Nuclear bodies contribute to non‐random organization of the human genome and nuclear function. Using a major prototypical nuclear body, the Cajal body, as an example, we suggest that these structures assemble at specific gene loci located across the genome as a result of high transcriptional activity. Subsequently, target genes are physically clustered in close proximity in Cajal body‐containing cells. However, Cajal bodies are observed in only a limited number of human cell types, including neuronal and cancer cells. Ultimately, Cajal body (...) depletion perturbs splicing kinetics by reducing target small nuclear RNA (snRNA) transcription and limiting the levels of spliceosomal snRNPs, including their modification and turnover following each round of RNA splicing. As such, Cajal bodies are capable of shaping the chromatin interaction landscape and the transcriptome by influencing spliceosome kinetics. Future studies should concentrate on characterizing the direct influence of Cajal bodies upon snRNA gene transcriptional dynamics.Also see the video abstract here. (shrink)

The problem of 'no fault' compensation for patients who suffer adverse effects as a result of their participation in clinical trials is discussed in the light of the guidelines issued by the Association of the British Pharmaceutical Industry (ABPI) and our recent experiences in reviewing protocols submitted to the local ethics of surgical research sub-committee. We have found a variety of qualifications being applied by pharmaceutical firms which are not in the spirit of the guidelines, let alone the interests of (...) the patient, and we suggest a means whereby the patients can be assured of fair treatment in the event of 'no fault' injury. (shrink)

Readers of C.L.R. James are familiar with the thinker’s careful reading of Melville’s Moby-Dick in his text Mariners, Renegades, and Castaways. In that work James proposes that Melville exposes the foundations of societal level fascism as exemplified by the monomaniacal purpose of Ahab. The purpose of this effort is to push further into the concept of societal division as exemplified by Moby-Dick by proposing that Melville is taking on the discourse of color (black vs. white) and its relationship to ontological (...) value (bad vs. good) by imploding the internal logic of Plato’s Phaedrus. What concerns this project is the relationship between the phenotypic “blackness” of the characters of African descent in Moby-Dick and ways in which Melville endeavors to destabilize skin color in the western imaginary as a means to correct the negative consequences of this flattening of the hierarchical nature of society on the part of Ahab. (shrink)

Conceptual engineering is to be explained by appeal to the externalist distinction between concepts and conceptions. If concepts are determined by non-conceptual relations to objective properties rather than by associated conceptions (whether individual or communal), then topic preservation through semantic change will be possible. The requisite level of objectivity is guaranteed by the possibility of collective error and does not depend on a stronger level of objectivity, such as mind-independence or independence from linguistic or social practice more generally. This means (...) that the requisite level of objectivity is exhibited not only by natural kinds, but also by a wide range of philosophical kinds, social kinds and artefactual kinds. The alternative externalist accounts of conceptual engineering offered by Herman Cappelen and Derek Ball fall back into a kind of descriptivism which is antithetical to externalism and fails to recognise this basic level of objectivity. (shrink)

In October 1984, Bruno Huisman stated with regards to Jean Cavaillès, ‘Let us be honest, or at least realistic: today, one can be a professor of philosophy without ever having read a single line of Cavaillès. Often invoked, sometimes quoted, the oeuvre of Cavaillès is little attended for itself’ (Huisman 1984). As for Albert Lautman, it would seem that the situation is even more extreme. In 1994, the publisher Hermann, under the impetus of Bruno Huisman and George Canguilhem, collected almost (...) the totality of the Jean Cavaillès papers in one volume (Oeuvres complètes de philosophie des sciences (Cavaillès 1994)). But, the Essai sur l’unité des mathématiques et divers écrits (Lautman 1977), published by the Union générale d’Éditions in 1977, had all but disappeared by the early 1980s and yet was never republished! This will remain one of the great indignities of French publishing, for as Jean Petitot rightly affirms: ‘Regarded as too speculative, in spite of his exceptional mathematical scholarship and his close connection with Hilbertian axiomatic structuralism, his mathematical philosophy has, until now, been devoid of any particular attention …. We would like to state clearly from the start, Albert Lautman represents, in our view, without exaggeration, one of the most inspired philosophers of this century’ (Petitot 1987, 79-80). (shrink)

Content externalism implies first, that there is a distinction between concepts and conceptions, and second, that there is a distinction between thoughts and states of mind. In this paper, I argue for a novel theory of self-knowledge: the partial-representation theory of self-knowledge, according to which the self-ascription of a thought is authoritative when it is based on a con-scious, occurrent thought in virtue of which it partially represents an underlying state of mind.

