Cellular identity and its response to external or internal signalling variations are encoded in a cell's genome as regulatory information. The genomic regions that specify this type of information are highly variable and degenerated in their sequence determinants, as it is becoming increasingly evident through the application of genome‐scale methods to study gene expression. Here, we speculate that the same scenario applies to the regulatory regions controlling where DNA replication starts in the metazoan genome. We propose that replication origins cannot (...) be defined as unique genomic features, but rather that DNA synthesis initiates opportunistically from accessible DNA sites, making cells highly robust and adaptable to environmental or developmental changes. (shrink)

The present study aimed to explore and map the views of Portuguese laypersons regarding the acceptability of downsizing and restructuring measures during a recession. Two hundred and seven participants with various levels of training in economics were presented with a number of realistic scenarios depicting various measures, and were asked to indicate the extent to which they considered them to be acceptable. The scenarios were created by varying three factors likely to have an impact on people’s views: the magnitude of (...) a company’s reduction in net sales, the magnitude of planned downsizing, and the way in which downsizing would be implemented, either through layoffs, job alliances or both. Six qualitatively different personal positions were found. Four of these following positions were expected: never acceptable, mainly depends on the magnitude of downsizing, mainly acceptable and job alliance. Two unexpected positions were also observed: drastic measures and undetermined. (shrink)

The present study aimed to explore and map the views of Portuguese laypersons regarding the legitimacy of bonuses for senior executives. Two hundred eight participants, with various levels of training in economics, were presented with a number of concrete scenarios depicting the circumstances in which senior executives have received bonuses of variable amounts, and they were asked to indicate the extent to which such bonuses may be considered as legitimate. The scenarios were created by varying four factors likely to have (...) an impact on people’s views: the extent to which the objectives fixed by the company have been met or not, the global economic context in which the company has performed, the availability of experienced senior executives in the sector under consideration, and the amount of money that has been awarded, in terms of both the euros and multiples of the average worker’s pay. Five qualitatively different personal positions were found. The most common positions were that executive bonuses were either never legitimate or not very legitimate. People without any background in economics were more likely to hold these views than people with a background in economics. The remaining 45 % of the participants supported the awarding of bonus, but their support was conditional, and the main condition was the extent to which the company’s objectives were met. Thus for most participants, the practice of awarding extra pay to senior executives was either never legitimate, or legitimate only when the company’s objectives have been attained, or legitimate only when, even in a time of economic crisis, the company’s objectives have been surpassed. (shrink)

O ato de amamentar apresenta diversos benefícios tanto à mãe quanto ao bebê. No entanto, amamentar um bebê com cardiopatia requer inúmeros desafios. Este estudo tem o propósito de compreender a vivência do aleitamento materno de bebês com cardiopatia congênita e as propostas dos serviços de saúde à paciente com essas condições. Estudo descritivo, qualitativo, realizado por meio de entrevista semiestruturada com mães de bebês internados em hospital de referência em cardiopediatria. Utilizou-se a técnica de análise de conteúdo de Minayo, (...) com referencial teórico específico para embasamento da discussão. Os resultados encontrados apontam para a dura realidade dessas mães que se deparam com inúmeras dificuldades diante do enfrentamento da doença e das repercussões emocionais e físicas advindas dela. O impacto emocional e inviabilização dos cuidados com a amamentação exige uma equipe de saúde especializada para oferecer suporte afetivo, fortalecer vínculo mãe-bebê e minimizar prejuízos que a doença pode ocasionar. (shrink)

