Apoptosis is a physiological mechanism for the removal of unwanted or damaged cells. Apoptotic cells are rarely seen in living tissues, however, because of their rapid and efficient removal by phagocytosis. Phagocytotic cells such as macrophages or dendritic cells recognize apoptotic cells by specific changes of cell surface markers, which usually are not present on normal cells. One such event is the exposure of phosphatidylserine, which moves from the plasma membrane inner leaflet to the outer leaflet in preapoptotic cells. An (...) unresolved problem, however, was the nature of the phosphatidylserine receptor on the phagocytotic cells. In a recent issue of Nature, Fadok et al.(1) have reported the cloning of a phosphatidylserine receptor using an antibody raised against activated macrophages. Antibody treatment of these macrophages blocks this capacity to engulf. BioEssays 22:878–881, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Cílem této studie je prozkoumat postavení metafory na poli zkoumání významu a následně představit potenciál metafory, a obrazných vyjádření obecně, zastávat pozici kritéria hodnocení teorií významu. Jako výchozí bod si práce bere několik vlivných pojetí metafory, na nichž ukazuje šíři bádání o metafoře a obraznosti a zároveň různorodost možných přístupů k vysvětlení těchto jazykových fenoménů. Dále je věnována pozornost několika sporným bodům opakovaně se objevujícím v různých teoriích metafory. Na základě analýzy těchto sporných bodů jsou předloženy argumenty zpochybňující předpokládanou odlišnost (...) mechanismů konstituování významu u obrazných a doslovných vyjádření. Následkem toho je pak vznesen návrh, zda by metafora, pro své kvalitativní a kvantitativní rysy, nemohla být chápána jako prubířský kámen teorií významu, tj. byla nástrojem k hodnocení těchto teorií, k jejich falsifikování, modifikování či přímo k jejich vytváření.The main aim of this study is to examine the role that metaphor plays in investigation of linguistic meaning and to present the potential of metaphor and figurative language in general to maintain a position of an evaluating criterion for theories of meaning. Several influential theories of metaphor are used as a starting point for this inquiry, to show how vast the field of investigation of metaphors and figurative language might be and how various approaches attempt to explain these language phenomena. I then focus on a number of problematic points repeatedly resurfacing in various theories of metaphor. My analysis of these problems issues in arguments questioning supposed difference between constituting mechanisms of literal and figurative meaning. Having this in place, I propose that, on account of its quantitative and qualitative features, metaphor could be understood as a touchstone of theories of meaning, i.e. the tool for their evaluating, refuting, modifying and even for creating new ones. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

Juros, H. Die "Objektschwäche" der Moraltheologie.--Nossol, A. Christsein als radikale Proexistenz.--Styczen', T. Personaler Glaube im Spannungsfeld von religiöser Autorität und Gewissensautonomie.--Piegsa, J. Die "Sache Jesu" und die Reformmarxisten.--Szostek, A. Zur gegenwärtigen Diskussion über den Utilitarismus.--Pryszmont, J. Die Wiederherstellung der gefallenen menschlichen Natur.--Theiner, J. Gedanken zur Sündenlehre Abaelards in seinem Werk "Ethica seu Scito teipsum".--Sikorski, T. Die Aporie des gemeinschaftlichen Lebens.--Kleber, K.-H. Der Christ und die Armut.--Wojtyła, K. Die menschliche Person im Kontext der ehelichen Hingabe und Elternschaft.--Tischner, J. Überlegungen zur Arbeitsethik.--Zeimentz, (...) H. Toleranz-Freiheit-Wahrheit. (shrink)

1. Matter and form -- 2. Maimonides' theory of the parable -- 3. The parable of adamic perfection -- 4. Physical matter and its limitations on intellects -- 5. Maimonidean skepticism I -- 6. Maimonidean skepticism II -- 7. In the inner chamber of the ruler's palace: the critique of the theory of separate intellects -- 8. The embodied life of an intellect -- 9. Excrement and exegesis, or shame over matter.

In this volume, Fr. Fuchs has brought together 12 exceptionally important essays which consider various aspects of the relationship between Christian morality ...

