The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally, experts assumed that this issue could be sufficiently addressed by insisting simply on the application of shared clinical terminologies or clinical information models. However, the use of the term ‘ontology’ has been steadily increasing more recently. We discuss criteria for distinguishing clinical ontologies from clinical terminologies and information models. Then, we briefly present the role clinical ontologies play in two multicentric research projects. Finally, (...) we discuss the interactions between these different kinds of knowledge representation artifacts and the stakeholders involved in developing interoperational real-world clinical applications. We provide ontology engineering examples from two EU-funded projects. (shrink)

Propomos uma tipologia dos artefatos de representação para as áreas de saúde e ciências biológicas, e a associação dessa tipologia com diferentes tipos de ontologia formal e lógica, chegando a conclusões quanto aos pontos fortes e limitações da ontologia de diferentes tipos de recursos lógicos, enquanto mantemos o foco na lógica descritiva. Consideramos quatro tipos de representação de área: (i) representação léxico-semântica, (ii) representação de tipos de entidades, (iii) representação de conhecimento prévio, e (iv) representação de indivíduos. Defendemos uma clara (...) distinção entre os quatro tipos de representação, de forma a oferecer uma base mais racional para o uso das ontologias e artefatos relacionados no avanço da integração de dados e interoperabilidade de sistemas de raciocínio associados. Destacamos que apenas uma pequena porção de fatos cientificamente relevantes em áreas como a biomedicina pode ser adequadamente representada por ontologias formais, quando estas últimas são concebidas como representações de tipos de entidades. Particularmente, a tentativa de codificar conhecimento padrão ou probabilístico pela utilização de ontologias assim concebidas é fadada à produção de modelos não intencionais e errôneos. (shrink)

The first academic overview of one of the most advanced and controversial approaches to sound studies, offering insight into its background, history, the present discourse surrounding it, and its likely future impact.

Dieser Beitrag untersucht drei Beispiele zur Überwindung von Vergänglichkeit und Endlichkeit, einer Inversion der Vanitas-Motivik, vor allem in den Klangkünsten: Wie ist es technisch möglich und kulturell zu bewerkstelligen, dem Verwehen von Klängen entgegenzuwirken? Die transhistorische Übertragungstheorie der médiologie von Régis Debray wird hierbei genutzt, um Formen und Strategien zur ‚ewigen Übertragung’ jeweils näher zu bestimmen. Ausgehend von Edisons Bewerbung des Phonographen als eines Hilfsmittels für hörbare Testamente von Verstorbenen wird die Aufführung von John Cages ORGAN 2/aslsp in Halberstadt, das (...) Vorhaben einer Millennium Clock der Long Now Foundation von Stewart Brand und Brian Eno sowie die Pressung der kremierten Asche eines Verstorbenen in einer Vinylschallplatte durch die Firma Andvinyly untersucht. (shrink)

Dieser Beitrag untersucht drei Beispiele zur Überwindung von Vergänglichkeit und Endlichkeit, einer Inversion der Vanitas-Motivik, vor allem in den Klangkünsten: Wie ist es technisch möglich und kulturell zu bewerkstelligen, dem Verwehen von Klängen entgegenzuwirken? Die transhistorische Übertragungstheorie der médiologie von Régis Debray wird hierbei genutzt, um Formen und Strategien zur ‚ewigen Übertragung’ jeweils näher zu bestimmen. Ausgehend von Edisons Bewerbung des Phonographen als eines Hilfsmittels für hörbare Testamente von Verstorbenen wird die Aufführung von John Cages ORGAN 2/aslsp in Halberstadt, das (...) Vorhaben einer Millennium Clock der Long Now Foundation von Stewart Brand und Brian Eno sowie die Pressung der kremierten Asche eines Verstorbenen in einer Vinylschallplatte durch die Firma Andvinyly untersucht. (shrink)

Dieser Beitrag erkundet und beschreibt das anthropologische Konzept einer sensorisch und besonders klanglich bestimmten Persona. Hintergrund bilden hierbei die künstlerischwissenschaflichen Forschungsmethoden des Soundwalks nach Hildegard Westerkamp, des Sensobiographic Walking oder Sensory Memory Walks nach Helmi Järviluoma sowie Jean-Luc Nancys Körperbegriff und Mario Perniolas Entwurf einer sensorisch verankerten Ideologie unter dem Begriff der Sensologie. Am Ende des Beitrags steht der Vorschlag einer Anthropologie, die sich dezidiert anti-normalistisch und nicht-heteronormativ versteht: eine Anthropologie nicht des Posthumanen, das allzu oft reale Diversität, soziale und (...) materiale Differenzen sowie die Partikularitäten und Idiosynkrasien ignoriert und verdrängt; stattdessen argumentiert dieser Beitrag für eine Anthropologie des Inhumanen, der sogenannten „humanoid aliens“. Diese Anthropologie versteht sich dann als eine Xenologie, als eine Erforschung des Fremden. (shrink)