This book is dedicated to clarify ambiguous concepts from the world of creativity and innovation. One of the initial triggers for the development of the book was the perceived ambiguity of the binomials Design vs. Design Thinking and Innovation vs. Invention. Frequently, designers and innovation consultants are questioned by their clients about the relationships between these kind of concepts. Has the second emerged through the first, or vice-verse? Is one part of the other? Where are the similarities and which are (...) the differences? This conceptual incomprehension makes itself noticeable between many ambiguous concepts in the world of innovation and creativity. What is the difference between Radical and Disruptive Innovation? Or is Social Innovation the same as Social Intervention? And regarding Creativity, are Creativity and Creative Thinking the same? In this book the reader will find answers to these kinds of questions and doubts. 28 authors from 10 different countries and cultural backgrounds are questioning current definitions and perceptions, by comparing different sources and ideas, or simply by giving their personal opinions. Some of the authors have an academic background, others a practical one, being either entrepreneurs, working with innovation in companies, or being innovation/design consultants. (shrink)

The COVID-19 pandemic challenged countries, regions, schools, and individuals. School closures due to lockdowns forced changes in the teaching practices and the learning support provided to children at home. This study aimed to provide insights on the changes between the first and the second lockdowns in Portugal, concerning remote teaching practices and family support to children's education. A self-report questionnaire was filled by 144 parents of third grade students. The results show that, between the two lockdowns, there was a significant (...) decrease in the amount of support provided at home to school assignments and activities, as well as in the amount of time spent by students in TV broadcasted lessons and in reading training supported by the family. Inversely, families reported a significant increase in the amount of time spent by students in independent reading activities and in the time spent in training reading guided by teachers. The number of synchronous lessons with a teacher and the number of times students trained reading during a synchronous lesson also increased in the second lockdown. Additionally, in the second lockdown, parents perceived synchronous lessons to be more effective at improving their child's reading skills and perceived themselves as more capable of supporting their child in reading acquisition. These findings are used to discuss school responses and remote teaching and learning practices during the COVID-19 pandemic. (shrink)

This study investigates whether employees attribute different motives to their organization's corporate social responsibility efforts and if these motives influence employee performance. Specifically, we investigate whether employees could distinguish between intrinsic and extrinsic CSR motives by surveying 229 employee–supervisor dyads from various industries , and the impact of these perceptions on in-role and extra-role performance of subordinates. We found that employee task performance increases when employees attribute both intrinsic and extrinsic motives for CSR. Moreover, when employees perceive that their organization (...) invests in a CSR practice that is both intrinsic and extrinsic, they also tend to exert extra effort in their work. Theoretical and practical implications are also discussed alongside future research directions. (shrink)

Microbiome research shows that human health is foundationally intertwined with the ecology of microbial communities living on and in our bodies. This challenges the categorical separation of organisms from environments that has been central to biomedicine, and questions the boundaries between them. Biomedicine is left with an empirical problem: how to understand causal pathways between host health, microbiota and environment? We propose a conceptual tool – environmentality – to think through this problem. Environmentality is the state or quality of being (...) an environment for something else in a particular context: a fully perspectival proposition. Its power lies partly in what Isabelle Stengers has called the efficacy of the word itself, contrasting the dominant sense of the word environment as something both external and fixed. Through three case studies, we argue that environmentality can help think about the causality of microbiota vis-a-vis host health in a processual, relational and situated manner, across scales and temporalities. We situate this intervention within historical trajectories of thought in biomedicine, focusing on the challenge microbiome research poses to an aperspectival body. We argue that addressing entanglements between microbial and human lives requires that the environment is brought into the clinic, thus shortening the conceptual gap between medicine and public health. (shrink)

In the context of the free will debate, both compatibilists and event-causal libertarians consider that the agent’s mental states and events are what directly causes her decision to act. However, according to the ‘disappearing agent’ objection, if the agent is nothing over and above her physical and mental components, which ultimately bring about her decision, and that decision remains undetermined up to the moment when it is made, then it is a chancy and uncontrolled event. According to agent-causalism, this sort (...) of problem can be overcome if one realizes that the agent herself, as an irreducible substance, is the true originator of her actions. I’ll present arguments that favor this view. Event-causalists have countered that if the agent identifies with some of the inner states that play the self-determining causal role in bringing about the action, then it is as though the action was directly caused by herself. I’ll object that this is not a distinctive aspect of free agency. Agent-causalism has been criticized from most naturalistically inclined fronts, and it must address risks of implausibility, contradiction and unintelligibility. Even though I’ll acknowledge these challenges, I’ll still argue that libertarian free will cannot be defended by any reductionist alternative, and that agent-causalism does not conflict with contemporary science but only with some of its unproven assumptions. (shrink)

