Whole eye transplantation (WET) remains experimental. Long presumed impossible, recent scientific advances regarding WET suggest that it may become a clinical reality. However, the ethical implications of WET as an experimental therapeutic strategy remain largely unexplored. This article evaluates the ethical considerations surrounding WET as an emerging experimental treatment for vision loss. A thorough review of published literature pertaining to WET was performed; ethical issues were identified during review of the articles.

Joan Mellen In the Realm of the Senses London: British Film Institute ISBN: 1 8445 7034 7.

Lindroos constructs an alternative interpretation on history, time, politics and art, approached through the moment of the Now (Jetztzeit). In the first section, she elaborates the critique of chronologic-linear way of understanding history. Through a close reading of Benjamin's "Work of Art" essay, the second section examines the problems of origins, authenticity and traditions of art through the ideas of artistic avant-garde and politicization of aesthetics. The end of the book discusses the concept of image and the new images as (...) an Image-Space (Bildraum) of action. (shrink)

In discussing the cultural history of the 19th century, Walter Benjamin diagnosed the emergence of the modern novel and its form of narration as the sign of a fracturing experience. The split in experience is related to the scattering of a homogeneous idea of space and time, constituted especially during the Enlightenment and in the German historicism. Benjamin's claim reflected the fracturing temporality of modern communities as well as the transformations in the understanding of the meaning of tradition. Here, I (...) begin by discussing Benjamin's conceptions of experience and memory in detail. Secondly, I consider his ideas on history in the framework of challenging the new forms of narration. In the end, I consider the loss of a unified community, especially by indicating ways in which the after-modern community reflects the relationship between aesthetics and politics in Jean-François Lyotard's thought. Key Words: Benjamin • community • experience • history • Lyotard • memory • narrative • remembrance • time. (shrink)

Abstractc‐Rel is a proto‐oncogene first identified as the cellular counterpart of the v‐Rel oncogene derived from the avian reticuloendotheliosis retrovirus (REV‐T). It was subsequently discovered that c‐Rel belongs to the NF‐κB/Rel transcription factor family whose members share a common DNA recognition motif and similar signaling pathways. Despite the similarities, however, each NF‐κB/Rel member possesses unique properties with regard to tissue expression pattern, response to receptor signals and target gene specificity. These differences are fairly evident from the non‐redundant phenotypes exhibited by (...) individual NF‐κB/Rel knockout mice. Hence the work described in this review will compare and contrast the various physiological functions of c‐Rel to those of other NF‐κB members, particularly with respect to the regulation of proliferation, survival and effector functions in multiple hematopoietic and immunological cell types. The study of c‐Rel knockout mice in several disease models will also be discussed as they reveal an important role for c‐Rel in response to allergens, auto‐antigens, allo‐antigens and pathogenic infection. BioEssays 25:767–780, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This essay uses the 2014 protests in Thailand in which demonstrators silently brandished The Hunger Games’s three-fingered salute as a lens through which to analyze nonverbal communication in contentious politics. Drawing on and extending J.L. Austin’s speech act theory, I explore the conditions of legibility of nonverbal language such as bodily gesture, signs and symbols. While neither verbal nor nonverbal speech guarantees an exact translation between intention and reception, nonverbal utterances operate along a looser terrain of legibility. I contend that (...) the attribution of meaning and intention to the speaker’s nonverbal utterance demands a reflexive consideration from the listener, founding a new community of meaning oriented around a shared context. This interpretive public, with its ambivalent emancipatory potential, is the space of politics. (shrink)