Uncertainty is a core issue and – as I would like to argue in this article – also a generative core quality of anthropological sensory practices. Research in particular and epistemologically meaningful endeavours in general are probably not even possible if moments and aspects of uncertainty are excluded or even avoided. Therefore, this article will start in the section ‘The sensory corpus’ with one example of auditory and sensory uncertainty by US-sound artist Maryanne Amacher. This example, the piece ‘Dense Boogie (...) I’, operates directly in the body, in the physical ear of the listeners, and can prove how the listening subject’s idiosyncratic sensibility can be a crucial instrument to proceed in researching and understanding. (shrink)

The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally, experts assumed that this issue could be sufficiently addressed by insisting simply on the application of shared clinical terminologies or clinical information models. However, the use of the term ‘ontology’ has been steadily increasing more recently. We discuss criteria for distinguishing clinical ontologies from clinical terminologies and information models. Then, we briefly present the role clinical ontologies play in two multicentric research projects. Finally, (...) we discuss the interactions between these different kinds of knowledge representation artifacts and the stakeholders involved in developing interoperational real-world clinical applications. We provide ontology engineering examples from two EU-funded projects. (shrink)

Dieser Beitrag untersucht, was es heißt, verwundet zu leben. Was auf den ersten Blick als eine mehr als gewöhnliche und kaum spektakuläre Frage erscheinen mag, wird nach Untersuchung der dominanten Phantasmen der Unverletzlichkeit als eine Grundfrage der historischen Anthropologie erkennbar: Wie entsteht und wandelt sich der tägliche Umgang mit eigener Verletzlichkeit und Verwundung im Menschenbild? Welche Wunden des Gewöhnlichen werden in den meisten Lebens- und Arbeitsumgebungen im Allgemeinen ignoriert und ausgeblendet? Worin bestehen die Idiosynkrasien eines empfindsamen Leibes, eines sensorisches Corpus? (...) Und in welchem Zusammenhang stehen die Begehren eines bestimmten Menschen zu seinen Wunden? Eine Körperanthropologie der Wunden bezieht die Verletzungen eines Menschen im Laufe seines Lebens als integraler Teil eines Menschenbildes mit ein. (shrink)

Dieser Beitrag erkundet einige mediologische, Dispositiv-theoretische und klangkulturwissenschaftliche Anschlüsse und Deutungen der performativen dichten Beschreibung von Elise v. Bernstorffs aufgrund ihrer Feldforschung in einer inklusiven Gesamtschule.

PurposeContinuous patient-reported outcomes to identify and address patients’ needs represent an important addition to current routine care. The aim of this study was to identify and determine important dimensions of health-related quality of life in routine oncological care.MethodsIn a cross-sectional qualitative study, interviews and focus groups were carried out and recorded. The interviewees were asked for their evaluation on HrQoL in general and specifically regarding cancer treatment. The material was transcribed and analyzed using qualitative content analysis based on Mayring. The (...) results were reviewed in an expert discussion.ResultsInterviews with patients and clinicians, as well as five focus groups with clinicians were conducted. Initially, nine deductive and two inductive categories on HrQoL were built. Four categories were excluded following the qualitative content analysis because they were hardly or not at all mentioned by participants. Following on from the analysis of the expert discussion, one dimension was added, and two further categories were excluded. The resulting system consisted of six dimensions: emotional health, physical ailments, autonomy, social functionality, dignity, and resources.ConclusionThe identified dimensions of HrQoL in routine oncological care were found to differ from those used in existing HrQoL measurements for patients. Further research is needed to test and evaluate the presented structure in a larger sample of cancer patients to further assess its psychometric properties. (shrink)

Proponents of mechanistic explanations have recently proclaimed that all explanations in the neurosciences appeal to mechanisms. The purpose of the paper is to critically assess this statement and to develop an integrative account that connects a large range of both mechanistic and dynamical explanations. I develop and defend four theses about the relationship between dynamical and mechanistic explanations: that dynamical explanations are structurally grounded, that they are multiply realizable, possess realizing mechanisms and provide a powerful top-down heuristic. Four examples shall (...) support my points: the harmonic oscillator, the Haken–Kelso–Bunz model of bimanual coordination, the Watt governor and the Gierer–Meinhardt model of biological pattern formation. I also develop the picture of “horizontal” and “vertical” directions of explanations to illustrate the different perspectives of the dynamical and mechanistic approach as well as their potential integration by means of intersection points. (shrink)

