When God gave humankind dominion over the earth he may not have known exactly what we would be able to do with it. The technical capacities to which the production and reproduction of our everyday life have given rise have grown at an astonishing and, it seems, ever-increasing rate. The instruments that we use to do work on the world have become sharper and more refined, and the implications of human interventions in the nonhuman environment are much more far-reaching than (...) could have been imagined even forty years ago. It has become something of a cliche to say that our technical abilities have outstripped the wisdom to know when, where, and how we should appropriately use them, but techniques such as genetic engineering invite the dusting-off of the cliche and the asking of the question implicit in it: We know we can splice genes, but should we splice them? We might of course come to the conclusion that we should only splice some of them some of the time, but even arriving at that conclusion presupposes that the ethical question has been asked and answered. (shrink)

When God gave humankind dominion over the earth he may not have known exactly what we would be able to do with it. The technical capacities to which the production and reproduction of our everyday life have given rise have grown at an astonishing and, it seems, ever-increasing rate. The instruments that we use to do work on the world have become sharper and more refined, and the implications of human interventions in the nonhuman environment are much more far-reaching than (...) could have been imagined even forty years ago. It has become something of a cliche to say that our technical abilities have outstripped the wisdom to know when, where, and how we should appropriately use them, but techniques such as genetic engineering invite the dusting-off of the cliche and the asking of the question implicit in it: We know we can splice genes, but should we splice them? We might of course come to the conclusion that we should only splice some of them some of the time, but even arriving at that conclusion presupposes that the ethical question has been asked and answered. (shrink)

Genetic engineering technologies are a subclass of the biotechnology family, and are concerned with the use of laboratory-based technologies to intervene with a given organism at the genetic level, i.e., the level of its DNA. This class of technologies could feasibly be used to treat diseases and disabilities, create disease-resistant crops, or even be used to enhance humans to make them more resistant to certain environmental conditions. However, both therapeutic and enhancement applications of genetic (...) class='Hi'>engineering raise serious ethical concerns. This paper examines various objections to genetic engineering (as applied to humans) which have been raised in the literature, and presents a new way to frame these issues, and to look for solutions. Specifically, this paper frames genetic engineering technologies within the ‘design turn in applied ethics’ lens and thus situates these technologies as covarying with societal forces. The value sensitive design (VSD) approach to technology design is then appropriated as the conceptual framework in which genetic engineering technologies can be considered so that they can be designed for important human values. By doing so, this paper brings further nuance to the scholarship on genetic engineering technologies by discussing the sociotechnicity of genetic engineering systems rather than framing them as value-neutral tools that either support or constrain values based on how they are used. (shrink)

This article contends that the environmental release of genetically engineered (GE) animals with heritable traits that are patented will present a challenge to the efforts of nations and indigenous peoples to engage in self‐determination. The environmental release of such animals has been proposed on the grounds that they could function as public health tools or as solutions to the problem of agricultural insect pests. This article brings into focus two political‐economic‐legal problems that would arise with the environmental (...) release of such organisms. To address those challenges, it is proposed that nations considering the environmental release of GE animals must take into account the underlying circumstances and policy failures that motivate arguments for the use of the modified animals. Moreover, countries must recognize that the UN International Covenant on Civil and Political Rights and the UN International Covenant on Economic, Social and Cultural Rights place on them an obligation to ensure that GE animals with patented heritable traits are not released without the substantive consent of the nations or indigenous peoples that could be affected. (shrink)

Genetic engineering evokes a number of objections that are not directed at the negative effects the technique might have on the health and welfare of the modified animals. The concept of animal integrity is often invoked to articulate these kind of objections. Moreover, in reaction to the advent of genetic engineering, the concept has been extended from the level of the individual animal to the level of the genome and of the species. However, the concept of (...) animal integrity was not developed in the context of genetic engineering. Given this external origin, the aim of this paper is to critically examine the assumption that the concept of integrity, including its extensions to the level of the genome and the species, is suitable to articulate and justify moral objections more specifically directed at the genetic engineering of animals. (shrink)

