Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging studies for meta-analysis, or generating new hypotheses. To promote these goals, the ImmPort data repository was created for the broader research community to explore the wide spectrum of clinical and basic research data and associated findings. The ImmPort ecosystem consists of four components–Private Data, Shared Data, Data (...) Analysis, and Resources—for data archiving, dissemination, analyses, and reuse. To date, more than 300 studies have been made freely available through the ImmPort Shared Data portal , which allows research data to be repurposed to accelerate the translation of new insights into discoveries. (shrink)

Medical Ethics, Law and Communication at a Glance presents a succinct overview of these key areas of the medical curriculum. This new title aims to provide a concise summary of the three core, interlinked topics essential to resolving ethical dilemmas in medicine and avoiding medico-legal action. Divided into two sections; the first examines the ethical and legal principles underpinning each medical topic; while the second focuses on communication skills and the importance of good communication. Medical Ethics, Law and Communication at (...) a Glance offers an accessible introduction to the fundamentals of good medical practice, and will provide indispensable support for undergraduate medical students and nurses, as well as newly qualified healthcare professionals. (shrink)

According to the PubMed resource from the U.S. National Library of Medicine, over 750,000 scientific articles have been published in the ~5000 biomedical journals worldwide in the year 2007 alone. The vast majority of these publications include results from hypothesis-driven experimentation in overlapping biomedical research domains. Unfortunately, the sheer volume of information being generated by the biomedical research enterprise has made it virtually impossible for investigators to stay aware of the latest findings in their domain of interest, let alone to (...) be able to assimilate and mine data from related investigations for purposes of meta-analysis. While computers have the potential for assisting investigators in the extraction, management and analysis of these data, information contained in the traditional journal publication is still largely unstructured, free-text descriptions of study design, experimental application and results interpretation, making it difficult for computers to gain access to the content of what is being conveyed without significant manual intervention. In order to circumvent these roadblocks and make the most of the output from the biomedical research enterprise, a variety of related standards in knowledge representation are being developed, proposed and adopted in the biomedical community. In this chapter, we will explore the current status of efforts to develop minimum information standards for the representation of a biomedical experiment, ontologies composed of shared vocabularies assembled into subsumption hierarchical structures, and extensible relational data models that link the information components together in a machine-readable and human-useable framework for data mining purposes. (shrink)

Mental representations remain the central posits of psychology after many decades of scrutiny. However, there is no consensus about the representational format(s) of biological cognition. This paper provides a survey of evidence from computational cognitive psychology, perceptual psychology, developmental psychology, comparative psychology, and social psychology, and concludes that one type of format that routinely crops up is the language-of-thought (LoT). We outline six core properties of LoTs: (i) discrete constituents; (ii) role-filler independence; (iii) predicate–argument structure; (iv) logical operators; (v) inferential (...) promiscuity; and (vi) abstract content. These properties cluster together throughout cognitive science. Bayesian computational modeling, compositional features of object perception, complex infant and animal reasoning, and automatic, intuitive cognition in adults all implicate LoT-like structures. Instead of regarding LoT as a relic of the previous century, researchers in cognitive science and philosophy-of-mind must take seriously the explanatory breadth of LoT-based architectures. We grant that the mind may harbor many formats and architectures, including iconic and associative structures as well as deep-neural-network-like architectures. However, as computational/representational approaches to the mind continue to advance, classical compositional symbolic structures – that is, LoTs – only prove more flexible and well-supported over time. (shrink)

Philosophical Issues, Volume 30, Issue 1, Page 273-292, October 2020.

