Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site‐specified subsignals, rather than single, homogeneous entities. In the context of cancer, searching for compounds that selectively block subsignals essential for tumor progression, but not those regulating “house‐keeping” functions, could help in producing drugs with reduced side effects compared to compounds that block signaling completely. The Ras‐ERK pathway has become a paradigm of how space can differentially shape signaling. Today, we know that Ras proteins are found (...) in different plasma membrane microdomains and endomembranes. At these localizations, Ras is subject to site‐specific regulatory mechanisms, distinctively engaging effector pathways and switching‐on diverse genetic programs to generate different biological responses. The Ras effector pathway leading to ERKs activation is also under strict, space‐related regulatory processes. These findings may open a gate for aiming at the Ras‐ERK pathway in a spatially restricted fashion, in our quest for new anti‐tumor therapies. (shrink)

With the arrival of the nineteenth century, a process of change guided the treatment of three basic elements in the development of mathematics: rigour, the arithmetization and the clarification of the concept of function, categorised as the most important tool in the development of the mathematical analysis. In this paper we will show how several prominent mathematicians contributed greatly to the development of these basic elements that allowed the solid underpinning of mathematics and the consideration of mathematics as an axiomatic (...) way of thinking in which anyone can deduce valid conclusions from certain types of premises. This nineteenth century stage shares, possibly with the Heroic Age of Ancient Greece, the most revolutionary period in all history of mathematics. (shrink)

The importance of mathematics in the context of the scientific and technological development of humanity is determined by the possibility of creating mathematical models of the objects studied under the different branches of Science and Technology. The arithmetisation process that took place during the nineteenth century consisted of the quest to discover a new mathematical reality in which the validity of logic would stand as something essential and central. Nevertheless, in contrast to this process, the development of mathematical analysis within (...) a framework that largely involves intuition and geometry is a fact that cannot go unnoticed amongst the mathematics community, as we shall show in this paper through the research made by Bernhard Riemann on complex variables. (shrink)

Fazer a genealogia do poder nunca foi o propósito claro de Foucault. No entanto, a questão do poder foi tema recorrente em suas investigações a ponto de estudiosos do trabalho do filósofo sugerirem uma divisão e organização de seu trabalho a partir de três eixos teóricos. Dentro dessa perspectiva, a analítica do poder marcaria a trajetória filosófica de Foucault na década de 1970. De fato, até 1994, ano de publicação do conjunto de textos, entrevistas e conferências de Foucault no Dits (...) et écrits, a questão da analítica do poder era majoritariamente conhecida a partir de livros como Surveiller et punir e Histoire de la sexualité I: la volonté de savoir. Com o início da publicação dos cursos no Collège de France a partir de 1997 as interpretações a respeito da analítica do poder sofrem um alargamento. Mas é somente em 2015 que a totalidade dos cursos de Foucault no Collège de France foram publicados, abrindo um importante caminho para a investigação a respeito das primeiras reflexões a respeito do poder. No presente artigo procuramos mostrar como os primeiros passos da analítica do poder de Michel Foucault se dá a partir de um contexto gauchiste ainda configurado em termos de dinástica do saber. Nesse sentido, procuramos mostrar como o período da dinástica corresponde a um esboço teórico, tentativas primeiras de conceituação do poder, marcadamente desenvolvido em contraposição com o marxismo. Essa contraposição se dá sobretudo na recusa tanto do esquema marxista de infra-superestrutura, quanto do modelo contratualista de sociedade estatal. (shrink)

Formas de representación de la violencia en El vuelo del tigre y Libro de navíos y borrascas de Daniel Moyano.

En 1919, la même année où Jean Giraudoux fait son « Adieu à la guerre », il écrit « Les morts d’Elpénor ». En 1926, à côté de trois autres histoires, ce texte intégrera le corps d’Elpénor, déterminant l’ensemble, une collection de quatre textes écrits pendant dix-huit ans, le premier étant « Cyclope », écrit en 1908 ; le deuxième, « Sirènes », en 1912 ; le troisième en 1919 ; et le dernier en 1926, « Les nouvelles morts d’Elpénor (...) ». Quand « Cyclope » et « Sirènes » sortent respectivement chez Le Matin en 1908 et chez Paris-Journal en 1912 aucun d’entre eux ne mentionne Elpénor. Bref, c’est avec le développement des deux dernières histoires, que Elpénor, cette figure effacée chez Homère et absente dans les deux premiers textes de Giraudoux, vole la vedette. Cet article voudrait montrer comment la mise à jour du héros et de ses histoires est en dialogue avec la guerre vécue par l’auteur, pour proposer comment les vieilles histoires, lorsqu’elles sont renouvelées, participent à un processus qui leur permet d’élaborer les défis du présent, communiquant le présent, à travers un code déjà public, l’Odyssée. (shrink)