The struggle over genetically-engineered (GE) maize in Mexico reveals a deep conflict over the criteria used in the governance of agri-food systems. Policy debate on the topic of GE maize has become “scientized,” granting experts a high level of political authority, and narrowing the regulatory domain to matters that can be adjudicated on the basis of scientific information or “managed” by environmental experts. While scientization would seem to narrow opportunities for public participation, this study finds that Mexican activists acting (...) “in defense of maize” engage science in multiple ways, using and producing scientific knowledge as well as treating scientific discussions as a stage for launching complex social critiques. Drawing from research in science and technology studies, this article assesses the impacts and pitfalls of three tactics used by maize activists that respond to the scientization of biotechnology politics: (1) using scientific information as a resource; (2) participating in scientific research; and (3) reframing policy problems as broadly social, rather than as solely scientific or technical. The obstacles that maize activists have faced in carrying out each of these efforts indicate that despite diverse and sophisticated engagements between social movements and the scientific field, scientization remains a significant institutional barrier to democratizing agricultural governance. (shrink)

Despite the application of 2.5 million tons ofpesticides worldwide, more than 40% of all potentialfood production is lost to insect, weed, and plantpathogen pests prior to harvest. After harvest, anadditional 20% of food is lost to another group ofpests. The use of pesticides for pest control resultsin an estimated 26 million human poisonings, with220,000 fatalities, annually worldwide. In the UnitedStates, the environmental and public health costs forthe recommended use of pesticides total approximately$9 billion/yr. Thus, there is a need for (...) alternativenon-chemical pest controls, and genetic engineering(biotechnology) might help with this need. Diseaseand insect pest resistance to various pests has beenslowly bred into crops for the past 12,000 years;current techniques in biotechnology now offeropportunities to further and more rapidly improve thenon-chemical control of disease and insect pests ofcrops. However, relying on a single factor, like theBacillus thuringiensis toxin that has beeninserted into corn and a few other crops for insectcontrol, leads to various environmental problems,including insect resistance and, in some cases, athreat to beneficial biological control insects andendangered insect species. A major environmental andeconomic cost associated with genetic engineeringapplications in agriculture relates to the use ofherbicide resistant crops (HRC). In general, HRCtechnology results in increased herbicide use but noincrease in crop yields. The heavy use of herbicidesin HRC technology pollutes the environment and canlead to weed control costs for farmers that may be2-fold greater than standard weed control costs. Therefore, pest control with both pesticides andbiotechnology can be improved for effective, safe,economical pest control. (shrink)

'It's all in the genes'. Is this true, and if so, _what_ is all in the genes? _Genes: A Philosophical Inquiry_ is a crystal clear and highly informative guide to a debate none of us can afford to ignore. Beginning with a much-needed overview of the relationship between science and technology, Gordon Graham lucidly explains and assesses the most important and controversial aspects of the genes debate: Darwinian theory and its critics, the idea of the 'selfish' gene, evolutionary psychology, (...) memes, genetic screening and modification, including the risks of cloning and 'designer' babies. He considers areas often left out of the genes debate, such as the environmental risks of genetic engineering and how we should think about genes in the wider context of debates on science, knowledge and religion. Gordon Graham asks whether genetic engineering might be introducing God back into the debate and whether the risks of a brave new genetic world outweigh the potential benefits. Essential reading for anyone interested in science, technology, and philosophy, _Genes: A Philosophical Inquiry_ is ideal for those wanting to find out more about the ethical implications of genetics and the future of biotechnology. (shrink)

This chapter contains sections titled: The Various Uses of Genetic Engineering The Disability Rights Challenge to the Prevention of Disabilities The Goal of a World without Disabilities Use of Genetic Engineering to Enhance Normal Function Environmental versus Genetic Changes When are Enhancements Benefits? The Magnitude of Enhancement The Means Used for Enhancement Who is Using Genetic Engineering? Impact of Genetic Engineering on Fairness and Inequality Acknowledgments.

Genetic engineering evokes a number of objections that are not directed at the negative effects the technique might have on the health and welfare of the modified animals. The concept of animal integrity is often invoked to articulate these kind of objections. Moreover, in reaction to the advent of genetic engineering, the concept has been extended from the level of the individual animal to the level of the genome and of the species. However, the concept of (...) animal integrity was not developed in the context of genetic engineering. Given this external origin, the aim of this paper is to critically examine the assumption that the concept of integrity, including its extensions to the level of the genome and the species, is suitable to articulate and justify moral objections more specifically directed at the genetic engineering of animals. (shrink)

Genetic modification leads to several important moral issues. Up until now they have mainly been discussed from the viewpoint that only individual living beings, above all animals, are morally considerable. The standpoint that also collective entities such as species belong to the moral sphere have seldom been taken into account in a more thorough way, although it is advocated by several important environmental ethicists. The main purpose of this article is to analyze in more detail than often has (...) been done what the practical consequences of this ethical position would be for the use of genetic engineering on animals and plants. The practical consequences of the holistic standpoint (focused on collective entities) of Holmes Rolston, III, is compared with the practical consequences of the individualistic standpoints (focused on individual living beings) of Bernard E. Rollin and Philipp Balzer, Klaus Peter Rippe, and Peter Schaber, respectively. The article also discusses whether the claim that species are morally considerable is tenable as a foundation for policy decisions on genetic engineering. (shrink)

