, knowledge, and meaning all can adequately be reconstructed in the context of modern information theory and that consequently there is no need to introduce a concept of semantic information. (shrink)

Divided into eight sections, each with introductory essays, the selections offer rich and detailed insights into a diverse multinational philosophical landscape. Revealed in this pathbreaking work is the way in which traditional philosophical issues related to ethics, metaphysics, and epistemology, for instance, take on specific forms in Africa's postcolonial struggles. Much of its moral, political, and social philosophy is concerned with the turbulent processes of embracing modern identities while protecting ancient cultures.

The concept of the future is re-emerging as an urgent topic on the academic agenda. In this article, we focus on the ‘politics of the future’: the social processes and practices that allow particular imagined futures to become socially performative. Acknowledging that the performativity of such imagined futures is well-understood, we argue that how particular visions come about and why they become performative is underexplained. Drawing on constructivist sociological theory, this article aims to fill this gap by exploring the question (...) ‘how do imagined futures become socially performative’? In doing so, the article has three aims to identify the leading social–theoretical work on the future; conceptualize the relationship of the imagination of the future with social practices and the performance of reality; provide a theoretical framework explaining how images of the future become performative, using the concepts ‘techniques of futuring’ and ‘dramaturgical regime’. (shrink)

For an arbitrary similarity type of Boolean Algebras with Operators we define a class of Sahlqvist identities. Sahlqvist identities have two important properties. First, a Sahlqvist identity is valid in a complex algebra if and only if the underlying relational atom structure satisfies a first-order condition which can be effectively read off from the syntactic form of the identity. Second, and as a consequence of the first property, Sahlqvist identities are canonical, that is, their validity is preserved under taking canonical (...) embedding algebras. Taken together, these properties imply that results about a Sahlqvist variety V van be obtained by reasoning in the elementary class of canonical structures of algebras in V. We give an example of this strategy in the variety of Cylindric Algebras: we show that an important identity called Henkin's equation is equivalent to a simpler identity that uses only one variable. We give a conceptually simple proof by showing that the firstorder correspondents of these two equations are equivalent over the class of cylindric atom structures. (shrink)

Statistics from both South Africa and the United States of America indicate that the phenomenon of violence amongst youths is increasing. This implies that a larger number of youths are being exposed to the experience of violence and thus present with the complex and multi-dimensional effects of such an experience. Past research has centred mostly on the causative factors that can be statistically represented, with little focus being paid to the juveniles’ in-depth, subjective experience of the phenomenon. For the male (...) adolescent, the experience of the phenomenon of violence is complex, diverse and may span across many aspects of his life, including physical, psychological, personal and social dimensions. Three participants were sourced from the Leeuwkop Juvenile Correctional Facility in Johannesburg and interviewed for the purpose of this study. The participants were selected based on their age (between 13 and 19 years of age) and the type of crime that they had committed (assault with intent to do grievous bodily harm, common assault or indecent assault). In accordance with the phenomenological approach, open-ended interviews were used as a research method in order to allow for the participants’ unique and subjective experience of the phenomenon to emerge. The researchers found that the phenomenon of violence is characterised by the juveniles’ experience of external events that provoke a certain response manifesting itself in violent behaviour. The responses described by the participants were mostly emotional in nature and included emotions such as anger, rage and fury. The experience of violence also holds certain consequences for the male juvenile offender. The most common consequence experienced by all three participants was their subsequent arrest and incarceration in a correctional facility. Indo-Pacific Journal of Phenomenology , Volume 11, Edition 1 May 2011, iii-v. (shrink)

The scientific study of living organisms is permeated by machine and design metaphors. Genes are thought of as the ‘‘blueprint’’ of an organism, organisms are ‘‘reverse engineered’’ to discover their func- tionality, and living cells are compared to biochemical factories, complete with assembly lines, transport systems, messenger circuits, etc. Although the notion of design is indispensable to think about adapta- tions, and engineering analogies have considerable heuristic value (e.g., optimality assumptions), we argue they are limited in several important respects. In (...) particular, the analogy with human-made machines falters when we move down to the level of molecular biology and genetics. Living organisms are far more messy and less transparent than human-made machines. Notoriously, evolution is an oppor- tunistic tinkerer, blindly stumbling on ‘‘designs’’ that no sensible engineer would come up with. Despite impressive technological innovation, the prospect of artificially designing new life forms from scratch has proven more difficult than the superficial analogy with ‘‘programming’’ the right ‘‘software’’ would sug- gest. The idea of applying straightforward engineering approaches to living systems and their genomes— isolating functional components, designing new parts from scratch, recombining and assembling them into novel life forms—pushes the analogy with human artifacts beyond its limits. In the absence of a one-to-one correspondence between genotype and phenotype, there is no straightforward way to imple- ment novel biological functions and design new life forms. Both the developmental complexity of gene expression and the multifarious interactions of genes and environments are serious obstacles for ‘‘engi- neering’’ a particular phenotype. The problem of reverse-engineering a desired phenotype to its genetic ‘‘instructions’’ is probably intractable for any but the most simple phenotypes. Recent developments in the field of bio-engineering and synthetic biology reflect these limitations. Instead of genetically engi- neering a desired trait from scratch, as the machine/engineering metaphor promises, researchers are making greater strides by co-opting natural selection to ‘‘search’’ for a suitable genotype, or by borrowing and recombining genetic material from extant life forms. (shrink)