In light of the upcoming anniversary of the Berlin University, this study of the philosopher Paul Hofmann analyzes his precarious position as lecturer at the Friedrich-Wilhelms-University, which was abruptly terminated in 1938 because of his Jewish ancestry and his anti-Nazi position. After years of inner migration, Hofmann resumed teaching as Ordinarius and with new impulses in 1945. At the core of his philosophy was the philosophy of humanity that developed from different positions in his major work “Sinn und Geschichte.” He (...) provided his philosophy with new accents after 1945, while already suffering from severe illness. The study is based on extensive archival material. (shrink)

Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress‐induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type (...) critical to pregnancy in humans, the decidual stromal cell, evolved from a cellular stress reaction. It is hypothesized that the stress reaction in these cells was elicited ancestrally via inflammation caused by embryo attachment. The present study proposes that SIEI is a distinct form of plasticity‐based evolutionary change leading to the origin of novel structures rather than adaptive transformation of pre‐existing characters. (shrink)

Our society is in the middle of the AI revolution. We discuss several applications of AI, in particular medical causality, where deep-learning neural networks screen through big data bases, extracting associations between a patient’s condition and possible causes. While beneficial in medicine, several questionable AI trading strategies have emerged in finance. Though advantages in many aspects of our lives, serious threats of AI exist. We suggest several regulatory measures to reduce these threats. We further discuss whether ‘full AI robots’ should (...) be programmed with a virtual consciousness and conscience. While this would reduce AI threats via motivational control, other threats such as the desire for AI—human socioeconomic equality could prove detrimental. (shrink)

" Because characters and the conception of characters are central to all studies of evolution, and because evolution is the central organizing principle of biology, this book will appeal to a wide cross-section of biologists.

2015 Reprint of Original 1936 American Edition. Exact facsimile of the original edition, not reproduced with Optical Recognition Software. Karl Mannheim was a Hungarian-born sociologist, influential in the first half of the 20th century and one of the founding fathers of classical sociology as well as a founder of the sociology of knowledge. His essays on the sociology of knowledge have become classics in the field. In "Ideology and Utopia" he argued that the application of the term ideology ought to (...) be broadened. He traced the history of the term from what he called a "particular" view. This view originally saw ideology as the perhaps deliberate obscuring of facts. Over time this view gave way to a "total" conception (most notably in Marx), which argued that a whole social group's thought was formed by its social position (e.g. the proletariat's beliefs were conditioned by their relationship to the means of production). However, he called for a further step, which he called a general total conception of ideology, in which it was recognized that everyone's beliefs-including the social scientist's-were a product of the context they were created in. Mannheim points out social class, location and generation as the greatest determinants of knowledge. He feared this could lead to relativism but proposed the idea of relationism as an antidote. To uphold the distinction, he maintained that the recognition of different perspectives according to differences in time and social location appears arbitrary only to an abstract and disembodied theory of knowledge. (shrink)

On the True Sense of Art collects essays by philosophers responding to John Sallis's Transfigurements: On the True Sense of Art as well as his other works on the philosophy of art, including Force of Imagination and Logic of Imagination. Each of the chapters, by some of the leading thinkers in Continental philosophy, engages Sallis's work on both ancient and new senses of aesthetics--a transfiguration of aesthetics--as a beginning that is always beginning again. With a responsive essay by Sallis himself, (...) On the True Sense of Art forms a critical introduction to the thought of this generation's most important aesthetician. (shrink)

Both the capability and the recognition approach are influential and substantial theories in social philosophy. In this contribution, we outline their main assumptions in their assessment of poverty. The two approaches are set in relation to each other, focusing mainly on (a) their moral evaluation of poverty, (b) issues of justification of their central normative claims, and (c) the role that is attributed to subjective experiences, feelings and emotions in these theories. This comparison reveals that in spite of significant differences, (...) both lead to the claim that poverty can never be adequately assessed without putting it into the context of a comprehensive ethical theory about the nature and function of societies. Drawing on this result, we conclude that the critical function of social philosophy plays an irreducible role in the study and understanding of poverty. (shrink)

