The TRIM/RBCC proteins are defined by the presence of the tripartite motif composed of a RING domain, one or two B‐box motifs and a coiled‐coil region. These proteins are involved in a plethora of cellular processes such as apoptosis, cell cycle regulation and viral response. Consistently, their alteration results in many diverse pathological conditions. The highly conserved modular structure of these proteins suggests that a common biochemical function may underlie their assorted cellular roles. Here, we review recent data indicating that (...) some TRIM/RBCC proteins are implicated in ubiquitination and propose that this large protein family represents a novel class of ‘single protein RING finger’ ubiquitin E3 ligases. BioEssays 27:1147–1157, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

This article provides a spatial analysis of the conceptual framework of fluid dynamics during the nineteenth century, focusing on the transition from the Euler equation to the Navier–Stokes equation. A dynamic version of Peter Gärdenfors's theory of conceptual spaces is applied which distinguishes changes of five types: addition and deletion of special laws; change of metric; change in importance; change in separability; addition and deletion of dimensions. The case instantiates all types but the deletion of dimensions. We also provide a (...) new view upon limiting case reduction at the conceptual level that clarifies the relation between the predecessor and successor conceptual framework. The nineteenth-century development of fluid dynamics is argued to be an instance of normal science development. (shrink)

La contribution s’intéresse aux transitions institutionnelles dans la formation en travail social et aux effets de ces évolutions dans le rapport au travail des formateurs. Elle a pour objet de repérer les mouvements mais aussi les tensions, les difficultés, les transactions nécessaires pour (re) donner du sens à l’activité et construire de nouveaux repères professionnels entre travail prescrit, travail rêvé/idéalisé et réel du travail de formation. Des entretiens ont été conduits dans quatre établissements de formation d’une même région. L’analyse du (...) corpus a permis de mettre à jour quelques grandes problématiques qui traversent le monde des formateurs en travail social, en prise avec les évolutions du secteur. Les résultats donnent à comprendre les remaniements identitaires et les formes d’implication des acteurs. Ils montrent la nécessite de « faire collectif », de retrouver des marges d’action et assurer sa mission de façon plus éclairée et mieux soutenue. (shrink)

Drawing on the Agency-Stewardship approach, which suggests that manager profile may range from the agent model to the steward model, this article aims to examine how important CEOs are to corporate social responsibility (CSR). Specifically, this exploratory study proposes the existence of a relationship between manager profile and CSR practices and that this relation is mediated by the perceived role of ethics and social responsibility. After applying a mediated regression analysis using survey information collected from 149 CEOs in Spain, results (...) show that those closer to the steward model are more inclined to attach great importance to ethics and social responsibility, and to implement CSR practices in their companies. Results also provide support for the suggested mediating effect. Thus, this article extends research in understanding top managers as drivers for CSR and suggests new ways to deal with this issue empirically. (shrink)

Models represent their target systems in one way or another. But what does it mean for a model to represent something beyond itself? This paper details different aspects of this problem and argues that the semantic view of theories does not provide us with an adequate response to any of these.

Festa, E., Roux, S. (2008). The Enigma of the Inclined Plane from Heron to Galileo. In: Laird, W.R., Roux, S. (eds) Mechanics and Natural Philosophy Before the Scientific Revolution. Boston Studies in the Philosophy of Science, vol 254. Springer, Dordrecht.

Cette contribution revient sur le dialogue qui s’est développé depuis dix ans entre des chercheurs en Études théâtrales et des chercheurs en Sound Studies dans le cadre de deux projets successifs. Après avoir rappelé le contexte dans lequel a été élaborée la présente réflexion, précisé ce que j’entends ici par Sound Studies et donné quelques informations sur les Études théâtrales, je montrerai comment la relation intense que les secondes ont entretenue avec les premières a contribué à l’élaboration d’une véritable réécriture (...) de l’histoire du théâtre et comment les théâtrologues ont pu, en s’appuyant sur leur bases disciplinaires propres, opposer des approches critiques au modèle des Sound Students. (shrink)

