Mutations in the CEBPA gene are present in 10–15% of acute myeloid leukemia (AML) patients. The most frequent type of mutations leads to the expression of an N‐terminally truncated variant of the transcription factor CCAAT/enhancer‐binding protein alpha (C/EBPα), termed p30. While initial reports proposed that p30 represents a dominant‐negative version of the wild‐type C/EBPα protein, other studies show that p30 retains the capacity to actively regulate gene expression. Recent global transcriptomic and epigenomic analyses have advanced the understanding of the distinct (...) roles of the p30 isoform in leukemogenesis. This review outlines direct and indirect effects of the C/EBPα p30 variant on oncogenic transformation of hematopoietic progenitor cells and discusses how studies of N‐terminal CEBPA mutations in AML can be extrapolated to identify novel gain‐of‐function features in oncoproteins that arise from recurrent truncating mutations in transcription factors. (shrink)

Many of our attitudes are non-culpable: there was nothing that we should have done to avoid holding them. I argue that we can still be blameworthy for non-culpable attitudes: they can impair our relationships in ways that make our full practice of apology and forgiveness intelligible. My argument poses a new challenge to indirect voluntarists, who attempt to reduce all responsibility for attitudes to responsibility for prior actions and omissions. Rationalists, who instead explain attitudinal responsibility by appeal to reasons-responsiveness, can (...) make sense of blameworthiness for non-culpable attitudes. In response, voluntarists could propose a revision of our actual practices. This would lead us into a quite different debate. (shrink)

An important debate in the current literature is whether “all truth-conditional effects of extra-linguistic context can be traced to [a variable at; LM] logical form” (Stanley, ‘Context and Logical Form’, Linguistics and Philosophy, 23 (2000) 391). That is, according to Stanley, the only truth-conditional effects that extra-linguistic context has are localizable in (potentially silent) variable-denoting pronouns or pronoun-like items, which are represented in the syntax/at logical form (pure indexicals like I or today are put aside in this discussion). According to (...) Recanati (‘Unarticulated Constituents’, Linguistics and Philosophy, 25 (2002) 299), extra-linguistic context can have additional truth-conditional effects, in the form of optional pragmatic processes like ‘free enrichment’. This paper shows that Recanati’s position is not warranted, since there is an alternative line of analysis that obviates the need to assume free enrichment. In the alternative analysis, we need Stanley’s variables, but we need to give them the freedom to be or not to be generated in the syntax/present at logical form, a kind of optionality that has nothing to do with the pragmatics-related optionality of free enrichment. (shrink)

In this paper I demonstrate that there is an explanation of the number marking we see on nouns when they combine with the numeral _zero_ which combines Martí’s (Semant. Pragmat., 2020a, https://doi.org/10.3765/sp.13.3 ) account of the morphosyntax and semantics of the numeral-noun construction with Bylinina and Nouwen’s (Glossa 3(1):98, 2018 ) semantics for _zero_ and which does not need to appeal to any further principles (e.g., agreement).

The central importance of Marx's concept of nature in the formulation of historical materialism has been largely neglected in the extensive literature on Marx. Alfred Schmidt, philosophical successor to Max Horkheimer and Theodor Adorno in Frankfurt, seeks to elucidate it in this original study.

Is freedom a plausible political value for animals? If so, does this imply that animals are owed legal personhood rights or can animals be free but remain human property? Drawing on different conceptions of freedom, I will argue that while positive freedom, libertarian self-ownership, and republican freedom are not plausible political values for animals, liberal ‘option-freedom’ is. However, because such option-freedom is in principle compatible with different legal statuses, animal freedom does not conceptually imply a right to legal self-ownership. Nonetheless, (...) a concern for animal option-freedom means that humans do have a pro tanto duty of non-interference. Arguments familiar from the liberal tradition moreover imply that such a duty speaks for drastic reforms of existing animal law. But it does not imply wholesale abolitionism: it neither rules out positive duties towards animals nor means that we should abandon all interactions with animals. (shrink)

Les dictionnaires et documents, tirés de la littérature ou des archives, qui sont examinés dans cet ouvrage disent plus de mal que de bien de la séduction. La séduction c'est « l'élan qui porte l'un vers l'autre », mais cet élan est dévié par la tromperie. La séduction peut être située dans la polémique de longue durée contre le maquillage et la vanité des femmes. Leon Battista Alberti compare la femme, qui a la déplorable habitude de se maquiller, à l'artiste (...) qui aurait l'habitude, to... (shrink)

