Alzheimer's disease is the most common form of dementia that gradually disrupts the brain network to impair memory, language and cognition. While the amyloid hypothesis remains the leading proposed mechanism to explain AD pathophysiology, anti-amyloid therapeutic strategies have yet to translate into useful therapies, suggesting that amyloid β-protein and its precursor, the amyloid precursor protein are but a part of the disease cascade. Further, risk of AD can be modulated by a number of factors, the most impactful being the ɛ4 (...) isoform of apolipoprotein E. A recent study reported a novel isoform-dependent transcriptional regulation of APP by apoE. These interesting new results add to the myriad of mechanisms that have been proposed to explain how apoE4 enhances AD risk, highlighting the complexities of not only apoE and AD pathophysiology, but also of disease itself. Also see the video abstract here: https://youtu.be/yd14MBdPkCY APP transcription is differentially modulated by apoE and its isoforms: how does this novel mechanism fit with the existing hypotheses? (shrink)

本书围绕全球正义的哲学论述、跨文明视野中人权与正义原则、民主与和平的政治哲学三个专题,收入论文15篇。.

The COVID-19 epidemic in the early 2020s is making a big difference for educators around the world. For the past 2 years, the curriculum and working patterns have been overturned in response to this epidemic, which has brought unprecedented challenges and physical and mental stress to preschool teachers. This situation can have a drastic impact on the acquisition of job well-being for preschool teachers. During this special time, the leader’s management style will also influence the psychological feelings of the organization’s (...) staff. For example, empowering leadership is an important management function that empowers subordinates, emphasizes the meaning of work, promotes participation in decision-making, and expresses confidence. Therefore, in the current COVID-19 pandemic context, it is worthwhile to explore the topic of empowering leadership to ensure preschool teachers’ well-being, by balancing work demands and work resources in a way that facilitates a sense of organizational support and reduces job stress, while relatively fewer studies have been conducted on the relationship between preschool teachers’ job well-being in the context of the COVID-19 pandemic. Based on this, this study proposed a research model from the theoretical perspective of the Job Demands-Resources Model to explore the influence of empowering leadership, sense of organizational support, and job stress on preschool teachers’ job well-being in the context of the COVID-19 pandemic. To achieve the purpose of this study, a convenience sampling method was used to invite 500 preschool teachers in China to complete a questionnaire survey, and after removing invalid samples and data with incomplete answers, reliability and validity analyses and model fit tests were conducted, followed by a structural equation modeling method for path analysis. The results of the study showed that in the kindergarten work context, empowering leadership showed a significant negative effect on job stress, but a significant positive effect on job well-being and a significant positive effect on sense of organizational support. Sense of organizational support had a significant negative effect on job stress but a significant positive effect on preschool teachers’ job well-being. Preschool teachers’ job stress and job well-being showed a significant negative effect. The contribution of this study was to explore the relationship between understanding leadership empowerment and preschool teachers’ job well-being in the context of the COVID-19 pandemic based on the Job Demands-Resources Model, which will facilitate educational organizational contexts to empower preschool teachers to work harder to reduce their job stress as well as enhance their sense of organizational support and promote the acquisition of job well-being. (shrink)

本书以个案研究和横向研究的方式梳理中西法学思想,梳理法学事件,于“真理、道理、情理与法理”的交融中审视法律、法学和法学家的时代使命。.

Ben shu dui ke xue mei xue si xiang shi de yan jiu dui xiang, ren wu he fang fa jin xing le xi tong di lun shu.

本书为法制研究文集,致力于探讨中国社会与人生所表达的生活方式,探索其中所蕴藏的活的规则,即自然之法,从追索中国自家的“立法”,讨一个“说法”,进而得出一个“活法”。.

本书介绍了职业道德的特征、社会主义职业道德的基本原则和规范,职业道德的教育、修养和评价等内容。.

In this paper, I provide a framework for accounting for the self, based on a reconstruction of Galen Strawson’s “theory of SESMETs,” or the Pearl view, with Barry Dainton’s continuous consciousness thesis. I argue that the framework I provide adequately accounts for the self and is preferable to solely adopting either Strawson’s or Dainton’s theory. I call my reconstruction the “Necklace” view of the self.

