While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA, it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential epigenetic role across diverse eukaryotes with biological consequences, which are distinct and possibly even opposite to the well‐studied 5‐methylcytosine mark. Adenine methyltransferases appear to have been independently acquired by eukaryotes on at least 13 occasions from prokaryotic restriction‐modification and counter‐restriction systems. On at least four to five instances, these methyltransferases were recruited as RNA methylases. Thus, (...) m6A marks in eukaryotic DNA and RNA might be more widespread and diversified than previously believed. Several m6A‐binding protein domains from prokaryotes were also acquired by eukaryotes, facilitating prediction of potential readers for these marks. Further, multiple lineages of the AlkB family of dioxygenases have been recruited as m6A demethylases. Although members of the TET/JBP family of dioxygenases have also been suggested to be m6A demethylases, this proposal needs more careful evaluation. (shrink)

Market-based social governance schemes that establish standards of conduct for producers and traders in international supply chains aim to reduce the negative socioenvironmental effects of globalization. While studies have examined how characteristics of social governance schemes promote socially responsible producer behavior, it has not yet been examined how these same characteristics affect consumer behavior. This is a crucial omission, because without consumer demand for socially produced products, the reach of the social benefits is likely to be limited. We develop a (...) comprehensive model that links twocharacteristics of market-based social governance schemes—(1) stringency and enforcement of requirements, and (2) promotion—to two conditions required for governance schemes to generate significant social benefits: (1) socially responsible behavior of participating firms; and (2) consumer demand for socially produced products which, in turn, expands products produced according to social governance schemes, and thus, the quantity of social benefits. We discuss market-based social governance schemes in the context of fair trade coffee. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

This paper brings a developmental perspective to the discussion of a longstanding issue surrounding the proper characterization of presuppositions. On an influential view (Stalnaker in Synthese 22(1–2):272–289, 1970; Stalnaker, in Milton, Unger (eds) Semantics and philosophy, New York University Press, New York, 1974; Karttunen in Theor Linguist 1:181–194, 1974), formal presuppositions reflect admittance conditions: an utterance of a sentence which presupposes _p_ is admitted by a conversational context _c_ only if _p_ is common ground in _c_. The theory distinguishes two (...) modes of satisfying this formal requirement: (i) presuppositions may have common ground status prior to utterance, or (ii) they may achieve common ground status post hoc, via accommodation, an adjustment of the common ground by cooperative listeners so as to meet the requirements of an uttered sentence. While intuitive and general, the theory has been criticized (among other things) on methodological grounds (see e.g. Gazdar in Pragmatics: implicature, presupposition and logical form, Academic Press, New York, 1979): the availability of accommodation makes it difficult to empirically examine the notion of presupposition as admittance conditions because a central tenet—pragmatic infelicity results whenever _c_ does not entail _p_—may be masked due to the pragmatic sophistication of language users. In this paper, we argue that child language presents an opportunity to avoid this intrinsic difficulty. In a series of behavioral experiments, we show that young children generate a default expectation that the presuppositions of an asserted sentence have common ground status prior to utterance. Furthermore and more tellingly, we also find that even when accommodation is the preferred option for adults, children fail to accommodate presuppositions in an adult-like manner. This pattern of behavior, we argue, is expected under the admittance theory: in a population where the interference from accommodation is reduced, the impact of failing to satisfy the formal admittance conditions becomes directly observable. (shrink)

The questions of how human beings produce and comprehend language continue to engage a variety of researchers and scholars, and it is becoming increasingly clear that only interdisciplinary approaches will yield productive answers. This complex issue of discourse processing is the subject of this volume, and the contributors address it from the varying perspectives of cognitive psychology linguistics, and computer science. The chapters provide a fascinating overview of emerging theories in the new discipline of cognitive science. A useful introductory chapter (...) by the editors explains the relationships of chapters to one another and outlines the long-term implications of the work they report. (shrink)

