Many innate immune response proteins recognize foreign nucleic acids from invading pathogens to initiate antiviral signaling. These proteins mostly rely on structural characteristics of the nucleic acids rather than their specific sequences to distinguish self and nonself. One feature utilized by RNA sensors is the extended stretch of double‐stranded RNA (dsRNA) base pairs. However, the criteria for recognizing nonself dsRNAs are rather lenient, and hairpin structure of self‐RNAs can also trigger an immune response. Consequently, aberrant activation of RNA sensors has (...) been reported in numerous human diseases. Yet, in most cases, the activating antigens remain unknown. Recent studies have developed sequencing techniques tailored to specifically capture dsRNAs and identified that various noncoding elements in the nuclear and the mitochondrial genome can generate dsRNAs. Here, the identity of endogenous dsRNAs, their recognition by dsRNA sensors, and their implications in the pathogenesis of human diseases ranging from inflammatory to degenerative are presented. (shrink)

Truth is one of the most debated topics in philosophy; Wolfgang Kunne presents a comprehensive critical examination of all major theories, from Aristotle to the present day. He argues that it is possible to give a satisfactory 'modest' account of truth without invoking problematic notions like correspondence, fact, or meaning. The clarity of exposition and the wealth of examples will make Conceptions of Truth an invaluable and stimulating guide for advanced students and scholars.

Business Ethics, the Environment & Responsibility, EarlyView.

Business Ethics, the Environment & Responsibility, Volume 31, Issue 1, Page 164-176, January 2022.

As the twentieth century draws to a close and the rush to globalization gathers momentum, political and economic considerations are crowding out vital ethical questions about the shape of our future. Now, Hans Kung, one of the world's preeminent Christian theologians, explores these issues in a visionary and cautionary look at the coming global society. How can the new world order of the twenty first century avoid the horrors of the twentieth? Will nations form a real community or continue to (...) aggressively pursue their own interests? Will the Machiavellian approaches of the past prevail over idealism and a more humanitarian politics? What role can religion play in a world increasingly dominated by transnational corporations? Kung tackles these and many other questions with the insight and moral authority that comes from a lifetime's devotion to the search for justice and human dignity. Arguing against both an amoral realpolitik and an immoral resurgence of laissez faire economics, Kung defines a comprehensive ethicfounded on the bedrock of mutual respect and humane treatment of all beingsthat would encompass the ecological, legal, technological, and social patterns that are reshaping civilization. If we are going to have a global economy, a global technology, a global media, Kung argues, we must also have a global ethic to which all nations, and peoples of the most varied backgrounds and beliefs, can commit themselves. "The world," he says, "is not going to be held together by the Internet." For anyone concerned about the world we are creating, A Global Ethic for Global Politics and Economics offers equal measures of informed analysis, compassionate foresight, and wise counsel. (shrink)

ABSTRACT Early modern alchemy studied both matter and life, much like today's life sciences. What material life is and how it comes about intrigued alchemists. Many found the answer by assuming a vital principle that served as the source and cause of life. Recent literature has presented important cases in which vitalist formulations incorporated corpuscular or mechanical elements that were characteristic of the New Science and other cases in which vitalist thinking influenced important figures of the Scientific Revolution. Not merely (...) speculative, vitalist ideas also motivated chymical practice. The unity of life science and material science that is found in many formulations of Renaissance alchemy disintegrated in Georg Ernst Stahl's version of post-Cartesian vitalism. (shrink)

This paper examines Georg Ernst Stahl's first book, the Zymotechnia Fundamentalis, in the context of contemporary natural philosophy and the author's career. I argue that the Zymotechnia was a mechanical theory of fermentation written consciously against the influential "fermentational program" of Joan Baptista van Helmont and especially Thomas Willis. Stahl's theory of fermentation introduced his first conception of phlogiston, which was in part a corpuscular transformation of the Paracelsian sulphur principle. Meanwhile some assumptions underlying this theory, such as the composition (...) of matter, the absolute passivity of matter and the "passions" of sulphur, reveal the combined scholastic and mechanistic character of Stahl's natural philosophy. In the conclusion I show that Stahl's theory of fermentation undermined the old fermentational program and paved the way for his dualist vitalism. (shrink)

