This work is a qualitative study of an organism''s physiological adaptative response to stress. The experimental data were selected from a previous study leading to the conclusion that stress may be considered as a topological retraction within a vital space that must be more precisely defined. The experimental methodology uses rat poisoning by neurotoxins. The control parameter is the intensity of the toxic doses. Measured parameters are the animals'' survival rate and the kinetics of cerebral acetylcholinesterase activity. The results, when (...) expressed as a function of the inverted doses, show a characteristic evolution. The pattern of the curve closely resembles a vortex profile. This analogy is studied more extensively in both the physical and biological domains. These findings help to clarify the concept of biological stress which presents the same vectorial properties as hydrodynamic vorticity. In particular, the dissipation of stress and the dissipation of vorticity seem to obey the same laws. This observation is valid for both diffusion and convection processes. The decompensation phase of stress could be compared with the instability and turbulence in flows.Our approach in this paper is mainly to establish a general and phenomenological description of the stress response fitting experimental observations. (shrink)

La loi dite Macron du 6 août 2015 introduit pour la première fois dans le Code du travail la notion de « travail en soirée », distincte du travail en journée et du travail de nuit, qui étaient jusque-là les deux seuls horaires journaliers définis juridiquement. À partir d’une analyse approfondie des pratiques nocturnes dans le commerce de détail parisien et des règles négociées sur le travail de nuit dans les entreprises, l’article étudie la sociogenèse de cette nouvelle catégorie juridique (...) afin d’en mesurer la signification et la portée. Il montre que cette invention contribue au processus de colonisation de la nuit, puisqu’elle permet de légaliser une pratique croissante – le travail salarié au-delà de 21 heures dans le commerce – qui était jusque-là illégale et jugée comme telle par les tribunaux. Cependant, ces « nocturnes » font l’objet d’acceptations différenciées de la part des salarié·es. D’ailleurs, cette innovation juridique résulte d’une intensification des conflits autou... (shrink)

Une forme de transmigration électronique est en train de s’opérer sous nos yeux. Le Dalaï Lama l’a bien compris, apportant récemment sa bénédiction à un grand projet de « téléchargement de l’esprit » ( mind uploading ). Quel lien entretient ce modèle « numérique » de la transmigration (celui que nous promettent les transhumanistes) avec les formes plus anciennes (brahmanique, bouddhiste, spirite, etc.)? Aurions-nous déjà opéré notre propre transmigration? Basculé dans une autre matrice? Serions-nous tous en train de devenir des (...) esprits sans le savoir? (shrink)

D'après le philosophe Pierre Hadot, la vocation de la philosophie, à son origine, est celle d'une conversion, autrement dit d'une transformation radicale de nous-mêmes et de notre rapport au monde. L'exemple donné pour un tel changement intérieur est la pensée de Bergson, dont l'intuition fondamentale de la durée implique non seulement un élargissement métaphysique de la perception, mais suppose aussi une reconsidération éthique de notre engagement dans l'existence. Ce livre, né d'une épreuve personnelle, cherche à montrer comment cette conversion bergsonienne (...) du regard peut devenir une philosophie de vie qui nous ouvre à nous-mêmes et nous unit au-delà."--Page 4 of cover. (shrink)

Il est impossible d’ouvrir un dossier consacré à la robotique sans rencontrer de multiples prophéties annonçant dans un futur proche que nous vivrons entourés de robots anthropomorphes ou zoomorphes et que nous nous machinerons par des voies que nous ne pouvons pour le moment qu’entrevoir. Peut-on envisager une approche de la robotique un peu moins prophétique et donc décevante, un peu plus pragmatique et donc plus surprenante, un peu plus réflexive et donc habitée par un principe de précaution? Faut-il continuer (...) à faire passer les machines pour autre chose que ce qu’elles sont ou doit-on arrêter de les prendre pour ce qu’elles ne sont pas (des animaux, des humains)? Faut-il considérer qu’elles constituent un « règne » à part entière, à côté du minéral et du végétal, ou bien faut-il continuer de les reléguer dans l’instrumental, ce grand bazar? Ce « manifeste » reprend quelques-unes des observations faites par ceux qui, dans le champ de l’anthropologie principalement, observent la « révolution robotique », suivent ses essais d’expérimentation/implémentation et abordent la diversité des interactions homme-machine avec les outils de l’enquête de terrain. (shrink)

Does the three‐dimensional (3D) conformation of interphase chromosomes merely reflect their function or does it actively contribute to gene regulation? The analysis of sex chromosomes that are subject to chromosome‐wide dosage compensation processes promises new insight into this question. Chromosome conformations are dynamic and largely determined by association of distant chromosomal loci in the nuclear space or by their anchoring to the nuclear envelope, effectively generating chromatin loops. The type and extent of such interactions depend on chromatin‐bound transcription regulators and (...) therefore reflects function. Dosage compensation adjusts the overall transcription activity of X chromosomes to assure balanced expression in the two sexes. Initial analyses of mammalian and Drosophila X chromosomes have led to the hypothesis that their conformations may not only reflect their functional state but may in turn contribute to the coordination of chromosome‐wide tuning of transcription. (shrink)