The figure of chiasmus, which plays a key role inside Merleau-Ponty’s thought, makes it possible to address the way Castoriadis defines the imaginary throughout his entire work from a new perspective, as well as to shed light on some complexities concerning the relation between instituted and instituting. Tthis article emphasizes the intertwining of three pair of concepts, each of which corresponds to a different but yet interrelated aspect of his philosophy: psyche-society, tradition-innovation, and autonomy-heteronomy.

El presente trabajo recoge un análisis comparativo realizado entre diversos códigos y recomendaciones de buen gobierno tanto a nivel nacional como internacional. Durante el estudio, se ha revisado una amplia muestra de códigos de gobierno corporativo, prestando especial atención a los aspectos incluidos en los mismos relativos a la composición de los consejos de administración, la voluntariedad versus obligatoriedad de las recomendaciones, el tratamiento otorgado a las figuras de Presidente y CEO, etc., identificando las principales diferencias y similitudes entre ellos (...) y mostrando la evolución temporal de las distintas recomendaciones en los diferentes países e instituciones analizadas. Tras el análisis comparativo se observa que la mayoría de los códigos se orientan en la misma dirección, incluyendo apartados similares en todos ellos, aunque también existen pequeñas matizaciones específicas que los diferencian. (shrink)

El estudio aborda cómo perciben un grupo de estudiantes de Grado de Educación Infantil la fase de seducción en el cortejo heterosexual en la actualidad. Este estudio forma parte de una investigación en la que se preguntaba a futuros docentes por películas determinantes que trabajarían en el aula. Las películas mostraron estereotipos sexistas y mitos del amor romántico. El estudio explora si los discursos con los que se narra la seducción comparten las representaciones del amor romántico.

The main objective of this piece of work is to reflect upon the evolution of the socially responsible mutual funds industry in Europe over the recent years. In order to do this, we shall analyse the evolution of the number of ethical funds offered, the growth of its assets, its size, the typology of commercialised funds, and the main companies included in its investment portfolios, showing the importance that socially responsible mutual funds are gaining in Europe over these first few (...) years of the 21st century. (shrink)

El propósito de este artículo es exponer la interpretación de la ideología en la obra_ Trabajo manual y trabajo intelectual. Una crítica de la epistemología_ de Alfred Sohn-Rethel entendida como inconsciente del sujeto transcendental, la cual pivota en torno al famoso término _abstracción real_ [_Realabstraktion_] como principio de síntesis social; y, por otro lado, medir someramente sus _alcances _y_ limitaciones _respecto de las nuevas lecturas de Marx, concretamente, de la crítica de la escisión del valor [_Wertabspaltungskritik_].

Over the last decade, our appreciation of the importance of the nucleolus for cellular function has progressed from the ordinary to the extraordinary. We no longer think of the nucleolus as simply the site of ribosome production, or a dynamic subnuclear body noted by pathologists for its changes in size and shape with malignancy. Instead, the nucleolus has emerged as a key controller of many cellular processes that are fundamental to normal cell homeostasis and the target for dysregulation in many (...) human diseases; in some cases, independent of its functions in ribosome biogenesis. These extra‐nucleolar or new functions, which we term “non‐canonical” to distinguish them from the more traditional role of the nucleolus in ribosome synthesis, are the focus of this review. In particular, we explore how these non‐canonical functions may provide novel insights into human disease and in some cases new targets for therapeutic development. (shrink)