The aim of the present study was to investigate the effects of communicative intention on action. In Experiment 1 participants were requested to reach towards an object, grasp it, and either simply lift it or lift it with the intent to communicate a meaning to a partner . Movement kinematics were recorded using a three-dimensional motion analysis system. The results indicate that kinematics was sensitive to communicative intention. Although the to-be-grasped object remained the same, movements performed for the ‘communicative’ condition (...) were characterized by a kinematic pattern which differed from those obtained for the ‘individual’ condition. These findings were confirmed in a subsequent experiment in which the communicative condition was compared to a control condition, in which the communicative exchange was prevented. Results are discussed in terms of cognitive pragmatics and current knowledge on how social behavior shapes action kinematics. (shrink)

_ Source: _Page Count 26 Is freedom a plausible political value for animals? If so, does this imply that animals are owed legal personhood rights or can animals be free but remain human property? Drawing on different conceptions of freedom, I will argue that while positive freedom, libertarian self-ownership, and republican freedom are not plausible political values for animals, liberal ‘option-freedom’ is. However, because such option-freedom is in principle compatible with different legal statuses, animal freedom does not conceptually imply a (...) right to legal self-ownership. Nonetheless, a concern for animal option-freedom means that humans do have a _pro tanto_ duty of non-interference. Arguments familiar from the liberal tradition moreover imply that such a duty speaks for drastic reforms of existing animal law. But it does not imply wholesale abolitionism: it neither rules out positive duties towards animals nor means that we should abandon all interactions with animals. (shrink)

"Cover " -- "Title Page " -- "Copyright " -- "Contents " -- "Preface to the English Edition" -- "Introduction" -- "1. The Substitute" -- "2. Animals, Machines, Cyborgs, and the Taxi " -- "3. Mind, Emotions, and Artificial Empathy " -- "4. The Other Otherwise " -- "5. From Moral and Lethal Machines to Synthetic Ethics " -- "Notes" -- "Works Cited" -- "Acknowledgments" -- "Credits.

In this article we tackle the core question of machine emotion research – “Can machines have emotions?” – in the context of “social robots”, a new class of machines designed to function as “social partners” for humans. Our aim, however, is not to provide an answer to the question “Can robots have emotions?” Rather we argue that the “robotics of emotion” moves us to reformulate it into a different one – “Can robots affectively coordinate with humans?” Developing a series of (...) arguments relevant to theory of emotion, philosophy of AI, and the epistemology of synthetic models, we argue that the answer to this different question is positive, and that it lays grounds for an innovative ethical approach to emotional robots. This ethical project, which we introduced elsewhere as “synthetic ethics”, rejects the diffused ethical condemnation of emotional robots as “cheating” technology. Synthetic ethics focuses not on an ideological refusal, but on the concrete sustainability of the emerging mixed human-robot social ecologies. On this basis, in contrast to a purely negative ethical approach to social robotics it promotes an analytical case by case ethical inquiry into the type of human flourishing that can result from human-robot affective coordination. (shrink)

Social robotics entertains a particular relationship with anthropomorphism, which it neither sees as a cognitive error, nor as a sign of immaturity. Rather it considers that this common human tendency, which is hypothesized to have evolved because it favored cooperation among early humans, can be used today to facilitate social interactions between humans and a new type of cooperative and interactive agents - social robots. This approach leads social robotics to focus research on the engineering of robots that activate anthropomorphic (...) projections in users. The objective is to give robots "social presence" and "social behaviors" that are sufficiently credible for human users to engage in comfortable and potentially long-lasting relations with these machines. This choice of ’applied anthropomorphism’ as a research methodology exposes the artifacts produced by social robotics to ethical condemnation: social robots are judged to be a "cheating" technology, as they generate in users the illusion of reciprocal social and affective relations. This article takes position in this debate, not only developing a series of arguments relevant to philosophy of mind, cognitive sciences, and robotic AI, but also asking what social robotics can teach us about anthropomorphism. On this basis, we propose a theoretical perspective that characterizes anthropomorphism as a basic mechanism of interaction, and rebuts the ethical reflections that a priori condemns "anthropomorphism-based" social robots. To address the relevant ethical issues, we promote a critical experimentally based ethical approach to social robotics, "synthetic ethics," which aims at allowing humans to use social robots for two main goals: self-knowledge and moral growth. (shrink)