Morality seems important, in the sense that there are practical reasons — at least for most of us, most of the time — to be moral. A central theoretical motivation for consequentialism is that it appears clear that there are practical reasons to promote good outcomes, but mysterious why we should care about non-consequentialist moral considerations or how they could be genuine reasons to act. In this paper we argue that this theoretical motivation is mistaken, and that because many arguments (...) for consequentialism rely upon it, the mistake substantially weakens the overall case for consequentialism. We argue that there is indeed a theoretical connection between good states and reasons to act, because good states are those it is fitting to desire and there is a conceptual connection between the fittingness of a motive and reasons to perform the acts it motivates. But while some of our motives are directed at states, others are directed at acts themselves. We contend that just as the fittingness of desires for states generates reasons to promote the good, the fittingness of these act-directed motives generates reasons to do other things. Moreover, we argue that an act’s moral status consists in the fittingness of act-directed feelings of obligation to perform or avoid performing it, so the connection between fitting motives and reasons to act explains reasons to be moral whether or not morality directs us to promote the good. This, we contend, de-mystifies how there could be non-consequentialist reasons that are both moral and practical. (shrink)

At the end of section §6 in the Analytic of the Beautiful, Kant defines taste as the “faculty for judging an object or a kind of representation through a satisfaction or dissatisfaction without any interest”. On the face of it, Kant’s definition of taste includes both; positive and negative judgments of taste. Moreover, Kant’s term ‘dissatisfaction’ implies not only that negative judgments of taste are those of the non-beautiful, but also that of the ugly, depending on the presence of an (...) actual displeasure. (shrink)

This article examines two early modern models of dissertation authorship that both relied on extensive collaboration between the degree candidate and his supervisor. The dissertation conducted on the traditional model, practiced until the eighteenth century at German universities, was a joint product of the supervisor, who prepared the thesis in writing, and the degree candidate, who defended it in the oral disputation. The two collaborators shared the credit for a successfully defended thesis in different forms: right for public recognition and (...) rights to use and reproduce the thesis. Instead of sharing the credit as two equal partners, each of them took advantage of his credit in ways that benefited his status. In the model that Albrecht von Haller introduced at Göttingen, the supervisor provided the student with a laboratory and experimental training, while the degree candidate wrote a thesis by himself based on the experiments he carried out, and defended the thesis without the supervisor chairing the disputation. The Haller model reveals two new elements that heralded the development of modern scientific education: divisibility of laboratory labor between the student’s experimentation and the research program to which it belongs; and feasibility of the requirement of experimental work in return for the exclusive authorship of the doctoral thesis. (shrink)

This article explores the cultural dimension in democratic struggle from the vantage point of the public sphere. It proposes that in the public sphere there take place competing and changing interpretations over the `public' through continuous articulation of two analytically distinct representations of public interest - democratic and communal discourses. In an empirical study of the recent credibility crisis in Hong Kong, the author demonstrates first, how the governing coalition sought to maintain its authority through a discourse of `administrative efficiency' (...) embedded in the hegemonic narrative of success, and second, how the challenging discourse of democracy regained momentum through de-mystification of the hegemonic narrative in the event of governing crises. The case study of the recent bird flu crisis offers a specific account of political and cultural challenge to bureaucratic paternalism in the postcolonial context. It is argued that the challenge was powerfully presented as the crisis became a dramatic moment of meaning reconstruction through ironic narrativizing and democratic encoding in the public sphere. (shrink)