Optando por la retórica, Las Casas busca un modelo antropológico nuevo, distinto tanto del humanismo elitista, como del erasmismo voluntarista. En esta búsqueda quisiéramos poner énfasis, argumentando a favor de un resultado revolucionario a la luz de sus objetivos prácticos: cesar el homicidio y garantizar la libertad a los indios en cada aspecto de su vida. Desde aquí, nos referiremos a esta postura revolucionaria que bebe de Aristóteles y de santo Tomás, pero que es capaz de superarlos, a favor de (...) una defensa de lo propiamente humano, que estriba precisamente en reconocer que todas las comunidades tienen la posibilidad de realizarse autónomamente. Por esto, creemos que se puede hallar, en Bartolomé de las Casas, una importante contribución a la cuestión del reconocimiento, pero aún más, un importante punto de partida para los desafíos de una filosofía intercultural. (shrink)

Should Lesbian and women's events have policies banning sadomasochists or sadomasochistic acts? This question is being heatedly debated in the Lesbian community. In this paper, I examine the moral and political problems with sadomasochism from a Lesbian-feminist perspective, concluding that sadomasochism is antifeminist and antiliberatory for many reasons. Then, given this conclusion, I explore how events such as women's music festivals should determine their policies about sadomasochism.

Este artigo aborda a temática ética na obra Suma Teológica de Tomás de Aquino. Mais precisamente visamos demonstrar a maneira em que se dá o tratamento da moralidade no âmbito social, no interior das comunidades. Tenho a intenção neste trabalho de ajudar a explicitar o caráter comunitário da ética de Tomás de Aquino, e mais precisamente, estou interessada em delimitar criticamente os elementos constitutivos da formulação filosófica por Tomás de Aquino do conceito de comunidade moral na Suma Teológica.

This book examines the history of cosmopolitanism from its origins in the ancient world up to its use in Kantian political philosophy. Taking the idea of 'common property of the land' as a starting point, the author makes the original case that attention to this concept is needed to properly understand the notion of cosmopolitan citizenship. Offering a reconstruction of cosmopolitanism from an interdisciplinary point of view, Toward Kantian Cosmopolitanism shows how the concept sits at the intersection between philosophical debates, (...) legal realities and the origins of the construction of the discipline of international law. Essential reading for all researchers and advances students of cosmopolitanism, political philosophy and the history of international law, it broadens the current understanding of the concept of cosmopolitanism and reflects on cosmopolitan studies from a historical and philosophical point of view. (shrink)

Desde mediados del siglo XX, el devenir de la salvaguarda relacionada con las viviendas ha avanzado desde la monumentalidad hasta el contexto, desde la individualización hasta la caracterización paisajística, desde las condiciones materiales hasta los aspectos vivenciales. Sin embargo, amparar el cuerpo de las residencias típicas de cada territorio, en especial en los dinámicos marcos urbanos, resultó —y resulta— un desafío. Las experimentaciones de propuestas hacia un amparo residencial a más largo plazo han coincidido en dos aspectos de interés: la (...) promoción de indicadores de sustentabilidad patrimonial, inscriptos en cada marco estatal-local preservacionista, junto con el reconocimiento y el tratamiento del rol usuario. En este sentido, desde variables histórico-arquitectónicas y sociales se propuso la construcción y la aplicación de indicadores de sustentabilidad patrimonial residencial para visibilizar problemas y potencialidades hacia una formulación de estrategias de preservación apropiadas. Para ello se abordó la ciudad de Mar del Plata, una aglomeración intermedia bonaerense paradigmática debido a sus dinamismos pasados y presentes, con foco en sus chalets “estilo Mar del Plata” y sus usuarios. Se analizaron dos barrios históricos —Stella Maris y La Perla—, donde sobrevive una relevante diversidad de chalets en un marco de múltiples riesgos que afectan su permanencia. Desde una perspectiva principalmente cualitativa, apoyada por datos cuantitativos, se articularon relevamientos in situ, fuentes escritas (investigaciones previas, artículos científicos, cartas patrimoniales), gráficas (planimetrías, fotografías, imágenes aéreas) y orales (encuestas, entrevistas). De esta manera, la indagación desarrollada permitió avanzar en renovados caminos para progresar en la salvaguarda del legado residencial contextual. (shrink)

Previous research has demonstrated that people are susceptible to developing false memories, that is to recall events that did not actually occur or recall them differently than they occurred (Dods...

