PURPOSE:To report the localization of a gene causing drusen and macular degeneration in a previously undescribed North American family. METHODS:Genetic mapping studies were performed using linkage analysis in a single family with drusen and atrophic macular degeneration. RESULTS:The clinical manifestations in this family ranged from fine macular drusen in asymptomatic middle-aged individuals to atrophic macular lesions in two children and two elderly patients. We mapped the gene to chromosome 6q14 between markers D6S2258 and D6S1644. CONCLUSIONS:In a family with autosomal dominant (...) drusen and atrophic macular degeneration, the gene maps to a 3.2-cM region on chromosome 6q14. This locus appears to be distinct from, but adjacent to, the loci for cone-rod dystrophy 7 (CORD7) and North Carolina macular dystrophy (MCDR1). Future identification of the gene responsible for the disease in this family will provide a better understanding of macular degeneration. (shrink)

Pickering & Garrod (P&G) argue that contemporary models of language use are inadequate. This has resulted largely because of an experimental focus on monologue rather than dialogue. I agree with the need for increased experimentation that focuses on the interplay between production and comprehension. However, I have some concerns about the Interactive Alignment model that the authors propose.

This is an abridgement of the complete translation of the New Essays, first published in 1981, designed for use as a study text. The material extraneous to philosophy - more than a third of the original - and the glossary of notes have been cut and a philosophical introduction and bibliography of work on Leibniz have been provided by the translators. The marginal pagination has been retained for ease of cross-reference to the full edition. The work itself is an acknowledged (...) philosophical classic, in which Leibniz argues point by point with Locke's Essay Concerning Human Understanding. The result is the single most important confrontation between the philosophical traditions of rationalism and empiricism. It makes an extremely suitable focus for the study of Leibniz's thought and of those two traditions in relation to one another. (shrink)

In three studies, we explored the retention and transfer of tool-making knowledge, learnt from an adult demonstration, to other temporal and task contexts. All studies used a variation of a task in which children had to make a hook tool to retrieve a bucket from a tall transparent tube. Children who failed to innovate the hook tool independently saw a demonstration. In Study 1, we tested children aged 4 to 6 years (N = 53) who had seen the original demonstration (...) 3 months earlier. Performance was excellent at the second time, indicating that children’s knowledge was retained over the 3 month period. In Studies 2 and 3 we explored transfer of the new knowledge to other tasks. In Study 2, children were given two variants of the apparatus that differed in surface characteristics (e.g. shape and colour). Participants generalised their knowledge to these new apparatuses even though the new pipecleaner also differed in size and colour. Five- to 6-year-olds (n = 22) almost always transferred their knowledge to problems where the same tool had to be made. Younger, 3- to 5-year-olds’ (n = 46), performance was more variable. In Study 3, 4- to 7-year-olds (N = 146) saw a demonstration of hook making with a pipecleaner, but then had to make a tool by combining pieces of wooden dowel (or vice versa: original training on dowel, transfer to pipecleaner). Children did not transfer their tool-making knowledge to the new material. Children retained tool-making knowledge over time and transferred their knowledge to new situations in which they needed to make a similar tool from similar materials, but not different materials. We concluded that children’s ability to use tool-making knowledge in novel situations is likely to depend on memory and analogical reasoning, with the latter continuing to develop during middle childhood. (shrink)

A uniform construction for sequent calculi for finite-valued first-order logics with distribution quantifiers is exhibited. Completeness, cut-elimination and midsequent theorems are established. As an application, an analog of Herbrand’s theorem for the four-valued knowledge-representation logic of Belnap and Ginsberg is presented. It is indicated how this theorem can be used for reasoning about knowledge bases with incomplete and inconsistent information.

This paper introduces a generalization of Reiter’s notion of “extension” for default logic. The main difference from the original version mainly lies in the way conflicts among defaults are handled: in particular, this notion of “general extension” allows defaults not explicitly triggered to pre-empt other defaults. A consequence of the adoption of such a notion of extension is that the collection of all the general extensions of a default theory turns out to have a nontrivial algebraic structure. This fact has (...) two major technical fall-outs: first, it turns out that every default theory has a general extension; second, general extensions allow one to define a well-behaved, skeptical relation of defeasible consequence for default theories, satisfying the principles of Reflexivity, Cut, and Cautious Monotonicity formulated by D. Gabbay. (shrink)

In the present paper we give the first proof-theoretical example of an embedding of classical logic into a quantum-like logic. This is performed in the framework of basic logic, where a proof-theoretical approach to quantum logic is convenient. We consider basic orthologic, that corresponds to a sequential formulation of paraconsistent quantum logic, and which is given by basic orthologic added with weakening and contraction, in a language with Girard's negation. In the paper we first consider a convenient cut-free calculus for (...) classical logic, in the same language; then, in a language enriched with a new kind of literals, we introduce basic orthologic with a primitive modality, where classical logic is embeddable. Similarly to Girard's negation, our modality is not a connective but conceivable as an operator defined inductively on the set of formulae. This allows us to obtain a calculus which enjoys cut-elimination. (shrink)