Cette contribution revient sur le dialogue qui s’est développé depuis dix ans entre des chercheurs en Études théâtrales et des chercheurs en Sound Studies dans le cadre de deux projets successifs. Après avoir rappelé le contexte dans lequel a été élaborée la présente réflexion, précisé ce que j’entends ici par Sound Studies et donné quelques informations sur les Études théâtrales, je montrerai comment la relation intense que les secondes ont entretenue avec les premières a contribué à l’élaboration d’une véritable réécriture (...) de l’histoire du théâtre et comment les théâtrologues ont pu, en s’appuyant sur leur bases disciplinaires propres, opposer des approches critiques au modèle des Sound Students. (shrink)

L'évangélisation des Indiens du Mexique fut entreprise dans une perspective messianique et eschatologique, notamment par les missionnaires franciscains formés aux idéaux des 'spirituels' et influencés par les prophéties millénaristes de Joachim de Flore. Dans leur esprit, l'Église, en voie de dépérissement dans le 'Vieux Monde' corrompu, allait 'renaître' dans ce monde 'nouveau', dont les populations semblaient vivre en état d'innocence et qui se laissaient convertir avec tant de docilité. Il fallut bientôt déchanter : l'idolâtrie persistait, les Indiens se revoltaient, ils (...) étaient massacrés, et bientôt décimés par des épidémies de caractère 'apocalyptique'. Alors on s'interrogeait : la violence peut-elle être acceptée comme une nécessité pour extirper le culte des démons, hâter l'évangélisation, consolider la conversion de ces peuples? (shrink)

La visión de la esen-cia divina constituye para la crea-tura intelectual la culminación de su deificación iniciada en el bau-tismo. Según el Aquinate, el beato contempla a Dios sin ningún inter-mediario puesto que la esencia divina actúa como especie impresa y expresa. Ningún intelecto creado está capacitado naturalmente para ver a Dios, pero puede ser elevado obediencialmente a esta visión debido a la inmaterialidad de su intelecto. La potencia intelectual creada debe ser confortada por el hábito de luz de gloria (...) para ade-cuarse a la sobrenaturalidad del acto beatífico. La visión beatífica implica eminentemente un cono-cimiento especulativo y afectivo, plenificando y rebalsando todas las potencias del beato. (shrink)

This paper based on the distinction between the instrumental and normative views of stakeholder management explores how business education and personal moral philosophies may influence the orientation adopted by an individual. A mediated regression analysis using survey information collected from 206 Spanish university students showed that those exposed to management theories were less willing to consider stakeholders when making business decisions if the consequent economic impacts on the firm were omitted. The results also provided support for a negative effect of (...) business education on idealism and a mediating effect of the latter on the relationship between education and stakeholder management orientation. This study thus raises awareness on the influence of business education on individuals’ ethical decision-making processes and suggests some possible changes for business education. (shrink)

Our goal in this paper is to reassess the relationship between norms and life by drawing on the philosophy of Georges Canguilhem, particularly some of his unpublished lectures about teratology and sexual determination. First, we discuss the difficulties Canguilhem identified in the introduction of life and sexuality as objects of philosophical reflection. Second, we reassess Canguilhem’s understanding of normativity as rooted in life and the axiological activity of the living. Third, we analyze how Canguilhem drew from past and contemporary teratology (...) to conceive of the notions of anomaly and abnormality. Finally, we reconstruct Canguilhem’s analysis of a case of hermaphroditism, highlighting how he presented it as evidence that sexual determination is the result of a normative choice. One of the key contributions of the paper to scholarly literature on Canguilhem is a better understanding of his notion of choice, which was considered not the conscious and intentional act of a subject but rather an axiological activity of the living. We conclude by positioning Canguilhem’s concept of normativity and his belief that norms are produced by the living in relation to the naturalist/normativist divide in medicine. (shrink)