At least since Aristotle’s famous 'sea-battle' passages in On Interpretation 9, some substantial minority of philosophers has been attracted to the doctrine of the open future--the doctrine that future contingent statements are not true. But, prima facie, such views seem inconsistent with the following intuition: if something has happened, then (looking back) it was the case that it would happen. How can it be that, looking forwards, it isn’t true that there will be a sea battle, while also being true (...) that, looking backwards, it was the case that there would be a sea battle? This tension forms, in large part, what might be called the problem of future contingents. A dominant trend in temporal logic and semantic theorizing about future contingents seeks to validate both intuitions. Theorists in this tradition--including some interpretations of Aristotle, but paradigmatically, Thomason (1970), as well as more recent developments in Belnap, et. al (2001) and MacFarlane (2003, 2014)--have argued that the apparent tension between the intuitions is in fact merely apparent. In short, such theorists seek to maintain both of the following two theses: (i) the open future: Future contingents are not true, and (ii) retro-closure: From the fact that something is true, it follows that it was the case that it would be true. It is well-known that reflection on the problem of future contingents has in many ways been inspired by importantly parallel issues regarding divine foreknowledge and indeterminism. In this paper, we take up this perspective, and ask what accepting both the open future and retro-closure predicts about omniscience. When we theorize about a perfect knower, we are theorizing about what an ideal agent ought to believe. Our contention is that there isn’t an acceptable view of ideally rational belief given the assumptions of the open future and retro-closure, and thus this casts doubt on the conjunction of those assumptions. (shrink)

Moving from a purely religious rebirth to works grounded in a personal philosophy or aesthetic vocation, the autobiographies considered in this book stand as episodes in a genealogy of conversion.

Uitgave ter gelegenheid van de vierhonderdste geboortedag van de Nederlandse jurist, diplomaat en schrijver Hugo de Groot (1583-1645).

This book launches a sustained defense of a radical interpretation of the doctrine of the open future. Patrick Todd argues that all claims about undetermined aspects of the future are simply false.

The text includes fragments of his work that have never before been translated.

Most definitions of radical emergentism characterize it epistemologically. This leads to misunderstandings and makes it hard to assess the doctrine's metaphysical worth. This paper puts forward purely metaphysical characterizations of emergentism and property emergence. It explores the nature of the necessitation relation between base and emergent and argues that emergentism entails a Humean account of causation and related relations. Then it presents arguments against emergentism, both as a wider metaphysic and as an account of consciousness. These maintain that emergentism makes (...) implausible claims about how the world works. The paper also stresses the doctrine's contemporary relevance: most current property dualists endorse views effectively identical to classical emergentism less its historical commitment to novel emergent forces. (shrink)

Perceptual systems respond to proximal stimuli by forming mental representations of distal stimuli. A central goal for the philosophy of perception is to characterize the representations delivered by perceptual systems. It may be that all perceptual representations are in some way proprietarily perceptual and differ from the representational format of thought (Dretske 1981; Carey 2009; Burge 2010; Block ms.). Or it may instead be that perception and cognition always trade in the same code (Prinz 2002; Pylyshyn 2003). This paper rejects (...) both approaches in favor of perceptual pluralism, the thesis that perception delivers a multiplicity of representational formats, some proprietary and some shared with cognition. The argument for perceptual pluralism marshals a wide array of empirical evidence in favor of iconic (i.e., image-like, analog) representations in perception as well as discursive (i.e., language-like, digital) perceptual object representations. (shrink)

Reliabilism—the view that a belief is justified iff it is produced by a reliable process—is often characterized as a form of consequentialism. Recently, critics of reliabilism have suggested that since it is a form of consequentialism, reliabilism condones a variety of problematic trade-offs involving cases where someone forms an epistemically deficient belief now that will lead her to more epistemic value later. In the present paper, we argue that the relevant argument against reliabilism fails because it equivocates. While there is (...) a sense in which reliabilism is a kind of consequentialism, it is not of a kind on which we should expect problematic trade-offs. (shrink)

Dispositionalism about belief has had a recent resurgence. In this paper we critically evaluate a popular dispositionalist program pursued by Eric Schwitzgebel. Then we present an alternative: a psychofunctional, representational theory of belief. This theory of belief has two main pillars: that beliefs are relations to structured mental representations, and that the relations are determined by the generalizations under which beliefs are acquired, stored, and changed. We end by describing some of the generalizations regarding belief acquisition, storage, and change.