The preschool education profession often faces many challenges and preschool teachers, as important members of the preschool education profession must respond to a variety of emergencies with young children, which also leads to high levels of job stress and can have a negative impact on their ongoing well-being. Past research has pointed out that a healthy lifestyle is one of the key factors in enhancing sustainable well-being in high-stress work situations and many studies have found that good leisure activity engagement (...) as a healthy lifestyle is associated with higher levels of well-being. However, the relationship between preschool teachers’ leisure engagement and sustainable well-being has been less explored. Therefore, this study proposed seven research hypotheses based on the engagement theory proposed by Fredricks et al. and developed a research model to explore the relationship between three types of leisure engagement, including behavioral, affective and cognitive, and preschool teachers’ job stress and sustainable well-being, using age as a control variable. This study used a cross-sectional web-based questionnaire with a convenience sample of 500 preschool teachers in China. The collected data were analyzed for reliability and validity, model fit testing and structural equation modeling for model validation after removing invalid data and incomplete responses. The results of the study showed that behavioral engagement was not related with either the job stress or sustainable well-being of preschool teachers; Emotional and cognitive engagement were negatively related to job stress but positively related to the sustainable well-being of preschool teachers; and Job stress was negatively related to the sustainable well-being of preschool teachers; Age is an effective control variable. From the above results, it is clear that not all three types of leisure engagement are effective in terms of reducing the work stress of preschool teachers. As well as being related to the sustainable well-being of preschool teachers emotional and cognitive engagement contributed more to sustainable well-being acquisition. (shrink)

Teacher education students, as an important reserve in the field of education, their growth and development are related to the future of science, economy, sustainable development of education. Through participation in the educational practice of STEAM, which integrates science, technology, engineering, art, and mathematics is more beneficial for them to acquire 21st century skills like communication, collaboration, learning innovation and critical thinking. However, little has been seen about the use and effectiveness of short videos in STEAM education activities and how (...) they can be used to support and promote teacher education students STEAM learning performance and sustainable inquiry behaviors. Therefore, this study combines the framework of triadic reciprocity determinism theory and technology acceptance theory to propose six research hypotheses and develop a research model to explore the relationship between collaborative self-efficacy, perceived usefulness of short videos, perceived ease of use, STEAM learning performance and teacher education students’ sustainable inquiry behavior. To achieve the purpose of this study, this study used purposive sampling and invited teacher education students from five classes of preschool education at a university in Guangxi Zhuang Autonomous Region, China, to participate in this study. A total of 8 h of instructional guidance was provided over a four-week period, in which participants used short videos for collaborative group learning and independent inquiry and applied STEAM concepts to kindergarten science activities. Participants’ STEAM performance was measured and surveyed during the fourth week. The results of the study validation showed that teacher education students CS-E had a positive effect on the PU and PEOU of short videos; Teacher’s education students PEOU of short videos had a positive effect on usefulness; Teacher’s education students PU and PEOU of short videos had a positive effect on STEAM learning performance; Teacher’s education students’ STEAM learning performance had a positive effect on sustainable inquiry behavior. (shrink)

本书对科技与政治交互作用空间的性质、结构及其张力进行了基本阐述,探讨科技政治空间价值张力的离合及有机统一的作用规律以及科技政治空间自由与干涉的权力张力及其作用规律等。.

This project examines the practice of taking red-envelope cash in contemporary Chinese journalism, which involves journalists accepting cash wrapped in an envelope that is provided by sources or other social agents. On the basis of focus group interviews, in-depth interviews, and personal communication, this project brings journalists’ perceptions on this practice to the fore. Journalists predominantly attribute the practice to Chinese cultural factors, especially the Chinese emphasis on guanxi. However, this research argues that culture alone is an insufficient explanation. This (...) project incorporates sociological studies of “informal relationships” to enrich our understanding of the practice. (shrink)

本书分四个部分:第一部分以梁漱溟先生的思虑为个案样本,探讨法的一般理念问题;第二部分论及宪政、普通法和近代西方法律教育与法学研究;第三部分意在研索“罪孽理念与罪刑关系”;第四部分为通讯体论文。.

