The centromere is the region of the chromosome where the kinetochore forms. Kinetochores are the attachment sites for spindle microtubules that separate duplicated chromosomes in mitosis and meiosis. Kinetochore formation depends on a special chromatin structure containing the histone H3 variant CENP‐A. The epigenetic mechanisms that maintain CENP‐A chromatin throughout the cell cycle have been studied extensively but little is known about the mechanism that targets CENP‐A to naked centromeric DNA templates. In a recent report published in Science,1 such de (...) novo centromere assembly of CENP‐A is shown to be dependent on heterochromatin and the RNA interference pathway. BioEssays 30:526–529, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Muss Philosophie immer eine bierernste Angelegenheit sein? Einer, der das vehement bestritten hat, war der griechische Denker Diogenes, jener berühmte Tonnen-Philosoph, der bis heute als eine der schillerndsten und originellsten Gestalten des Altertums gilt. Seine Gesellschaftskritik lebte er mit einer nachgerade schockierenden Konsequenz vor. Seine Forderung: nicht mehr und nicht weniger als der konsequente Ausstieg aus der Zivilisation. Karl-Wilhelm Weeber stellt in diesem locker geschriebenen Band den scharfzüngigen, schlagfertigen und respektlosen Philosophen und seine Ideenwelt vor.

Zeigt, wie der äTonnenphilosophä in einer unsicheren Zeit eine auch heute noch gültige Überlebensphilosophie für das Individuum entwickelte und praktizierte.

Prolog -- Eros : auf dem Weg zur Erkenntnis -- Liebe als einheitsstiftende Macht -- Das tragische Chorspiel der Hellenen und ihre Imaginationen von Liebe -- Narkissos : die unstillbare Selbstliebe und das Spiegelmotiv -- Gnosis als erlösende Erkenntnis der Liebe -- Liebe in der kontemplativen Metaphysik Plotins -- Das Eine und das Viele -- Kontemplation und Liebe : das Mysterium Sacrum -- Sensorisches und Imaginatives : Weisen der Vergeistigung der Liebe -- Mystische Liebe : Gott-Leiden und Gott-Lieben in der (...) "Rheinischen Mystik" (Eckhart, Tauler, Seuse, Ruusbroec) -- Figurationen der Liebe auf den Brettern, die "die Welt bedeuten" (Wissen, Macht, Liebe, Tod) -- Amor fati : die Liebe zum Schicksal -- Die Liebe auf der Bühne des Theatrum Mundi -- Reflexionen und Mythopoetik der Liebe : philosophisch, theologisch, poetisch -- Liebe in der Theologie des Alten Bundes -- Liebe in der Theologie des Neuen Bundes. (shrink)

I. THE TASK OF DOGMATICS As a theological discipline dogmatics is the scientific self- examination of the Christian Church with respect to the content of ...

Karl Jaspers gehört zu den Ziehvätern der Psychopathologie, einer der Grundlagenwissenschaften der Psychiatrie. In diesem Zusammenhang wird gemeinhin auf sein systematisches Lehrbuch verwiesen, die Allgemeine Psychopathologie von 1913. Die wesentlichen Züge seiner Methodologie und den Gegenstand der neuen Wissenschaft fixierte Jaspers jedoch schon in den hier versammelten Arbeiten, die zwischen 1909 und 1913 erschienen: Seine Kritik am dominanten Reduktionismus und an der damals noch jungen Psychoanalyse sind in diesen Texten bereits gültig formuliert, ebenso - und nicht zuletzt - die (...) Dichotomie zwischen Erklären und Verstehen. Neben der Dissertation “Heimweh und Verbrechen” enthält der vorliegende Band unter anderem den bahnbrechenden und wirkungsvollen Aufsatz “Die phänomenologische Forschungsrichtung in der Psychiatrie” sowie die bis heute kontrovers diskutierte Abhandlung “Kausale und 'verständliche' Zusammenhänge zwischen Schicksal und Psychose bei der Dementia praecox (Schizophrenie)”. Der Kommentar verortet die einzelnen Beiträge sowohl im wissenschaftshistorischen als auch im werkgeschichtlichen Kontext. (Quelle: buchhandel.de). (shrink)

This edition of McLellan's comprehensive selection of Marx's writings includes carefully selected extracts from the whole range of Marx's most important pieces alongside a fully revised and updated bibliography and editorial commentary on each document. New editorial introductions to each section of the book provide the reader with the background and context of Marx's writing in each period. Essential reading for anyone wishing for a detailed overview of Marx's political philosophy.

Taken from the Great Philosphers, Volume II.