ABSTRACTThis paper provides a naturalistic account of inference. We posit that the core of inference is constituted by bare inferential transitions, transitions between discursive mental representations guided by rules built into the architecture of cognitive systems. In further developing the concept of BITs, we provide an account of what Boghossian [2014] calls ‘taking’—that is, the appreciation of the rule that guides an inferential transition. We argue that BITs are sufficient for implicit taking, and then, to analyse explicit taking, we posit (...) rich inferential transitions, which are transitions that the subject is disposed to endorse. (shrink)

Management and Morality provides a comprehensive and accessible overview of the moral and ethical dimension to organizational and individual behavior, while adding an original, developmental perceptive. Management and Morality combines organizational theory and behavior with approaches to organizational and individual development. The first two sections of the book, Ethical Thinking and Management Practice, and Moral Issues in Organizations, provide a clear and thorough coverage of these areas relevant to ethical behavior in and of organizations. On this basis, the third section, (...) A Developmental Perspective, develops a new approach to ethical development of organizations and individuals concerned with the improvement of organizational structures, processes, and practices so as to allow for individual morality and individual moral behavior. Rich in its coverage of the field and variety of ideas, Management and Morality will be essential reading to students and academics in management, business and organizational ethics, organizational behavior and development, and organizational sociology. (shrink)

Most theories of concepts take concepts to be structured bodies of information used in categorization and inference. This paper argues for a version of atomism, on which concepts are unstructured symbols. However, traditional Fodorian atomism is falsified by polysemy and fails to provide an account of how concepts figure in cognition. This paper argues that concepts are generative pointers, that is, unstructured symbols that point to memory locations where cognitively useful bodies of information are stored and can be deployed to (...) resolve polysemy. The notion of generative pointers allows for unresolved ambiguity in thought and provides a basis for conceptual engineering. (shrink)

I argue that some perceptual experiences are vague. To do so, I identify a characteristic feature of vagueness and show that some perceptual experiences have this feature. These include blurry experiences, experiences of color under low lighting, and experiences of number, as in the case of the speckled hen. The conclusion that these experiences are vague has two noteworthy consequences. First, it presses us to see whether and how existing theories of vagueness can be extended to perceptual experience. Second, it (...) sheds light on several puzzles in the philosophy of perception. (shrink)

It is widely accepted that there is what has been called a non-hypocrisy norm on the appropriateness of moral blame; roughly, one has standing to blame only if one is not guilty of the very offence one seeks to criticize. Our acceptance of this norm is embodied in the common retort to criticism, “Who are you to blame me?”. But there is a paradox lurking behind this commonplace norm. If it is always inappropriate for x to blame y for a (...) wrong that x has committed, then all cases in which x blames x (i.e. cases of self-blame) are rendered inappropriate. But it seems to be ethical common-sense that we are often, sadly, in position (indeed, excellent, privileged position) to blame ourselves for our own moral failings. And thus we have a paradox: a conflict between the inappropriateness of hypocritical blame, and the appropriateness of self-blame. We consider several ways of resolving the paradox, and contend none is as defensible as a position that simply accepts it: we should never blame ourselves. In defending this startling position, we defend a crucial distinction between self-blame and guilt. (shrink)

In information societies, operations, decisions and choices previously left to humans are increasingly delegated to algorithms, which may advise, if not decide, about how data should be interpreted and what actions should be taken as a result. More and more often, algorithms mediate social processes, business transactions, governmental decisions, and how we perceive, understand, and interact among ourselves and with the environment. Gaps between the design and operation of algorithms and our understanding of their ethical implications can have severe consequences (...) affecting individuals as well as groups and whole societies. This paper makes three contributions to clarify the ethical importance of algorithmic mediation. It provides a prescriptive map to organise the debate. It reviews the current discussion of ethical aspects of algorithms. And it assesses the available literature in order to identify areas requiring further work to develop the ethics of algorithms. (shrink)

Remontant aux sources vives de la sagesse, Patrick Mandala a choisi de confronter les textes de l'Antiquité grecque et des sages de l'Inde. Les correspondances entre ces deux philosophies sont nombreuses, riches et fécondes. Le texte grec est mis en regard avec plusieurs textes indiens. A plusieurs époques, dans sa quête de la connaissance de soi, la pensée grecque a rejoint la sagesse indienne. Cette rencontre est un message intemporel et universel. Autant de textes qui amènent la réflexion et (...) la méditation la plus profonde qui répondent aux trois grandes questions de l'humanité : "D'où venons-nous? Qui sommes-nous? Où allons-nous?". (shrink)