Argues that affirming the irreducible differences between men and women can lead to more transformative politics than the struggle for abstract equality between the sexes. In The Symbolic Order of the Mother Luisa Muraro identifies the bond between mother and child as ontologically fundamental to the development of culture and politics, and therefore as key to achieving truly emancipatory political change. Both corporeal development and language acquisition, which are the sources of all thinking, begin in this relationship. However, Western (...) civilization has been defined by men, and Muraro recalls the admiration and envy she felt for the great philosophers as she strove to become one herself, as well as the desire for independence that opposed her to her mother. This conflict between philosophy and culture on the one hand and the relationship with the mother on the other constitutes the root of patriarchy’s symbolic disorder, which blocks women’s (and men’s) access to genuine freedom. Muraro appeals to the feminist practice of gratitude to the mother and the recognition of her authority as a model of unconditional nurture and support that must be restored. This, she argues, is the symbolic order of the mother that must overcome the disorder of patriarchy. The mediating power of the mother tongue constitutes a symbolic order that comes before all others, for both women and men. Luisa Muraro is Professor Emeritus of Philosophy at the University of Verona, Italy. Francesca Novello is an instructor at the University of Oklahoma. Timothy S. Murphy is Houston-Truax-Wentz Professor and Regents Professor of English at Oklahoma State University. (shrink)

The present study examined the effects of thought suppression on sleep-onset mentation. It was hypothesized that the decrease of attentional control in the transition to sleep would lead to a rebound of a suppressed thought in hypnagogic mentation. Twenty-four young adults spent two consecutive nights in a sleep laboratory. Half of the participants were instructed to suppress a target thought, whereas the other half freely thought of anything at all. To assess target thought frequency, three different measures were used in (...) the wake state and mentation reports were repeatedly prompted by a computer at sleep onset. In support of the hypothesis, results revealed a reversal of target thought frequency at sleep onset: Participants instructed to suppress reported fewer target thoughts than did controls before falling asleep, but more target thoughts afterwards. (shrink)

How a human observer perceives duration depends on the amount of events taking place during the timed interval, but also on psychological dimensions, such as emotional-wellbeing, mindfulness, impulsivity, and rumination. Here we aimed at exploring these influences on duration estimation and passage of time judgments. One hundred and seventeen healthy individuals filled out mindfulness (FFMQ), impulsivity (BIS-11), rumination (RRS), and depression (BDI-sf) questionnaires. Participants also conducted verbal estimation and production tasks in the multiple seconds range. During these timing tasks, subjects (...) were asked to read digits aloud that were presented on a computer screen. Each condition of the timing tasks differed in terms of the interval between the presentation of the digits, i.e., either short (4-s) or long (16-s). Our findings suggest that long empty intervals (16-s) are associated with a relative underestimation of duration, and to a feeling that the time passes slowly, a seemingly paradoxical result. Also, regarding more mindful individuals, such a dissociation between duration estimation and passage of time judgments was found, but only when empty intervals were short (4-s). Relatively speaking, more mindful subjects showed an increased overestimation of durations, but felt that time passed more quickly. These results provide further evidence for the dissociation between duration estimation and the feeling of the passage of time. We discuss these results in terms of an alerting effect when empty intervals are short and events are more numerous, which could mediate the effect of dispositional mindfulness. (shrink)

En su infancia Mohamed Chukri se ve arrastrado por la miseria, la violencia intrafamiliar, consume prostitución y se prostituye, fuma kif, trasnocha en los bares, roba y trabaja con contrabandistas. Todo ello lo narra en la novela El pan a secas (1973). En este artículo se analiza la novela en clave de esperanza/desesperanza. La novela se divide en dos: episodios de infancia (negativos, desesperanza) y de adolescencia (positivos, esperanza recuperada). Resiliencia, libertad y esperanza están íntimamente ligadas.

The volume presents the illuminating research carried out by international scholars of Locke’s thought and the early modern period in general. The essays address the theoretical and historical contexts of Locke’s analytical methodology and come together in a multidisciplinary approach that sets biblical hermeneutics in relation to his philosophical, historical, and political thought, and to the philological and doctrinal culture of his time. Centring on the last decade of Locke’s life and the publication of his posthumous works, these studies illustrate (...) the influence that his interpretation of the Bible and the Christian tradition had on eighteenth-century thinkers and controversialists. The contextualization of Locke’s biblical hermeneutics within the contemporary reading of the Bible contributes to the analysis of the figure of Christ and the role of Paul, St.’s theology in political and religious thought from the seventeenth century to the Enlightenment. The volume sheds light on how Locke was appreciated by his contemporaries as a biblical interpreter and exegete. It also offers a reconsideration that overarches interpretations confined within specific disciplinary ambits and his own intellectual biography to address Locke’s thought in a global historic context. (shrink)

Venant de Belgique, où elle poursuit des recherches comparatives de longue durée sur les femmes dans les mouvements mystiques médiévaux, dans lesquels les béguines anversoises ont joué un rôle décisif, Luisa Muraro s’est arrêtée à Paris et le séminaire qu’elle a donné à la Maison des sciences de l’Homme, le 25 mars 1999, fut l’occasion d’une rencontre avec une personnalité exceptionnelle, dont l’itinéraire, l’expérience, le non-conformisme, la recherche inquiète soucieuse de prendre à bras-l...

