IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

Se ofrece una posible lectura de la trascendencia levinasiana desde el fenómeno de la responsabilidad, lectura que no es posible desde la lógica de la libertad, sino en cuanto que trascendencia del retorno sin partir de ninguna parte. Esto exige aceptar que la sensibilidad es el punto cero de la situación, con lo que se pone de manifiesto que el hombre, antes de trascender y responder, está encarnado. Por lo tanto, la corporalidad del cuerpo es el hecho desde el cual (...) un sujeto responsable es posible. (shrink)