Thomas Aquinas has argued that the passion of hope is the movement of the sensitive appetite and the first of the irascible passion. The first part of the article aims to explore the cause and the mechanism of the passion of hope, and tries to clarify the relationship between the passion of hope and the perception. In human beings, it is possible that the passion of hope is caused by false judgement of the perception, which will lead to the result (...) of false hope. In Aquinas’s argument, the problem of false hope could be solved through the moral virtue and the prudence. In the second part of this article, the aim is to analyse how the virtue of magnanimity, humility and the prudence work impact on the passion of hope and perfect it.Contribution: This research concentrates on the topic of the passion of hope of Thomas Aquinas, and provides a new perspective on the understanding of the relationship between the passion and the virtue. (shrink)

The subject of this work is the worldview of subculture and its complex interaction with the elements and structure of these groups. To do this, various types of subcultures are analyzed in detail in order to identify their unique ideological features and characteristics. The main purpose of the research is to find links between the worldview of subcultures and their structural elements, as well as to understand the impact of these links on socio-cultural processes. By analyzing these issues, the study (...) seeks to expand our understanding of subcultural dynamics and their place in the modern sociocultural context. The results of this work can be useful for further research in the field of anthropology, sociology, cultural studies, as well as for the development of practical strategies for managing and supporting subcultural communities. To achieve the goals of the study, an anthropological analysis of subcultures is used, which includes an analysis of synchronous and diachronic aspects of the subcultural worldview, as well as comparative analysis. The scientific novelty of this work is manifested in a deep and comprehensive analysis of the diversity of types of worldview representation in various subcultures and their impact on a wide range of socio-cultural processes. The analysis presented in the study reveals unique aspects of the subcultural worldview and its diverse manifestations, which not only contributes to a deeper understanding of the socio-cultural dynamics of modern society, but also expands our knowledge of the mechanisms of formation and functioning of subcultural communities. The conclusions of this work are important both for academic research in the field of anthropology and sociology, and for practical applications, for example, those aimed at effective management and support of subcultural groups in modern society, including the development of policies and programs that promote inclusivity, cultural diversity and socio-cultural harmony. (shrink)

本书是关于新意识形态批评的论文集,本书要论述的意图是:以理论与社会生活的密切关系而言,中国文论家可以创造出自己的“本位话语”,其具体问题集中为两个,即文化转型中的当代中国的精神建构和建立文学理论的本位 话语。.

本书内容包括:孔子思想的主要特征、老子思想的文化地位、墨子思想的历史影响、孟子思想的历史影响、董仲舒在学术思想史上的地位、张衡在中国思想文化上的地位等内容。.

本书简要地介绍了《周易》的一些重要概念及其在二十一世纪的可能应用,指出以《周易》为代表的东方文明对人类社会在新世纪的可持续发展所可能做出的贡献。.

许地山(1894~1941),名赞〓,字地山,笔名落华生,乳名叔丑,著名文学家.

In this paper we prove the uncompactness of every stit logic that contains a generalized refref conditional and is a sublogic of the stit logic with refref equivalence, a syntactical condition of uncompactness that covers infinitely many stit logics. This result is established through the uncompactness of every stit logic whose semantic structures contain no chain of busy choice sequences with cardinality , where is any natural number . The basic idea in the proof is to apply the notion of (...) companions to stit sentences in finding busy choice sequences in structures, and to make use of a relation between chains of busy choice sequences and generalized refref conditionals in connecting the two conditions of uncompactness mentioned above. (shrink)

本书辑录了作者近年来已发表的一些文章,包括:求索时代精神:个人思想历程、语言与哲学:学术研究偶得、现实与虚构:世纪之交的思想文化争论、事实与责任:历史反思等。.

本书内容包括传统道德的现代价值、更加重视世界观问题、环保意识的觉醒、做好社区的思想工作、压岁钱的变迁等。.

本书收录了汉语法学界近年关于法律信仰的九篇论文,包括《法律信仰与法制现代化》、《法律信仰与民族国家》、《法律如何信仰》等。.