Semantic theories of fictional names generally presuppose, either explicitly or implicitly, that fictional predicates are guaranteed a referent. I argue that this presupposition is inconsistent with anti-realist theories of fictional characters and that it cannot be taken for granted by realist theories of fictional characters. The question of whether a fictional name refers to a fictional character cannot be addressed independently of the much-neglected question of whether a fictional predicate refers to a fictional property.

The author draws on arguments from contemporary philosophy of mind to provide an argument for sociological collectivism. This argument for nonreductive individualism accepts that only individuals exist but rejects methodological individualism. In Part I, the author presents the argument for nonreductive individualism by working through the implications of supervenience, multiple realizability, and wild disjunction in some detail. In Part II, he extends the argument to provide a defense for social causal laws, and this account of social causation does not require (...) any commitment to intentionality or agency on the part of individuals. (shrink)

This article focuses on emergence in social systems. The author begins by proposing a new tool to explore the mechanisms of social emergence: multi agent–based computer simulation. He then draws on philosophy of mind to develop an account of social emergence that raises potential problems for the methodological individualism of both social mechanism and of multi agent simulation. He then draws on various complexity concepts to propose a set of criteria whereby one can determine whether a given social mechanism generates (...) emergent properties, in the sense that their explanation cannot be reduced to a mechanistic account of individuals and their interactions. This combined account helps to resolve the competing claims of methodological individualists and social realists. The author’s conclusion is that the scope of mechanistic explanation may be limited due to the extreme complexity of many social systems. (shrink)

In this paper I argue first, that a contrastive account of self-knowledge and the propositional attitudes entails an anti-individualist account of propositional attitude concepts, second, that the final account provides a solution to the McKinsey paradox, and third, that the account has the resources to explain why certain anti-skeptical arguments fail.

Though full of promise, Big Data research success is often contingent on access to the newest, most advanced, and often expensive hardware systems and the expertise needed to build and implement such systems. As a result, the accessibility of the growing number of Big Data-capable technology solutions has often been the preserve of business analytics. Pay as you store/process services like Amazon Web Services have opened up possibilities for smaller scale Big Data projects. There is high demand for this type (...) of research in the digital humanities and digital sociology, for example. However, scholars are increasingly finding themselves at a disadvantage as available data sets of interest continue to grow in size and complexity. Without a large amount of funding or the ability to form interdisciplinary partnerships, only a select few find themselves in the position to successfully engage Big Data. This article identifies several notable and popular Big Data technologies typically implemented using large and extremely powerful cloud-based systems and investigates the feasibility and utility of development of Big Data analytics systems implemented using low-cost commodity hardware in basic and easily maintainable configurations for use within academic social research. Through our investigation and experimental case study, we found that not only are solutions like Cloudera’s Hadoop feasible, but that they can also enable robust, deep, and fruitful research outcomes in a variety of use-case scenarios across the disciplines. (shrink)

In this article I argue for a novel theory of representational content, which I call ‘subjective externalism’. The view combines an internal, subjective constraint on the attribution of thought content which traditionally underpins internalist theories of thought, and an external, objective constraint on the attribution of thought content which traditionally underpins externalist theories of thought. While internalism and externalism are mutually inconsistent, the constraints to which each theory is committed are not. It is this realization that opens up the conceptual (...) space for subjective externalism, according to which the correct attribution of thought content to an individual is essentially constrained by her nonrepresentational relations to objective manifest properties in her wider reality. (shrink)

In this paper I argue first, that a contrastive account of self-knowledge and the propositional attitudes entails an anti-individualist account of propositional attitude concepts (the concepts of belief, desire, regret, and so on), second, that the final account provides a solution to the McKinsey paradox, and third, that the account has the resources to explain why certain anti-skeptical arguments fail.

This paper considers the relevance of the Duhem-Quine thesis in economics. In the introductory discussion which follows, the meaning of the thesis and a brief history of its development are detailed. The purpose of the paper is to discuss the effects of the thesis in four specific and diverse theories in economics, and to illustrate the dependence of testing the theories on a set of auxiliary hypotheses. A general taxonomy of auxiliary hypotheses is provided to demonstrate the confounding of auxiliary (...) hypotheses with the testing of economic theory. (shrink)