A landmark study in the field of political science, The Changing Architecture of Politics charts the profound structural changes taking place in the late twentieth-century state. Looking at both theory and practice, Cerny argues that political structures--states in the broadest sense--are the key to understanding both the history and the future of modern politics. Included for discussion are such salient topics as the problem of locating institutional and structural theory within political and social science, how to describe and classify the (...) main elements of political structures, and a penetrating analysis of the structured action field that lies at the crossroads of political structuration. In addition, he explores several core areas in practice, including how states will operate in the next century and how states will interact with the manifold changes in social and economic processes--at both the domestic and international levels. Through his masterly portrayal of the architecture of contemporary politics, Cerny lays the foundations for an understanding of new political structures that are needed if the pursuit of human values is to continue into the next century. As such, this fascinating volume will appeal to all those interested in the paradigms of political and social science, whether from a purely theoretical or from a more empirical standpoint. "This is the best introduction available in English to contemporary academic discussions about the purpose and prospects of applying the comparative method to political science. Cerny's book is comprehensive in scope and accomplishes three, quite rare tasks: it brings together material on North America, Western Europe, and Japan; it combines theories of comparative politics and international relations; it pays equal attention to systems of party competition and of interest intermediation, although its primary focus is upon the state. Philip Cerny has produced a tour de force, an intelligent, erudite, and comprehensive text that cuts decisively through artificial barriers within the discipline." --Political Science Quarterly. (shrink)

We consider a class of graphs embedded in $R^2$ as noncommutative proof-nets with an explicit exchange rule. We give two characterization of such proof-nets, one representing proof-nets as CW-complexes in a two-dimensional disc, the other extending a characterization by Asperti. As a corollary, we obtain that the test of correctness in the case of planar graphs is linear in the size of the data. Braided proof-nets are proof-nets for multiplicative linear logic with Mix embedded in $R^3$ . In order to (...) prove the cut-elimination theorem, we consider proof-nets in $R^2$ as projections of braided proof-nets under regular isotopy. (shrink)

This short note considers the formulation of Full Intuitionistic Linear Logic given by Hyland and de Paiva . Unfortunately the formulation is not closed under the process of cut elimination. This note proposes an alternative formulation based on the notion of patterns.

We present a cut-elimination proof for simple type theory with an axiom of choice formulated in the language with an epsilon-symbol. The proof is modeled after Takahashi's proof of cut-elimination for simple type theory with extensionality. The same proof works when types are restricted, for example for second-order classical logic with an axiom of choice.

This paper examines conceptual issues that arise in applications of Darwinian natural selection to cultural systems. I argue that many criticisms of cultural selectionist models have been based on an over-detailed reading of the analogy between biological and cultural units of selection. I identify five of the most powerful objections to cultural selection theory and argue that none cuts to its heart. Some objections are based on mistaken assumptions about the simplicity of the mechanisms of biological heredity. Other objections are (...) attributable, rather, to mistaken inferences from observations of biological subject matter to what is essential in natural selection. I argue that such features are idiosyncratic of biological systems, but not essential for natural selection. My arguments throughout are illustrated by examples from biological and cultural evolution, and counter-factual illustrations from the history of theoretical biology. Introduction Cultural Selection Theory First Objection: Lamarckianism Second Objection: Genotype–Phenotype Distinction Third Objection: Common Hereditary Architecture Fourth Objection: Biological Analogue for Cultural Units 6.1 Regarding strict analogues 6.2 Regarding the trait analogue 6.3 Regarding the virus analogue Fifth Objection: Environmental Interaction Conclusion CiteULike Connotea Del.icio.us What's this? (shrink)

Global properties of canonical derivability predicates in Peano Arithmetic) are studied here by means of a suitable propositional modal logic GL. A whole book [1] has appeared on GL and we refer to it for more information and a bibliography on GL. Here we propose a sequent calculus for GL and, by exhibiting a good proof procedure, prove that such calculus admits the elimination of cuts. Most of standard results on GL are then easy consequences: completeness, decidability, finite model property, (...) interpolation and the fixed point theorem. (shrink)

Human values, by their very nature, are situational and culture specific. It would, therefore, be unrealistic to think that we can 'transplant' or 'transport' values from one country or culture to another with ease. This text identifies suitable human values which cut across national boundaries and cultures to facilitate organisations wishing to advance their businesses and strategic management capabilities towards a functionally humane organisation (FHO).

This paper is concerned. with the contrast between simulation- and deduction-based approaches to reasoning about physical objects. We show that linear logic can give a unified account of both simulation and deduction concerning physical objects; it also allows us to draw a principled distinction between simulation and deduction, since simulations correspond to cut-free proofs, whereas deductions correspond to proofs in general.

Steven Rose regards oversimplification of biology as the supreme sin, inevitably leading to evil consequences, and requiring an unique distortion of scientific practice to avoid it. To avoid this, he proposes a short-cut to scientific knowledge by defining certain areas of biology that are intrinsically flawed. But this achieves only a subordination of science to politics. There are no general-purpose shortcuts for evaluating the validity of theories, and no substitutes for testing specific theories using relevant evidence.

"In his Phenomenology of Cognition, Cassirer provides a comprehensive and systematic account of the dynamic process involved in the whole of human culture as it progresses from the world of myth and its feeling of social belonging to the highest abstractions of mathematics, logic and theoretical physics. Cassirer engages with the most sophisticated and cutting-edge work in fields ranging from ethnology to classics, egyptology and assyriology to ethology, brain science and psychology to logic, mathematics and theoretical physics. His command (...) of philosophy, literature, and the arts is superb. Echoing his work on Kant, Cassirer begins ThePhilosophy of Symbolic Formswith the problem posed by the meaning of being for philosophy since Plato. But Cassirer also shows that this problem gains new significance with Kant and with the development of modern culture. Cassirer weaves his conception of the development of knowledge into a broadly Kantian and German idealist dynamic-historical conception of significance and of experience that refuses to accept a fundamental opposition between literary, philosophical and scientific culture. In consequence of his great vision grounded in careful reflection and argument, Cassirer's systematic conception of the Copernican cosmopolitan-cosmological revolution is still philosophically and scientifically unmatched in contemporary philosophy on both sides of the Atlantic and of the Pacific." - Pierre Keller, Professor of Philosophy, University of California, Riverside, USA. This new translation makes Cassirer's seminal work available to a new generation of scholars. Each volume includes an introduction by Steve Lofts, a foreword by Peter Gordon, a glossary of key terms, and an index. Steve Lofts is Professor of Philosophy at King's University College, Canada. He is the translator of Cassirer's The Logic of the Cultural Sciences and The Warburg Years : Essays on Language, Art, Myth, and Technology. (shrink)

