In response to nutrient limitation, many animals, including Caenorhabditis elegans, slow or arrest their development. This process requires mechanisms that sense essential nutrients and induce appropriate responses. When faced with nutrient limitation, C. elegans can induce both short and long‐term survival strategies, including larval arrest, decreased developmental rate, and dauer formation. To select the most advantageous strategy, information from many different sensors must be integrated into signaling pathways, including target of rapamycin (TOR) and insulin, that regulate developmental progression. Here, how (...) nutrient information is sensed and integrated into developmental decisions that determine developmental rate and progression in C. elegans is reviewed. (shrink)

This work examines the influence of the school of Muhyiddin Ibn 'Arabi on the well-known Kubrawi masters. This path-breaking book is a study of major Kubrawi works and the manner in which the Kubrawis approached Ibn 'Arabi's ideas. By delving into the most important cornerstones of Ibn 'Arabi's worldview, such as wahdat al-wujud (unity of existence), al-insan al-kamil (Perfect Human Being) and asma wa sifat (God's Names and Attributes), this work provides a comparative study of their reception in the thought (...) of major Kubrawi mystics, especially that of Najm al-Din Kubra, Sa'd al-Din amuyah, Aziz al-Din Nasafi, Ala al-Dawlah Simnani, and Sayyid 'Ali Hamadani. (shrink)

Averroes, según el autor, argumenta en defensa de la unidad de la verdad y de la razón, tanto en la filosofía como en la religión. Para probarla, primero traslada una de las dos verdades y razones a la otra por medio de la interpretación demostrativa. En segundo lugar, aleja la filosofía de las desviaciones teológica, el llamado Kalam, y sufí. Finalmente, liberada la filosofía del sufismo y del Kalam, Averroes persigue el objetivo del la filosofía como ser en sus tres (...) niveles (sustancia, movimiento, relación), y como causalidad. (shrink)

Critical study of the Yogarūḍhivāda of the Tattvacintāmaṇi of Gaṅgeśa, 13th cent., work on verbal epistemology of the neo-Nyaya school in Hindu philosophy.

The aim of the paper is to analyse whether and to what extent the network concept has become the Leitbild of an emerging new economy. The analysis is based on a company survey conducted in eight European territories. There is empirical evidence that only a minority of companies have applied the network concept as a dominant restructuring model, while various types of Fordism are still influencing companies' view on efficient techno-organisational forms. The regional analysis demonstrates that there is not only (...) one path into an informational economy. Some territories still stick to low-tech Fordism, while others apply a technology-based flexi-Fordism, in which ICT functions as a key mechanism to make Fordist structures more flexible. Only in a minority of territories is an informational network economy emerging in which ICT has the function of enabling and supporting communication and co-operation within decentralised organisational forms. (shrink)

Against the common association of voyages of exploration with discovery and the arrival of modernity, this essay argues that maintenance and repair were essential to the success of such voyages and that maintenance and innovation are best seen as fundamentally integrated. Using the Russian circumnavigatory voyage of Adam von Krusenstern and Urey Lisianskii in 1803–7 as a case study, the essay explores the diverse forms and roles of infrastructure and repair work in enabling a voyage of exploration, and reveals the (...) tensions and debates that considerations of maintenance evoked among ships’ officers, crews, and the peoples they encountered. (shrink)