,Etwa zwei Monate vor dem Tode sagte Husserl:,Man solle seine Vergangenheit nicht trivialisieren. ' "1 Die Herausforderung dieser Worte lieB sich nur schwer abschatzen, als ich dem Stifter des Husserl-Archivs, meinem Freund Pater Van Breda, im Januar I974- zwei Monate vor seinem unzeitigen Hingang- den von ihm so sehr begruBten und geforderten EntschluB, eine Husserl-Bio­ graphie zu schreiben, naher erlauterte. Mancherlei ware darin ein­ zubringen gewesen: Ubersicht uber die Geschicke des Bismarck­ Staates und das aufkommende Hitler-Reich, Vertrautheit mit Stifter und (...) Hofmannsthal, Kenntnis der Theorie mathematischer Funktionen wie der Psychologie der Wurzburger Schule, Einsicht in die Einfuhlungslehre von Lipps wie auch Heideggers Seins­ frage. Aber solche Absicht erwies sich hauptsachlich deswegen als undurchfiihrbar, weil es derzeit noch am Notigsten fehlt: an einer verlaBlichen Durcharbeitung von Husserls Denken und seiner Entwicklung, wie sie sich in den veroffentlichten Werken, vor al­ lem aber im Meer bewahrter Manuskripte niederschlug. Hier galt es, da viel bisher im Dunkeln liegt, die Materialien zu einer Bio­ graphie erst einmal bereitzustellen und, wenn auch oft nur um­ riBhaft, fur die Zukunft sicherzustellen. Ergebnis dieser Beschei­ dung ist die vorliegende Chronik. GewiB, Husserl ware selbst der befugteste interpres sui gewe­ sen. Doch was er unterm 20. Juni rg2r an den Meiner Verlag schrieb - der,Stand seiner Lebensarbeit" erlaube es ihm zur Zeit nicht, zu der in diesem Verlag erscheinenden Reihe von Selbstdarstellungen einen Beitrag zu liefern (F I r8/r + 25) -, galt, wie gerade unsere Chronik deutlich macht, fur ihn zeitlebens. (shrink)

Karl Buhler (1879-1963) was one of the leading theoreticians of language of the twentieth century. This is an English translation of Buhler's theory that begins with a survey on 'Buhler's legacy' for modern linguistics (Werner Abraham), followed by the Theory of Language, and finally with a special 'Postscript: Twenty-five Years Later!'.

First published in English in 1953, this important book from eminent philosopher Karl Jaspers deals with the philsophy of the history of mankind. More specifically, its avowed aim is to assist in heightening our awareness of the present by placing it within the framework of the long obscurity of prehistory and the boundless realm of possibilities which lie within the undecided future.This analysis is split into 3 parts: World history The present and the future The meaning of history.

First Published in 2004. Routledge is an imprint of Taylor & Francis, an informa company.

Karl Ameriks here collects his most important essays to provide a uniquely detailed and up-to-date analysis of Kant's main arguments in all three major areas of his work: theoretical philosophy (Critique of Pure Reason), practical philosophy (Critique of Practical Reason), and aesthetics (Critique of Judgment). Guiding the volume is Ameriks's belief that one cannot properly understand any one of these Critiques except in the context of the other two. The essays can be read individually, but read together they offer (...) a comprehensive guide to the main themes of the most influential of all modern philosophical systems. (shrink)

Karl Jaspers (1883-1969)--"founder of German existentialism" (Martin Heidegger) and "a lucid and flexible intelligence in the service of a genuine and ...

Reflecting a revival of Peirce studies and the rediscovery of the pragmatist tradition in American philosophical thinking, this study articulates a contemporary and relevant interpretation that may offer a challenge to neo-pragmatists.

The increasing use of Artificial Intelligence for making decisions in public affairs has sparked a lively debate on the benefits and potential harms of self-learning technologies, ranging from the hopes of fully informed and objectively taken decisions to fear for the destruction of mankind. To prevent the negative outcomes and to achieve accountable systems, many have argued that we need to open up the “black box” of AI decision-making and make it more transparent. Whereas this debate has primarily focused on (...) how transparency can secure high-quality, fair, and reliable decisions, far less attention has been devoted to the role of transparency when it comes to how the general public come to perceive AI decision-making as legitimate and worthy of acceptance. Since relying on coercion is not only normatively problematic but also costly and highly inefficient, perceived legitimacy is fundamental to the democratic system. This paper discusses how transparency in and about AI decision-making can affect the public’s perception of the legitimacy of decisions and decision-makers and produce a framework for analyzing these questions. We argue that a limited form of transparency that focuses on providing justifications for decisions has the potential to provide sufficient ground for perceived legitimacy without producing the harms full transparency would bring. (shrink)