The Grolier Club of New York has been mounting exhibitions of books and prints since 1884, and many of them are recognized as landmark treatments of their subjects. Most of them have also been accompanied by published catalogs or related books. A recent instance was the exhibition, in the early months of 2021, drawn from Steven Lomazow's vast collection of American magazines, consisting of over eighty-three thousand separate issues from 1731 to the present. The substantial and profusely illustrated book that (...) has resulted is a welcome new survey of the subject, for it contains not only a record of the comprehensive exhibition but also fifteen essays written by Lomazow and seven other contributors (five chronological chapters, ten topical ones).The appearance of this book is an occasion for thinking about the status of magazines as research material. Although there is a considerable literature devoted to the history of magazines, they still do not always receive the attention they deserve. For example, author bibliographies generally give detailed physical descriptions of an author's books but simply list the magazine contributions. The illogic of this approach should be obvious, for magazines are printed matter, just as books are, and are thus subject to all the same complications. Two examples will illustrate how copies of supposedly identical issues can vary. In the nineteenth century, individual issues were often reprinted when the supply ran low, so that the publisher would be able to make up complete volumes for sale in a publisher's binding at the end of the year; these second printings were not labeled as such, but they could of course contain textual differences, both intentional and accidental. In the twentieth century, some American magazines had regional “editions” in which the text was shifted around in order to accommodate different advertising, keyed to local markets (the New Yorker is an example); as a result, page citations for a given contribution might not be the same in different copies (and cutting of text could also occur).The illogic of neglecting magazines has implications for biographical, as well as bibliographical and textual, study. There are many instances in which periodical publication was crucial for an author's career. It often provided an author's first public exposure and at any point in a career might have reached a larger audience than the books. Collectors, on whom preservation of the evidence initially depends, have been as guilty as bibliographers of slighting magazines. For instance, they have traditionally paid attention to anthologies that contain first book appearances of particular works (because they are “books”), without recognizing that issues of magazines are also anthologies (and frequently of more significance for promoting an author's reputation). Preservation relies also on institutional libraries to do their part; but (although “little magazines” now seem to be safe from further destruction) mainstream and mass-circulation magazines (both present and past) are continually being discarded by libraries in favor of digital reproductions. And reproductions are no more adequate as substitutes for the originals of magazines than they are for books, since they do not provide a basis for studying the unreproducible physical details that affect the reading experience and are essential for bibliographical research. Furthermore, since copies of a magazine issue can vary (just as copies of a book can), the number of copies that are preserved is a serious concern.These are among the considerations that make one glad to see Lomazow's book, for here is a collector who has focused on magazines for their own sake. Even though his book does not go into the matters I have raised, it can still serve to publicize the cause. One hopes that it, along with the wide attention his exhibition received, will stimulate appreciation of the importance of magazines in cultural history and the consequent need to collect and preserve them. (shrink)

The issue of assessing priorities is one that has become the subject of much debate in the National Health Service particularly in the wake of various documents on priorities from central Government. It has become even more so with the prospect of real cuts in expenditure. Economists claim that their science, or perhaps more accurately art can assist in determining not only how best to achieve various ends but also whether and to what extent competing objectives should be pursued. Such (...) choices cannot be made in the absence of some ethical considerations and it is important that health service decision makers (and in particular the medical profession) are aware if the relationship between economics (and especially cost-benefit analysis) and medical ethics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 15.2 (2005) 199-210 [Access article in PDF] Conflict-of-Interest Policy at the National Institutes of Health: The Pendulum Swings Wildly* Evan G. DeRenzo **This article addresses the National Institutes of Health (NIH) employee conflict-of-interest (COI) policy that went into effect February 2005. It is not, however, merely an account of another poorly crafted government policy that cries out for revision. Instead, it is also a (...) story about one of our nation's most important and prestigious institutions and its struggles to navigate the crosscurrents of scientific aspirations, power politics, public ambivalence toward capitalist economics in the biosciences, and the media's inclination to exaggerate problems and under report complicated facts. It is also a tale of greed, politics, purgatory, and redemption. The dramatic and abrupt change in the NIH COI policy demonstrates the difficulty of balancing the production of cutting-edge science with the demands for transparency resulting from work performed in the public interest on the public tab. It is an unhappy chapter in the life of a government agency that is also a national treasure. And, one hopes, it will be an example of how harmful and ill-conceived law can be revised and amended to advance national health and well-being. What is the New NIH COI Policy? The new NIH COI employee policy, more accurately referred to as the Interim Final Rule (Federal Register 2005), is a sweeping set of prohibitions on activities and holdings to reduce the possibility that NIH employees will have any actual [End Page 199] or apparent conflicts of interest. For the most part, the prohibitions are applied across-the-board—i.e., without distinction to employee category or function. The new policy includes prohibitions on outside activities, stock holdings, and awards. It prohibits all NIH employees from engaging in any compensated or uncompensated employment, including consulting, serving on advisory or other such boards, and compensated teaching, speaking, writing, or editing with certain kinds of entities. The first class of such entities is referred to as substantially affected organizations, defined as biotechnology, pharmaceutical, medical device companies, and others with similar interests. But these are not the only entities included in the prohibitions. Other organizations from which NIH employees now are cut off are hospitals, clinics, and other health care institutions; health, science, or health research-related professional associations and consumer and advocacy groups. Included also are educational institutions and not-for-profit independent research institutes that are, or were, recent NIH funding applicants, grantees, contractors, or cooperative research and development agreement (CRADA) partners. The only exemptions appear to be for health care institutions at which NIH employees provide clinical care and some forms of writing—e.g., an NIH physician who moonlights at her/his local hospital's emergency room or submits a manuscript to a peer-reviewed journal that receives only unrestricted funding from a prohibited entity. Prohibited and/or restricted holdings include stock in biotechnology, pharmaceutical, and medical device companies and others in research, development, or manufacture of medical devices, equipment, preparations, treatments, or products. The prohibitions apply to senior NIH employees; restrictions in the amount of such holdings apply to all remaining employees. Both apply to the spouses and minor children of NIH employees. If an NIH employee wins an award, the monetary allowance in most cases is limited to $200. In sum, the scope of this policy is vast, too vast to be reasonable. Too many employees are restricted in too many ways. Where appropriate restrictions have been placed on senior NIH employees, even these constructive aspects of the policy are overshadowed by the unfairness and destructiveness of other aspects. This policy far exceeds anything that could be considered sound. Fortunately, the policy has a built-in assessment process to begin at the end of the policy's first year of implementation. One can only hope that a fair and open evaluation will be conducted, the results of which surely must result in major revisions to what is now bad regulation. Why the Policy... (shrink)

