Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise, computerized cognitive training and a combined groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited. In this study we report intervention-related changes in plasma biomarkers and structural-MRI and how they (...) related to changes in physical activity and individual variables and their potential role as mediators in the cognitive changes. Our results show that although there were no significant changes in molecular biomarker concentrations in any intervention group, changes in ICAM-1 and SDF1-α were negatively associated with changes in physical activity outcomes in AE and COMB groups. Brain volume changes were found in the CCT showing a significant increase in precuneus volume. Sex moderated the brain volume change in the AE and COMB groups, suggesting that men may benefit more than women. Changes in molecular biomarkers and brain volumes did not significantly mediate the cognitive-related benefits found previously for any group. This study shows crucial initial molecular and brain volume changes related to lifestyle interventions at early stages and highlights the value of examining activity parameters, individual difference characteristics and using a multi-level analysis approach to address these questions. (shrink)

The connection between brain and mind is an important scientific and philosophical question that we are still far from completely understanding. A crucial point to our work is noticing that thermodynamics provides a convenient framework to model brain activity, whereas cognition can be modeled in information-theoretical terms. In fact, several models have been proposed so far from both approaches. A second critical remark is the existence of deep theoretical connections between thermodynamics and information theory. In fact, some well-known authors claim (...) that the laws of thermodynamics are nothing but principles in information theory. Unlike in physics or chemistry, a formalization of the relationship between information and energy is currently lacking in neuroscience. In this paper we propose a framework to connect physical brain and cognitive models by means of the theoretical connections between information theory and thermodynamics. Ultimately, this article aims at providing further insight on the formal relationship between cognition and neural activity. (shrink)

Studies on the ethical culture of organizations have mainly focused on ethical culture at the organizational level. This study explores ethical culture at the team level because this can add a more detailed understanding of the ethics of an organization, which is necessary for more customized and effective management interventions. To find out whether various teams within an organization can have different ethical cultures, we employ the differentiation perspective and conduct a survey of 180 teams from one organization. The results (...) show that there are significant differences between the ethical cultures of teams. These differences are relevant given the different relationships that were established between high and low clusters of team ethical culture and two outcome variables. The results also show that the dimensions of ethical cultures among teams have different patterns, which indicates the usefulness of using a multidimensional scale for capturing further differences among team ethical cultures. (shrink)

Studies on the ethical culture of organizations have mainly focused on ethical culture at the organizational level. This study explores ethical culture at the team level because this can add a more detailed understanding of the ethics of an organization, which is necessary for more customized and effective management interventions. To find out whether various teams within an organization can have different ethical cultures, we employ the differentiation perspective and conduct a survey of 180 teams from one organization. The results (...) show that there are significant differences between the ethical cultures of teams. These differences are relevant given the different relationships that were established between high and low clusters of team ethical culture and two outcome variables. The results also show that the dimensions of ethical cultures among teams have different patterns, which indicates the usefulness of using a multidimensional scale for capturing further differences among team ethical cultures. (shrink)

Studies on the ethical culture of organizations have mainly focused on ethical culture at the organizational level. This study explores ethical culture at the team level because this can add a more detailed understanding of the ethics of an organization, which is necessary for more customized and effective management interventions. To find out whether various teams within an organization can have different ethical cultures, we employ the differentiation perspective and conduct a survey of 180 teams from one organization. The results (...) show that there are significant differences between the ethical cultures of teams. These differences are relevant given the different relationships that were established between high and low clusters of team ethical culture and two outcome variables. The results also show that the dimensions of ethical cultures among teams have different patterns, which indicates the usefulness of using a multidimensional scale for capturing further differences among team ethical cultures. (shrink)

This paper analyses the arguments for and against what we have called automatic organ procurement model in relation to the organs of the deceased. For this purpose, this work provides empirical evidence to assess the potential impact of this model on donation rates and on public opinion. Specifically, we examine first the reasons supporting this model, with special reference to utilitarian and justice arguments. On the other hand, we analyse both the approaches based on the violation of pre mortem and (...) post mortem interests opposing this theoretical model and the rejection the model would generate in the population. Finally, we point out the aspects that, in our opinion, should be exhaustively regulated if this model were implemented. In particular, we refer to the legal status of the human body, the treatments for end-of-life patients, the incentives for health professionals and the recognition of the right to conscientious objection. (shrink)