Genetically engineered animals that are meant for release in the wild could significantly impact ecosystems given the interwoven or entangled existence of species. Therefore, among other things, it is all too important that regulatory agencies conduct entity appropriate, rigorous risk assessments that can be used for informed decision-making at the local, national and global levels about the release of those animals in the wild. In the United States, certain GE animals that are intended for release in the wild may be (...) regulated as new animal drugs by the Food and Drug Administration. This paper argues that the decision to treat them as new animal drugs is attributable to the influence of neoliberalism on the US biotechnology regulatory policy framework. The case is made that there should be public democratic deliberations and decision-making about the values and concerns that should guide the nation’s biotechnology regulatory policy paradigm, including the risk assessment process for GE animals meant for release in the wild. -/- . (shrink)

The Swiss expert report suggests thatthe inherent dignity of a living being be identifiedwith its inherent value. But the phrase ``inherentvalue of a living being'' seems to connote two conceptsof inherent value. One has a morally obligatingcharacter but is counterintuitive because of itsegalitarianism. The other is one of non-moral value.It is more compatible with considered intuitions butinsufficient for substantiating the expert report'sclaim that human beings have moral duties towardsanimals and plants. The paper discusses theseconcepts. Consideration is then given to the (...) problemof how discursive support can be generated for theexpert report's claim that human beings have the moralduty to abstain from impairing those functions andabilities of a nonuman being that members of itsspecies as a rule can practice. (shrink)

This book describes specific, well-know controversies in the genetic modification debate and connects them to deeper philosophical issues in philosophy of technology. It contributes to the current, far-reaching deliberations about the future of food, agriculture and society. Controversies over so-called Genetically Modified Organisms regularly appear in the press. The biotechnology debate has settled into a long-term philosophical dispute. The discussion goes much deeper than the initial empirical questions about whether or not GM food and crops are safe for human (...) consumption or pose environmental harms that dominated news reports. In fact, the implications of this debate extend beyond the sphere of food and agriculture to encompass the general role of science and technology in society. The GM controversy provides an occasion to explore important issues in philosophy of technology. Researchers, teachers and students interested in agricultural biotechnology, philosophy of technology and the future of food and agriculture will find this exploration timely and thought provoking. (shrink)

Human genetic engineering may soon be possible. The gathering debate about this prospect already threatens to become mired in irresolvable disagreement. After surveying the scientific and technological developments that have brought us to this pass, _The Ethics of Genetic Engineering_ focuses on the ethical and policy debate, noting the deep divide that separates proponents and opponents. The book locates the source of this divide in differing framing assumptions: reductionist pluralist on one side, holist communitarian on the other. (...) The book argues that we must bridge this divide, drawing on the resources from both encampments, if we are to understand and cope with the distinctive problems posed by genetic engineering. These problems, termed "fractious problems," are novel, complex, ethically fraught, unavoidably of public concern, and unavoidably divisive. Berry examines three prominent ethical and political theories – utilitarianism, Kantianism, and virtue ethics – to consider their competency in bridging the divide and addressing these fractious problems. The book concludes that virtue ethics can best guide parental decision making and that a new policymaking approach sketched here, a "navigational approach," can best guide policymaking. These approaches enable us to gain a rich understanding of the problems posed and to craft resolutions adequate to their challenges. (shrink)

Many of the existing ethical analyses of genetic engineering technologies (GET) focus on how they can be used to enhance individuals—to improve individual well-being, health and cognition. There is a gap in the current literature about the specific ways enhancement technologies could be used to improve our populations and species, viewed as a whole. In this paper, I explore how GET may be used to enhance the species through improvements in the gene pool. I argue one aspect of (...) the species that may be desirable to enhance is ‘persistence’ or long-term viability. I then look at some of the ways in which GET could be used to improve human persistence and argue that the use of GET to secure benefits for individuals may compromise persistence. This suggests conflicts between uses of GET to enhance individuals and uses to promote the persistence of the species may occur. As GET are further developed, the likelihood that these conflicts will actually arise, and how we should resolve them if they do, will need to be considered. (shrink)