In this paper we address the modelling of reasoning processes in natural agents. We focus on a very basic kind of non-monotonic inference for which we identify a simple and plausible underlying process, and we develop a family of logical models that allow to match this process. Partial worlds models, as we call them, are a variant of Kraus, Lehmann and Magidor’s cumulative models. We show that the inference relations they induce form a strict subclass of cumulative relations and tackle (...) the issue of providing sound and complete sets of rules to characterise them. Taking inspiration from the work of Gabbay and Schlechta, we analyse the question in terms of definable sets of partial worlds and conclude that completeness is probably unreachable using a standard propositional language. This brings us to enrich our language with an additional connective, which makes it possible to distinguish between two kinds of disjunction in the partial worlds context. Within this renewed framework, we provide two representation theorems: one for inference relations induced by precisification-free smooth models, and the other for inference relations induced by precisification-free ranked models. Finally we give an aperçu of how partial worlds models lend themselves to the modelling of learning. (shrink)

This book closely examines our commonly held beliefs about human suffering, and offers unique insights into God's role in why we suffer. Dr. Perri critically examines what it means to be human from a Judeo-Christian perspective, and extrapolates from the work of Carl Gustav Jung showing a deeply complex development of human transcendence in human suffering. On an interpersonal level, Dr. Perri elaborates on the work of Martin Buber and Emanuel Levinas and shows how our suffering can be shared and (...) lessened by our unconditionality and presence for the other. Scriptural passages are quoted from both the Hebrew and New Testament texts, and are used to depict the suffering of humankind as seen in the face of Job. It was this face, according to Perri, that Jesus saw in the faces of those He came to redeem, and that ultimately brought Him to the crucifix of redemption. Dr. Perri challenges Sartre's position that our existence precedes our essence, and draws on the work of Abraham Joshua Heschel and Christian theology in this regard. He further elaborates a neurodevelopmental paradigm that creates essence as the basis of our freedom to choose. This book can be read and studied by both professionals in the helping and healing professions, and lay persons seeking to better understand our suffering, and how to better help those who suffer. Dr. Perri offers specific ways in how to be present for those who suffer, how to read and receive the hidden language of human suffering, and how to use silence as a communication skill. (shrink)

The draft Code of Conduct for Research is an important initiative towards assisting the scientific community in complying with the provisions of the Protection of Personal Information Act 4 of 2013 (POPIA). However, its approach towards cross-border data sharing should be reconsidered to clarify the ambiguities inherent in the legal requirements for the cross-border sharing of health data in the POPIA. These ambiguities include the concept of ‘transfer of information’, the application of adequacy as a legal mechanism for transfer, the (...) nature of consent for cross-border sharing and the scope of the recipient third party. We suggest that the draft Code of Conduct for Research can be improved by: Explaining or defining the concept of ‘transfer of information’ and when it applies to cross-border sharing in research Clarifying the application of adequacy as a legal mechanism for transfer vis-à-vis the other alternatives Expanding on the interpretation and application of consent as a legal mechanism for cross-border transfers Expanding the category of persons who may be recipients of personal information in a third country. (shrink)

Language, like other human traits, could only have evolved during one or more stages of development. We enlist the theoretical framework of human life history to account for certain aspects of linguistic evolution, with special reference to initial phases in the process. It is hypothesized that selection operated at several developmental stages, the earlier ones producing new behaviors that were reinforced by additional, and possibly more powerful, forms of selection during later stages, especially adolescence and early adulthood. Peer commentaries have (...) provided opportunities to explain human life history more comprehensively, and to add details to our account of spoken language. We made no attempt to explain syntax in the target article, but we propose here that selection for “vocal plumage” may have increased our species’ capacity for utterance complexity, a development that would have benefited all levels of language. (shrink)

In this timely book L.W. Sumner addresses these issues within the wider context of palliative care for patients in the dying process.

The genetic modification of pigs as a source of transplantable organs is one of several possible solutions to the chronic organ shortage. This paper describes existing ethical tensions in xenotransplantation (XTx) that argue against pursuing it. Recommendations for lifelong infectious disease surveillance and notification of close contacts of recipients are in tension with the rights of human research subjects. Parental/guardian consent for pediatric xenograft recipients is in tension with a child’s right to an open future. Individual consent to transplant is (...) in tension with public health threats that include zoonotic diseases. XTx amplifies concerns about justice in organ transplantation and could exacerbate existing inequities. The prevention of infectious disease in source animals is in tension with the best practices of animal care and animal welfare, requiring isolation, ethologically inappropriate housing, and invasive reproductive procedures that would severely impact the well-being of intelligent social creatures like pigs. (shrink)

Rationality requires us to respond to apparent normative reasons. Given the independence of appearance and reality, why think that apparent normative reasons necessarily provide real normative reasons? And if they do not, why think that mistakes of rationality are necessarily real mistakes? This paper gives a novel answer to these questions. I argue first that in the moral domain, there are objective duties of respect that we violate whenever we do what appears to violate our first-order duties. The existence of (...) these duties of respect, I argue, ensures that apparent moral reasons are exceptions to the independence of appearance and reality. I then extend these arguments to the domain of overall reason. Just as there are objective duties of respect for moral reasons that explain moral blameworthiness, so there are objective duties of respect for reasons that explain blameworthiness in the court of overall reason. The existence of these duties ensures that apparent reasons are exceptions to the independence of appearance and reality. (shrink)