Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the cell leading to toxicity and death. Here we exploit the information contained in protein, RNA and DNA interaction networks to provide a comprehensive view of the regulation layers controlling the concentration‐dependent formation of assemblies in the cell. We present the emerging concept that RNAs can act as scaffolds to promote the formation ribonucleoprotein complexes and coordinate the post‐transcriptional layer of gene regulation. We describe (...) the structural and interaction network properties that characterize the ability of protein and RNA molecules to interact and phase separate in liquid‐like compartments. Finally, we show that presence of structurally disordered regions in proteins correlate with the propensity to undergo liquid‐to‐solid phase transitions and cause human diseases. Also see the video abstract here https://youtu.be/kfpqibsNfS0. (shrink)

Il CRED, Centro di ricerca per l’estetica del diritto, ha sede presso il Dipartimento di Giurisprudenza ed Economia dell’Università Mediterranea di Reggio Calabria.

Infinità e dialettica dell'Infinito-finito sono i due temi su cui si concentra il conflitto filosofico che vede impegnati nella veste di protagonisti assoluti il Bruno, il Vico e lo Hegel, accompagnati dallo Spaventa che ne interpreta le focali istanze prodotte dal pensiero che tutto muove e promuove sia nello scorrere della vita dell'Universo sia di quella degli uomini, divenendo a tal punto consapevole del loro destino futuro. Esso si costruisce passando pure per il discorso, ovvero per la filologia che riconosce, (...) tuttavia, e sempre, il ruolo peculiare del pensiero che non è solo quello proprio, ma anche quello degli altri col quale puntigliosamente si confronta, per aspirare, in realtà, a conoscere la verità esaustivamente in tutte le forme da esso preconizzate. (shrink)

The 1830s and 1840s are the formative years of modern public health in Britain, when the poor law bureaucrat Edwin Chadwick conceived his vision of public health through public works and began the campaign for the construction of the kinds of water and sewerage works that ultimately became the standard components of urban infrastructure throughout the developed world. This book first explores that vision and campaign against the backdrop of the great "condition-of-England" questions of the period, of what rights and (...) expectations working people could justifiably have in regard to political participation, food, shelter and conditions of work. It examines the ways Chadwick's sanitarianism fit the political needs of the much-hated Poor Law Commission and of Whig and Tory governments, each seeking some antidote to revolutionary Charitism. It then reviews the Chadwickians' efforts to solve the host of problems they met in trying to implement the sanitary idea: of what responsibilities central and local units of government, and private contractors, were to have; of how townspeople could be persuaded to embark on untried public technologies; of where the new public health experts were to come from; and of how elegant technical designs were to be fitted to the unique social, political and geographic circumstances of individual towns. Rejecting the view that Chadwick's program was a simple response to an obvious urban problem Professor Hamlin argues that at the time a "public health" focusing narrowly on sanitary public works represented a retreat of public medicine from involvement with the great social issues of the Industrial Revolution. In exploring the views of medical men who were critical of Chadwick, Hamlin suggests the parameters of a public health that might have been, in which concern for health and well-being becomes the foundation of a public medicine that is a principal guarantor of social justice. This book offers modern public heatlh professionals elements of a forgotten professional heritage that might be useful in responding to the bewildering range of health problems we now confront. (shrink)

The 1830s and 1840s are the formative years of modern public health in Britain, when the poor law bureaucrat Edwin Chadwick conceived his vision of public health through public works and began the campaign for the construction of the kinds of water and sewerage works that ultimately became the standard components of urban infrastructure throughout the developed world. This book first explores that vision and campaign against the backdrop of the great "condition-of-England" questions of the period, of what rights and (...) expectations working people could justifiably have in regard to political participation, food, shelter and conditions of work. It examines the ways Chadwick's sanitarianism fit the political needs of the much-hated Poor Law Commission and of Whig and Tory governments, each seeking some antidote to revolutionary Charitism. It then reviews the Chadwickians' efforts to solve the host of problems they met in trying to implement the sanitary idea: of what responsibilities central and local units of government, and private contractors, were to have; of how townspeople could be persuaded to embark on untried public technologies; of where the new public health experts were to come from; and of how elegant technical designs were to be fitted to the unique social, political and geographic circumstances of individual towns. Rejecting the view that Chadwick's program was a simple response to an obvious urban problem Professor Hamlin argues that at the time a "public health" focusing narrowly on sanitary public works represented a retreat of public medicine from involvement with the great social issues of the Industrial Revolution. In exploring the views of medical men who were critical of Chadwick, Hamlin suggests the parameters of a public health that might have been, in which concern for health and well-being becomes the foundation of a public medicine that is a principal guarantor of social justice. This book offers modern public heatlh professionals elements of a forgotten professional heritage that might be useful in responding to the bewildering range of health problems we now confront. (shrink)