Las directrices anticipadas aún no se encuentran legisladas en todos los estados de la República mexicana. En algunos de los estados en los que sí se encuentran legisladas, se prohíbe expresamente su validez durante el periodo de gestación. Lo anterior representa dilemas bioéticos y jurídicos importantes, los cuales revisamos para esclarecer las diversas interrogantes que surgen en materia de la protección tanto del bebé como de la madre gestante. Concluimos que existe una necesidad de desarrollar una ley federal que homologue (...) las directrices anticipadas, garantizando una muerte digna a todos los mexicanos, y que establezca que en caso de encontrarse en periodo de gestación, se busque asesoría por un comité de bioética que apoye a determinar en cada caso particular, las condiciones que favorezcan el desarrollo y supervivencia del bebé, siempre que sea posible, sin recurrir a tratamientos y/o medidas extraordinarias que pongan el riesgo la muerte digna y libre de sufrimiento de la madre. (shrink)

Type 2 diabetes has been considered a public health threat due to its growing prevalence, particularly in the older population. It is important to know the effects of psychosocial stress and its potential consequences for some basic cognitive processes that are important in daily life. Currently, there is very little information about how people with T2D face acute psychosocial stressors, and even less about how their response affects working memory, which is essential for their functionality and independence. Our aim was (...) to characterize the response to an acute laboratory psychosocial stressor and its effects on WM in older people with T2D. Fifty participants with T2D from 52 to 77 years old were randomly assigned to a stress or control condition. Mood and physiological responses to tasks were measured. In addition, participants completed a WM test before and after the stress or control task. Our results showed that the TSST elicited higher negative affect and greater C and sAA responses than the control task. No significant differences in WM were observed depending on the exposure to stress or the control task. Finally, participants who showed higher C and sAA responses to the stressor had lower WM performance. Our results indicate that medically treated older adults with T2D show clear, typical mood and physiological responses to an acute psychosocial stressor. Finally, the lack of acute psychosocial stress effects on WM suggests that it could be related to aging and not to this disease, at least when T2D is adequately treated. (shrink)

Resumen: El presente trabajo pretende contribuir a la discusión sobre la interculturalidad, en perspectiva crítica, desde la filosofía de la praxis histórica de Ignacio Ellacuría, y de la filosofía del reconocimiento de Raúl Fornet Betancourt. Esta propuesta surge como contribución desde la comprensión de una realidad histórica en permanente proceso, dinamismo, respectividad y novedad, y en donde la praxis histórica permite entenderla como apropiación de posibilidades y transformación social: This paper aims to contribute to the discussion on interculturality, in critical (...) perspective, from the philosophy of the historical practice of Ignacio Ellacuría, and the philosophy of the recognition of Raúl Fornet Betancourt. This proposal arises as a contribution from the understanding of a historical reality in a permanent process, dynamism, respectivity and novelty, and where historical praxis allows understanding it as an appropriation of possibilities and social transformation. (shrink)

In this study I intend to prove that there is a close connection between ethical purposes of Environmental Philosophy as World Philosophy and the idea of sacred nature as part of the “world” in a phenomenological sense, which includes sacred space as defined in the philosophy of religion. The main points that intersect here are: the idea of sacred space; the perception of virtue in a sacred world; the beauty of creation: nature, life, human sensibility. The theoretical background of this (...) study contains points of view that express phenomenological, hermeneutic, theological, and aesthetic conceptions belonging to authors and exegetes such as Mircea Eliade, William E. Paden, David Cave, Ion Ianoși, Douglas Allen, Arnold Berleant, and Vincent Blok. I believe that the neglect of the environment-as-a-condition-of-life (the consequences of which can already be seen in ecological imbalances) is caused by, among other factors, the desacralization of human attitudes towards nature and the world of life. Few people still have a feeling of sacred nature or the aesthetic emotion of perceiving beauty in natural forms. The relationship with the environment and nature is reduced to its exploitation as a source of economic profit or as a way for spending free time, a source of personal comfort devoid of any spiritual significance. Surely we cannot go back to archaic religions or medieval Christianity, but we can reintegrate into our moral values something of those cultures’ admiration and respect for the beauty/sublimity of nature and the world as expressions of divine creation, as something sacred. Philosophical debates related to this retrieval and their dissemination could be part of solving the ecological problems of the contemporary world. (shrink)