Dans sa thèse de médecine de 1943 sur le normal et le pathologique, Georges Canguilhem se sert largement des idées de Kurt Goldstein lorsqu’il définit la normalité comme la capacité de l’organisme à créer de nouvelles normes de vie dans un débat polarisé avec son milieu. Pourtant, il déclara ensuite que les conceptions de Goldstein avaient constitué pour lui un « encouragement et non une inspiration ». Les archives personnelles de Canguilhem nous permettent effectivement de considérer le rapport de Canguilhem (...) à Goldstein comme une convergence plutôt que comme une influence mais surtout, l’usage que Canguilhem fait de Goldstein nous permet de mieux saisir la portée de ses propres idées. Nous interrogeons dans une première partie la conception holiste de l’organisme de Goldstein, dans ses rapports à la gestalt-théorie et à Kant, conception qui se réfère au processus d’actualisation de l’essence de l’organisme dans son rapport avec le milieu. Ceci nous permet d’appréhender l’usage que fait Canguilhem de certains concepts et idées de Goldstein pour élaborer son propre concept de normativité vitale. Dans une deuxième partie, nous nous proposons de comprendre la manière dont Canguilhem pose le problème du rapport de la connaissance à la normativité vitale à partir de sa lecture des textes du neurologue allemand. (shrink)

This paper is based on a criterion recently proposed by Richard Fumerton for demarcating philosophy of mind and cognitive science. I suggest to extend it to a demarcation criterion between philosophy and science in general, and put it in the context of the historical changes of boundaries between the philosophical and the scientifi c fi eld. I point to a number of philosophical claims and approaches that have been made utterly obsolete by the advancement of science, and conjecture that a (...) similar thing may happen in the future with today’s philosophy of mind: under the supposition that cognitive science manages to progress very successfully in a certain direction, our concepts for mental states could change, and the type of philosophical interest we put in them, thus reshaping thewhole debate on the subject. (shrink)

To Shh, or not to Shh: that is the question. Paraphrasing Hamlet, one of the main ethical dilemmas for workers and organisations can be represented: to blow the whistle or to remain silent when facing a wrongdoing. Whistleblowing is analysed from psychological, normative and organisational points of view, but the implementation in the company is less represented. And it should not be like that, since internal whistleblowing mechanisms allow organisational wrongdoing staying inside the organisation, where it can be remedied and (...) its reputational effects, alleviated. With a content analysis methodology, this paper analyses disclosed information about the implementation of whistleblowing mechanisms in Spanish listed companies (Ibex35), a country where corruption scandals have once again brought to the fore the problem of reporting wrongdoing. The implementation of whistleblowing mechanisms is heterogeneous in terms of denominations, channels and procedures, identifying weak points in the reporting of irregularities in CSR and sustainability reports. (shrink)

The Walter Burley's physics: his theory about the number of principles of generation. In terms of originality and influence, the Doctor Planus et Perspicuus was one of the most significant thinkers of the fourteenth century. In this article, I offer an introduction to the Burley's physical thinking restricted to his theory of matter and privation. Burley replaces a nominal interpretation for a real one of privation. In fact, the Burley's theory is a direct attack on Ockham's views expressed in this (...) Expositio librorwn Physico rum. Burley answer each argument proposed by Ockham, concerning the identification of matter and privation; and he defends the view of an exaggerated realism. (shrink)

In this Abelarde's work called Dialogus inter philosophum, iudaeum et christianum we will find three personages that come from different ways and different religions. I want to play special attention not only to why but how and where living away the arts of the Trivium. This work written while Abelarde was living in retirement in Cluny, is like he went back to his young years, to his fightings, to his discusions... The personages of this altercatio will be a dialectician, a (...) rethoric and a grammarian. The dialectic that argues against the Jewish and the Christian wants to guide then through the arts of languaje which manage as nobody do... Beside this, in the Dialogus... Abelarde open a new tradition which will help the use of the reason to protect the faith. (shrink)