L'économie politique, qui ose se constituer en science vers le milieu du XVIIIe siècle, n'a cessé de passionner Voltaire. S'il n'est pas un théoricien de l'économie, il en est un observateur attentif et critique, et un acteur même de l'économie pratique: financier avisé, il construit, au fil de sa longue vie, l'une des grandes fortunes du royaume. Patrick Neiertz présente ici la première étude d'ensemble des idées économiques de Voltaire en analysant l'application expérimentale qu'il fait des théories de son (...) temps (Melon, Quesnay, Turgot, Adam Smith...) dans sa propre pratique de consommateur, de gestionnaire de ses biens, enfin, d'entrepreneur. Se font jour les réactions du patriarche de Ferney aux conceptualisations économiques en formation: sur les finances publiques, sur la consommation des biens superflus, sur l'agriculture, sur l'avenir de l'industrie, sur la liberté du commerce. Il entretient auprès de ses correspondants ou lecteurs ce flux d'influence à sa manière d'écrivain, faite d'érudition et d'ironie, et à sa manière d'intellectuel engagé, en faveur de la liberté de faire comme de dire. Les idées de Voltaire sur la dette publique, sur l'assiette fiscale, sur le plein emploi, et sur le rôle de l'Etat ont une singulière modernité au siècle actuel. Son autorité n'est pas seulement celle d'un philosophe des Lumières. Elle est aussi celle d'un praticien de l'économie appliquée, 'chose qui n'est pas ordinaire aux gens de lettres'. (shrink)

The question of whether perception is encapsulated from cognition has been a major topic in the study of perception in the past decade. One locus of debate concerns the role of attention. Some theorists argue that attention is a vehicle for widespread violations of encapsulation; others argue that certain forms of cognitively driven attention are compatible with encapsulation, especially if attention only modulates inputs. This paper argues for an extreme thesis: no effect of attention, whether on the inputs to perception (...) or on perceptual processing itself, constitutes a violation of the encapsulation of perception. (shrink)

Short‐term memory in vision is typically thought to divide into at least two memory stores: a short, fragile, high‐capacity store known as iconic memory, and a longer, durable, capacity‐limited store known as visual working memory (VWM). This paper argues that iconic memory stores icons, i.e., image‐like perceptual representations. The iconicity of iconic memory has significant consequences for understanding consciousness, nonconceptual content, and the perception–cognition border. Steven Gross and Jonathan Flombaum have recently challenged the division between iconic memory and VWM by (...) arguing against the idea of capacity limits in favor of a flexible resource‐based model of short‐term memory. I argue that, while VWM capacity is probably governed by flexible resources rather than a sharp limit, the two memory stores should still be distinguished by their representational formats. Iconic memory stores icons, while VWM stores discursive (i.e., language‐like) representations. I conclude by arguing that this format‐based distinction between memory stores entails that prominent views about consciousness and the perception–cognition border will likely have to be revised. (shrink)

Perceptual representations pick out individuals and attribute properties to them. This paper considers the role of perceptual attribution in determining or guiding perceptual reference to objects. We consider three extant models of the relation between perceptual attribution and perceptual reference–all attribution guides reference, no attribution guides reference, or a privileged subset of attributions guides reference–and argue that empirical evidence undermines all three. We then defend a flexible-attributives model, on which the range of perceptual attributives used to guide reference shifts adaptively (...) with context. This model underscores the remarkable and dynamic intelligence of our perceptual capacities. We elucidate implications of the model for the boundary between perception and propositional thought. (shrink)