The purpose of this study was to identify the relative contribution of individual and contextual predictors to students’ attitudes toward the acceptability of cheating and plagiarism. A group of 324 students from a tertiary institution in New Zealand completed an online survey. The findings indicate that gender, justice sensitivity, and understanding of university policies regarding academic dishonesty were the key predictors of the students’ attitudes toward the acceptability of cheating and plagiarism, both as agents of dishonest conduct and as witnesses (...) of misconduct among their peers. The implications of these findings for the development of policies and initiatives in tertiary institutions are discussed. (shrink)

Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error‐prone segregation is an issue, an aneuploidy‐selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates (...) a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:So Close and Other EssaysOn Hélène Cixous’s writingJoana Masóce n’est jamaispar l’intérieurni par le centreque je passe—Antonin Artaud, Cahiers d’Ivry, (1947–1948)At the end of the sixteenth century, the genre of the essay transformed the relationship between the subject and object of writing, since the essay emerged as a reaction against other literary forms—such as the commentary, the gloss or the treatise—in which the object of study is not problematized. (...) The gloss, the commentary, or the treatise deal with disciplines or thematic topics—astronomy, agronomy, theology, physics, history—in the proper sense, whereas the essay tends to focus on the approach to those issues. To put it differently, the essay is not strictly concerned with these issues or topics in themselves, but with the approach to them by means of writing.With Michel de Montaigne, specifically in his Essays published between 1580 and 1595, we are faced with writing where the knowledge of the object is no longer the sole center of the text. Despite being actually concerned with the Greek philosophical tradition, sixteenth-century religious wars, and, among many other topics, European colonialism in America, Montaigne’s Essays try to contest the privilege of the object, the privilege of the referent of writing, in [End Page 131] favor of its subject: the subject of writing and the writing itself, what we call in French une écriture de soi.As is well known, in his Essays Montaigne’s writing conveys neither message nor knowledge regarding things and topics, but what he calls “la continuelle mutation et branle” des êtres [“nostre estre”] et des objects [“ des objects”]: “the continual and perpetual mutation” of “beings” and “objects” (257).This epistemological crisis of the essay—abandoning the privilege of the object or theme for an emphasis on questioning the subject of writing and the modalities of the approach to the object—is explicit in the etymology of the word essay. Beyond the notion of attempt—in French, essayer means “to try,” “to attempt to do something”—essayer, from the Latin verb ex-agere, is a compound word of the verb agere, “to act,” in French agir. In Latin, the meaning of agere—“to act”—differs from facere, as agir does in French from faire, “to do”; it is in this way that these two verbs designate a different relationship between the subject and the object of the action. Although agere and facere both refer to action, the verb agere at the origin of the word essay designates an action accomplished by a subject, whereas facere is a transitive verb whose emphasis is placed on the object.While, on the one hand, facere is to be read in the register of transitivity—as is explicit in the following Latin phrases: facere litteram, “to write a letter,” or facere furtum, “to commit theft”—on the other hand, agere, although a transitive verb in Latin, underscores and anticipates the kind of intransitivity of action we will later find in Roman languages. In these Latin phrases, one can see that in Latin, at the same time that, the syntactic construction of agere requires an object, this object is not, strictly speaking, the real object produced by the verb, because in the phrases agere vitam, agere aetatem, or agere aevum, “to spend time or to live,” time is not the real object produced by the verb “to spend.” In Latin, “life,” vitam, “age,” aetatem, or “lifetime,” aevum, are not the real objects produced by the verb agere. This perhaps explains the evolution of the verb in French, or in English, where “to act” and agir have become intransitive verbs, reinforcing the idea that the essay appears to be a genre where whatever has to be done or said is not simply presented as an object.Moreover, instead of the conclusive verb facere, which designates the action as a result or an achievement—the letter is already written, or the theft is already commited—the temporality of agere, in Latin, is a durative one, as in the phrases agere vitam, aetatem, or aevum, “to live.” By its emphasis, not on the object... (shrink)