Normal 0 false false false PT-BR JA X-NONE Este ensaio é constituído por reflexões a respeito de alteridade na educação, defendendo a necessidade de olhar o Outro como fonte de aprendizagem, visando o desenvolvimento de relações dialógicas e alteritárias. De início, analisa-se a construção da subjetividade moderna cuja centralidade é o sujeito autônomo e racional que pensa e define as relações a partir de princípios pretensamente universais, os quais muitas vezes procuram assimilar o Outro em si mesmo. A sustentação teórica (...) do texto é o pensamento de Emmanuel Levinas, e daí emerge a proposta de pensar o Outro em sua diferença não para objetivá-lo, mas acolhendo-o em sua realidade concreta. Assim, a presente proposição defende processos de mediação educativa, onde os sujeitos, pela presença do rosto do Outro, deixam-se despertar para a responsabilidade e abertura à exterioridade. (shrink)

Este artículo analiza a partir, muy especialmente, de las declaraciones públicas de sus responsables, cómo han definido las universidades jesuitas centroamericanas su misión, con la intención de intentar explicar por qué surge en conflicto con el inicial objetivo fundacional de las universidades y, al tiempo, considerar los límites y contradicciones de este esfuerzo.

According to a grand narrative that long ago ceased to be told, there was a seventeenth century Scientific Revolution, during which a few heroes conquered nature thanks to mathematics. When this grand narrative was brought into question, our perspectives on the question of mathematization should have changed. It seems, however, that they were instead set aside, both because of a general distrust towards sweeping narratives that are always subject to the suspicion that they overlook the unyielding complexity of real history, (...) and because of a shift in our interests. The more obscure and idiosyncratic they are, an alchemist, a patron of the sciences or a lunatic collector is nowadays honored in journals of the history of sciences. As for the general issues involved in the question of mathematization, they are rejected as obsolete, or reserved for specialized journals in the history of mathematics. The article « Forms of mathematization » examines in general the notion of mathematization, distinguishes different forms of mathematization and defends a renewed study of the forms of mathematization in the history of the early sciences. (shrink)

Este artículo examina cómo la tragedia griega, especialmente Antígona de Sófocles recupera y amplia el mito. En efecto, el mito encuentra en la tragedia un despliegue tal que en muchas ocasiones llega a competir con el canon mítico. Es también nuestra intención analizar de qué modo opera el mito en la dinámica dramática; esto es, en qué medida le es funcional a la representación trágica. This article examines how the Greek tragedy, especially Sophocles' Antigone recuperates and expands the myth. Indeed, (...) the tragedy displays the myth in a way that it can compete with the mythic canon in many occasions. It is also our intention to examine how the myth operates in the dramatic dynamics, that is, to what extent it is functional to the tragic representation. (shrink)

Thought experiments being central to contemporary philosophy and science, the following questions were asked in recent literature. What is their definition? Are they heuristic devices, arguments, paradoxes? Are they comparable to real experiments? Do intuition and conceivability intervene? Equally imaginative thought experiments are found in ancient, medieval, and Renaissance texts. Paying attention to prime historical examples of thought experiments, we show that historical perspectives help answer these general questions.

This is the first volume of a two-volume project whose aim is to publish all the known Middle English manuscript translations of the French Somme le mi, a thirteenth-century manual of religious instruction offering teaching on the Decalogue, the seven deadly sins and their remedies, compiled by the Dominican friar Laurent of Orleans. The project extends and deepens our knowledge of the influence of this popular French text, known today only from the versions entitled The Ayen bite of Inwit and (...) The Book of Vices and Virtues, published in 1866 and 1942, respectively. This volume presents the versions extant in BL MSS Royal 18. A. x and Add. 37677; the second will cover the versions in Cambridge, Corpus Christi College, MS 494, Oxford, Bodleian Library, MS Ashmole 1286, and Oxford, Bodleian Library, MS e Musaeo 23. The texts of both volumes have been prepared with the help of the recently-published edition of the French text, a circumstance from which the earlier English editions were unable to benefit. It is likely that the versions edited here for the first time will make a considerable contribution to our understanding of the processes of textual transmission and to that of translation itself in English literary circles of the fifteenth century. (shrink)