The use of genetic engineering is increasingly discussed for nature conservation. At the same time, recent animal ethics approaches debate whether humans should genetically engineer wild animals to improve their welfare. This paper examines if obligations towards wild sentient animals require humans to genetically engineering wild animals, while arguing that there is no moral need to do so. The focus is on arguments from animal ethics, but they are linked to conservation ethics, highlighting the often neglected overlap (...) between the two fields. The paper emphasizes that a) the benefits of genetic engineering are overestimated and at the same time harms from its development and use underestimated, b) the assumption that genetic engineering is an appropriate ‘last resort’ tool is wrong, c) many arguments in favor of genetic engineering are based on an inadequate understanding of ecology and biotechnological processes, and d) the debate downplays the importance of self-determination for wild animals. (shrink)

In the past few decades, increased awareness of environmental pollution has led to the exploitation of microbial metabolic potential in the construction of several genetically engineered microorganisms (GEMs) for bioremediation purposes. At the same time, environmental concerns and regulatory constraints have limited the in situ application of GEMs, the ultimate objective behind their development. In order to address the anticipated risks due to the uncontrolled survival/dispersal of GEMs or recombinant plasmids into the environment, some attempts have been made (...) to construct systems that would contain the released organisms. This article discusses the designing of safer genetically engineered organisms for environmental release with specific emphasis on the use of bacterial plasmid addiction systems to limit their survival thus minimizing the anticipated risk. We also conceptualize a novel strategy to construct “Suicidal Genetically Engineered Microorganisms (SGEMs)” by exploring/combining the knowledge of different plasmid addiction systems (such as antisense RNA‐regulated plasmid addiction, proteic plasmid addiction etc.) and inducible degradative operons of bacteria. BioEssays 27:563–573, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

The ArgumentMuslims share with others both the interest in and the concern about genetic engineering. Naturally their reactions and views stem from general Islamic dogma and from Islamic medical ethics, but they are not unaware of Western scientific data. Particularly relevant is the Islamic religious prohibition against “changing what Allah has created.” Muslim muftis try to offer practical solutions for individuals. Islamic law is concerned about maintaining pure lineage. Consanguineous matings are very common, but induced abortions are usually (...) ruled out. Cloning has reawakened among Muslims an old debate over the positive as well as hazardous aspects of genetic engineering. (shrink)

Genetic engineering is a social invention as much as a biological one. Ordinary citizens interested in the well-being of life on the planet should therefore be involved in the ethical debates concerning the future of nonhuman animals. The creations of genetic engineers ought to be evaluated on a case-by-case basis by what the American philosopher R. G. Frey calls Frey is an advocate for putting animals in perspective, which means that animals matter, but not as much as (...) humans. He therefore supports the prevailing moral orthodoxy, which currently in the West means that animals can be eaten, dissected, hunted, and exhibited, provided that these things are done humanely and that the benefits to humans outweigh the harms to the animals. The he suggests, would have no objection to humans killing animals as long as the animals do not suffer. In the present paper, my aim is to raise some of the ethical, welfare, and social issues from an animal-protectionist perspective which ordinary citizens would need to consider if they were ever asked to vote on the benefits or otherwise of the impact of genetic engineering on animal welfare. (shrink)

Currently our assessment of whether someone is a good parent depends on the environmental inputs (or lack of such inputs) they give their children. But new genetic intervention technologies, to which we may soon have access, mean that how good a parent is will depend also on the genetic inputs they give their children. Each new piece of available technology threatens to open up another way that we can neglect our children. Our obligations to our children and (...) our susceptibilities to corresponding legal and moral sanctions may be about to explosively increase. In this paper I argue that we should treat conventional neglect and 'genetic neglect'– failing to use genetic intervention technologies to prevent serious diseases and disabilities – morally consistently. I conclude that in a range of cases parents will have a moral obligation to use genetic treatments to prevent serious disabilities in their children. My particular focus is on prenatal interventions and their impact of the bodily integrity of expectant mothers. I conclude that although bodily integrity constrains moral obligations, it is outweighed in a range of cases. (shrink)

I consider the contribution that a biocentric perspective might make to the ethical debate concerning the practice of genetic engineering. I claim that genetic engineering itself raises novel ethical questions, and particularly so when confronted with biocentric sensibilities. I outline the nature of these questions and describe the biocentric basis for them. I suggest that fundamentalist opposition to projects of genetic engineering is unhelpful, but that biocentric claims should now be a feature of ethical (...) consideration. I conclude, though, that while environmental ethicists can contribute powerfully to debates concerning the future of genetic engineering, the ultimate direction it takes is likely to be beyond their control. (shrink)

Should we continue to support publicly funded research on genetically engineered herbicide resistant crops? In Part One, I discussed the difference between science and ethics, presented a brief history of weed control, and explained three moral principles undergirding my environmentalist perspective. I then argued that unqualified endorsement (E) of the research is unjustified, as is unqualified opposition (O). In Part Two, I argue against qualified endorsement (QE), and for qualified opposition (QO).