I want to suggest that it would be bad if compatibilism were true, and that this gives us good reason to think that it isn't. This is, you might think, an outlandish argument, and the considerable burden of this paper is to convince you otherwise. There are two key elements at stake in this argument. The first is that it would be ‐ in a distinctive sense to be explained ‐ bad if compatibilism were true. The thought here is that (...) compatibilism ultimately presents us with a picture on which, in principle, powerful manipulators can effectively guarantee that finite moral agents should become blameworthy. To my mind, this isn't just false ‐ though I think that it is ‐ it is also such that it would be bad (unfortunate, undesirable…) if it were true. The second is that the fact that it would be ‐ in this sense ‐ bad if true gives us reason to think that it isn't. It may be bad that there is no afterlife. But that, in itself, hardly gives us reason to think that there is an afterlife. That is true, but ‐ as others before me have suggested ‐ when the object of the relevant badness is morality itself, the inference seems secure. A more general aim of the paper is to investigate the nature of this very form of argument in itself, and I compare my argument (inter alia) to a recent argument from Sayre–McCord against the possibility of genuine moral dilemmas. (shrink)

According to one important proposal, the difference between perception and cognition consists in the representational formats used in the two systems (Carey, 2009; Burge, 2010; Block, 2014). In particular, it is claimed that perceptual representations are iconic, or image-like, while cognitive representations are discursive, or language-like. Taking object perception as a test case, this paper argues on empirical grounds that it requires discursive label-like representations. These representations segment the perceptual field, continuously pick out objects despite changes in their features, and (...) abstractly represent high-level features, none of which appears possible for purely iconic representations. (shrink)

Incompatibilism about responsibility and determinism is sometimes directly construed as the thesis that if we found out that determinism is true, we would have to give up the reactive attitudes. Call this "the consequence". I argue that this is a mistake: the strict modal thesis does not entail the consequence. First, some incompatibilists (who are also libertarians) may be what we might call *resolute responsibility theorists* (or "flip-floppers"). On this view, if we found out that determinism is true, this would (...) not be to find out that no one is responsible; instead, what this would suggest is that incompatibilism is after all false. Second, some incompatibilists may instead deny the claim that if we found out that no one deserves the reactiveattitudes, we would have to give up the reactive attitudes. Call this position *innocent incompatibilism*. I explore several different reasons why the fact that no one deserves the reactive attitudes likely does not translate into a requirement for us to give up the reactive attitudes. The upshot: incompatibilism may be practically irrelevant, even if true. (shrink)

According to a classic but nowadays discarded philosophical theory, perceptual experience is a complex of nonconceptual sensory states and full-blown propositional beliefs. This classical dual-component theory of experience is often taken to be obsolete. In particular, there seem to be cases in which perceptual experience and belief conflict: cases of known illusions, wherein subjects have beliefs contrary to the contents of their experiences. Modern dual-component theories reject the belief requirement and instead hold that perceptual experience is a complex of nonconceptual (...) sensory states and some other sort of conceptual state. The most popular modern dual-component theory appeals to sui generis propositional attitudes called ‘perceptual seemings’. This article argues that the classical dual-component theory has the resources to explain known illusions without giving up the claim that the conceptual components of experience are beliefs. The classical dual-component view, though often viewed as outdated and implausible, should be regarded as a serious contender in contemporary debates about the nature of perceptual experience. (shrink)

It is an orthodoxy in cognitive science that perception can occur unconsciously. Recently, Hakwan Lau, Megan Peters and Ian Phillips have argued that this orthodoxy may be mistaken. They argue that many purported cases of unconscious perception fail to rule out low degrees of conscious awareness while others fail to establish genuine perception. This paper presents a case of unconscious perception that avoids these problems. It also advances a general principle of ‘phenomenal coherence’ that can insulate some forms of evidence (...) for unconscious perception from the methodological critiques of Lau, Peters and Phillips. (shrink)