We describe a categorial system (PPTS) based on partial proof trees(PPTs) as the building blocks of the system. The PPTs are obtained byunfolding the arguments of the type that would be associated with a lexicalitem in a simple categorial grammar. The PPTs are the basic types in thesystem and a derivation proceeds by combining PPTs together. We describe theconstruction of the finite set of basic PPTs and the operations forcombining them. PPTS can be viewed as a categorial system incorporating someof (...) the key insights of lexicalized tree adjoining grammar, namely the notionof an extended domain of locality and the consequent factoring of recursionfrom the domain of dependencies. PPTS therefore inherits the linguistic andcomputational properties of that system, and so can be viewed as a middleground between a categorial grammar and a phrase structure grammar. We alsodiscuss the relationship between PPTS, natural deduction, and linear logicproof-nets, and argue that natural deduction rather than a proof-net systemis more appropriate for the construction of the PPTs. We also discuss howthe use of PPTs allows us to localize the management of resources, therebyfreeing us from this management as the PPTs are combined. (shrink)

In setting up a formal system to specify a grammar formalism, the conventional (mathematical) wisdom is to start with primitives (basic primitive structures) as simple as possible, and then introduce various operations for constructing more complex structures. An alternate approach is to start with complex (more complicated) primitives, which directly capture some crucial linguistic properties and then introduce some general operations for composing these complex structures. These two approaches provide different domains of locality, i.e., domains over which various types of (...) linguistic dependencies can be specified. The latter approach, characterized as complicate locally, simplify globally (CLSG), pushes non‐local dependencies to become local, i.e., they arise in the basic primitive structures to start with.The CLSG approach has led to some new insights into syntactic description, semantic composition, language generation, statistical processing, and psycholinguistic phenomena, all these with possible relevance to the cognitive architecture of language. In this paper, we will describe these results in an introductory manner making use of the framework of lexicalized tree‐adjoining grammar (LTAG), a key example of the CLSG approach, thereby describing the interplay between formal analysis on the one hand and linguistic and processing issues on the other hand. (shrink)

We describe a categorial system (PPTS) based on partial proof trees(PPTs) as the building blocks of the system. The PPTs are obtained byunfolding the arguments of the type that would be associated with a lexicalitem in a simple categorial grammar. The PPTs are the basic types in thesystem and a derivation proceeds by combining PPTs together. We describe theconstruction of the finite set of basic PPTs and the operations forcombining them. PPTS can be viewed as a categorial system incorporating someof (...) the key insights of lexicalized tree adjoining grammar, namely the notionof an extended domain of locality and the consequent factoring of recursionfrom the domain of dependencies. PPTS therefore inherits the linguistic andcomputational properties of that system, and so can be viewed as a ’middleground‘ between a categorial grammar and a phrase structure grammar. We alsodiscuss the relationship between PPTS, natural deduction, and linear logicproof-nets, and argue that natural deduction rather than a proof-net systemis more appropriate for the construction of the PPTs. We also discuss howthe use of PPTs allows us to ’localize‘ the management of resources, therebyfreeing us from this management as the PPTs are combined. (shrink)

In the 10 years after the launch of the United Nations Global Compact (GC), there have been very few empirical assessments of the initiative in the academic literature. In this study, drawing from institutional theory and the resource-based view of the firm, we examine motivations of business participants to adopt the GC principles in the Spanish context. Using survey data from Spain – the country reporting the highest volume of business participants in the GC – we find that external institutional (...) forces as well as internal organisational resources shape motivations for adopting GC principles. In particular, we find that early and late adopters are motivated similarly by the perceived opportunity of achieving image gains, while late adopters are motivated more by economic gains than early adopters. We further find that regardless of the extent of internal intangible resources possessed, firms are similarly motivated by economic gains. The results also show that companies with more intangible resources are motivated more by image gains than those with fewer resources. Our findings indicate that contrary to its earlier days, economic gains have emerged as an important motivator for the adopters of the GC principles with image gains still being an important motivator. (shrink)