The main purpose of this paper is to introduce a class of algebraic structures related to many-valued ukasiewicz algebras. They are symmetrical Heyting algebras with a set of modal operators indexed by a finite completely symmetric poset. A representation theorem is given for these (not functionally complete) algebras.

The views of Celia Amorós, which are dealt with here, originate in the ideas which appeared, especially in the Enlightenment, and which demanded equality for women. Following this line of thought she studies some of the most powerful theories of Western philosophical tradition in order to carry out a critical feminist deconstruction. Since her work is a critique of the philosophical critique of the Enlightenment, one can identify traces , today almost forgotten, of a feminist tradition of thought which can (...) be considered as a discourse of emancipation. Furthermore, this critical exercise becomes an intellectual and social non-patriarchal project of a society free from gender restrictions. In this sense, Celia Amoros’ philosophical work develops into philosophical feminism, not only in terms of being critical revision of the history of ideas, but also and principally because it takes shape as critical reflection and as direct dialogue with present-day philosophical discourse. (shrink)

Frente a la naturalización, lo que llama “deshistoricización”, Pierre Bourdieu, desde su “estructuralismo constructivista” o su “constructivismo genético”, analiza cómo el poder es constitutivo de la sociedad y existe en las cosas y en los cuerpos, incorporándose a los habitus mismos que definen la subjetividad. De este modo, sus análisis abren la puerta a una reconsideración teórico-crítica de las relaciones entre los sexos y, precisamente por ello, son de interés para una perspectiva crítico-feminista, si bien hay que reseñar la escasa (...) atención bourdiueana a la producción de tal perspectiva. (shrink)

Hablar de las herencias del pensamiento moderno y referirse a Kant resulta una obviedad. Pero cuando Putnam asevera que Kant fue �el primer realista interno� parece de suyo tomarlo en consideración. Centrándonos tan sólo en la fase de este realismo interno putnamiano �y en particular tal como se expresa en Razón, verdad e historia�, este trabajo se propone detectar algunos de los lugares textuales de la Crítica de la razón pura que avalan esa afirmación y la dotan de sentido. Qué (...) entienden ambos textos por racionalidad y por verdad nos guiará a la hora situar dónde ambos pensadores, más allá de la distancia teórica e histórica, vienen a encontrase. (shrink)

Damaris Cudworth Masham was convinced that the “useful knowledge” has a theoretical, practical and pedagogic content. Man has a social destiny and we cannot offend the divine wisdom assuming that religion precludes this approach and expects the breakdown of society. Reason therefore has a prominent character on the will and free will is the pillar of moral practice. This thought reveals an affinity with the Lockean concept of “person” and “identity” and the central role of individual liberty for love of (...) God and for an ordered and social life. Thanks also to her intellectual relationship with Locke, her “philosophical salon” at Oates become the meeting point for overseas and English scholars, such as Jean Le Clerc, Pierre Des Maizeaux, Pierre Coste, the III Earl of Shaftesbury. Through original sources the paper focus the intellectual legacy of Damaris Masham. (shrink)

(2005). Freedom in Responsibility: On the Relevance of “Sin” As a Hermeneutic Guiding Principle in Bioethical Decision Making. Christian Bioethics: Vol. 11, No. 2, pp. 147-165.

Jana Sawicki uses the work and methods of Foucault to explore the possibility of a politics of difference. I argue that Foucault may help us overcome some forms of dogmatism inherited from men's political philosophy of the past, but Foucault is otherwise useless, or worse: misleading. Because Sawicki presents a politics of diversity among women regardless of, and independent from, a politics of sexual difference, I believe Foucault is misleading.

Muraro’s article begins from the philosophical question of the ‘unthought’, and asks how our very image of thought is transformed when the thinking subject is a woman, and her thought is specifically linked to the experience of a body. On the basis of a feminist interrogation of sexual difference which reveals the forms of violence inherent in certain claims to universality, Muraro tries to develop a thinking of politics which would rest on its symbolic distance or independence from power. Through (...) readings of Freud, Macbeth, Saint Paul and women’s narratives, Muraro investigates the dangers borne by the fusion of power and politics and explores the ways in which they could be disjoined. (shrink)