Most epistemologists hold that knowledge entails belief. However, proponents of this claim rarely offer a positive argument in support of it. Rather, they tend to treat the view as obvious and assert that there are no convincing counterexamples. We find this strategy to be problematic. We do not find the standard view obvious, and moreover, we think there are cases in which it is intuitively plausible that a subject knows some proposition P without—or at least without determinately—believing that P. Accordingly, (...) we present five plausible examples of knowledge without (determinate) belief, and we present empirical evidence suggesting that our intuitions about these scenarios are not atypical. (shrink)

Drawing on recent work in developmental and comparative psychology, this paper argues that demonstratives function to coordinate the interlocutors' joint focus of attention, which is one of the most basic functions of human communication. The communicative importance of demonstratives is reflected in a number of properties that together characterize them as a particular word class: In contrast to other closed-class expressions, demonstratives are universal, they are generally so old that their roots cannot be traced back to other linguistic items, they (...) are among the earliest words that children learn, and they are closely tied to a particular gesture. Moreover, demonstratives play an important role in the organization of discourse and the diachronic evolution of grammar, which arguably is also motivated by their communicative function to establish joint attention. (shrink)

In this paper, we propose a regularity theory of causation. The theory aims to be reductive and to align with our pre‐theoretic understanding of the causal relation. We show that our theory can account for a wide range of causal scenarios, including isomorphic scenarios, omissions, and scenarios which suggest that causation is not transitive.

During much of the past century, it was widely believed that phonemes--the human speech sounds that constitute words--have no inherent semantic meaning, and that the relationship between a combination of phonemes (a word) and its referent is simply arbitrary. Although recent work has challenged this picture by revealing psychological associations between certain phonemes and particular semantic contents, the precise mechanisms underlying these associations have not been fully elucidated. Here we provide novel evidence that certain phonemes have an inherent, non-arbitrary emotional (...) quality. Moreover, we show that the perceived emotional valence of certain phoneme combinations depends on a specific acoustic feature--namely, the dynamic shift within the phonemes' first two frequency components. These data suggest a phoneme-relevant acoustic property influencing the communication of emotion in humans, and provide further evidence against previously held assumptions regarding the structure of human language. This finding has potential applications for a variety of social, educational, clinical, and marketing contexts. (shrink)

Platonic Patterns is a reprint collection of many of Holger Thesleff's studies in Plato—spanning from 1967 to 2003. It includes three books, four articles and a new introduction by the author, which sets the general outline of his interpretation of Plato. Whereas much of the scholarship on Plato has tended to operate within the frame of one language and/or a single school of thought, Thesleff constructively combines several discoveries and theories of various scholars with his own research, focusing on (...) how Plato can be understood in his own context. The work represents small but significant breakthroughs in research on Plato from an internationally inclusive standpoint. Having previously been published mainly in Finland by scholarly societies, availability outside the Nordic countries has, up until now, been minimal. Thesleff employs his singular expertise of Greek language and literature to make innovative contributions to the study and interpretation of Plato. He thematically stresses the significance of the less overt elements found in Plato's dialogues, such as Plato's use of humor and his linguistic expression, while taking into account the chronology and/or the intended audience. (shrink)

We aim to devise a Ramsey test analysis of actual causation. Our method is to define a strengthened Ramsey test for causal models. Unlike the accounts of Halpern and Pearl ([2005]) and Halpern ([2015]), the resulting analysis deals satisfactorily with both over- determination and conjunctive scenarios.

Epigenetic modifications, such as DNA methylation and post‐translation modifications of histones, have been shown to play an important role in chromatin structure, promoter activity, and cellular reprogramming. Large protein complexes, such as Polycomb and trithorax, often harbor multiple activities which affect histone tail modification. Nevertheless, the mechanisms underlying the deposition of these marks, their propagation during cell replication, and the alteration on their distribution during transformation still require further study. Here we review recent data on those processes in both normal (...) and cancer cells, and we propose that the unscheduled expression of oncogenic transcription factors causes reprogramming of normal cells into cancer stem cells. (shrink)