The ability to sequence individual genomes is leading to the identification of an increasing number of genetic risk factors for serious diseases. Knowledge of these risk factors can often provide significant medical and psychological benefit, but also raises complex ethical and social issues. This paper focuses on one area of rapid progress: the identification of mutations causing long QT syndrome and other cardiac channel disorders, which can explain some previously unexplained deaths in infants (SIDS) and children and adults (SUDS) and (...) prevent others from occurring. This genetic knowledge, discovered posthumously in many cases, has implications for clinical care for surviving family members who might carry the same mutations. The information obtained from genetic testing, in the context of personal and family history, can guide individually tailored interventions that reduce risk and save lives. At the same time, obtaining and disclosing genetic information raises difficult issues about confidentiality and decision making within families. We draw on the experience of the Montefiore-Einstein Center for Cardiogenetics, which has played a leading role in the genetic diagnosis and clinical management of cardiac channel diseases, to explore some of the challenging ethical questions arising in affected families with adolescent children. We focus on the related issues of (1) family confidentiality, privacy and disclosure and (2) adolescent decision making about genetic risk, and argue for the value of interdisciplinary dialogue with affected families in resolving these issues. (shrink)

This article presents Minobe Tatsukichi’s emperor organ theory as a novel understanding of the temporality of founding. In contrast to a conventional framework of founding which legitimizes the constitution by postulating the pre-constitutional power of “the people,” emperor organ theory invents “the people” out of the Meiji Constitution as a democratically empowered subject to-come. In so doing, emperor organ theory calls upon the transformation of shin-min (臣民), the presumed subject of the emperor, into koku-min (国民), the people of this constitutional (...) state. However, emperor organ theory also highlights the contingency of founding moments: though koku-min emerged through the Diet as a conceptually new political actor in Japan’s nascent constitutional state, it never solidified its sovereign status as “the people.”. (shrink)

This cross-sectional study, which included men aged 20–40 years, aimed to determine the relationships among type D personality, depressive symptoms and lower urinary tract symptoms in young men. An internet-based questionnaire was administered, and General demographics, International Prostate Symptom Scores, Type D Scale-14 scores, and Depression and Somatic Symptom Scale scores were analyzed. A total of 3,127 men were included; of these, 762 reported moderate/severe lower urinary tract symptoms, and 1,565 met the criteria for type D personality. Men with type (...) D personality had significantly higher body mass index and total and sub-scores for the International Prostate Symptom Score and Depression and Somatic Symptom Scale. Furthermore, the type D personality group had a higher prevalence of lower urinary tract symptoms, particularly voiding symptoms. Univariate analysis revealed that all parameters, except for body mass index, were significant predictors of moderate/severe lower urinary tract symptoms. Multivariate analysis showed that age >30 years, type D personality, and depressive and somatic Depression and Somatic Symptom Scale sub-scores were independent predictors of moderate/severe lower urinary tract symptoms. Regarding Type D Scale-14 subscales, social inhibition, rather than negative affectivity, impacted moderate/severe lower urinary tract symptoms. Mediation analysis revealed that depressive symptoms mediated the relationship between type D personality and lower urinary tract symptoms. This study established correlations between type D personality, depressive symptoms, and lower urinary tract symptoms. As previous studies suggested that patients with type D personality are less likely to consult and adhere to treatment, and are at higher risk for depression, urologists should therefore actively recognize patients with TDP. (shrink)

In this study, we investigated endorsement of two types of prescriptive views of aging, namely active aging and altruistic disengagement. The study comprised a large international sample of middle-aged and older adults, covering the age range from 40 to 90 years. Participants rated their personal endorsement of prescriptive views of active aging and altruistic disengagement targeting older adults in general. Findings showed that endorsement was higher for prescriptions for active aging than for prescriptions for altruistic disengagement. Age groups in the (...) sample differed regarding their endorsement of both prescriptive views of active aging and altruistic disengagement with older adults showing higher endorsement than middle-aged adults did. Prescriptive views of active aging and altruistic disengagement related positively to each other and to the superordinate social belief that older adults should not become a burden, which attests to their functional similarity. In contrast, prescriptive views of active aging and altruistic disengagement were associated with psychological adjustment in opposite ways, with endorsement of active aging being related to better adjustment outcomes such as life satisfaction and subjective health. Our findings highlight the internalization of prescriptive views of aging in older people and their implications for their development and well-being. (shrink)