In the present article, the role of Gestalt concepts in clarifying the issues of perception is evaluated. Grounded in anti-atomism, Gestalt assumed organizing forces intrinsic to perception. Insofar these were identified with singularity preference, Gestalt is criticized for having failed to distinguish between perception and thought.

v. 1. Teorica dei governi e governo parlamentare -- v. 2. Elementi di scienza politica.

This book offers a new and original hypothesis on the origin of modal ontology, whose roots can be traced back to the mathematical debate about incommensurable magnitudes, which forms the implicit background for Plato’s later dialogues and culminates in the definition of being as dynamis in the Sophist. Incommensurable magnitudes – also called dynameis by Theaetetus – are presented as the solution to the problem of non-being and serve as the cornerstone for a philosophy of difference and becoming. This shift (...) also marks the passage to another form of rationality – one not of the measure, but of the mediation. The book argues that the ontology and the rationality which arise out of the discovery of incommensurable constitutes a thread that runs through the entire history of philosophy, one that leads to Kantian transcendentalism and to the philosophies derived from it, such as Hegelianism and philosophical hermeneutics. Readers discover an insightful exchange with some of the most important issues in philosophy, newly reconsidered from the point of view of an ontology of the incommensurable. These issues include the infinite, the continuum, existence, and difference. This text appeals to students and researchers in the fields of ancient philosophy, German idealism, philosophical hermeneutics and the history of mathematics. (shrink)

The aim of this study is to analyse a passage of the pseudoepigraphic Carmen de resurrectione which relates to insipientes, interpreted as those who do not accept that the rational observation of nature proves the existence of a unique creator God. Such a refusal is believed to make them worthy of eternal damnation. The resulting concept of sapientia involves both ratio and voluntas; it is also connected with gnoseology and soteriology. A similar concept can be found in the Aquitanian poetry (...) of the fifth century and in the theology of the so-called Semipelagians. This similarity calls into question the traditional dating and the supposed area of origin of the Carmen. (shrink)

The aim of this study is to determine the historical and cultural context of the pseudoepigraphic Carmen de resurrectione. The Carmen treats poetically many subjects of Christian eschatology: the second coming of Christ, the final judgement, heaven and hell, the universal conflagration. The author believes that the end time is imminent. This perception is common to all the Christians who experienced tribulations: persecutions, natural calamities, barbarian invasions. These painful events urged the Christians to undertake a path of true conversion, in (...) the religious and moral sense. Unlike other poets, the Anonymous author emphasises the virtuous value of the hope of divine reward rather than the fear of divine punishment. The same perspective can be found in the poets and in the monks of early fifth-century Gaul, who suffered the barbarian invasion of 406. (shrink)

Il saggio evidenzia come il «diritto naturale» rappresenti il cuore nevralgico della «scienza» di Giambattista Vico. Questi, nell’opporsi allo scetticismo, da un lato, e al giusnaturalismo, dall’altro, fa del «diritto naturale» il punto di incontro di molteplici questioni, dalla politica alla giurisprudenza, dall’«equità» alla «Ragion di Stato».