Summary Between the 1860s and the 1910s, British acoustics was transformed from an area of empirical research into a mathematically organized field. Musical motives—improving musical scales and temperaments, making better musical instruments, and understanding the nature of musical tones—were among the major driving forces of acoustical researchers in nineteenth-century Britain. The German acoustician, Helmholtz, had a major impact on British acousticians who also had extensive interactions with American and French acousticians. Rayleigh's acoustics, reflecting all these features, bore remarkable fruit in (...) his treatise The Theory of Sound, which successfully subjected empirical acoustics to analytical mathematics. His accomplishments made British acoustics a subfield of physics, thus distinguishing it from the ‘new acoustics’ in early twentieth-century America. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:St. Thomas Aquinas's Appeal to St. John the Baptist as a Benchmark of Spiritual GreatnessJohn Baptist Ku, O.P.When we think of sources of St. Thomas Aquinas's speculative theology, we rightly recall teachings given in Scripture—such as that sin came into the world through one man (Rom 5:12) or that all that the Father has belongs also to the Son (John 16:15)—as well as teachings, based on Scripture, imparted by (...) Church councils or Fathers, such as that Christ is one person with two natures1 or that the human nature of Christ is an instrument of his divinity.2 In the project of faith seeking understanding, these teachings lead expeditiously to distinctions and clarifications concerning person and nature, habit and action, primary and instrumental causality, intellect and will, faith and reason, and the like. However, the saints themselves too serve as a source for Aquinas's speculative theological reflection. Though they admittedly constitute a less abundant source than scriptural, conciliar, or patristic teaching, the saints' contribution to Aquinas's theology merits our attention.For instance, in "Jean-Baptiste: figure du prêcheur chez Thomas d'Aquin," Jean-Pierre Torrell observes that Aquinas's research into the Fathers of the Church for the Catena aurea bore considerable influence on his subsequent works, and Torrell documents how Aquinas's treatment of John the Baptist is a precise case that shows this influence.3 More recent [End Page 1119] scholarship has, fortunately, taken note of the saints' contribution to Aquinas's theology—in the figures of St. Benedict and the virgin martyrs.4This article will therefore examine St. John the Baptist as just such a source of Aquinas's speculative theology. Aquinas appeals to St. John as a benchmark of spiritual greatness against which to situate other figures: Christ, angels, Mary, apostles, prophets, evangelists, priests, and the people of God. By examining these cases, we will not only observe the Angelic Doctor's appreciation of the saints as our teachers, as examples to be imitated, and as proofs of God's love in transformative grace; we will also witness aspects of the Dominican master's theological method, that is, in his manner of interpreting Scripture and his application of reason to scriptural data to make arguments and draw conclusions.5 For instance, in his treatment of the least in the kingdom of heaven, Scripture will definitively confirm what theological reasoning can determine concerning the knowledge of those with the beatific vision. Furthermore, his exposition on the Blessed Virgin will reveal that he reads the Bible as a whole with one divine author, in support of traditional interpretations.6 However, he is not naive about diverse human authorship and the literal versus the spiritual senses [End Page 1120] of Scripture,7 and his methodology unveils his explicit conviction that Scripture must be the basis of theological claims.8My presentation will unfold in five sections. After (1) a glance at some of Aquinas's comments on the authority of various sources of theology so as to situate our conversation about the saints as a source of theology, I will review Aquinas's enlistment of John the Baptist as a standard by which to establish: (2) three simple points about Christians and Christ—that all of the articles of faith must be accepted, that prepubescent children can enter religious life, and that Christ's baptism manifests divine power—(3) the superiority of angels to wayfarers, among whom John the Baptist is the greatest, followed by apostles, prophets, and evangelists; (4) the eminence of John the Baptist and a ranking, in order, of God, angels, John the Baptist, prophets, priests, and then God's people; and (5) the holiness of Mary the Mother of God.The Authority of Various Sources of TheologyIn just a few lines in the Summa theologiae, Aquinas identifies the roles of reason and authority in theology. On one hand, "it is most proper" to theology to offer "proofs from authority," since theology's "principles are known through revelation"—making theological arguments dependent on "the authority of those making the revelation." But on the other hand, theology "also uses human reason, not to... (shrink)

On the seventh page of the People's Daily for April 15, 1958, Ma T'e published an article entitled "Discussions of Problems of Logic." In his conclusion he critically evaluates many people and even classifies me as a revisionist who must be criticized. I have studied this article closely and feel that it is shot through with difficulties.

The present paper is divided into two parts. Part one is an attempt to reconstruct the semiotic models of Freudian-Lacanian psychoanalysis, in which conceptsfrom De Saussure, C. S. Peirce, Jakobson, Lotman, Eco are drawn for mutual illumination and synthesis. Psychoanalytic semiotics is considered a particular areaand discipline in semiotics, aiming at the unconscious dimension of the subject. Lacan could be considered a post-structuralist revision and extension of Freud. Part two is an application of psychoanalytic semiotics to the interpretation of dream (...) painting, focusing on the Dali example. Essential issues in psychoanalytic semiotics of dream painting are explored in the Dali example, such as dream indexes, dream mechanisms, self-portraits as imago and icon, and psychoanalytic Nirvana as a recovery and memory of a non-alienated subject. My reading of Dali demonstrates the possibility of a convergence of semiotics, psychoanalysis, and art criticism. (shrink)

Summary The resonator and the tuning fork were major instruments in acoustics in the latter half of the nineteenth-century. In particular, the third Baron Rayleigh made extensive use of these instruments throughout his long career as an experimentalist. These instruments underwent a number of alterations during their use as central experimental tools in acoustics. Functional and structural alterations were introduced in the adaptation of these instruments to several major acousticians’ experimental settings. Rayleigh not only adopted the two instruments as objects (...) of mathematical and experimental investigation but also employed them ingeniously for various purposes. His continuing creation of a variety of uses and forms of these instruments contributed to focusing acoustics on pure tones and musical sounds until the early twentieth century. (shrink)

ABSTRACTAt the end of 2016, Taiwan witnessed a string of massive protest demonstrations held by both ends of the ideological debate on marriage equality. These public demonstrations can be seen as...