Ingarden distinguishes four strata making up the structure of the literary work of art: the stratum of word sounds and sound-complexes; the stratum of meaning units; the stratum of represented objectivities (characters, actions, settings, and so forth); and the stratum of schematized aspects (perspectives under which the represented objectivities are given to the reader). It is not only works of literature which manifest this four-fold structure but also certain borderline cases such as newspaper articles, scientific works, biographies, and so forth. (...) Ingarden specifies what is characteristic of a work of literature by asserting that all declarative sentences appearing in the stratum of meaning units of such work possess what he calls a quasi-judgmental character. We discuss here Ingarden’s theory of quasi-judgments and draw out its implication that all works of literature are works of fiction through and through. (shrink)

Volume 2 of Josef Pieper's three-part autobiography is here presented for the first time in English translation. The volume represents not just a simple continuation of a seamless story. The first volume dealt with Pieper's life from his birth in 1904 to the time of World War 2. The current volume deals with the post-war years, 1945-1964, offering a personal documentation of the institutional rubble through which an emerging academic and philosopher had to find his way. This included finding (...) work, re-establishing himself in the family home, completing his academic education, and beginning to teach philosophy in a climate of despair and disillusionment. In this context, the quintessential Pieper emerges. His positive philosophy of being, firmly based on Plato and Thomas Aquinas, finds extraordinary resonance with students, who flock to his lectures in surprising numbers -- seeking and finding a positive way forward. His dedication to training teachers sees him declining higher academic posts in Germany in favor of work which, though less lucrative and more obscure, he considered more fruitful. These years are also marked by his fiercely independent stance over against the Catholic hierarchy -- despite his staunch adherence to the tradition values of Christianity. His popularity as a philosopher and teacher quickly spread to America, where he was invited to teach at famous universities. His fame led to further travels -- to Switzerland, England, France, Spain, India, China, Saigon, and Thailand. Such travels enriched his thinking and nourished the open-mindedness of the Western philosopher. (shrink)

This is a work by Josef Pieper, one of this century's most profound and lucid expositors of the thought of St. Thomas Aquinas.

Given the recent interest in the subjective or phenomenal dimension of consciousness it is no wonder that many authors have once more started to speak of the need for pheno- menological considerations. Often however the term ‘phenomenology’ is being used simply as a synonym for ‘folk psychology', and in our article we argue that it would be far more fruitful to turn to the argumentation to be found within the continental tradition inaugurated by Husserl. In order to exemplify this claim, (...) we criticize Rosenthal's higher-order thought theory as well as Strawson's recent contribution in this journal, and argue that a phenomenological analysis of the nature of self-awareness can provide us with a more sophisticated and accurate model for understanding both phenomenal consciousness and the notion of self. (shrink)

Together, Daisaku Ikeda and Josef Derbulav explore a wide range of topics, starting with a discussion of the tension between tradition and modernization in Japan and elsewhere. They compare humanism in East and West, and Buddhism and Christianity. Focusing on the crucial topic of education, they consider the roles of ethics and religion, and zero in on concrete problems and issues: education and political authority, absenteeism, violence in schools, and juvenile delinquency.

Studien zur Wissenschaftsgeschichte und Wissenschaftssystematik im 19. Jahrhundert Josef M. Werle. Drittes Kapitel Argumente zugunsten der Zukunft der Philosophie II: Wissenschaftsgeschichtliche und wissenschaftssystematische ...

This book examines new concept of evolutionary ontology based on the idea of radically different “ontic orders” – natural and cultural being. It explains how culture evolved out of nature and how it became “anti-natural”. The remedy is seen in the global biophilous reconstruction of culture. The value of the “live planet” Earth and the “subject” capable of creative activity and evolution are given fundamental philosophical interpretation.

This title, which at first sight seems curious, shows Pieper's philosophical work as rooted in the basics. He takes his inspiration from Plato - and his Socrates - and Thomas Aquinas. With them, he is interested in philosophy as pure theory, the theoretical being precisely the non-practical. The philosophizer wants to know what all existence is fundamentally about, what "reality" "really" means. With Plato, Pieper eschews the use of language to convince an audience of anything which is not the truth. (...) If Plato was opposed to the sophists - among them the politicians - Pieper is likewise opposed to discourse that leads to the "use" of philosophy to bolster a totalitarian regime or any political or economic system. A fundamental issue for Pieper is "createdness." He sees this as the fundamental truth of our being - all being - and the fundamental virtue we can practice is the striving to live according to our perception of real truth in any given situation. The strength and attraction of Pieper's writing is its direct and intuitive character which is independent of abstract systematization. He advocates staying in touch with the "real" as we experience it deep within ourselves. Openness to the totality of being - in no matter what context being reveals itself - and the affirmation of all that is founded in this totality are central pillars of all his thinking. Given the "simplicity" of this stance, it is no surprise that much of it is communicated - and successfully - through his gift for illustration by anecdote. Like Plato, this philosopher is a story-teller and, like him, very readable. (shrink)