Il libro ripercorre alcune fra le tappe fondamentali del pensiero di Gian Vincenzo Gravina, inquadrandole all' interno dei generi letterari maggiormente praticati dall' autore calabrese e facendo emergere la sua capacità di padroneggiare vari aspetti della cultura del suo tempo. Il panorama intellettuale, politico e sociale del periodo compreso fra la fine del Seicento e i primi anni del Settecento, con la sua complessità, traspare dai dialoghi e dai trattati del pensatore, per il quale si fa strada l' esigenza di (...) tornare a quei valori della tradizione classica che coincidono con il bisogno di recuperare le virtù tipiche della letteratura antica per promuovere un rinnovamento culturale, politico e civile della società. (shrink)

Charles-Louis de Secondat, barón de La Brède y de Montesquieu, es uno de los personajes intelectuales más significativos del "siglo de las Luces". Todavía hoy, a doscientos cincuenta años de su muerte, son de gran actualidad algunas de sus fundamentales teorías y formulaciones, como el principio de la división de poderes dentro de un Estado, la concepción de la existencia de un "espíritu" característico de cada pueblo, el rechazo de la tortura y la necesidad de conmensurar las penas a los (...) delitos. La relevancia, la complejidad y la riqueza de los temas afrontados por el filósofo francés hacen comprender claramente el motivo por el que autores ilustres se han visto influidos por su pensamiento, y esto sería motivo suficiente para recopilar todos sus escritos. (shrink)

This essay emphasizes how Vico was one of the modern philosophers to set himself the goal to reconstruct the history of the primitive world. Differently from several authors who preceded him and also other contemporary thinkers, the Neapolitan philosopher showed that the world of the origin wasn’t idyllic, but it was affected by fear, anguish and basic needs. What mainly characterizes Vico, however, is the fact that he represented the primitive world not as a unitary and fixed block, but as (...) a world made of different historical phases and of class and social conflicts. As there were no written documents, Vico elaborated a reconstruction of history, basing it on a new and revolutionary theory of myths which, being based on creativity induced by fantasy, are called “universali fantastici”. (shrink)

Partindo das discussões que Gadamer realiza em Verdade e Método sobre a Crítica do Juízo de Kant, e em particular sobre a distinção entre beleza livre e beleza aderente, o objetivo deste texto é mostrar as implicações políticas do projeto de Gadamer. Contra as interpretações niilistas e conservadoras de Verdade e Método, queremos argumentar que o verdadeiro objetivo de Gadamer é conceber uma verdade que seja emancipadora, ou melhor, que, enquanto vivenciada e histórica, ultrapasse as condições de verdade como conformidade (...) a uma dada regra. A verdade extrametódica, de que fala Gadamer, é função de uma “universalidade intensional” que envolve a abertura de um domínio dado, entendido tanto em termos científicos (reino de verdades constituídas) quanto em termos políticos (reino de exercício do poder). Essa é, para Gadamer, a função da experiência da verdade na arte e, em geral, nas ciências do espírito. (shrink)

It is well known that, from the second year of life, children engage in imaginative activities and pretend play. Pretending is changing the nature of perceptual inputs at will. In this paper I shall take up the question of young children’s knowledge about the pretend-real distinctions. According to Josef Perner, they have an immature concept, called prelief, because they do not differentiate between believing and pretending. But, we know that belief and pretense have different inputs. Imagination is at the whim (...) of our intentions, belief not. And, on the side of outputs, when children pretend, they carry out behavioral sequences “as if” they really had beliefs, but belief and pretense have different causal roles in action tendencies. So, when a boy pretends, he acts out his pretense within the scope of a supposition, but, why doesn’t he go all the way? That is, how are we to explain the limits children place on their activity? I shall answer these questions arguing that pretense is tied to conceptual knowledge. This will enable me to give a metaphysical account of this phenomenon, because it is based on the intentional manipulation of the identity of things and their properties. (shrink)

It is well known that, from the second year of life, children engage in imaginative activities and pretend play. Pretending is changing the nature of perceptual inputs at will. In this paper I shall take up the question of young children’s knowledge about the pretend-real distinctions. According to Josef Perner, they have an immature concept, called prelief, because they do not differentiate between believing and pretending. But, we know that belief and pretense have different inputs. Imagination is at the whim (...) of our intentions, belief not. And, on the side of outputs, when children pretend, they carry out behavioral sequences “as if” they really had beliefs, but belief and pretense have different causal roles in action tendencies. So, when a boy pretends, he acts out his pretense within the scope of a supposition, but, why doesn’t he go all the way? That is, how are we to explain the limits children place on their activity? I shall answer these questions arguing that pretense is tied to conceptual knowledge. This will enable me to give a metaphysical account of this phenomenon, because it is based on the intentional manipulation of the identity of things and their properties. (shrink)