An in-situ transmission electron microscopy straining technique has been used to investigate the dynamics of dislocation-defect interactions in ion-irradiated copper and the subsequent formation of defect-free channels. Defect removal frequently required interaction with multiple dislocations, although screw dislocations were more efficient at annihilating defects than edge dislocations were. The defect pinning strength was determined from the dislocation curvature prior to breakaway and exhibited values ranging from 15 to 175 MPa. Pre-existing dislocations percolated through the defect field but did not show (...) long-range motion, indicating that they are not responsible for creating the defect-free channels and have a limited contribution to the total plasticity. Defect-free channels were associated with the movement of many dislocations, which originated from grain boundaries or regions of high stress concentration such as at a crack tip. These experimental results are compared with atomistic simulations of the interaction of partial dislocations with defects in copper and a dispersed-barrier-hardening crystal plasticity model to correlate the observations to bulk mechanical properties. (shrink)

The book focuses on the modern understanding of human life-forms as constructs that followed an evolutionary history. The author thus finds science confronted with two questions: firstly, how the transgression of the virtual threshold between natural and cultural history was possible, secondly, how the socio-cultural constructs were able to develop in the course of history the way they did. The discussion concentrates on the problem of determining a processual logic in the development of societal structures as well as in the (...) development of cognition. The focus of attention is the historico-genetic reconstruction of cognition. The book was originally published in German as Historisch-genetische Theorie der Kultur (Weilerswist 2000: Velbrück). (shrink)

The significance and development of Mannheim's sociology Ancient data such as the Code of Hammurabi, the Old Testament, the Confucian Classics, ...

Two welcome extensions of evolutionary thinking have come to prominence over the last thirty years: the so-called ’extended evolutionary synthesis’ (EES) and debate about biological kinds and individuals. These two agendas have, however, remained orthogonal to one another. The EES has mostly restricted itself to widening the explanations of adaptation offered by the preceding ’modern evolutionary synthesis’ by including additional mechanisms of inheritance and variation; while discussion of biological kinds has turned toward philosophical questions of essential vs. contingent properties of (...) life forms and realist vs. epistemological approaches to categorization and classification. Here we attempt to broaden the explanatory scope of evolutionary theory by linking these two agendas. We expand on the mechanistic orientation of the EES, using new understandings of networked systems of components in order to engage the distinct intellectual challenge of the origination of “historical kinds”. With this phrase we designate a subset of natural kinds that acquires, through evolutionary processes, a quasi-independent lineage-history. Such kinds emerge in both biology and culture, and we enlarge the limited number of historical kinds that have thus far been recognized in evolutionary biology in a series of paradigmatic exemplars, from genes and cell types to rituals and music. For each exemplar we discern specific mechanisms by which it arose and persists; comparing these, we suggest a general unity in the ways in which diverse historical kinds originate. (shrink)

mit Beitr. v. Günter C. Behrmann. hrsg. v. Günter Saße. ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- Z 65.262-1447.

Research on the effectiveness of case studies in teaching engineering ethics in higher education is underdeveloped. To add to our knowledge, we have systematically compared the outcomes of two case approaches to an undergraduate course on the ethics of technology: a detached approach using real-life cases and a challenge-based learning approach with students and stakeholders acting as co-creators. We first developed a practical typology of case-study approaches and subsequently tested an evaluation method to assess the students’ learning experiences and outcomes (...) and staff interpretations and operationalizations, seeking to answer three questions: Do students in the CBL approach report higher basic needs, motivation and competence development compared to their peers in the detached approach? What is the relationship between student-perceived co-creation and their basic needs, motivation and competence development? And what are the implications of CBL/CC for engineering-ethics teaching and learning? Our mixed methods analysis favored CBL as it best supported teaching and research goals while satisfying the students’ basic needs and promoting intrinsic motivation and communication competences. Competence progress in other areas did not differ between approaches, and motivation in terms of identified regulation was lower for CBL, with staff perceiving a higher workload. We propose that our case typology model is useful and that as a method to engage students as co-creators, CBL certainly merits further development and evaluation, as does our effectiveness analysis for engineering ethics instruction in general and for case-study approaches in particular. (shrink)

Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position‐effect variegation (PEV) therefore, gene inactivation results from a change in chromatin structure. PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components. Consequently, many genes have been identified which, when mutated, act (...) as dominant modifiers (suppressors or enhancers) of PEV. Data available already demonstrate that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin components, and hence to fundamental aspects of chromosome structure and function. (shrink)