-/- Irony is an intriguing topic, central to the study of meaning in language. This book provides an introduction to the pragmatics of irony. It surveys key work carried out on irony in a range of disciplines such as semantics, pragmatics, philosophy and literary studies, and from a variety of theoretical perspectives including Grice's approach, Sperber and Wilson's echoic account, and Clark and Gerrig's pretense theory. It looks at a number of uses of irony and explores how irony can be (...) misunderstood cross-culturally, before delving into the key debates on the pragmatics of irony: is irony always negative? Why do speakers communicate via irony, and which strategies do they usually employ? How are irony and sarcasm different? Is irony always funny? To answer these questions, basic pragmatic notions are introduced and explained. It includes multiple examples and activities to enable the reader to apply the theoretical frameworks to actual everyday instances of irony. (shrink)

Irony is acknowledged to be usually critical: the ironic speaker tends to exhibit an apparent positive attitude in order to communicate a negative valuation. The reverse is considered to be also possible though: the ironic speaker can praise by apparent blaming, although it seldom happens. This unbalance between the two sorts of ironic examples is the so-called asymmetry issue of irony. Here I shall deny the possibility of being ironic without criticizing — hence the asymmetry issue is an illusion. By (...) claiming that irony is always critical I suggest an even stronger claim: criticism is what distinguishes irony from the similar phenomenon of metaphor. (shrink)

Cada concepción de la persona responde a un modelo antropológico determinado. Sin embargo, todas confluyen como mínimo, en dos aspectos: todas las personas son receptoras de su vida y todas comparten un anhelo último de felicidad. Pero, ¿qué implicaciones tiene esto en la búsqueda del éxito del hombre? ¿Es compatible con la vinculación al otro? ¿Qué implica ser altruista y qué rol desempeña esta conducta en la consecución del éxito? ¿Es el ser humano altruista de forma innata? De este modo, (...) se pretende analizar el fenómeno del altruismo, su origen y su sentido en la persecución del éxito de la persona desde las dimensiones biológica, psicológica y antropológica que conforman a la persona. (shrink)

The cognitive reserve is widely accepted as the active ability to cope with brain damage, using preexisting cognitive and compensatory processes. The common CR proxies used are the number of formal years of education, intelligence quotient or premorbid functioning, occupation attainment, and participation in leisure activities. More recently, it has employed the level of literacy and engagement in high-level cognitive demand of professional activities. This study aims to identify and summarize published methodologies to assess the CR quantitatively. We searched for (...) published studies on PubMed, ScienceDirect, and Web of Science between September 2018 and September 2021. We only included those studies that characterized the CR assessment methodology. The search strategy identified 1,285 publications, of which 25 were included. Most of the instruments targeted proxies individually. The lack of a gold standard tool that incorporates all proxies and cognitive tests highlights the need to develop a more holistic battery for the quantitative assessment of CR. Further studies should focus on a quantitative methodology that includes all these proxies supported by normative data to improve the use of CR as a valid measure in clinical contexts. (shrink)

The sensible and conflicting scenario of the pandemic postulated many challenges to societies around the world in 2020. Part of this problem refers to how the differences between politics and science are not comprehended in their particularities. The recognition of limits and power of science and politics can not only contribute to reaching the actions and strategies facing novel coronavirus but also optimized many domains of society.

