Neurons of organisms with complex and flexible behavior, especially humans, must precisely control protein localization and activity to support higher brain functions such as learning and memory. In contrast, simpler organisms generally have simpler individual neurons, less complex nervous systems and display more limited behaviors. Strikingly, however, many key neuronal proteins are conserved between organisms that have very different degrees of behavioral complexity. Here we discuss a possible mechanism by which conserved neuronal proteins acquired new attributes that were crucial in (...) the evolution of complexity of nervous system structure and function. Specifically, we hypothesize that vertebrate‐specific post‐translational palmitoylation sites and PDZ‐binding protein‐protein interaction motifs act as gain‐of‐function mutations, increasing the regulatory potential of conserved proteins without affecting their core functions. We further hypothesize that the additional regulation of neurotransmitter receptors and other membrane proteins made possible by these sites and motifs is critical for the function of complex nervous systems. (shrink)

Waste has often been a target of literature and policy promoting pro-environmental behaviour. However, little attention has been paid to how subjects interpret and construct waste in their daily lives. In this article we develop a synthesis of practice theory and psycho-social concepts of attachment and transitional space to explore how biographically patterned relationships and attachments to practice shape subjects' understandings of resource consumption and disposal. Deploying biographical interview data produced by the Energy Biographies Project, we illustrate how tangible, intersubjective (...) and interdependent experiences rub up against cultural and behavioural norms, reshaping the meanings and strategies through which subjects interpret and manage waste. (shrink)