In the 10 years after the launch of the United Nations Global Compact (GC), there have been very few empirical assessments of the initiative in the academic literature. In this study, drawing from institutional theory and the resource‐based view of the firm, we examine motivations of business participants to adopt the GC principles in the Spanish context. Using survey data from Spain – the country reporting the highest volume of business participants in the GC – we find that external institutional (...) forces as well as internal organisational resources shape motivations for adopting GC principles. In particular, we find that early and late adopters are motivated similarly by the perceived opportunity of achieving image gains, while late adopters are motivated more by economic gains than early adopters. We further find that regardless of the extent of internal intangible resources possessed, firms are similarly motivated by economic gains. The results also show that companies with more intangible resources are motivated more by image gains than those with fewer resources. Our findings indicate that contrary to its earlier days, economic gains have emerged as an important motivator for the adopters of the GC principles with image gains still being an important motivator. (shrink)

ABSTRACT:We extend the Base of the Pyramid (BoP) poverty-alleviation approach by recognizing the poor as valuable suppliers—specifically of intellectual property. Although the poor possess huge reserves of intellectual property, they are unable to participate in global knowledge networks owing to their illiteracy and poverty. This is a crippling form of social exclusion in today’s growing knowledge economy because it adversely affects their capabilities for advancement at several levels. Providing the poor access to global knowledge networks as rightful participants—as suppliers of (...) intellectual property—leads to poverty alleviation as a result of their increased social inclusion, not only through economic benefits, but also through the poor’s improved well-being as a result of their increased self-esteem and dignity. Using concepts from social network theory, we develop a poverty-alleviation approach to harness and integrate the intellectual property of the poor into global knowledge networks through trust-based partnerships among the poor, non-governmental organizations, and multinational corporations. (shrink)

We evaluate the richness of the child’s input in semantics and its relation to the hypothesis space available to the child. Our case study is the acquisition of the universal quantifier every. We report two main findings regarding the acquisition of every on the basis of a corpus study of child-directed and child-ambient speech. Our first finding is that the input in semantics is rich enough to systematically eliminate instances of the subset problem of language acquisition: overly general hypotheses about (...) the meaning of every can violate pragmatic constraints, making such hypotheses incompatible with the child’s input. Our second finding is that the semantic input is too poor to eliminate instances of what we refer to as the superset problem, the mirror image of the subset problem. We argue that at least some overly specific hypotheses about the meaning of every are compatible with the child’s input, suggesting either that those hypotheses are not made available by UG or that non-trivial inductive biases are involved in children’s acquisition of every. (shrink)

This paper is an update of the documents we have concerning the Acts of the Christian martyrs, focused on three main aspects: 1) the kind of acts we know of and their classification from the point of view of their historic value; 2) the versions or editions of the texts that are most accepted by scholars; 3) the relevance of the different parts that make up these documents in order to discern the original text from passages that were rewritten or (...) underwent later variations. In this way, the article offers an exhaustive list of the documents for use in researching Christian martyrs in the Roman period. (shrink)

We introduce LTAG-spinal, a novel variant of traditional Lexicalized Tree Adjoining Grammar (LTAG) with desirable linguistic, computational and statistical properties. Unlike in traditional LTAG, subcategorization frames and the argument-adjunct distinction are left underspecified in LTAG-spinal. LTAG-spinal with adjunction constraints is weakly equivalent to LTAG. The LTAG-spinal formalism is used to extract an LTAG-spinal Treebank from the Penn Treebank with Propbank annotation. Based on Propbank annotation, predicate coordination and LTAG adjunction structures are successfully extracted. The LTAG-spinal Treebank makes explicit semantic relations (...) that are implicit or absent from the original PTB. LTAG-spinal provides a very desirable resource for statistical LTAG parsing, incremental parsing, dependency parsing, and semantic parsing. This treebank has been successfully used to train an incremental LTAG-spinal parser and a bidirectional LTAG dependency parser. (shrink)

It is shown that the 33 complex rays in three dimensions used by Penrose to prove the Bell-Kochen-Specker theorem have the same orthogonality relations as the 33 real rays of Peres, and therefore provide an isomorphic proof of the theorem. It is further shown that the Peres and Penrose rays are just two members of a continuous three-parameter family of unitarily inequivalent rays that prove the theorem.