We describe a short model-theoretic proof of an extended normal form theorem for derivations in predicate logic which implies in PRA a normal form theorem for the arithmetic derivations . Consider the Gentzen-type formulation of predicate logic with invertible rules. A derivation with proper variables is one where a variable b can occur in the premiss of an inference L but not below this premiss only in the case when L is () or () and b is its eigenvariable. Free (...) variables of such derivation are eigenvariables and free variables of its last sequent. Then any sequent derivable in predicate logic has a cut-free derivation with proper variables where the main formula of any antecedent rule is underivable. The proof is by a simple modification of the construction of a countermodel of the formula from the open branch of its canonical proof-search tree. It extends to intuitionistic and higher order systems. The proof of the corresponding normalization theorem outlined in [8] uses the passage to the infinitary derivations enriched by finitary derivations. The normal form after a modification to make it decidable can be considered as a realization of Gentzen's idea stated at the end of [2], that his notion of reduction for arithmetic can be extended to other fields of mathematics. (shrink)

We describe a natural deduction system NDIL for the second order intuitionistic linear logic which admits normalization and has a subformula property. NDIL is an extension of the system for !-free multiplicative linear logic constructed by the author and elaborated by A. Babaev. Main new feature here is the treatment of the modality !. It uses a device inspired by D. Prawitz' treatment of S4 combined with a construction $<\Gamma>$ introduced by the author to avoid cut-like constructions used in $\otimes$ (...) -elimination and global restrictions employed by Prawitz. Normal form for natural deduction is obtained by Prawitz translation of cut-free sequent derivations. (shrink)

New ideas are seldom received with moderation. When Spengler's Decline of the West appeared it was greeted with wild enthusiasm, which collapsed like a pricked bubble under criticism. Now that Toynbee, a generation later, has taken up the theme, there seems to be a determination not to be caught a second time. His critics have no wish to be unfair, and much of what they say is true enough; but to anybody who has a sympathetic understanding of what he is (...) attempting most of it seems entirely irrelevant and misleading. Toynbee's critics fall broadly into two classes—those for whom he says too little, and those for whom he says too much. In the first class are those who complain that he does not define his civilizations, that he does not say whether he is for or against Christianity, or that he does not explain how the deterministic aspects of his results can be reconciled with his liberalism and his avowed belief in free will. Yet if Toynbee had given precise answers to these and other questions, if he had come forward with a cut-and-dried philosophical system, these same critics might well have been the first to complain that he was imposing a priori conceptions on the facts of history—a charge that has been made against every philosophy of history, and one which it is very difficult to refute. Surely we can respect the integrity of a historian who declines to go beyond the facts, or adopt opinions before compelled by the evidence. (shrink)

The essays in this book not only examine the variety of atheist expression and experience in the Western context, they also explore how local, national and international settings may contribute to the shaping of atheist identities. By addressing identity at these different levels, the book explores how individuals construct their own atheist-or non-religious-identity, how they construct community and how identity factors into atheist interaction at the social or institutional levels. The book offers an interdisciplinary comparative approach to the analysis of (...) issues relating to atheism, such as demography, community engagement, gender politics, stigmatism and legal action. It covers such themes as: secularization; the social context of atheism in various Western countries; the shifting of atheist identities based on different cultural and national contexts; the role of atheism in multicultural settings; how the framework of "reasonable accommodation" applies to atheism; interactions and relationships between atheism and religion; and how atheism is represented for political and legal purposes. Featuring contributions by international scholars at the cutting edge of atheism studies, this volume offers unique insights into the relationship between atheism and identity. It will serve as a useful resource for academics, journalists, policy makers and readers interested in secular and religious studies, identity construction and identity politics as well as atheism in general. (shrink)

Decision-making is an intricate subject in neuroscience. It is often argued that laboratorial research is not capable of dealing with the necessary complexity to study the issue. Whereas philosophers in general neglect the physiological features that constitute the main aspects of thought and behaviour, I advocate that cutting-edge neuroscientific experiments can offer us a framework to explain human behaviour in its relationship with will, self-control, inhibition, emotion and reasoning. It is my contention that self-control mechanisms can modulate more basic (...) stimuli. Assuming the aforementioned standpoints, I show the physiological mechanisms underlying social assessment and decision-making. I also establish a difference between veridical and adaptive decision-making, useful to create experimental designs that can better mimic the complexity of our day-by-day decisions in more ecologically relevant laboratorial research. Moreover, I analyse some experiments in order to develop an epistemological reflection about the necessary neural mechanisms to social assessment and decision-making. (shrink)

We present a complete and cut-free proof-system for a fragment of MTL, where modal operators are only labelled by bounded intervals with rational endpoints.

