The mode and timing of germ-cell specification has been studied in diverse organisms, however, the molecular mechanism regulating germ-cell-fate determination remains to be elucidated. In some model organisms, maternal germ-cell determinants play a key role. In mouse embryos, some germ-line-specific gene products exist as maternal molecules and play critical roles in a pluripotential cell population at preimplantation stages. From those cells, primordial germ cells (PGCs) are specified by extracellular signaling mediated by tissue, as well as cell–cell interaction during gastrulation. Thus, (...) establishment of germ-cell lineage in mammalian embryos appears to be regulated by a multistep process, including formation and maintenance of a pluripotential cell population, as well as specification of PGCs. PGCs can be generated from pluripotential embryonic stem (ES) cells in a simple monolayer culture in which tissue interaction does not occur. This raises the possibility that ES cells, as well as, possibly, pluripotential cells in preimplantation embryos, are more closely related to the PGC precursors than pluripotential cells after implantation. BioEssays 27:136–143, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Many scholars have claimed that the psychology of the indirect passions in the Treatise is meant to capture how we come to regard persons as morally responsible agents. My question is exactly how the indirect passions relate to responsibility. In elucidating Hume’s account of responsibility, scholars have often focused not on the passionate responses themselves, but on their structural features. In this paper, I argue that locating responsibility in the structural features is insufficient to make sense of Hume’s account of (...) responsibility. I argue this on the grounds that without reference to the passions, Hume does not have the resources to distinguish between responsible and non-responsible entities. Instead, I attribute to Hume a distinctive, sympathy-based response-dependent conception of responsibility. (shrink)

In the concluding section of the Book One of the Treatise, Hume confronts radical scepticism about the standards of correct reasoning. According to the naturalistic interpretations, Hume resolves this scepticism by appealing to some psychological facts. A common criticism of this interpretation is that the alleged naturalistic epistemic norm seems to be merely Hume’s report of his psychology, and it remains unclear why this seemingly mere psychological description can provide a principled reason to overcome his scepticism. In this paper, I (...) will argue that Hume’s discussions of the “indirect passions” and social identity provide a constitutivist ground for the naturalistic epistemic standards in the “Conclusion”: being the object of the indirect passions constitutes what kind of person one is, and being the kind of person (philosopher in Hume’s case) gives non-optional reason to pursue certain kinds of reasoning. (shrink)

To articulate their understanding of Hume’s discussion of ‘distinctions of reason’, commentators have often taken what I refer to as a ‘respect-first view’ on resemblance, in which they cat...

Ascidian tadpole larvae, composed of only about 2500 cells, have a primitive nervous system which is derived from the neural plate. The stereotyped cell cleavage pattern and well characterized cell lineage in these animals allow the isolation and culture of identified blastomeres in variable combinations. Ascidian embryos express cell‐type‐specific markers corresponding to their cell fates, even when cultured under cleavage‐arrest by cytochalasin B. This system provides us with a unique opportunity to study the roles of cell lineage and cell contact (...) in early neuronal differentiation in the absence of events associated with complex morphogenesis. In addition, the isolated, cleavage‐arrested blastomeres are ideally suited to electrical recording, permitting the use of ionic channels as specific markers for differentiation. In the cleavage‐arrested embryos, suppression of one type of K+ channel, and induction of two types of Na+ channels, occur following cell contact with the vegetal blastomere. The combination of molecular and electrophysiological analyses on this simple animal system may provide insights into the nature of the cell interactions important in early neurogenesis, both in ascidians and in vertebrates. (shrink)