Critical types of infrastructure are provided by the state to maintain the people’s livelihood, ensure economic development, and systematic government operations. Given the development of ever more complicated critical infrastructure systems, increasing importance is being attached to the protection of the components of this infrastructure to reduce the risk of failure. Power facilities are one of the most important kinds of critical infrastructure. Developing an effective risk detection system to identify potential failure modes of power supply equipment is crucial. This (...) study seeks to improve upon prior approaches for risk assessment by proposing a hybrid risk-assessment model using the concepts of failure mode and effect analysis and multiple-criteria decision-making. The proposed model includes a cost-based factor for decision-makers. The subjectivity and uncertainty in FM assessment are adjusted through the rough number method. The original risk priority number can be expanded by including the entropy weights in the risk index. Furthermore, to rank the risk priorities in a rational manner, a modified technique for order preference by similarity to ideal solution is adopted. The applicability and effectiveness of the proposed method were demonstrated by considering an example of a turbine steam engine in a nuclear power plant. (shrink)

The reversible phosphorylation of proteins on serine/threonine residues preceding proline (Ser/Thr‐Pro) is a major regulatory mechanism for the control of a series of cell cycle events. Although phosphorylation is thought to regulate protein function by inducing conformational changes, little is known about most of these conformational changes and their significance. Recent studies indicate that the conformation and function of a subset of these phosphorylated proteins are controlled by the prolyl isomerase Pin1 through isomerization of specific phosphorylated Ser/Thr‐Pro bonds. Furthermore, compelling (...) evidence supports the idea that proline‐directed phosphorylation and subsequent isomerization play a critical role not only in cell cycle control, but also in the development of Alzheimer's disease, where postmitotic neurons display various cell cycle markers, especially mitotic events, prior to degeneration. BioEssays 25:174–181, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Reindeer meat, traditional food and knowledge are vital for the culture, health, and economy of Sámi reindeer herders. Nevertheless, the practices of reindeer meat smoking have barely been part of scientific research or reindeer herding management. We investigated Sámi reindeer herders’ approach to meat smoking in Northern Norway performed in the traditional Sámi tent, the lávvu. The investigation included workshops, interviews, participatory observations, and co-analyze meetings. Our findings reveal a typology of the traditional Sámi smoking practices. Sámi reindeer herders use (...) a variety of wood species and plant parts to control the smoke based on a complex system of traditional knowledge. Yet there is a need for education, industry, and research acknowledging, supporting, and maintaining the Sámi meat-smoking process and associated worldviews, knowledge, and practices to ensure ethical, sustainable, and healthy food production. (shrink)

COVID-19 is a disease that affects the quality of life in all aspects. However, the government policy applied in 2020 impacted the lifestyle of the whole world. In this sense, the study of sentiments of people in different countries is a very important task to face future challenges related to lockdown caused by a virus. To contribute to this objective, we have proposed a natural language processing model with the aim to detect positive and negative feelings in open-text answers obtained (...) from a survey in pandemic times. We have proposed a distilBERT transformer model to carry out this task. We have used three approaches to perform a comparison, obtaining for our best model the following average metrics: Accuracy: 0.823, Precision: 0.826, Recall: 0.793 and F1 Score: 0.803. (shrink)

Wellbeing in schools is often focused at the individual level, exploring students’ or teachers’ individual traits, habits, or actions that influence wellbeing. However, studies rarely take a whole-school approach that includes staff wellbeing, and frequently ignore relational and organizational level variables. We take a systems informed positive psychology approach and argue that it is essential to build greater understanding about organizational and relational influences on wellbeing in order for schools to support educator wellbeing. Our study evaluated the relative contributions of (...) individual, relational, and organizational factors to educator wellbeing. Our measure of wellbeing focused on the life satisfaction and flourishing of 559 educators in 12 New Zealand schools. We used a social network analysis approach to capture educators’ relational ties, and demographic data and psychometric scales to capture individual and organizational level variables. Results of hierarchical blockwise regressions showed that individual, relational, and organizational factors were all significantly associated with educator wellbeing; however, it was educators’ perceptions of trusting and collaborative school conditions that were most strongly associated with their wellbeing. The number of relational ties educators had explained the least amount of variance in wellbeing. Educators were more likely to experience high levels of support when their close contacts also experienced high levels of support. However, for many educators, there was a negative association between their most frequent relational ties and their reported levels of support. Our results suggest that attending to the organizational factors that influence wellbeing, through creating trusting and collaborative school conditions, may be one of the most influential approaches to enhancing educator wellbeing. We call for whole-school approaches to wellbeing that not only consider how to support and enhance the wellbeing of school staff as well as students, but also view the conditions created within a school as a key driver of wellbeing within schools. (shrink)