This chapter introduces the edited volume, The Oxford Handbook of Philosophy and Psychiatry. Published in 2013, the centenary of Karl Jaspers' General Psychopathology, the chapter draws lessons from the last hundred years for the coming century. No predictions are made. Instead, five 'conditions for flourishing' are set out: 1) Particular Problems - the importance of focussing on well-defined particular problems rather than general theory building, 2) Product- orientation - remaining always responsibly product oriented in the specific sense that both sides (...) put in the work necessary to 'go deep' with each other's fields, 3) Partnership - working in partnerships of one kind or another, 4) Process - constant reflection on process based on peer review but leaving scope for the occasional rogue voice to cut innovatively against the grain, and 5) Q - a condition of a different kind, Q is an empirically derived measure of the balance between in-group cohesion and out-group openness required to support creativity. Illustrations are given of how these five conditions for flourishing have underpinned the rapid expansion of philosophy and psychiatry in the closing decades of the twentieth century, and, correspondingly, are also reflected in the Handbook as a whole. Overviews and commentaries on individual contributions to the Handbook are given in extended editorial introductions to each of its eight sections. (shrink)

A construction principle for natural deduction systems for arbitrary, finitely-many-valued first order logics is exhibited. These systems are systematically obtained from sequent calculi, which in turn can be automatically extracted from the truth tables of the logics under consideration. Soundness and cut-free completeness of these sequent calculi translate into soundness, completeness, and normal-form theorems for natural deduction systems.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 12.3 (2005) 229-234 [Access article in PDF] Nonlinear Dynamics at the Cutting Edge of Modernity: A Postmodern View Gordon Globus Keywords nonlinear dynamics, modernity, postmodernity, quantum brain theory, free will, self-organization, autopoiesis, autorhoesis Although nonlinear dynamical conceptu-alizations have been applied to psychia-try for over 20 years,1 they have not had significant impact on the field. Unfortunately Heinrichs' very thoughtful contribution to the discussion is (...) unlikely to move such disinterest. Pragmatically successful paradigms in the phase of Kuhnian "normal science" are highly resistant to change. There is no crisis that besets triumphalist biological psychiatry that might lead to clinical or scientific revolution. At the same time, as I suggest at the end of this commentary, the ideas of nonlinear dynamics may not be revolutionary enough, remaining staunchly within the framework of modernity.In what follows I discuss four issues related to Heinrichs' article. First, I try to enrich his presentation of nonlinear dynamics by bringing in the role of self-organization in the evolution of nonlinear dynamical brain systems and by making the nonlinear dynamics "tunable." Second, I discuss whether Heinrichs succeeds in avoiding the dualism of the biopsychosocial model that he criticizes. Third, I look at the issue of "free will," which Heinrichs would understandably like to avoid. Finally, I mention a new form of dynamics, namely thermofield dynamics, which I think is more promising than nonlinear dynamics. Self-Organizing Self-Tuning Nonlinear Dynamical Systems In the case of psychiatry, we are not considering nonlinear dynamical systems like the weather or an ecosystem, but the brain's neural networks in terms of nonlinear dynamics with all its chaos. There is a principle of such systems of neural networks that Heinrichs does not bring out, although it is extremely important for them. These systems are self-organizing under a Hamiltonian principle of "least energy." To use Hopfield and Tank's (1986) terms, nonlinear dynamical neural networks self-organize toward attractors that minimize the "computational energy" of the system, or for Smolensky (1988), self-organize toward "harmony," or for Globus (1995, 2003), in a Heideggerian vein, self-organize to maximize "belonging-together." In this elaborated framework, rational deliberation is one constraint among many on a self-organizing nonlinear dynamical process. [End Page 229]Heinrichs brings out beautifully the nonlinear dynamical way of thinking clinically. This is not the dynamics of mechanistic psychodynamics, which features psychological forces in vectorial conflict—id versus superego and their compromises—but a flowing evolution of states in which small changes in initial state may have large effects (nonlinearity) on the state trajectory. To live a life is often to feel surprise, which nonlinear dynamics with its chaotic regimes well portrays.But there is a way that classical Freud and nonlinear dynamical neural networks do come together—in the "economics," discharges and conservations of libidinal energy, expenditures and credits in Derrida's (1978) accounting. Heinrichs does not mention this similarity. The economic principles differ between Freud's late nineteenth-century thermodynamics and Heinrichs' late twentieth-century nonlinear dynamics, it is true, but it is all economics.Freud called this economic functioning the "pleasure principle" in which "libido" seeks to discharge its instinctual energy store, reducing the level of instinctual tension. This "primary process" proceeds to an attractor by the quickest, most direct way possible, whereas the "secondary process" defers reduction in instinctual tension, subjecting the primary process to thought. Self-organizing directly to the attractor is the primary process with which the secondary process interferes, introducing deferral.The economy of nonlinear dynamics pictures a "landscape," a variegated topography with peaks and valleys. Each point on the topography represents a state. Peak points are repellors—for example, states in which the phobic object is approached—and the lowest points of the valleys are attractors—for example, obsessions and compulsions. The path of occupied states self-organizes away from repellors and toward attractors. This topography is an energy landscape. Its dynamics spontaneously tends—"self-organizes"—toward least energy/high-constraint satisfaction. Freud's pleasure principle is just the Hamiltonian least energy... (shrink)