In this paper we introduce canonical extensions of partially ordered sets and monotone maps and a corresponding discrete duality. We then use these to give a uniform treatment of completeness of relational semantics for various substructural logics with implication as the residual(s) of fusion.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.2 (2001) 292-294 [Access article in PDF] Secada, Jorge. Cartesian Metaphysics: The Scholastic Origins of Modern Philosophy. New York: Cambridge University Press, 2000. Pp. xii + 333. Cloth, $59.95. Descartes scholars can welcome this book. Secada supports trends in scholarship that criticize seeing Descartes as merely an anti-skeptical foundationalist, and he challenges many prominent interpretations of Descartes's metaphysics. In addition, Secada helpfully references (...) Scholastic sources to provide context for Descartes's views. This book is also valuable for philosophers in contemporary metaphysics and epistemology. Secada uses the tools and idiom of analytic philosophy to explain and defend Descartes, and he is sympathetic to Descartes's project, even if he grants that aspects of it "are difficult to articulate clearly and convincingly" (174).The book's central theme is the contrast between Descartes's "essentialism" and the "existentialism" of Scholastics. Secada explains the distinction as follows: "Essentialism (existentialism) is the doctrine, first, that one cannot know the existence (essence) of any substance without first knowing its essence (existence), and, secondly, that one can know the essence (existence) of some substance without knowing its existence (essence)" (8). Cartesian Metaphysics interprets Descartes's corpus as a defense of essentialism in the light of Scholastic existentialism.The first three chapters set the stage. Chapter One distinguishes essentialism from existentialism. Chapter Two provides historical background necessary to understand the role of Scholasticism in Descartes's thought. Chapter Three discusses the role of Christian Platonism in both Descartes and the Scholastics, especially their shared Augustinian presupposition that knowledge of essences is of "how things are in themselves" (56).The next three chapters discuss the metaphysical status of ideas. In Chapter Four, Secada contrasts Descartes's "immanent" theory according to which "the immediate objects of ideas must exist in the mind" (85) with the "realist Scholastic" theory that "takes mental acts to be immediately directed towards things" (83). In Chapter Five, this account is applied to an interpretation of the Second Meditation as a defense of intellectualist essentialism against Scholastics and empiricists. "Contrary to the Scholastics and other empiricists, Descartes attributed to the intellect and not to the senses the power to reach the world of substances existing outside of the inner theatre of the mind" (116). Through comparing Descartes with Suarez and Gassendi, Secada argues that all the proofs of existence in the Meditations, including for the cogito, argue from [End Page 292] knowledge of essence to knowledge of existence. Chapter Six turns to Descartes's proofs for the existence of God. According to Secada, even for a posteriori proofs, knowledge of God's existence depends on knowledge of his essence.The last three chapters examine Descartes's theory of substance. Chapter Seven reconstructs Descartes's distinction between substances and properties. A substance is something that "exists without inhering" and "exists uncaused" (185). Secada discusses the nature of substance, how substances other than God can be "uncaused," and the plausibility of Descartes's sharp distinction between substances and properties. The chapter ends by arguing that Descartes's doctrine about the relationship between substances and properties inadvertently "heralds Spinoza's pantheism" (185). Chapter Eight examines real and essential properties in Cartesian metaphysics in contrast to Suarez and Fonseca, and ends with a partial defense of Descartes's ontological argument. Chapter Nine offers a detailed discussion of two fundamental substances in Descartes's metaphysics: body and mind. Secada argues that Descartes offers no satisfactory explanations of body, mind, or the relationship between the two.As is clear from this brief summary, Cartesian Metaphysics is a rich book. It presents important historical details without endless irrelevant details (see especially the sketch of Descartes's Scholastic background on 27-33). The exegetical arguments make strong cases for new interpretations of Descartes. Secada effectively shows that Descartes is more concerned with metaphysics than with refuting skepticism. Comparisons with Suarez and Fonseca shed new light on Cartesian arguments. Reconstructions of Cartesian arguments even tempt one to take Descartes seriously in contemporary metaphysics. And the criticisms of Descartes are thought-provoking.Unfortunately, the... (shrink)

Primeaux and Stieber clearly articulate that good ethics maximize profits. The authors show that in the long run business must operate within the value systems of a society.

Epistemic Consequentialism Consequentialism is the view that, in some sense, rightness is to be understood in terms conducive to goodness. Much of the philosophical discussion concerning consequentialism has focused on moral rightness or obligation or normativity. But there is plausibly also epistemic rightness, epistemic obligation, and epistemic normativity. Epistemic rightness is often denoted with talk … Continue reading Consequentialism Epistemic →.