Science aims to transform the subjectivity of individual observations and ideas into more objective and universal knowledge. Yet if there is any area in which first-person experience holds a particularly special and delicate role, it is the sciences of the mind. According to a widespread view, first-person methods were largely discarded from psychology after the fall of introspectionism a century ago and replaced by more objective behavioral measures, a step that some authors have begun to criticize. To examine whether these (...) views are sufficiently informed by actual scientific practice, we conducted a review of methodological approaches in the cognitive science literature. We found that reports of subjective experience are in fact still widely used in a broad variety of different experimental paradigms, both in studies that focus on subjective experience, and in those that make no explicit reference to it. Across these studies, we documented a diverse collection of approaches that leveraged first-person reports, ranging from button presses to unstructured interviews, while continuing to maximise experimental reproducibility. Common to these studies were subjects acting as sensors, intentionally communicating their experience to the experimenter, which we termed “second-person” methods. We conclude that, despite views to the contrary, first-person experience has always been and is still central to investigations of the mind even if it is not recognized as such. We suggest that the conversation ought to be reframed: instead of debating whether to accept subjects’ first-person knowledge we should discuss how best to do so. (shrink)

Introduction: Ethical conflict is a phenomenon that has been under study over the last three decades, especially the types moral dilemma and moral distress in the field of nursing care. However, ethical problems and their idiosyncrasies need to be further explored. Aim: The objectives of this study were, first, to obtain a transcultural Portuguese-language adaptation and validation of the Ethical Conflict Nursing Questionnaire–Critical Care Version and, second, to analyse Portuguese critical care nurses’ level of exposure to ethical conflict and its (...) characteristics. Methods: A cross-cultural validation and descriptive, prospective and correlational study. The sample was made for 184 critical care nurses in 2016. Ethical Considerations: The study was authorised by Bioethics Commission of the University of Barcelona, the Associaçâo de Apoio ao Serviço de Cuidados Intensivos do Centro Hospitalar do Porto and the Sociedade Portuguesa de Enfermagem de Saúde Mental. Findings: The Portuguese version of the Ethical Conflict Nursing Questionnaire–Critical Care Version was a valid and reliable instrument to measure exposure to conflict. Moral outrage was the most common type of conflict. The most problematic situations were the ineffectiveness of analgesic treatments, the administration of treatments considered futile and the mismanagement of resources. (shrink)

Does the interaction between climactic demands, monetary resources, and freedom suggest a more general relationship between the environmental challenges that human societies face and their resources to meet those challenges? Using data on press freedom (Van de Vliert 2011a), we found no evidence of a similar interaction with natural resources (as measured by oil exports) or risk for natural disasters.

What happens when we unexpectedly see an attractive potential partner? Previous studies in laboratory settings suggest that the visualization of attractive and unattractive photographs influences the perception of time. The major aim of this research is to study time perception and attraction in a realistic social scenario, by investigating if changes in subjective time measured during a speed dating are associated with attraction. The duration of the dates was variable and participants had to estimate the time that passed. Among other (...) measures, participants also rated the potential partners in terms of their physical attractiveness before and after the dates and reported if they would like to exchange contact with them. Results showed that, in a real speed dating situation, when there is a perception of the partner as being physically more attractive, women tend to overestimate the duration of that meeting, whereas men tend to underestimate its duration. Such changes may reflect evolutionary adaptations which make the human cognitive system more responsive in situations related to reproductive fitness. (shrink)

Apresenta-se uma análise fílmica do videodocumentário Roda o Tererê com vistas a investigar se e como o filme dirigido pela cineasta brasileira Lilian Solá Santiago contribui para uma descolonização do olhar, da estética e da política das imagens. Interessa identificar até que ponto o videodocumentário tensiona o regime de visibilidade dominante na sociedade nacional problematizado por teóricos localizados fora do eixo cultural da Europa. Conclui-se que, ao inscrever-se enquanto cineasta, Lilian Santiago não transforma a sua câmera apenas em voz; transforma (...) o microfone em ouvido, e faz dele uma caixa de ressonância para que as pessoas ouçam e vejam aqueles que vem sendo historicamente apagados dos espaços do aparecer. (shrink)

Understanding cultural evolution is one of the most challenging and indispensable scientific tasks for the survival of humankind on our planet. This task demands, besides an adoption of theories and models from biological evolution, theories for culture-specific processes as well. Language evolution and language acquisition offer interesting objects of study in this respect. (Published Online November 9 2006).