Societal evaluation of new technologies, specifically nanotechnology and genetically engineered organisms , challenges current practices of governance and science. Employing environmental risk assessment for governance and oversight assumes we have a reasonable ability to understand consequences and predict adverse effects. However, traditional ERA has come under considerable criticism for its many shortcomings and current governance institutions have demonstrated limitations in transparency, public input, and capacity. Problem Formulation and Options Assessment is a methodology founded on three key concepts in risk (...) assessment and three in governance . Developed through a series of international workshops, the PFOA process emphasizes engagement with stakeholders in iterative stages, from identification of the problem through comparison of multiple technology solutions that could be used in the future with their relative benefits, harms, and risk. It provides “upstream public engagement” in a deliberation informed by science that identifies values for improved decision making. (shrink)

Societal evaluation of new technologies, specifically nanotechnology and genetically engineered organisms, challenges current practices of governance and science. When a governing body is confronted by a technology whose use has potential environmental risks, some form of risk analysis is typically conducted to help decision makers consider the range of possible benefits and harms posed by the technology. Environmental risk assessment is a critical component in the governance of nanotechnology and genetically engineered organisms because the uncertainties and complexities surrounding (...) these technologies pose such risk potential. However, GEOs are unique technologies, and there is widespread, international recognition that many traditional forms of ERA are not well-suited for evaluating them. Nanotechnology products are also likely to need different models of risk assessment, as there is very little information on their fate, transport, and impacts in the environment. (shrink)

Intrinsic value and animal integrity are two key concepts in the debate on the ethics of the genetic engineering of laboratory animals. These concepts have, on the one hand, a theoretical origin and are, on the other hand, based on the moral beliefs of people not directly involved in the genetic modification of animals. This ‘external’ origin raises the question whether these concepts need to be adjusted or extended when confronted with the moral experiences and opinions of (...) people directly involved in the creation or use of transgenic laboratory animals. To answer this question, 35 persons from the practice of biomedical research who are directly involved in genetic engineering (scientists, biotechnicians, animal caretakers and laboratory animal scientists) were interviewed. They were asked to give their moral opinion on different aspects of the genetic engineering of animals and to react to statements about the concepts of intrinsic value and animal integrity. Analysis of the interviews showed that, contrary to what is often assumed, the respondents embraced these concepts, even those senses that (more) specifically apply to genetic engineering. And although the respondents raised some objections that go beyond issues of animal welfare, these objections could quite well be expressed in terms of the concepts of intrinsic value and animal integrity. In short, the results of the present study strongly suggest that these concepts do not have to be adjusted or extended in the light of the moral experiences and opinions from practice. (shrink)

Genes are the fundamental chemical codes that determine the physical nature of all living things, from the tiniest single-celled organism to human beings. Genes make up the DNA, the cell-level master plan which determines how the organism is going to develop in all ways that are not environmentally influenced.

Designer Biology: The Ethics of Intensively Engineering Biological and Ecological Systems consists of thirteen chapters that address the ethical issues raised by technological intervention and design across a broad range of biological and ecological systems. Among the technologies addressed are geoengineering, human enhancement, sex selection, genetic modification, and synthetic biology.

The ability of medical science to clone and perhaps even predetermine characteristics of certain species conflicts dramatically with many claims of the religious establishment. Opening with a description of various developments in plant, animal, and human genetics, Made in Whose Image? highlights the progress genetic research has achieved, its future promise, and its social impact. The developments are analyzed from the perspective of Christian ethics, as expounded by Roman Catholic and Protestant theorists, to give an overview of crucial ethical (...) issues. In reviewing the advances of genetic research, noted religion and ethics professor Thomas A. Shannon covers general ethical themes, such as the value of life, materialism, freedom, individuality, the concept of nature, and health and disease. In addition, he discusses problems in genetic engineering and misconceptions of the church. Shannon explores prenatal diagnosis, gene therapy, genes and behavior, freedom and responsibility, and the Human Genome Project. The book concludes with a powerful and groundbreaking methodological discussion of how to approach ethical problems in genetic engineering. (shrink)