It has been argued that Kant's all-consuming efforts to place autonomy at the center of philosophy have had, in the long-run, the unintended effect of leading to the widespread discrediting of philosophy and of undermining the notion of autonomy itself. The result of this 'Copernican revolution' has seemed to many commentators the de-centring, if not the self-destruction, of the autonomous self. In this major reinterpretation of Kant and the post-Kantian response to his critical philosophy, Karl Ameriks argues that such (...) a view of Kant rests on a series of misconceptions. By providing the first systematic study of the underlying structure of the reaction to Kant's critical philosophy in the writings of Reinhold, Fichte and Hegel, Karl Ameriks challenges the presumptions that dominate popular approaches to the concept of freedom, and to the interpretation of the relation between the Enlightenment, Kant and post-Kantian thought. (shrink)

A bracing, concise, and accessible overview of the entirety of Marx's thought, by a major figure of twentieth-century Western Marxism.

This paper explores how transformative experience generates decision-making problems of particular seriousness in medical settings. Potentially transformative experiences are especially likely to be encountered in medicine, and the associated decisions are confronted jointly by patients and clinicians in the context of an imbalance of power and expertise. However in such scenarios the principle of informed consent, which plays a central role in guiding clinicians, is unequal to the task. We detail how the principle’s assumptions about autonomy, rationality and information handle (...) transformative experiences poorly, appealing to several difficult cases for medical decision-making to illustrate the resulting problem, and we consider how the existing literature on complications with consent fails to offer a resolution. We argue that recognition of the problem has a role to play in achieving a more effective response to transformative decisions. In Sect. 1 we introduce several representative cases of challenging patient decision-making that clinicians might face. In Sect. 2 we detail how transformative experience has been analysed in the recent literature, before outlining in Sect. 3 the theoretical basis of the principle of informed consent, which plays a central role in how clinicians are expected to support decision-making. In Sect. 4, having laid the groundwork for a clear description, we return to the cases given in Sect. 1 to confirm how their transformative nature presents a problem: either clinicians treat the decisions faced by these patients as ‘normal’, encouraging them to focus on information provision that patients may be unable to act on, or they treat them as transformative, in which case they lack the resources to recognise whether they are helping patients make (subjectively) good decisions. In Sect. 5 we argue that the existing literature does not offer any escape from this problem. We close in Sect. 6 by noting the significant impact that appreciating the problem of transformative experience could have on supporting transformative decisions in medicine and briefly suggesting how we might aim to develop new approaches to dealing with these. (shrink)

In his preface to the English edition, Apel (identified with critical theory) explains that the title of his two-volume German collection connotes both a reconstruction of the process of hermeneutic transformation in recent philosophy and the author's semiotical transformation of transcendental logic. The emphasis here is on the latter with discussions of the a priori nature of language per Wittgenstein, Peirce, and Chomsky, and its implications for a rational foundation for ethics in modern science. Includes a new foreword. Name index (...) only. Annotation copyrighted by Book News, Inc., Portland, OR. (shrink)

Bd. 1. Sprachanalytik, Semiotik, Hermeneutik. Bd. 2. Das Apriori der Kommunikationsgemeinschaft.

According to internalism about rationality, the ir/rationality of a subject depends only on how things appear from her subjective perspective. According to culpabilism, rationality is a normative standard such that violations of rationality are (at least sometimes) blameworthy. According to a classical line of reasoning, culpabilism entails internalism. I argue that, to the contrary, culpabilism entails that internalism is false. The internalist cannot accommodate the possibility of culpable irrationality.

Karl Giberson and Mariano Artigas offer an informed analysis on the views of Stephen Jay Gould, Richard Dawkins, Edward O. Wilson, Carl Sagan, Stephen Hawking and Steven Weinberg; carefully distinguishing science from philosophy and religion in the writings of the oracles.

Collected together for the first time in English, Karl-Otto Apel’s most recent work covers a broad spectrum of philosophical issues. Highly original, this work will be valuable to academics and students concerned with (post-) analytic philosophy, epistemology, history of science, Heidegger’s fundamental ontology, current debates about transcendental modes of argument, second-generation Frankfurt School thinkers and American pragmatists. It will be no less useful to all those interested in reformulations of Kantian themes and redefinitions of older ideas within the linguistic (...) paradigm, as well as those who, being familiar with Habermas’s work, wish to know more about the controversies and debates within the circle of the Frankfurt School itself. (shrink)