A public health emergency, as the COVID-19 pandemic, may lead to shortages of potentially life-saving treatments. In this situation, it is necessary, justifiable and proportionate to have decision tools in place to enable healthcare professionals to triage and prioritise access to those resources. An ethically sound framework should consider the principles of beneficence and fair allocation. Scientific Societies across Europe were concerned with this problem early in the pandemic and published guidelines to support their professionals and institutions. This article aims (...) to compare triage policies from medical bodies across Europe, to characterise the process of triage and the ethical values, principles and theories that were proposed in different countries during the first outbreak of COVID-19. (shrink)

It has been proposed that individuals with autism spectrum disorder struggle both with response initiation and with response inhibition, both of which are functions of the executive system. Experimental tasks are unlikely pure measures of a single cognitive domain, and in this study we aim at understanding the contributions of response initiation difficulties to possible deficits in inhibitory control in autism. A sample of adults diagnosed with ASD and a control sample participated in this study. To participants it was asked (...) to perform a sentence-completion task with two different condition: Part A—targeting response initiation and Part B—engaging inhibitory processes. Importantly, we have analyzed the B-A latencies that have been proposed for the removal of the response initiation confound effect. Results show that no differences between the groups were found in accuracy measures, either in Part A nor Part B. However, in both conditions autistic participants were significantly slower to respond than the group of participants with typical development. Critically, we show that when subtracting the response times of Part A from Part B no group differences attributable to inhibitory processes remained. With this study we corroborate the existence of difficulties with response initiation in autism and we question the existence of troubles in inhibition per se. (shrink)

AimThe aim of our study was to analyze physical activity levels, sitting time, physical fitness, and their relationship with depressive symptoms after home confinement in previously active older adults.MethodsThis cross-sectional study sample comprised 68 older adults from a community-based exercise program conducted in Porto, Portugal. After home confinement, participants were assessed in person for lower-body strength, cardiorespiratory fitness, agility/dynamic balance, handgrip strength, and anthropometry. Telephone interviews were performed to evaluate depressive symptoms with the Geriatric Depression Scale – 15 items and (...) physical activity levels through the International Physical Activity Questionnaire. Individuals were also asked to self-report changes in their physical activity levels and time spent sitting.ResultsNinety percent of older adults self-reported a decrease in overall physical activity levels, and nearly 65% increased daily sitting time during the home confinement. However, previously active older adults still presented high levels of physical fitness after 11 weeks of home confinement. Overall, 52.9% of participants scored 5 or more points on GDS-15, which is suggestive of depression. Higher levels of moderate-to-vigorous physical activity and cardiorespiratory fitness were found in the non-depressed group compared with the depressed group. Finally, results from multiple regression analysis revealed that MVPA was negatively associated with depression. This model explained 16.4% of the variability seen in depression score, controlled for age, gender, and education.ConclusionEven reporting a decline in physical activity, older adults who previously participated in a formal exercise program, still presented high levels of physical fitness after 11 weeks of home confinement. However, MVPA, but not physical fitness, seems to be an associated depression score in previously active older adults. These results reinforce the importance of older adults to remain physically active, since higher levels of MVPA may have a protective effect on depressive symptoms and, therefore, mitigate the negative impact of home confinement on mental health. Future longitudinal research studies are needed to ascertain these results. (shrink)