Landgrebe and Smith provide an argument for the impossibility of Artificial General Intelligence based on the limits of simulating complex systems. However, their argument presupposes a very contemporary vision of artificial intelligence as a model trained on data to produce an algorithm executable in a modern digital computing system. The present contribution explores what it means to be artificial. Current artificial intelligence approaches on modern computing systems are not the only conceivable way in which artificial intelligence technology might be created. (...) If there are conceivable routes by which an artificial intelligence might be developed that are not constrained in the same way as the current generation of artificial neural networks, then these might be plausible routes towards the engineered generation of artificial general intelligence that are not precluded by the Landgrebe and Smith argument against the possibility of artificial general intelligence. (shrink)

Most recent accounts of personal autonomy acknowledge that the social environment a person lives in, and the personal relationships she entertains, have some impact on her autonomy. Two kinds of conceptualizing social conditions are traditionally distinguished in this regard: Causally relational accounts hold that certain relationships and social environments play a causal role for the development and on-going exercise of autonomy. Constitutively relational accounts, by contrast, claim that autonomy is at least partly constituted by a person’s social environment or standing. (...) The central aim of this paper is to raise the question how causally and constitutively relational approaches relate to the fact that we exercise our autonomy over time. I argue that once the temporal scope of autonomy is opened up, we need not only to think differently about the social dimension of autonomy. We also need to reconsider the very distinction between causally and constitutively relational accounts, because it is itself a synchronic (and not a diachronic) distinction. (shrink)

Statements about the behavior of biochemical entities (e.g., about the interaction between two proteins) abound in the literature on molecular biology and are increasingly becoming the targets of information extraction and text mining techniques. We show that an accurate analysis of the semantics of such statements reveals a number of ambiguities that have to be taken into account in the practice of biomedical ontology engineering: Such statements can not only be understood as event reporting statements, but also as ascriptions of (...) dispositions or tendencies that may or may not refer to collectives of interacting molecules or even to collectives of interaction events. (shrink)

The pressures that led to the evolution of episodic memory have recently seen much discussion, but a fully satisfactory account of them is still lacking. We seek to make progress in this debate by taking a step backward, identifying four possible ways that episodic memory could evolve in relation to simulationist future planning—a similar and seemingly related ability. After distinguishing each of these possibilities, the paper critically discusses existing accounts of the evolution of episodic memory. It then presents a novel (...) argument in favor of the view that episodic memory is a by-product of the evolution of simulationist future planning. The paper ends by showing that this position allows for the maintenance of the traditional view that episodic memory operates on stored memory traces, as well as explaining a number of key features of episodic memory: its being subject to frequent and systematic errors, its neural co-location with the capacity for simulationist future planning, and the potential existence of non-human episodic memory. (shrink)

The paper provides a formal representation of goal systems. The focus is on three properties: consistency, conflict, and coherence. An aim is to attain conceptual clarity of these properties. It is argued that consistency is adequately regarded as a property relative to the decision situation or, more specifically, the set of alternatives that the agent faces. Moreover, as a condition of rationality, consistency is stronger than some writers have claimed. Conflict is adequately regarded as a relation over subsets of a (...) given goal system and should likewise be regarded as relative to the set of alternatives that the agent faces. Coherence is given a probabilistic interpretation, based on a support relation over subsets of goal systems. (shrink)

In this paper, we analyse actual causation in terms of production. The latter concept is made precise by a strengthened Ramsey Test semantics of conditionals: \ iff, after suspending judgement about A and C, C is believed in the course of assuming A. This test allows us to verify or falsify that an event brings about another event. Complementing the concept of production by a weak condition of difference-making gives rise to a full-fledged analysis of causation.

Ohne den Verleger Hermann Niemeyer hätte es keine DVjs gegeben. Am Beispiel dieser Zeitschrift untersucht der Beitrag auf der Grundlage unveröffentlichter Korrespondenzen, unter welchen historischen Bedingungen und Konstellationen eine funktionierende Infrastruktur für wissenschaftliches Publizieren im Deutschland der 1920er und 1930er Jahre geschaffen und unterhalten wurde.

This paper offers a review of research on demonstratives from an interdisciplinary perspective. In particular, we consider the role of demonstratives in current research on language universals, language evolution, language acquisition, multimodal communication, signed language, language and perception, language in interaction, spatial imagery, and discourse processing. Traditionally, demonstratives are analyzed as a particular class of spatial deictics. Yet, a number of recent studies have argued that space is largely irrelevant to deixis and that demonstratives are primarily used for social and (...) interactive purposes. Synthesizing findings in the literature, we conclude that demonstratives are a very special class of linguistic items that are foundational to both spatial and social aspects of language and cognition. (shrink)