Over the last 25 years, there has been an increasing fascination with the “dark” side of leadership. The term “destructive leadership” has been used as an overarching expression to describe various “bad” leader behaviors believed to be associated with harmful consequences for followers and organizations. Yet, there is a general consensus and appreciation in the broader leadership literature that leadership represents much more than the behaviors of those in positions of influence. It is a dynamic, cocreational process between leaders, followers, (...) and environments, the product of which contributes to group and organizational outcomes. In this paper, we argue that, despite this more holistic recognition of leadership processes within the broader leadership literature, current conceptualizations and analyses of destructive leadership continue to focus too heavily on behaviors and characteristics of “bad” leaders. In our view, to achieve a more balanced understanding of destructive leadership, it is important to adopt more integrative approaches that are based in the contemporary leadership discourse and that recognize flawed or toxic leaders, susceptible followers, and conducive environments as interdependent elements of a broader destructive leadership process. To this end, we offer a critique of the destructive leadership literature, propose a broader definition of destructive leadership, and highlight gaps in our understanding of leaders, followers, and environments in contributing to destructive leadership processes. Finally, we conclude by discussing strategies for examining destructive leadership in a broader, more holistic fashion. (shrink)

Behaving ethically depends on the ability to recognize that ethical issues exist, to see from an ethical point of view. This ability to see and respond ethically may be related more to attributes of corporate culture than to attributes of individual employees. Efforts to increase ethical standards and decrease pressure to behave unethically should therefore concentrate on the organization and its culture. The purpose of this paper is to discuss how total quality (TQ) techniques can facilitate the development of a (...) cooperative corporate culture that promotes and encourages ethical behavior throughout an organization. (shrink)

The aim of this paper is to show that the truth of content externalism can be grounded in purely epistemological considerations in which no appeal is made to Twin‐Earth style cases. Content externalism is required to provide an adequate account of perceptual warrant.

Words change meaning over time. Some meaning shift is accompanied by a corresponding change in subject matter; some meaning shift is not. In this paper I argue that an account of linguistic meaning can accommodate the first kind of case, but that a theory of concepts is required to accommodate the second. Where there is stability of subject matter through linguistic change, it is concepts that provide the stability. The stability provided by concepts allows for genuine disagreement and ameliorative change (...) in the context of conceptual engineering. (shrink)

Following suggestions by Joseph Margolis and Richard K. Sawyer, in this paper I apply the notion of emergence to the philosophy of art. I will argue that the interpretation of works of art cannot be reduced either to the perceptive experience of the manifest qualities of the art object, nor to the identification of the author’s intentions, nor to the understanding of the practices of the historic context of production. I suggest, instead, that the identity of a work of (...) art emerges, on the one hand, from the artist’s interactions with forms, materials and artistic genres and, on the other, from the relationships between the artwork and the changing contexts of its reception. Moreover, I maintain that artistic categories are formed through artistic practices and that, therefore, they cannot be assumed as undisputable criteria for the identification and evaluation of artworks. I will thus argue that the emerging normativity of improvisational interaction in the performing art provides a suitable model to account for the “dynamic” ontological identity of artistic phenomena. (shrink)

This paper looks at the debates between internalism and externalism in mind and epistemology. In each realm, internalists face what we call 'The Connection Problem', while externalists face what we call 'The Problem of Opacity'. We offer an integrated account of thought content and epistemic warrant that overcomes the problems. We then apply the framework to debates between internalists and externalists in metaethics.

This is a contribution to the symposium on Herman Cappelen’s book Fixing Language. Cappelen proposes a metasemantic framework—the “Austerity Framework”—within which to understand the general phenomenon of conceptual engineering. The proposed framework is austere in the sense that it makes no reference to concepts. Conceptual engineering is then given a “worldly” construal according to which conceptual engineering is a process that operates on the world. I argue, contra Cappelen, that an adequate theory of conceptual engineering must make reference to concepts. (...) This is because concepts are required to account for topic continuity, a phenomenon which lies at the heart of projects in conceptual engineering. I argue that Cappelen’s own account of topic continuity is inadequate as a result of the austerity of his metasemantic framework, and that his worldly construal of conceptual engineering is untenable. (shrink)

This paper provides an externalist account of talk and thought that clearly distinguishes the two. It is argued that linguistic meanings and concepts track different phenomena and have different explanatory roles. The distinction, understood along the lines proposed, brings theoretical gains in a cluster of related areas. It provides an account of meaning change which accommodates the phenomenon of contested meanings and the possibility of substantive disagreement across theoretical divides, and it explains the nature and value of conceptual engineering in (...) a way that addresses recent prominent concerns. (shrink)

Can we understand important social issues by studying individual personalities and decisions? Or are societies somehow more than the people in them? Sociologists have long believed that psychology can't explain what happens when people work together in complex modern societies. In contrast, most psychologists and economists believe that if we have an accurate theory of how individuals make choices and act on them, we can explain pretty much everything about social life. Social Emergence takes a new approach to these longstanding (...) questions. Sawyer argues that societies are complex dynamical systems, and that the best way to resolve these debates is by developing the concept of emergence, focusing on multiple levels of analysis - individuals, interactions, and groups - and with a dynamic focus on how social group phenomena emerge from communication processes among individual members. This book makes a unique contribution not only to complex systems research but also to social theory. (shrink)

