Stress-induced brain-mediated immunoregulation is effected by two pathways: autonomic outflow and (neuro)endocrine outflow. Particular attention is given to the interaction-effects of chronic an acute stress. Recent data have established that cells of the immune system produce neuro-peptides and hormones. In concert with cytokines released by these immune cells the brain can be informed on the nature of ongoing immune activity. The significance of conditioning of immune responses is discussed.

In this article we will describe the emergence of a great number of small, regionally concentrated, innovative biotech companies. We see these organizations as “hosts” of concepts and ideas, greatly influencing their spreading over the sector. We have chosen an evolutionary perspective following individual companies in their struggle for survival, describing it as “obtaining food” and “fooling predators.” This struggle gives insight in the behavior of the biotech companies and related institutions as a “system of innovation.” One of our findings (...) is that the variety of biotech companies is conditioned by their selection environment, but that this selection environment allows great variety and even encourage variety by keeping the companies small. (shrink)

In this article we will describe the emergence of a great number of small, regionally concentrated, innovative biotech companies. We see these organizations as “hosts” of concepts and ideas, greatly influencing their spreading over the sector. We have chosen an evolutionary perspective following individual companies in their struggle for survival, describing it as “obtaining food” and “fooling predators.” This struggle gives insight in the behavior of the biotech companies and related institutions as a “system of innovation.” One of our findings (...) is that the variety of biotech companies is conditioned by their selection environment, but that this selection environment allows great variety and even encourage variety by keeping the companies small. (shrink)

The term “evolution” is often used in the administrative sciences to designate dynamic processes of change in general. In biology, evolution has a very specific meaning, namely the application of a generative variation-selective retention scheme to change. Applying this to the administrative sciences is more exacting: describing what the variation consists of, how replication of the generated variation occurs and delineating the population from which the selection is made are far from easy. While it is the intention of this special (...) issue as a whole to provide some empirical examples of evolutionary change in the public and private sectors, this introduction will lay out the main lines of thought in what is often referred to as universal Darwinism and what this means in the administrative sciences. Key concepts here are generative variation, selective retention, and selective institutional environment. According to the authors, the Darwinian scheme of evolutionary theory focuses on how new ideas or concepts arise, how they propagate and influence wider actor thinking and on how the institutional environment in which they operate affects their differential survival. This evolutionary process is an interplay between actors and replicators (sounds, images, and in this context mostly words) in which it cannot be said in advance which one is fooling the other. (shrink)

The term “evolution” is often used in the administrative sciences to designate dynamic processes of change in general. In biology, evolution has a very specific meaning, namely the application of a generative variation-selective retention scheme to change. Applying this to the administrative sciences is more exacting: describing what the variation consists of, how replication of the generated variation occurs and delineating the population from which the selection is made are far from easy. While it is the intention of this special (...) issue as a whole to provide some empirical examples of evolutionary change in the public and private sectors, this introduction will lay out the main lines of thought in what is often referred to as universal Darwinism and what this means in the administrative sciences. Key concepts here are generative variation, selective retention, and selective institutional environment. According to the authors, the Darwinian scheme of evolutionary theory focuses on how new ideas or concepts arise, how they propagate and influence wider actor thinking and on how the institutional environment in which they operate affects their differential survival. This evolutionary process is an interplay between actors and replicators (sounds, images, and in this context mostly words) in which it cannot be said in advance which one is fooling the other. (shrink)