Kia kaha Aotearoa, be strong New ZealandTo bear witness to the aftermath of a terrorist atrocity as a national outpouring of grief and a memorialising of those who have passed away is a very touchi...

Ðio straipsnio pavadinime uþkoduota ir tyrimo problema. Èia bus svarstomas filosofijos ir literatûrossuartëjimo prieigø dekonstrukcinis tyrimas Jacques Derrida postfilosofijoje. Kantas simbolizuoja klasikinæ filosofo, Kafka – literato laikysenà. Taèiau tai tik straipsnio autorës iðmonë. Bus atsispirta nuo to,kaip Derrida perskaito Kafkos parabolæ Prieð ástatymà romane Procesas. Autorë pripaþins, kad ið tiesøsodieèio kaip kantininko ir durininko kaip paties Derrida suprieðinimas leidþia geriau suvokti Derridaiðrastos sàvokos différance konotacijas. Kita vertus, taip suprasta skirtis iðveda á singuliarumo, paraðo,paslapties sàvokø judëjimà Derrida tekstuose. Taèiau lieka neaiðku, (...) ar ið tiesø Derrida neprieðtaraujasavo teiginiui, kad raðymas vyksta anapus filosofijos ir literatûros, kai prieina prie iðvados, kad sodietis--kantininkas negalëjo suprasti jam skirto áëjimo singuliarumo, nes turëjo problemø su literatûra. Ar taireiðkia, kad literatûra, skirtingai nei filosofija, lieka atvira paslapèiai ir neþinojimui? O filosofija tampasusijusi su þinojimu ir paslapties áminimu? Autorës nuomone, paties Derrida hermeneutikos dekonstrukcija knygoje Pentinai: Nietzsche’s stiliai tokiai iðvadai prieðtarautø.Pagrindiniai þodþiai: differénce, Derrida, Kafka, sodietis-kantininkas, filosofija ir literatûra. (shrink)

Straipsnyje tiriamos dvi XX a. viduryje iðplëtotos funkcionalistinio sàmonës aiðkinimo kryptys: D. Armstrongo ir D. Lewiso analitinis funkcionalizmas ir H. Putnamo komputacinis funkcionalizmas. Siekiamaparodyti, kad ðios dvi kryptys ið esmës sutampa metodologiniu poþiûriu, taèiau jø atstovai suteikiasavøjø teorijø metodologiniam pagrindui skirtingas ontologines interpretacijas. Sutardami, kad fizikinio bûvio ir funkcinio bûvio sàvokos skiriasi, jie nesutaria dël to, ar funkcinio bûvio sàvokà reikialaikyti iðskirianèia atskirà ontologinæ bûviø kategorijà, ar ði sàvoka iðreiðkia tik skirtingà tø paèiø fizikiniø bûviø identifikavimo realiame pasaulyje bûdà. Ðiame (...) nesutarime ið esmës uþsimezga ðiuolaikineisàmonës filosofijai bûdinga kontroversija klausimu: savybiø ontologija turi bûti rekonstruojama intensiniu ar ekstensiniu pagrindu?Pagrindiniai þodþiai: funkcionalizmas, materializmas, ávairiopa realizacija, reduktyvistinës sàmonës teorijos. (shrink)