This paper discusses what constitutes good teaching, taking as its cue the ‘aesthetic’ concept treated in everyday aesthetics and ‘internal good’ accounted by McIntyre. Teaching is viewed as practice, not merely as a basic action, due to its epistemological nature as everyday work. What everyday aesthetics teaches us is that even in the practice of teaching, sensory experiences such as comfort, familiarity, discomfort, ordinariness, etc. can be viewed as aesthetic experience. This kind of aesthetic experience constitute intuition supporting ’good teaching’ (...) that confirmed by examining Dreyfus et al. This ‘good teaching’ sensitivity is not specific to the individual practitioner, but is considered to be an ‘in-practice value (internal good?)’ (McIntyre) shared by the community of practice. From the aesthetic perspective, this value could be called ‘aesthetic value in practice’. In the teaching community of practice, ‘good teaching’ is both ‘beautiful teaching’ and ‘ethically good’ teaching. Teaching should be seen as a relational practice, and for this reason, The Ethico-Aesthetics of Teaching should be constructed. (shrink)

The purpose of the study was twofold: Experiment 1 tested the possibility that the mere recollection of food aroused a state of hunger and that different types of food influenced the state of hunger differently; Experiment 2 tested the possibility that food cues affected altruistic behavior. In Experiment 1, 28 participants reported how hungry they felt before and after their recollection of certain foods. Results suggest that recollection of food increased hunger and that the type of food influenced the degree (...) of hunger = 31.88, p <.001, η2 =.54). In Experiment 2, 63 participants were randomly assigned to one of three recollection conditions: noodles, pudding, and control. Participants in the two conditions described each food in detail; control group participants did not. Participants were then asked how much they would be willing to participate in an ostensible experiment. Results indicate that recollection-induced hunger reduced altruistic behavior = 4.11, p =.021, η2 =.12). Cue reactivity theory and the hierarchy of needs could explain these results. (shrink)

本书针对未成年人道德建设研究普遍缺乏学理性、忽视社会转型的影响和成年人因素等不足,试图从学理上把当今中国未成年人道德建设放在社会转型时期由成年人与未成年人所构成的代际关系框架中加以审视和反思,力求还原 中西文化中未成年人道德境况的历史本相,揭开当代未成年人双重道德境遇的现实面纱.

In lieu of an abstract, here is a brief excerpt of the content:Editors’ IntroductionElizabeth S. Radcliffe and Mark G. SpencerThis issue opens with the winning essay in the Second Annual Hume Studies Essay Prize competition: “Hume’s Passion-Based Account of Moral Responsibility,” by Taro Okamura. Dr. Okamura’s essay was chosen as the 2022 winner from among papers submitted by emerging scholars from August 2021 through July 2022. Dr. Okamura received his Ph.D. from the University of Alberta in 2022. (...) He is currently a Japan Society for the Promotion of Science Research Fellow at the Graduate School of Humanities and Sociology at the University of Tokyo.The competition for the Third Prize closed on August 1, 2023, and the winner will be announced in our next issue. Please see the Call for Papers for the fourth competition in the back of this issue. The competition is open to authors ten or fewer years from the Ph.D.A special aspect of our current issue is its spotlight on Hume’s Essays, Moral, Political, and Literary. Renowned Dutch Enlightenment scholar, Frederic L. van Holthoon, presents his analysis of some of Hume’s essays, which he argues constitute Hume’s project of writing on political, or public, issues—a goal he did not get to complete with the Treatise. Also, established Hume scholar Lorne Falkenstein offers an extended review of the newly published Clarendon edition of Hume’s essays, in two volumes (edited by Tom L. Beauchamp and Mark A. Box, with Michael Silverthorne, J. A. W. Gunn, and F. David Harvey).Finally, we want to bring to the attention of our readers that, in fewer than two years, Hume Studies will be marking the 50th anniversary of its first publication. For this event, we are planning a special jubilee issue, 50:1 (April 2025). We hope to include among the unique features of that issue paragraphs or statements from our readers in answer to this query: “Of all of the articles that have been published in Hume Studies over the past 50 years, which one is most noteworthy to you? Why so?” Please see the “Call for Entries” in the back of this issue and on the Hume Studies website. We invite your responses! [End Page 193]Copyright © 2023 Hume Studies... (shrink)