The present work aims to offer an interpretation of Wolff’s place in the history of Early Modern Philosophy: we intend to argue that Wolff, relevantly indebted to German university Schulphilosophie, enriches this tradition by incorporating intellectual innovations coming from European modern science. In order to defend this thesis, the essay is divided into two parts. The first is devoted to elucidate Wolff’s conception of philosophy through an analysis of his programmatic “Discursus praeliminaris de philosophia in genere”. After first clarifying Wolff’s (...) conception of philosophy, the second part consists of a reflection on the extent to which German Schulphilosophie and European modern science converge in Wolffian philosophy. (shrink)

En el presente artículo se argumenta que la Medicina mentis de E. W. von Tschirnhaus participa del alejamiento respecto a la Metafísica escolástica ejemplificado tanto por la Logica vetus et nova de Johannes Clauberg de modo moderado y conciliador como por la Einleitung zur Vernunft-Lehre de Christian Thomasius con mayor radicalidad. Para ello, el artículo consta de tres partes. En la primera, se bosqueja el proceso por el que la Schulmetaphysik adquiere presencia y relevancia en las universidades germanas del siglo (...) XVII. A continuación, se analizan las mencionadas obras de Clauberg y Thomasius para descubrir en qué medida ambos pensadores dialogan críticamente con la tradición susodicha. Finalmente, se culmina el trabajo con una reflexión sobre los vínculos existentes entre la obra de Tschirnhaus y las Lógicas de Clauberg y Thomasius. (shrink)

Homework have different familiar impact in each familiar environment. In order to uncover the attitudes parents take towards their children’s homework, a national study about family balance, where 471 people have been interviewed, is done. The results show that women are more likely to help children doing homework. The study concludes making evidence some changes.

Many organizations have adopted an organizational ethics program to prevent unethical behavior within the organization. Decoupling the adoption of ethics programs from their implementation has been identified in the literature as an explanation for the ineffectiveness of such programs. In addition to this so-called policy–practice decoupling, means–ends decoupling may also occur when a well-implemented ethics program is nevertheless ineffective. This study investigates whether team ethical culture (TEC) acts as a coupling mechanism that mediates the effects of a well-implemented ethics program (...) on unethical behavior in teams. We conducted a survey of 202 teams working in a business organization in the UK. The results of a structural equation analysis support the claim that TEC mediates this relationship. Based on this team-level case study, we argue that organizations that aim to implement an effective ethics program should acknowledge and manage TECs to avoid means-ends decoupling. (shrink)

Spanish legislation on insurance and reinsurance mediation stipulates that intermediary can only receive commissions and fees for the management of their policies and prohibits any other form of remuneration. However, it is possible that financial intermediaries who manage larger risks wait until the end of the legal deadline to settle with insurance companies. This common practice in the insurance market hides additional remuneration in defiance of the law. It also means that the risk is not covered within the prescribed period (...) and would, involve a commercial payment to the client, and, on the other hand, affect sustainable claims management. (shrink)

The discovery of F.M. Dostoyevsky by young E. M. Cioran marks a turning point for a better understanding of his first Romanian work and his later production in French. His first work, Pe culmile disperării [On the Heights of Despair] has a tragic breath, typically dostoyevskyan, which reminds us of the tragical and sick conscience of the hero of his Notes from the Underground.

In this much-anticipated revision and translation of Scienza e Retorica, Marcello Pera argues that rhetoric is central to the making of scientific knowledge. Pera begins with an attack of what he calls the "Cartesian syndrome"--the fixation on method common to both defenders of traditional philosophy of science and its detractors. He argues that in assuming the primacy of methodological rules, both sides get it wrong. Scientific knowledge is neither the simple mirror of nature nor a cultural construct imposed (...) by contingent interests, thus we must replace the idea of the scientific method with that of scientific rhetoric. Pera proposes a new dialectics of science to overcome the tension between normative and descriptive philosophies of science by focusing on the rhetoric in the proposition, defense, and argumentation of theories. Examining the uses of rhetoric in debates drawn from Galileo’s Dialogues, Darwin’s Origins, and the Big Bang-Steady State controversy in cosmology, Pera shows how the conduct of science involves not just nature and the inquiring mind, but nature, the inquiring mind, and a questioning community which, through the process of attack, defense, and dispute, determines what is science. Rhetoric, then, is an essential element in the constitution of science as the practice of persuasive argumentation through which results gain acceptance. (shrink)