In recent literature, panpsychism has been defended by appeal to two main arguments: first, an argument from philosophy of mind, according to which panpsychism is the only view which successfully integrates consciousness into the physical world (Strawson 2006; Chalmers 2013); second, an argument from categorical properties, according to which panpsychism offers the only positive account of the categorical or intrinsic nature of physical reality (Seager 2006; Adams 2007; Alter and Nagasawa 2012). Historically, however, panpsychism has also been defended by appeal (...) to a third argument based on considerations about the nature and observability of causation. This argument has not been much discussed in recent times. Here is a concise version from William James: "… the concrete perceptual flux, taken just as it comes, offers in our own activity-situations perfectly comprehensible instances of causal agency … If we took these experiences as the type of what actual causation is, we should have to ascribe to cases of causation outside of our life, to physical cases also, an inwardly experiential nature. In other words, we should have to espouse a so-called “pan-psychic” philosophy" (James 1911: 218). James here suggests that we have direct experience of causation in our own agency. He thereby directly contradicts David Hume, who famously denied that we have any experience of causation. James goes on to claim that if this experience is representative of causation in general, it follows that all causation is mental, and that panpsychism is true. This kind of argument for panpsychism can be called the argument from (experience of) causation. This chapter offers, first, a history of this argument and arguments closely related to it, and second, an analysis of the argument – is it valid, are its premises in any way defensible, and how does it relate to the other, more popular arguments for panpsychism from philosophy of mind and categorical properties? (shrink)

Studies on the conservation of the inferred transcriptional regulatory network of prokaryotes have suggested that specific transcription factors are less‐widely conserved in comparison to their target genes. This observation implied that, at large evolutionary distances, the turnover of specific transcription factors through loss and non‐orthologous displacement might be a major factor in the adaptive radiation of prokaryotes. However, the recent work of Hershberg and Margalit1 suggests that, at shorter phylogenetic scales, the evolutionary dynamics of the bacterial transcriptional regulatory network might (...) exhibit distinct patterns. The authors find previously unnoticed relationships between the regulatory mode (activation or repression), the number of regulatory interactions and their conservation patterns in γ‐proteobacteria. These relationships might be shaped by the differences in the adaptive value and mode of operation of different regulatory interactions. BioEssays 29:625–629, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Ibn al-ʻArabī, 1165-1240; views on freedom; Sufism; Islamic philosophy.

. The problem of reconstructing digital images from degraded measurements is regarded as a problem of importance in various fields of engineering and imaging science. The main goal of denoising is to restore a noisy image to produce a visually high quality image. In this paper, we propose a novel transform domain technique that uses multispinning for image denoising. The proposed method uses multiple cyclic shifted versions of an image, where each of them would capture more detail information during decomposition. (...) Discrete wavelet transform and contourlet transform in association with multispinning is used. The results are compared with traditional transform and spatial domain techniques. The visual and quantitative evaluation suggests that the proposed method yields better results. (shrink)

Although existing research evaluates the growth and motivations behind global corporate social responsibility activity, there is little understanding whether these growing commitments generate strategic benefits to their adherents. In this article, we analyze the organizational attributes that underlie the firm’s ability to generate competitive advantage from the adoption of a global CSR framework. We develop hypotheses on economic and reputational benefits and test whether firm performance, organizational resources, and access to business and CSR networks determine these benefits in CSR frameworks. (...) Results from a survey of 213 Spanish global compact business participants strongly support our arguments. (shrink)