Abstract This essay examines the conditions under which the great medieval Jewish rabbinic figure Moses Maimonides (1138?1204) took war to be justified. In particular, it argues that Maimonides did not hold that universal belief in one deity, on the model of a (Christian or Almohad) holy war or religious crusade, is a sufficient condition to justify the pursuit of a war. At most a war is justified if it enables the creation of a monotheistic environment for the Jewish people within (...) their own boundaries or national territory. Among other topics, the essay also analyzes Maimonides' distinction between ?commanded? wars and ?optional wars?, his concept of idolatry, and his account of jus in bellum. (shrink)

"One of the most important philosophy titles published in the twentieth century, Josef Pieper's Leisure, the Basis of Culture is more significant, even more crucial, today than it was when it first appeared more than fifty years ago. This special new edition now also includes his little work The Philosophical Act. Leisure is an attitude of the mind and a condition of the soul that fosters a capacity to perceive the reality of the world. Pieper shows that the Greeks (...) and medieval Europeans, understood the great value and importance of leisure. He also points out that religion can be born only in leisure; a leisure that allows time for the contemplation of the nature of God. Leisure has been, and always will be, the first foundation of any culture. Pieper maintains that our bourgeois world of total labor has vanquished leisure, and issues a startling warning: Unless we regain the art of silence and insight, the ability for non-activity, unless we substitute true leisure for our hectic amusements, we will destroy our culture; and ourselves. Pieper's message for us is plain. The idolatry of the machine, the worship of mindless know-how, the infantile cult of youth and the common mind; all this points to our peculiar leadership in the drift toward the slave society. Pieper's profound insights are impressive and even formidable. Pieper has subjects involved in everyone's life; he has theses that are so counter to the prevailing trends as to be sensational; and he has a style that is memorably clear and direct." --Publisher. (shrink)

This book makes four bold claims: 1) life is an ultimate datum, open to philosophical analysis and irreducible to physical reality; hence all materialist-reductionist explanations - most current theories - of life are false. 2) All life presupposes soul (_entelechy_) without which a being would at best _fake_ life. 3) The concept of life is _analogous_ and the most direct access to life in its irreducibility is gained through consciousness; 4) All life possesses an objective and intrinsic value that needs (...) to be respected, human life possesses beyond this an inviolable dignity. Life and personal life are pure perfections, it being absolutely better to possess (personal) life than not to possess it. Chapter 1: the metaphysical essence and the many meanings of 'life,' as well as its 'transcendental' character. Chapter 2: the irreducibility of _biological life_, its amazing empirical and philosophically intelligible essential features, and the ways of knowing them. Chapter 3: the immediate evidence and indubitable givenness of mental, conscious life as well as questions of (brain-) death and immortality. Chapter 4: the inviolable objective dignity of personal life and its self-transcendence; a new theory of the fourfold source of human dignity and rights. Chapter 5 (in dialogue-form): methods and results of philosophy versus those of empirical life-sciences. (shrink)

We propose that typical schizophrenic delusions develop on the background of preexisting anomalies of self-experience. We argue that disorders of the Self represent the experiential core clinical phenomena of schizophrenia, as was already suggested by the founders of the concept of schizophrenia and elaborated in the phenomenological psychiatric tradition. The article provides detailed descriptions of the pre-psychotic or schizotypal anomalies of self-experience, often illustrated through clinical vignettes. We argue that delusional transformation in the evolution of schizophrenic psychosis reflects a global (...) reorganization of consciousness and existential reorientation, both of which radiate from a fundamental alteration of the Self. We critically address the contemporary cognitive approaches to delusion formation, often finding them inconsistent with the clinical features of schizophrenia or implausible from a phenomenological point of view. (shrink)

In all his dialogues, the aim of Daisaku Ikeda has been to find a meeting point for the great traditions of East and West. As spiritual leader of an international lay Buddhist movement with eleven million followers, he is a knowledgeable spokesman for the Asian tradition. And in his partner in this latest dialogue - educationalist and philosopher Josef Derbolav - he has found a wise and accomplished voice from the West. The two men explore a wide range of (...) topics, beginning with a discussion of the tension between tradition and modernity in Japan and elsewhere. They go on to compare humanism in East and West, the role in society of ethics and religion, and the encounter between Christianity and Buddhism. Focusing on the central topic of education, and the business of changing attitudes and minds, their discussion zeroes in on concrete problems and issues: education and political authority; absenteeism and violence in schools; and juvenile delinquency. The dialogue concludes with a reflection on the future for the human race, looking to an inner revolution - a radical alteration in our way of thinking - which will conquer the daunting problems currently facing the planet and its people. (shrink)