Cosmetic surgery is a fast-growing medical practice. In 1997 surgeons in the United States performed the four most common cosmetic procedures443,728 times, an increase of 150% over the comparable total for 1992. Estimated total expenditures for cosmetic surgery range from $1 to $2 billion. As managed care cuts into physicians' income and autonomy, cosmetic surgery, which is not covered by health insurance, offers a financially attractive medical specialty.

Bruno and Arora (2018) present a range of important ethical issues emerging from the development of procedures for uterine transplant (UT). They approach those issues by drawing on parallels to oth...

Supervaluationism is often described as the most popular semantic treatment of indeterminacy. There’s little consensus, however, about how to fill out the bare-bones idea to include a characterization of logical consequence. The paper explores one methodology for choosing between the logics: pick a logic thatnorms beliefas classical consequence is standardly thought to do. The main focus of the paper considers a variant of standard supervaluational, on which we can characterizedegrees of determinacy. It applies the methodology above to focus ondegree logic. (...) This is developed first in a basic, single-premise case; and then extended to the multipremise case, and to allowdegreesof consequence. The metatheoretic properties of degree logic are set out. On the positive side, the logic is supraclassical—all classical valid sequents are degree logic valid. Strikingly, metarules such as cut and conjunction introduction fail. (shrink)

Most of the time when historians study chemistry the subject dealt with is what might be called élite chemistry. This is chemistry at the cutting edge, chemistry which makes a difference to how we come to understand the properties of matter, molecules, reactions, and so on. Other associated matters which may be explored by historians of chemistry concern social, economic or political relationships with élite chemistry. In this Debus Lecture I want to consider what possibilities there were that the (...) working-class would be able to learn about chemistry in the earlier part of the nineteenth century, and how and why this was achieved. (shrink)

Cutting across the boundary of philosophy and theology, this book serves as an introduction to the living tradition of Catholic moral philosophy.

Clinicians and ethicists routinely encounter complex ethical dilemmas that seem intractable, which have been described as ethical Gordian knots. How can they best assist patients and surrogate decision makers who are entangled in struggles around the capacity to make life-or-death treatment decisions? In this article I describe unconventional and unorthodox approaches to help slice through these dilemmas.

Gentzen writes in the published version of his doctoral thesis Untersuchungen über das logische Schliessen that he was able to prove the normalization theorem only for intuitionistic natural deduction, but not for classical. To cover the latter, he developed classical sequent calculus and proved a corresponding theorem, the famous cut elimination result. Its proof was organized so that a cut elimination result for an intuitionistic sequent calculus came out as a special case, namely the one in which the sequents have (...) at most one formula in the right, succedent part. Thus, there was no need for a direct proof of normalization for intuitionistic natural deduction. The only traces of such a proof in the published thesis are some convertibilities, such as when an implication introduction is followed by an implication elimination [1934–35, II.5.13]. It remained to Dag Prawitz in 1965 to work out a proof of normalization. Another, less known proof was given also in 1965 by Andres Raggio.We found in February 2005 an early handwritten version of Gentzen's thesis, with exactly the above title, but with rather different contents: Most remarkably, it contains a detailed proof of normalization for what became the standard system of natural deduction. The manuscript is located in the Paul Bernays collection at the ETH-Zurichwith the signum Hs. 974: 271. Bernays must have gotten it well before the time of his being expelled from Göttingen on the basis of the racial laws in April 1933. (shrink)

As the author of these columns describing cutting edge physics and astronomy, I get quite a few letters and E-mail from readers who are more interested in “over-the-edge physics and astronomy”. One recurring theme is various alternatives to the standard model of Big Bang cosmology. Perhaps the universe is not expanding; it’s just that light “gets tired” on its path from far away and loses some of its energy. Perhaps quasars are closer than we think, particularly since some of (...) them appear to be linked to closer galaxies. Perhaps relativity is wrong, and it’s the speed of light that is different in different parts of the universe or changing with time. Perhaps quasars are the tailpipes of nearby alien spaceships, and they have such large red shifts because we only see them when they are moving away from us. And so on…. (shrink)

The "standard account" of Wittgenstein’s relations with the Vienna Circle is that the early Wittgenstein was a principal source and inspiration for the Circle’s positivistic and scientific philosophy, while the later Wittgenstein was deeply opposed to the logical empiricist project of articulating a "scientific conception of the world." However, this telegraphic summary is at best only half-true and at worst deeply misleading. For it prevents us appreciating the fluidity and protean character of their philosophical dialogue. In retrospectively attributing clear-cut positions (...) to Wittgenstein and his interlocutors, it is very easy to read back our current understanding of familiar distinctions into a time when those terms were used in a much more open-ended way. The paper aims to to provide a broader perspective on this debate, starting from the protagonists’ understanding of their respective positions. Too often, the programmatic statements about the nature of their work that are repeated in manifestoes, introductions, and elementary textbooks have occupied center stage in the subsequent secondary literature. Consequently, I focus on a detailed examination of a turning point in their relationship. That turning point is Wittgenstein's charge, in the summer of 1932, that a recently published paper of Carnap's, "Physicalistic Language as the Universal Language of Science", made such extensive and unacknowledged use of Wittgenstein's own ideas that Wittgenstein would, as he put it in a letter to Schlick, "soon be in a situation where my own work shall be considered merely as a reheated version or plagiarism of Carnap’s." While the leading parties in this dispute shared a basic commitment to the primacy of physicalistic language, and the view that all significant languages are translatable, there was a remarkable lack of mutual understanding between them, and deep disagreement about the nature of the doctrines they disputed. Three quarters of a century later, we are so much more conscious of the differences that separated them than the points on which they agreed that it takes an effort of historical reconstruction to appreciate why Wittgenstein once feared that his own work would be regarded as a pale shadow of Carnap’s. (shrink)