The set of 60 real rays in four dimensions derived from the vertices of a 600-cell is shown to possess numerous subsets of rays and bases that provide basis-critical parity proofs of the Bell-Kochen-Specker (BKS) theorem (a basis-critical proof is one that fails if even a single basis is deleted from it). The proofs vary considerably in size, with the smallest having 26 rays and 13 bases and the largest 60 rays and 41 bases. There are at least 90 basic (...) types of proofs, with each coming in a number of geometrically distinct varieties. The replicas of all the proofs under the symmetries of the 600-cell yield a total of almost a hundred million parity proofs of the BKS theorem. The proofs are all very transparent and take no more than simple counting to verify. A few of the proofs are exhibited, both in tabular form as well as in the form of MMP hypergraphs that assist in their visualization. A survey of the proofs is given, simple procedures for generating some of them are described and their applications are discussed. It is shown that all four-dimensional parity proofs of the BKS theorem can be turned into experimental disproofs of noncontextuality. (shrink)

A diagrammatic representation is given of the 24 rays of Peres that makes it easy to pick out all the 512 parity proofs of the Kochen-Specker theorem contained in them. The origin of this representation in the four-dimensional geometry of the rays is pointed out.

It is shown how the 300 rays associated with the antipodal pairs of vertices of a 120-cell (a four-dimensional regular polytope) can be used to give numerous “parity proofs” of the Kochen–Specker theorem ruling out the existence of noncontextual hidden variables theories. The symmetries of the 120-cell are exploited to give a simple construction of its Kochen–Specker diagram, which is exhibited in the form of a “basis table” showing all the orthogonalities between its rays. The basis table consists of 675 (...) bases (a basis being a set of four mutually orthogonal rays), but all the bases can be written down from the few listed in this paper using some simple rules. The basis table is shown to contain a wide variety of parity proofs, ranging from 19 bases (or contexts) at the low end to 41 bases at the high end. Some explicit examples of these proofs are given, and their implications are discussed. (shrink)

Greek text, english translation and commentary on the surviving fragments of Empedocles (fragments as known in 1981, does not include more recent finds).

Contrary to Vaesen's argument that humans are unique with respect to nine cognitive capacities essential for tool use, we suggest that although such cognitive processes contribute to variation in tool use, it does not follow that these capacities arenecessaryfor tool use, nor that tool use shaped cognition per se, given the available data in cognitive neuroscience and behavioral biology.

There are obvious benefits to be gained from the study of logic: heightened ability to express ideas clearly and concisely, increased skill in defining one's terms, enlarged capacity to formulate arguments rigorously and to analyze them critically. But the greatest benefit, in my judgment, is the recognition that reason can be applied in every aspect of human affairs.

What are conspiracy theories? And what, if anything, is epistemically wrong with them? I offer an account on which conspiracy theories are a unique way of holding a belief in a conspiracy. Specifically, I take conspiracy theories to be self-insulating beliefs in conspiracies. On this view, conspiracy theorists have their conspiratorial beliefs in a way that is immune to revision by counter-evidence. I argue that conspiracy theories are always irrational. Although conspiracy theories involve an expectation to encounter some seemingly disconfirming (...) evidence (allegedly planted by the conspirators), resistance to all counter- evidence cannot be justified on these grounds. (shrink)

This paper is devoted to the study of some subvarieties of the variety Qof Q-Heyting algebras, that is, Heyting algebras with a quantifier. In particular, a deeper investigation is carried out in the variety Q 3 of three-valued Q-Heyting algebras to show that the structure of the lattice of subvarieties of Qis far more complicated that the lattice of subvarieties of Heyting algebras. We determine the simple and subdirectly irreducible algebras in Q 3 and we construct the lattice of subvarieties (...) (Q 3 ) of the variety Q 3. (shrink)