Traditionally it has been thought that scientific controversies can always be resolved on the basis of empirical data. Recently, however, social constructionists have claimed that the outcome of scientific debates is strongly influenced by non-evidential factors such as the rhetorical prowess and professional clout of the participants. This volume of previously unpublished essays by well-known philosophers of science presents historical studies and philosophical analyses that undermine the plausibility of an extreme social constructionist perspective while also indicating the need for a (...) richer and more realistic account of scientific rationality. (shrink)

We present a characterization of confluence for term rewriting systems, which is then refined for special classes of rewriting systems. The refined characterization is used to obtain a polynomial time algorithm for deciding the confluence of ground term rewrite systems. The same approach also shows the decidability of confluence for shallow and linear term rewriting systems. The decision procedure has a polynomial time complexity under the assumption that the maximum arity of a function symbol in the signature is a constant.

Several European countries are approving legislative reforms moving to a presumed consent system in order to increase organ donation rates. Nevertheless, irrespective of the consent system in force, family's decisional capacity probably causes a greater impact on such rates. In this contribution we have developed a systematic methodology in order to analyse and compare European organ procurement laws, and we clarify the weight given by each European law to relatives' decisional capacity over individual's preferences (expressed or not while alive) regarding (...) the destination of his or her organs after death. In this sense, the results constitute the first comprehensive and comparative legislative mapping on European transplantation laws. (shrink)

Emotion in Interaction offers a collection of original studies that explore emotion in naturally occurring spoken interaction.

Negative self-views have proved to be a consistent marker of vulnerability for depression. However, recent research has shown that a particular kind of cognitive conflict, implicative dilemma, is highly prevalent in depression. In this study the relevance of these conflicts is assessed as compared to the cognitive model of depression of a negative view of the self. In so doing, 161 patients with major depression and 110 controls were assessed to explore negative self-construing (self-ideal discrepancy) and conflicts (implicative dilemmas), as (...) well as severity of symptoms. Results showed specificity for the clinical group indicating a pattern of mixed positive and negative self-descriptions with a high rate of conflict. Regression analysis lent support to the conflict hypothesis in relation to clinically relevant indicators such as symptom severity, global functioning. However, self-ideal discrepancy was a stronger predictor of group membership. The findings showed the relevance of cognitive conflicts to compliment the well-consolidated theory of negative self-views. Clinical implications for designing interventions are discussed. (shrink)

El propósito de este artículo es aproximarnos al tratamiento que la cuestión del sentido antropológico ha recibido por parte de dos egregios filósofos españoles. El primer gran bloque estará dedicado a explorar —siguiendo a José Ortega y Gasset— cómo la vida auténtica es genuinamente proyectiva, una empresa mediante la cual se despliega el sentido personal. De este modo podremos ahondar en nociones tan relevantes como la vocación, el destino o el fondo insobornable. En la segunda y última parte, José Gómez (...) Caffarena nos ayudará a cuestionar si la experiencia de sentido es indisociable de la gran pregunta por el Sentido, entendido como el horizonte meta-físico de la vida humana. (shrink)

La Historia sólo toma sentido dentro del historicismo. O, dicho de otro modo, cualquier intento de dar sentido a la Historia ha de caer en las redes del historicismo. Se trata de una telaraña en la que se dejan enredar con entusiasmo las gentes en busca del ideal a que entregan sus vidas. Funciona como un ideal regulativo que distorsiona los acontecimientos pasados poniéndolos al servicio de la consecución de un plan que se concretará en el modelo final que le (...) da razón de ser a todo el proceso. Sánchez Ferlosio se adentra en los mecanismos psicológicos y pedagógicos con los que el sistema político va obnubilando la capacidad crítica de las gentes hasta que, identificándose con el Todo histórico que les permite huir del mosaico descolocado de la realidad humana, sacrifican generosamente sus vocaciones y motivos de recreo. (shrink)

Una aproximación a dos reflexiones filosóficas contemporáneas. En primer lugar, abordamos las últimas aportaciones de Michel Foucault sobre la ética, en el marco de la noción de “cuidado de sí”. En segundo lugar, nos ocupamos de la ética de Emmanuel Levinas, centrada en la idea del prójimo. El mismo marco de una ética del otro permite un enlace con algunas ideas de Simone Weil. Sin pretenderlas congruentes, estas dos filosofías conllevan una importante crítica de la noción de sujeto y de (...) una ética basada en el reconocimiento. Con ello, nos dan elementos para plantear posibles posicionamientos para la filosofía en la actualidad. (shrink)