Rooting, defined as a spectator’s demonstrative encouragement of a contestant’s effort, ideally has the morally positive aspects of benevolent concern and helpfulness but in practice strains against reasonable standards of conduct by being rude, excessively biased, exploitative, fanatical, and superstitious. Rooting may activate an atavistic, morally cogent sense of fighting for one’s group that is at odds with the universalism of civilized morality. The ‘merely play’ excuse can cut both ways, deflecting moral objections but also removing moral credit from rooting. (...) Although rooting is often not humane, humane rooting can occur and is supported by humane commentary by sports participants, broadcasters, and journalists. Humane rooting supports the premise of benevolence theories (Mengzi, Hutcheson) that morally ideal benevolence has a foothold in an innate general benevolence – seen in this area especially in benevolence toward efforts. Being partisan, excited, and demonstrative, rooters cannot perfectly embody ‘universal calm benevolence’, but they can consciously minimize the inhumane aspects of rooting and achieve a more fully prosocial satisfaction. (shrink)

Final value accrues to objects that are good for their own sakes, while instrumental value accrues to objects that are good for the sake of their effects. The following paper aims to show that this distinction cuts across some surprising areas of the evaluative domain. This means that there may be some unexpected types of value that can come in a final or instrumental form. The argument proceeds by looking at two prominent types of value, namely kind-value and personal value. (...) The former accrues to objects that are good as the kinds of things that they are, while the latter accrues to objects that are good for someone. Substantive examples are offered in support of the idea that these types of value can come in final or instrumental form. The substantive examples are then given additional support by considering the structure and behavior of fitting attitudes. (shrink)

Nonmonotonic conditionals (A |∼ B) are formalizations of common sense expressions of the form “if A, normally B”. The nonmonotonic conditional is interpreted by a “high” coherent conditional probability, P(B|A) > .5. Two important properties are closely related to the nonmonotonic conditional: First, A |∼ B allows for exceptions. Second, the rules of the nonmonotonic system p guiding A |∼ B allow for withdrawing conclusions in the light of new premises. This study reports a series of three experiments on reasoning (...) with inference rules about nonmonotonic conditionals in the framework of coherence. We investigated the cut, and the right weakening rule of system p. As a critical condition, we investigated basic monotonic properties of classical (monotone) logic, namely monotonicity, transitivity, and contraposition. The results suggest that people reason nonmonotonically rather than monotonically. We propose nonmonotonic reasoning as a competence model of human reasoning. (shrink)

This fascinating and timely volume explores current thinking on vital topics in moral psychology, spanning the diverse disciplines that contribute to the field. Academics from cognitive science, evolutionary biology, anthropology, philosophy, and political science address ongoing and emerging questions aimed at understanding the thought processes and behaviors that underlie our moral codes-and our transgressions. Cross-cutting themes speak to individual, interpersonal, and collective morality in such areas as the development of ethical behavior, responses to violations of rules, moral judgments in (...) the larger discourse, and universal versus specific norms. This wide-angle perspective also highlights the implications of moral psychology research for policy and justice, with cogent viewpoints from: Philosophy: empiricism and normative questions, moral relativism. Evolutionary biology: theories of how altruism and moral behavior evolved. Anthropology: common moral values seen in ethnographies from different countries. Cognitive and neural sciences: computational models of moral systems and decision-making. Political science: politics, governance, and moral values in the public sphere. Advice on moral psychology research-and thoughts about its future-from prominent scholars. With the goal of providing a truly multidisciplinary forum for moral psychology, this volume is sure to spark conversations across disciplines and advance the field as a whole. Sampling the breadth and depth of an equally expansive and transformative field, Moral Psychology: A Multidisciplinary Guide will find an engaged audience among psychologists, philosophers, evolutionary biologists, anthropologists, political scientists, neuroscientists, lawyers, and policymakers, as well as a more general audience interested better understanding the complexity of moral psychology research. (shrink)

In Frogs Aristophanes presents the comic katabasis of Dionysus, whose quest is to bring back the recently deceased Euripides and restore him to the Athenian literary scene. In the prologue Dionysus and his slave, Xanthias, seek out Heracles and ask his advice about the journey below. After some comic play, as they consider various short-cuts, Heracles finally gives Dionysus a serious lesson in Underworld geography . The various items on this itinerary – Charon, terrifying beasts, filth and excrement, sinners, μσται (...) – are all encountered on Dionysus' journey, each transformed for humorous effect. Dionysus crosses the lake on Charon's barque, but is forced to row . At this point we have the introduction of the off-stage chorus that gives the play its name. In what appears to be a kind of false parodos Dionysus engages in a metrical tug-of-war with the frogs that finally spoils his rowing rhythm. After disembarking, he is joined by Xanthias, who was forced to walk around the lake, and they find themselves in the place of σκτος κα βρβορος , where they see the miscreants . In place of εις and θηρα μυρα δειτατα , our heroes are terrified by the figure of Empousa, who is seen by Xanthias alone . When Empousa is gone, there appears the chorus of initiates, whose song constitutes the parodos. (shrink)