It is well known that Maimonides rejects the Kalam argument for the existence of God because it assumes the temporal creation of the world, a premise for which he says there is no “cogent demonstration (burhan qat'i) except among those who do not know the difference between demonstration, dialectics, and sophistic argument.”Moses Maimonides, The Guide of the Perplexed, trans. Shlomo Pines (Chicago: University of Chicago Press, 1963), I:71:180. All references are to this translation; parenthetic in-text references are to part, chapter, (...) and page. By contrast, he claims to establish belief in the existence of God “through a demonstrative method as to which there is no disagreement in any respect” (I:71:182). Taken at his word, Maimonides’ proofs for the existence of the deity, like Aquinas’s five ways, have traditionally been read as models of medieval natural theology: of the power of human reason to independently establish revealed truth. In recent years, however, the same demonstrations have assumed a second kind of significance. For scholars, like myself, who argue that Maimonides holds severe views about the limitations of human knowledge of divine science and metaphysics, these demonstrations are the strongest conceivable counterevidence.The locus classicus for this view is Shlomo Pines, “The Limitations of Human Knowledge According to Al-Farabi, Ibn Bajja, and Maimonides,” in Studies in Medieval Jewish History and Literature, ed. I Twersky, 3 vols. (Cambridge: Harvard University Press, 1979), I:82–109. See also his “Les Limites de la Métaphysique selon Al-Farabi, ibn Bajja et Maimonide; Sources et Antitheses de ces Doctrines chez Alexandre d’Aphrodise et Chez Themistius,” Miscellanea Mediaevalia 13 (1981): 211–25; “Dieu et L’Etre Selon Maimonide: Exégese d’Exode 3,14 et doctrine connexe,” in Celui qui est: Interprétations juives et chrétiennes d’Exode 3, 14, ed. A. de Libera et E. Zum Brunn (Paris: Les Editions du Cerf [Collection “Patrimoines”], 1986), 15–24; and “The Relation between Maimonides’ Halakhic and non-Halakhic Works,” in Maimonides and Philosophy, ed., S. Pines and Y. Yovel (Dordrecht: Martinus Nijhoff, 1987). Pines concludes, on the basis of the limitations of the intellect with respect to knowledge of metaphysics, that Maimonides, like Kant, gives priority to the practical over the theoretical. For arguments drawing different ‘skeptical’ conclusions, see my “Maimonides in the Skeptical Tradition,” ms.; “Maimonides on the Growth of Knowledge and the Limitations of the Intellect,” to appear in Tony Levy, ed., Maimonide: Traditions philosophiques et scientifiques médievales arabe, hébraique, latine; “Logical Syntax as a Key to a Secret of the Guide of the Perplexed,” (in Heb.), Iyyun 38 (1989): 137–66; “Maimonides on Language and the Science of Language,” in Maimonides and the Sciences, ed., H. Levine and R. Cohen (Dordrecht: Kluwer, 2000), pp. 173–226; and The Matter and Form of Maimonides’ Guide (forthcoming). If Maimonides really held that humans cannot apprehend metaphysical truths about the deity, how could he have demonstrated (or even thought he could demonstrate) the existence of God? If he does demonstrate it, then humans evidently do have knowledge of metaphysics. As one distinguished scholar has recently protested, it is nothing less than “perverse” to interpret Maimonides as “meaning that the existence of God is unknowable when he in fact prides himself on having demonstrated the existence of God in four different ways.”Herbert A. Davidson, “Maimonides on Metaphysical Knowledge,” Maimonidean Studies 3 (1992–1993): 49–103, 86. See also Alfred L. Ivry, “The Logical and Scientific Premises of Maimonides’ Thought,” in Perspectives on Jewish Thought and Mysticism, ed. Alfred L. Ivry, Elliot R. Wolfson, and Allan Arkush (Amsterdam: Harwood Publishers, 1998), pp. 63–97, 70. (shrink)

We translate Socrates’ famous saying I know that I know nothing into the arithmetical sentence I prove that I prove nothing. Then it is easy to show that this translated saying is formally undecidable in formal arithmetic, using Gödel’s Second Incompleteness Theorem. We investigate some variations of this Socrates-Gödel sentence. In an appendix we sketch a ramified epistemic logic with propositional quantifiers in order to analyze the Socrates-Gödel sentence in a more logical way, separated from the arithmetical context.