In this paper, I argue that an adequate meta-semantic framework capable of accommodating the range of projects currently identified as projects in conceptual engineering must be sensitive to the fact that concepts (and hence projects relating to them) fall into distinct kinds. Concepts can vary, I will argue, with respect to their direction of determination, their modal range, and their temporal range. Acknowledging such variations yields a preliminary taxonomy of concepts and generates a meta-semantic framework that allows us both to (...) accommodate the full range of cases and to identify a proper subset of concepts for special ameliorative consideration. Ignoring such variations, in contrast, leads to a restricted meta-semantic framework that accommodates only a subset of the particular projects while generating implausible accounts of others. (shrink)

This is a defence of the claim that names are predicates with a demonstrative element in their singular use.

The author draws on arguments from contemporary philosophy of mind to provide an argument for sociological collectivism. This argument for nonreductive individualism accepts that only individuals exist but rejects methodological individualism. In Part I, the author presents the argument for nonreductive individualism by working through the implications of supervenience, multiple realizability, and wild disjunction in some detail. In Part II, he extends the argument to provide a defense for social causal laws, and this account of social causation does not require (...) any commitment to intentionality or agency on the part of individuals. (shrink)

The interdisciplinary field of the learning sciences encompasses educational psychology, cognitive science, computer science, and anthropology, among other disciplines. The Cambridge Handbook of the Learning Sciences, first published in 2006, is the definitive introduction to this innovative approach to teaching, learning, and educational technology. In this significantly revised third edition, leading scholars incorporate the latest research to provide seminal overviews of the field. This research is essential in developing effective innovations that enhance student learning - including how to write textbooks, (...) design educational software, prepare effective teachers, and organize classrooms. The chapters illustrate the importance of creating productive learning environments both inside and outside school, including after school clubs, libraries, and museums. The Handbook has proven to be an essential resource for graduate students, researchers, consultants, software designers, and policy makers on a global scale. (shrink)

In a series of recent articles, Robin Jeshion has developed a theory of singular thought which she calls ‘cognitivism’. According to Jeshion, cognitivism offers a middle path between acquaintance theories—which she takes to impose too strong a requirement on singular thought, and semantic instrumentalism—which she takes to impose too weak a requirement. In this article, I raise a series of concerns about Jeshion's theory, and suggest that the relevant data can be accommodated by a version of acquaintance theory that distinguishes (...) unsuccessful thoughts of singular form from successful singular thoughts, and in addition allows for ‘trace-based’ acquaintance. (shrink)

In Part I, the author argued for nonreductive individualism (NRI), an account of the individual-collective relation that is ontologically individualist yet rejects methodological individualism. However, because NRI is ontologically individualist, social entities and properties would seem to be only analytic constructs, and if so, they would seem to be epiphenomenal, since only real things can have causal power. In general, a nonreductionist account is a relatively weak defense of sociological explanation if it cannot provide an account of how social properties (...) can participate in causal relations. In this article, the author extends NRI to address this weakness and provides an account of social causation that he refers to as supervenient causation. Key Words: individualism • collectivism • social realism • social causation. (shrink)

Juhani Yli-Vakkuri has argued that the Twin Earth thought experiments offered in favour of semantic externalism can be replaced by a straightforward deductive argument from premisses widely accepted by both internalists and externalists alike. The deductive argument depends, however, on premisses that, on standard formulations of internalism, cannot be satisfied by a single belief simultaneously. It does not therefore, constitute a proof of externalism. The aim of this article is to explain why.

In this paper, I argue that content externalism and privileged access are compatible, but that one can, in a sense, have privileged access to the world. The supposedly absurd conclusion should be embraced.

Despite extinction-based processes demonstrating efficacy in the animal extinction and human anxiety literatures, extinction for substance use disorders has shown poor efficacy. Reasons for this lack of success include common threats to extinction, such as renewal and reinstatement. In recent decades, research on mindfulness for SUD has flourished, and a key aspect of these mindfulness-based interventions includes teaching individuals to stay present with whatever experience they have, even if unpleasant, without trying to change/escape/avoid it. Similarly, CET teaches individuals to not (...) escape/avoid conditioned responses by engaging in drug use behavior. This paper discusses how mindfulness-based research and practices could positively influence CET through future research, with the long-term goal of improving SUD treatment. (shrink)