In this paper I critique two popular, non-scientific attitudes toward genetically engineered foods. In doing so, I will be employing the concepts of ambiguity, purity/impurity, control/resistance, and unity/diversity as developed by Latina feminist metaphysicians. I begin by casting a critical eye toward a specific anti-biotech account of transgenic food crops, an account that I will argue relies on an anti-feminist metaphysics. I then cast that same critical eye toward a specific pro-biotech account, arguing that it also relies on such an (...) anti-feminist metaphysics. I will argue further that this metaphysics yields a less accurate account of genetics. I end by arguing that if we adopt a Latina feminist metaphysics we can more accurately understand plants, genetics, and genetic engineering. (shrink)

The advent of CRISPR has drastically moved the possibility of genetically modifying human genomes from the space of science fiction into nearby reality. Whether one considers the positive results f...

Intrinsic value and animal integrity are two key concepts in the debate on the ethics of the genetic engineering of laboratory animals. These concepts have, on the one hand, a theoretical origin and are, on the other hand, based on the moral beliefs of people not directly involved in the genetic modification of animals. This ‘external’ origin raises the question whether these concepts need to be adjusted or extended when confronted with the moral experiences and opinions of (...) people directly involved in the creation or use of transgenic laboratory animals. To answer this question, 35 persons from the practice of biomedical research who are directly involved in genetic engineering (scientists, biotechnicians, animal caretakers and laboratory animal scientists) were interviewed. They were asked to give their moral opinion on different aspects of the genetic engineering of animals and to react to statements about the concepts of intrinsic value and animal integrity. Analysis of the interviews showed that, contrary to what is often assumed, the respondents embraced these concepts, even those senses that (more) specifically apply to genetic engineering. And although the respondents raised some objections that go beyond issues of animal welfare, these objections could quite well be expressed in terms of the concepts of intrinsic value and animal integrity. In short, the results of the present study strongly suggest that these concepts do not have to be adjusted or extended in the light of the moral experiences and opinions from practice. (shrink)

The concept of intrinsic value is often invoked to articulate objections to the genetic engineering of animals, particularly those objections that are not directed at the negative effects the technique might have on the health and welfare of the modified animals. However, this concept was not developed in the context of genetic engineering. Given this external origin, this paper critically examines the assumption that the concept of intrinsic value is suitable to articulate and justify moral objections (...) more specifically directed at the genetic engineering of animals. I discuss four different theories of intrinsic value, two of which defend a moral concept of intrinsic value and two a non-moral one. I conclude that only a particular non-moral concept of intrinsic value is suitable to express specific objections to genetic engineering, because these objections can only be defended in the form of indirect duties regarding animals. (shrink)

The use of genetic engineering inagriculture has been the source of much debate. Todate, arguments have focused most strongly on thepotential human health risks, the flow of geneticmaterial to related species, and ecologicalconsequences. Little attention appears to have beengiven to a more fundamental concern, namely, who willbe the beneficiaries of this technology?Given the prevalence of chronic hunger and thestark economics of farming, it is arguable thatfarmers and the hungry should be the mainbeneficiaries of agricultural research. However, theapplication of (...) genetic engineering appears unlikely tobenefit either of these two groups. This technology islargely controlled by the private sector, and itscontinued development hinges on its profitability.Thus, the only likely beneficiaries of the applicationof genetic engineering in agriculture are companieswith the capacity to use it. (shrink)

This book consists of thirteen chapters that address the ethical issues raised by technological intervention and design across a broad range of biological and ecological systems. Among the technologies addressed are geoengineering, human enhancement, sex selection, genetic modification, and synthetic biology.

The commercial introduction of genetically modified organisms (GMOs) has revealed a broad range of views among scientists and other stakeholders on perspectives of genetic engineering (GE) and if and how GMOs should be regulated. Within this controversy, the precautionary principle has become a contentious issue with high support from skeptical groups but resisted by GMO advocates. How to handle lack of scientific understanding and scientific disagreement are core issues within these debates. This article examines some of the key (...) issues affecting precaution as a legal standard and as an approach to the use of science in decision-making processes. It is pointed out that there is a need for reflection over the level of scientific evidence required for applying the precautionary principle as well as who should have the burden of proof when there are uncertainties. Further, an awareness of the broader scientific uncertainties found in GMO risk assessment implies that a precautionary approach must be elaborated: both for acknowledging uncertainties and for identification of scientific responses. Since precaution is an important issue within the sustainable development framework, it is suggested that sustainability can provide a normative standard that can help to reveal the influence and negotiate the importance of the various forms of uncertainty. Wise management of uncertainties and inclusion of normative aspects in risk assessment and management may help to ensure sustainable and socially robust GMO innovations at present and in the future. (shrink)