"Reason and the Sacred" alludes to the relation between Philosophy and Sacred Doctrine, or between reason and faith, considering both as necessary and indispensable faculties of the human psyche, one not negating the other vis-a-vis the immanent reaches of the psyche as to its purpose, but one enhancing the other in the perfection of each's domain. Faith is thus not antithetical to reason except if one is employed on the domain of the other so as to attain certainty and experience (...) truth. The latter part of this compilation, namely Book III, includes "Ancient Ethiopia: Gold beneath Wax," an essay on the history of conceivably the oldest civilization, following a meditative writing on faith, contemplation and mystic spirituality, and a religio-anthropological and historical essay about the ancient Church of Abyssinia.". (shrink)

v. 1. History of linguistics.--v. 2. Contemporary linguistics.

Many people find modern art, in whatever medium, meaningless. Its radical questioning of all aesthetic norms, its wild experimentation and its lack of direction stand in stark contrast to the past, with its great tradition of meaningful artistic expression. Of course, it can be argued that modern artists are simply feeling much more deeply what anyone alive today must sense, however vaguely and superficially: a deeply pessimistic and often nihilistic mood. And if art is to have integrity, artists cannot escape (...) that. However, anyone who believes in a first and last ground of meaning of the world and man, even at a time of the disintegration of traditions, can scarcely believe in a definitive chaos of art: if art is a genuine representation of the realities of our time, it should be possible, by understanding it more deeply, to find greater meaning the other side of seeming meaninglessness. This, briefly stated, is the argument of Hans Kueng's latest study, both profound and provocative, which introduces a new and important dimension to his thought. (shrink)

Drawing on contemporary debates and responding to an analytic lacuna in organization and management studies and calls from organizational practice, Phenomenology of the Embodied Organization explores the fundamental and integral role of the body and embodiment in organizational life-worlds.

Highly intelligent... It is understandable while being scholarly and should be read by anyone seeking an overview of ethical history as it relates to the present. -- Church and Synagogue Library Association.

This book argues that the meaning of negation, perhaps the most important logical constant, cannot be defined within the framework of the most comprehensive theory of proof-theoretic semantics, as formulated in the influential work of Michael Dummett and Dag Prawitz. Nils Kürbis examines three approaches that have attempted to solve the problem - defining negation in terms of metaphysical incompatibility; treating negation as an undefinable primitive; and defining negation in terms of a speech act of denial - and concludes that (...) they cannot adequately do so. He argues that whereas proof-theoretic semantics usually only appeals to a notion of truth, it also needs to appeal to a notion of falsity, and proposes a system of natural deduction in which both are incorporated. Offering new perspectives on negation, denial and falsity, his book will be important for readers working on logic, metaphysics and the philosophy of language. (shrink)

We present a hierarchical integrated model of self-regulation in which executive function is the cognitive component of the model, together with emotional, behavioral, physiological, and genetic components. These five components in the model are reciprocally and recursively related. The model is supported by empirical evidence, primarily from a single longitudinal study with good measurement at each level of the model. We also find that the model is consistent with current thinking on related topics such as cybernetic theory, the theory of (...) allostasis and allostatic load, and the theory of skill development in harsh and unpredictable environments, referred to as “hidden talents.” Next, we present literature that the integrative processes are susceptible to environmental adversity, poverty-related risk in particular, while positive social interactions with caregivers would promote self-regulatory processes or mitigate the adverse effect of early risk on the processes. A hierarchical integrative model of self-regulation advances our understanding of self-regulatory processes. Future research may consider broader social contexts of the integrative self-regulation system, such as neighborhood/community contexts and structural racism. This can be an integral step to provide children with equitable opportunities to thrive, even among children living in socioeconomically and psychosocially disadvantaged environments. (shrink)