This book is open access under a CC BY 4.0 license. We must find new and innovative ways of conceptualizing transboundary energy issues, of embedding concerns of ethics or justice into energy policy, and of operationalizing response to them. This book stems from the emergent gap; the need for comparative approaches to energy justice, and for those that consider ethical traditions that go beyond the classical Western approach. This edited volume unites the fields of energy justice and comparative philosophy to (...) provide an overarching global perspective and approach to applying energy ethics. We contribute to this purpose in four sections: setting the scene, practice, applying theory to practice, and theoretical approaches. Through the chapters featured in the volume, we position the book as one that contributes to energy justice scholarship across borders of nations, borders of ways of thinking and borders of disciplines. The outcome will be of interest to undergraduate and graduate students studying energy justice, ethics and environment, as well as energy scholars, policy makers, and energy analysts. (shrink)

This paper explores the intimate connection between love and hope. Building on insights from Pamela Sue Anderson’s writings on vulnerable love, it focuses on the often-overlooked insight that love is saturated with risks, including the risk of rejection. Even though love intensifies vulnerabilities, it remains creative, albeit in a dangerous way. Hope addresses the problems love poses by temporizing them, but hope is not without risks and ambiguities itself. The distinction between “hope for” and “hope in” someone, a move which (...) is crucial for a Christian understanding of love and hope, can help to address this insufficiency. (shrink)

Recent investigations with non‐model species and whole‐genome approaches have challenged several paradigms in animal epigenetics. They revealed that epigenetic variation in populations is not the mere consequence of genetic variation, but is a semi‐independent or independent source of phenotypic variation, depending on mode of reproduction. DNA methylation is not positively correlated with genome size and phylogenetic position as earlier believed, but has evolved differently between and within higher taxa. Epigenetic marks are usually not completely erased in the zygote and germ (...) cells as generalized from mouse, but often persist and can be transgenerationally inherited, making them evolutionarily relevant. Gene body methylation and promoter methylation are similar in vertebrates and invertebrates with well methylated genomes but transposon silencing through methylation is variable. The new data also suggest that animals use epigenetic mechanisms to cope with rapid environmental changes and to adapt to new environments. The main benefiters are asexual populations, invaders, sessile taxa and long‐lived species. (shrink)

Appearing in English for the first time, Schelling’s 1842 lectures develop the idea that many philosophical concepts are born of religious-mythological notions.

Das Buch spielt mit einem neuen, ganzheitlichen Vorstellungsbild des Menschen, der aus drei Einheiten zusammengesetzt gedacht wird: das analytische Denken residiert in einer computer¿lichen linken Gehirnh¿te, die kreative Intuition sitzt wie ein naturbelassenes neuronales Netzwerk in der rechten. Der Mensch denkt, wohin ihn das dritte System lenkt: Ein hyperschneller Anzeichen-Identifizierer alarmiert etwa bei gef¿lichen Ereignissen die Aufmerksamkeit, unbewusst, ohne Denken. Bis auf ein paar Zeilen mathematischer Erkl¿ng ist dieses Buch fulminante Philosophie. Wichtige Ansichten dieser Welt werden gedreht und bleiben zum (...) Teil auf dem Kopf stehen. Die Lehren von Platon, Aristoteles, Konfuzius, Epikur, Freud & Co. erscheinen als notwendige Philosophien verschiedener Gehirnnutzungsvarianten. Das Buch ist eine scharfsinnig-bissig-humorvolle und sehr pers¿nliche Auseinandersetzung mit dem, was wir "Lebenssinn" nennen. (shrink)

Las depresiones y los estados depresivos varían de una persona a otra. Si se quiere trabajar para mejorar la situación de las víctimas de estos males, sería indicado saber en qué se distinguen los diferentes fenómenos y dónde se encuentra la causa. Pues las depresiones a menudo cumplen una función que suele aparecer camuflada./////Depression and depressive moods are varying from one person to another one. When working to alleviate the situation of the victims of these complaints it is advisable to (...) distinguish between different phenomena and to find the fundamental cause. Because depressions many times have a veiled function for the person in question. (shrink)