First published in 1998, this volume why and how genetic engineering has emerged as the technology most likely to change our lives, for better or worse, in the opening century of the third millennium. Over twenty international experts, including moral philosophers and social scientists, describe the issues and controversies surrounding modern biotechnology and genetic engineering. They explore ways in which lay individuals and groups can join in an effective and constructive dialogue with scientists and industrialists over (...) the assessment, exploitation and safe management of these new and important technologies. Topics covered include a discussion of the issues surrounding 'Dolly', the cloned sheep, the politics and ethics of the international research programme to sequence the entire human genome, the ethical questions raised by the creation of transgenic farm animals, the morality of genetic experimentation on animals, the controversy surrounding the patenting of genetic material and of the transgenic animals themselves, the ethical implications of engineering animals for transplanting their organs into humans, and the environmental hazards of releasing genetically engineered organisms. (shrink)

A controversial question among contemporary scholars is whether advanced industrial societies are still in modernity, or whether they are on the threshold of, or even have entered, a new postmodern order. In The Consequences of Modernity Anthony Giddens writes: ‘Beyond modernity, we can perceive a new and different order, which is “post-modern”, but this is quite distinct from what is at the moment called by many “post-modernity”’. However, he does recognize that there is something perceptibly different about the present, which (...) he characterizes as ‘late modernity’, an era in which the consequences of modernity are more radicalized and globalized than before. (shrink)

For the last six months or so, some of us at The Hastings Center have been participating in a kind of short-term book group. Together we have been thinking about the contribution of moral psychology to bioethics. One of our questions is whether bioethics’ understanding of moral values should draw on what moral psychology tells us about moral values. Bioethics tends to look to philosophy for guidance. Can it learn from insights in moral psychology into the biological, environmental, and (...) cultural influences on morality? The question can be taken in many directions. One that I've wrestled with has to do with debates about genetic engineering, where a common concern is that genetic alteration of other organisms, and maybe also of humans, doesn't sit well with the kind of relationship that people want to have to nature. (shrink)

Biotechnology applied to traditional foodanimals raises ethical issues in three distinctcategories. First are a series of issues that arise inthe transformation of pigs, sheep, cattle and otherdomesticated farm animals for purposes that deviatesubstantially from food production, including forxenotransplantation or production of pharmaceuticals.Ethical analysis of these issues must draw upon theresources of medical ethics; categorizing them asagricultural biotechnologies is misleading. The secondseries of issues relate to animal welfare. Althoughone can stipulate a number of different philosophicalfoundations for the ethical assessment of welfare,most (...) either converge on Bernard Rollins principle ofwelfare conservation (Rollin, 1995), or devolve intodebates over the ethical significance of animaltelos or species integrity. The principle of welfareconservation prohibits disfunctional geneticengineering of food animals, but would permit alteringanimals biological functions, especially when (as inmaking animals less susceptable to pain or suffering)do so improves an individual animals well being.Objections to precisely this last form of geneticengineering stress telos or species integrity asconstraints on modification of animals, and thisrepresents the third class of ethical issues. Most whohave formulated such arguments have failed to developcoherent positions, but the notion of species being,derived from the 19th century German tradition,presents a promising way to analyze the basis forresisting the transformation of animal natures. (shrink)

The 1992 incorporation of an article by referendum in the SwissConstitution mandating that the federal government issue regulations onthe use of genetic material that take into account the dignity ofnonhuman organism raises philosophical questions about how we shouldunderstand what is meant by ``the dignity of nonhuman animals,'' andabout what sort of moral demands arise from recognizing this dignitywith respect to their genetic engineering. The first step in determiningwhat is meant is to clarify the difference between dignity when (...) appliedto humans and when applied to nonhumans. Several conceptions of humandignity should be rejected in favor of a fourth conception: the rightnot to be degraded. This right implies that those who have it have thecognitive capacities that are prerequisite for self-respect. In the caseof nonhuman organisms that lack this capacity, respecting their dignityrequires the recognition that their inherent value, which is tied totheir abilities to pursue their own good, be respected. This value isnot absolute, as it is in the case of humans, so it does not prohibitbreeding manipulations that make organisms more useful to humans. But itdoes restrict morally how sentient animals can be used. In regard togenetic engineering, this conception requires that animals be allowedthe uninhibited development of species specific functions, a positionshared by Holland and Attfield, as opposed to the Original Purposeconception proposed by Fox and the Integrity of the Genetic Make-upposition proposed by Rolston. The inherent value conception of dignity,as here defended, is what is meant in the Swiss Constitution article. (shrink)