Applying Thomas Aquinas’s account of the intellectual virtue of art to teaching yields valuable results both for those who wish to understand teaching better and those looking for models of the approach to virtue epistemology Roberts and Wood call “regulative.” To vindicate that claim, this article proceeds in four steps: First, I introduce Thomas’s taxonomy of the intellectual virtues in light of a pair of distinctions between practical and speculative knowledge and between immanent and transient operations. In the second section, (...) I consider teaching’s relation to each of Thomas’s intellectual virtues and argue that it belongs most properly to art. Next, I describe Thomas’s taxonomy of art by distinguishing among four cross-cutting categories that characterize species of that virtue. Finally, I outline an account of the art of teaching that treats it, with respect to those categories, as performative, deliberative, cooperative, and intersubjective. (shrink)

Applying Thomas Aquinas’s account of the intellectual virtue of art to teaching yields valuable results both for those who wish to understand teaching better and those looking for models of the approach to virtue epistemology Roberts and Wood call “regulative.” To vindicate that claim, this article proceeds in four steps: First, I introduce Thomas’s taxonomy of the intellectual virtues in light of a pair of distinctions between practical and speculative knowledge and between immanent and transient operations. In the second section, (...) I consider teaching’s relation to each of Thomas’s intellectual virtues and argue that it belongs most properly to art. Next, I describe Thomas’s taxonomy of art by distinguishing among four cross-cutting categories that characterize species of that virtue. Finally, I outline an account of the art of teaching that treats it, with respect to those categories, as performative, deliberative, cooperative, and intersubjective. (shrink)

Following on from British Scientists of the Nineteenth Century, this volume covers six eminent British scientists whose work and personality have not receded into the same depth of perspective as their predecessors of the Nineteenth Century, but the tremendous changes following the two world wars have already cut them off sharply from this generation.

In lieu of an abstract, here is a brief excerpt of the content:Operating Through HatredAndrew G. Shuman“You’re not cutting my ***ing neck. The cancer is in my ***ing mouth.”While many patient encounters are memorable, Mr. K’s introduction to the head and [End Page 20] neck surgical oncology clinic is indelibly imprinted into the minds of all of the clinicians present on that certain autumn morning. This was, quite simply, a man who resonated hate. He was rude and disruptive. He (...) insisted on an expedited workup “without any waiting.” He questioned the ethnicity and nationality of his care providers. He told me, in no uncertain terms, that he did not appreciate my Jewish heritage—the swastika tattooed on his bicep underscored the point. He bragged about his recent incarceration for armed robbery. While my colleagues and I were tempted to simply refuse to assume his care, Mr. K had a bad problem—his recurrent tongue cancer required a major operation in order to offer him any hope for cure.Mr. K initially received an abbreviated course of radiation at an outside institution, which was limited by his non–compliance. While one might debate the wisdom of this decision in retrospect—in general, surgery is preferred for his type of tumor—the die was already cast. A heroic attempt at surgical salvage was now his only curative option. He previously sought care elsewhere... only to be fired by this original surgeon when Mr. K physically threatened him in the outpatient office during preoperative consultation. [It was the doctor’s fault for insulting him in the first place, Mr. K maintained... and no charges were filed.] We were, indeed, his last resort. Other than his recurrent cancer, Mr. K was robust; he was in his sixth decade, physically fit, and on the whole, fairly healthy. In the classic surgical lexicon, he was a reasonable surgical candidate. But was it reasonable to operate on such a person?I remember thinking, at the time, about our obligation to care for such an individual. Of course, being a medical professional carries with it many obligations, including a judicious assumption of personal risk. And, working in a tertiary care center begets the responsibility to assist referring clinicians in the management of difficult cases. Although professional obligations certainly have their limits, defining their bounds is decidedly more difficult. Paramount is creating an atmosphere of mutual trust and acceptance. Naturally, this was easier said than done in regard to Mr. K.Perhaps against our better judgment, we agreed to operate under the condition that he abide by strict behavioral ground rules, on our terms. We agreed upon the extent of the necessary operation (which indeed involved cutting his ***ing neck, much to his chagrin and reluctant acceptance). Mr. K promised to follow instructions for postoperative care. He assured us that he would not swear or yell (again). And, in the presence of hospital security, who reinforced our institutional policies regarding patient behavior, he guaranteed that he would not be verbally or physically violent or inappropriate, and would not make disparaging comments to other patients or staff. It seemed, at least, that we had an understanding.Needless to say, these rules were broken shortly after he awoke from surgery. I vividly remember being summoned from the OR when he threatened to murder his impressionable and terrified nurse a few days later, who would not acquiesce to his unreasonable demands. From that point onward, hospital security was deployed to his room regularly, and anything resembling a potential weapon was safeguarded. Any semblance of a mutual doctor–patient bond was shattered. At this point, everyone’s goal was simply to get Mr. K home.My visceral reactions to his behavior, while intense, were not unexpected, and fell in line with those of the entire team of clinicians caring for him. His antics brought his healthcare team together in collective unity (and condemnation). However, my surgical colleagues and I also felt somewhat guilty and responsible. While surgeons can choose to assume some degree of inherent personal danger in caring for a violent and angry patient, we also put the safety and soundness of the entire perioperative team in jeopardy, without necessarily seeking their input. But once we had decided to... (shrink)