This book is a philosophically sophisticated and scientifically well-informed discussion of the moral and social issues raised by genetically engineering animals, a powerful technology which has major implications for society. Unlike other books on this emotionally charged subject, the author attempts to inform, not inflame, the reader about the real problems society must address in order to manage this technology. Bernard Rollin is both a professor of philosophy, and physiology and biophysics, and writes from a uniquely well-informed perspective on (...) this topic. The style is non-technical and anecdotal and will ensure that the book can be used on a wide range of courses on bioethics, biotechnology, veterinary medicine and public policy. The book could also appeal to a general, non-academic reader with a serious interest in genetic engineering. (shrink)

In March 1986, a public symposium took place in Heidelberg about the “unresolved potential dangers of genetic engineering”. The event was organized by institutions affiliated with the environmental movement. Choosing this symposium as an example, the article shows how the public appearance of scientists can be understood as a form of political activism. The article shows how specialists from fields as diverse as biology, chemistry, physics, law and political sciences tried to place political messages by putting themselves (...) in the limelight as independent scientists. I argue that the symposium was both: a place of science communication intertwined with political agitation that, as should be noted, happened in a time when the West German government was working on the legislation of genetic engineering, legitimated by relying on independent expertise. It can be concluded that the discourse of scientific independence became a strategic tool in the controversial debate about the uses and dangers of genetic engineering. Thus, it draws attention to a dimension of political-scientific activity which cannot be fully grasped by the concept of ‘the expert’ that is established in the history of science. (shrink)

Whilst there has been much debateregarding the importance of public acceptance ofgenetic engineering and its applications, there isevidence to indicate that objections to the technologyare likely to focus on specific applications of thetechnology, rather than genetic engineering per se.Thus it becomes important to examine the extent ofobjections associated with individual applications,rather than to assess public feeling regarding thetechnology overall. Survey data were collected from200 respondents regarding their objections to generalapplications of genetic engineering (where thetangible benefits (...) were not obvious). Similar objectiondata were collected from 200 different respondents,who were presented with specific applications withmore obvious tangible benefits. Overall patterns ofobjection to different applications were identifiedusing a novel method of objection mapping, inconjunction with analysis of variance to identifyindividual differences in the samples. For generalapplications, the results indicate that mostrespondents object less to applications involvingplants and microorganisms than to those involvinganimals or human genetic material. Individualdifferences in objection focus on applicationsinvolving animals or human genetic material, withwomen and those who are very concerned with theenvironment having greatest objections to theseapplications. Individual differences tend to reducewhen specific applications are used as stimuli,although the focus of concern is still on applicationsinvolving animals and human genetic material. However,gender differences were not statistically significant,and those respondents who have high levels ofenvironmental concern are differentiated by increasedobjections to large-scale agricultural applications.It is argued that effective communication regardingthe technology should focus on specific applications,and address issues of environmental impact within thecontext of these applications, if the public is tomake an informed choice regarding their acceptance ofthe products of the technology. (shrink)

The U.S. oversight system for genetically engineered organisms was evaluated to develop hypotheses and derive lessons for oversight of other emerging technologies, such as nanotechnology. Evaluation was based upon quantitative expert elicitation, semi-standardized interviews, and historical literature analysis. Through an interdisciplinary policy analysis approach, blending legal, ethical, risk analysis, and policy sciences viewpoints, criteria were used to identify strengths and weaknesses of GEOs oversight and explore correlations among its attributes and outcomes. From the three sources of data, hypotheses and broader (...) conclusions for oversight were developed. Our analysis suggests several lessons for oversight of emerging technologies: the importance of reducing complexity and uncertainty in oversight for minimizing financial burdens on small product developers; consolidating multi-agency jurisdictions to avoid gaps and redundancies in safety reviews; consumer benefits for advancing acceptance of GEO products; rigorous and independent pre- and post-market assessment for environmental safety; early public input and transparency for ensuring public confidence; and the positive role of public input in system development, informed consent, capacity, compliance, incentives, and data requirements and stringency in promoting health and environmental safety outcomes, as well as the equitable distribution of health impacts. Our integrated approach is instructive for more comprehensive analyses of oversight systems, developing hypotheses for how features of oversight systems affect outcomes, and formulating policy options for oversight of future technological products, especially nanotechnology products. (shrink)