BackgroundStory recall tests have shown variable sensitivity to rate of cognitive decline in individuals with Alzheimer’s disease biomarkers. Although SR tasks are typically scored by obtaining a sum of items recalled, item-level analyses may provide additional sensitivity to change and AD processes. Here, we examined the difficulty and discrimination indices of each item from the Logical Memory SR task, and determined if these metrics differed by recall conditions, story version, lexical categories, serial position, and amyloid status.Methodsn = 1,141 participants from (...) the Wisconsin Registry for Alzheimer’s Prevention longitudinal study who had item-level data were included in these analyses, as well as a subset of n = 338 who also had amyloid positron emission tomography imaging. LM data were categorized into four lexical categories, and by serial position. We calculated difficulty and discriminability/memorability by item, category, and serial position and ran separate repeated measures ANOVAs for each recall condition, lexical category, and serial position. For the subset with amyloid imaging, we used a two-sample t-test to examine whether amyloid positive and amyloid negative groups differed in difficulty or discrimination for the same summary metrics.ResultsIn the larger sample, items were more difficult in the delayed recall condition across both story A and story B. Item discrimination was higher at delayed than immediate recall, and proper names had better discrimination than any of the other lexical categories or serial position groups. In the subsample with amyloid PET imaging, proper names were more difficult for Aβ+ than Aβ−; items in the verb and “other” lexical categories and all serial positions from delayed recall were more discriminate for the Aβ+ group compared to the Aβ− group.ConclusionThis study provides empirical evidence that both LM stories are effective at discriminating ability levels and amyloid status, and that individual items vary in difficulty and discrimination by amyloid status, while total scores do not. These results can be informative for the future development of sensitive tasks or composite scores for early detection of cognitive decline. (shrink)

To commemorate 40 years since the founding of the Journal of Business Ethics, the editors in chief of the journal have invited the editors to provide commentaries on the future of business ethics. This essay comprises a selection of commentaries aimed at creating dialogue around the theme Technology, Megatrends and Work. Of all the profound changes in business, technology is perhaps the most ubiquitous. There is not a facet of our lives unaffected by internet technologies and artificial intelligence. The Journal (...) of Business Ethics established a dedicated section that focuses on Technology and Business Ethics, yet issues related to this phenomenon run right through all the sections. Kirsten Martin, editor of the Technology and Business Ethics section, joins our interim social media editor, Hannah Trittin-UIbrich, to advance a human-centric approach to the development and application of digital technologies that places Business Ethics at centre of the analysis. For Shuili Du, technology is the defining condition for a new era of Corporate Social Responsibility—CSR 3.0—which she defines as “a company’s socially responsible strategies and practices that deal with key ethical and socio-technical issues associated with AI and related technologies on the one hand and leverage the power of AI and related technologies to tackle social and environmental problems on the other hand.” It is not just technologies that are a determining feature of our lives but technology companies, an argument made by Glen Whelan as he examines Big Business and the need for a Big Business Ethics as we try to understand the impact of Big Tech on our post-work world. Indeed, as noted by Ernesto Noronha and Premilla D’Cruz, megatrends in addition to advancement in technologies, namely globalization, the greening of economies, and changes in demographics and migration, are shaping the future for workers in ways previously unimaginable. Contributing to this important debate, Praveen Parboteeah considers the influence of another longstanding but oft overlooked megatrend, the role of religion in the workplace. Given the enormity of the influence of technology and other megatrends in our world, it is not surprising that this essay introduces ground-breaking ideas that speak to the future of business ethics research. (shrink)

Recent reports of CRISPR/Cas9 genome editing in parasitic helminths open up new avenues for research on these dangerous pathogens. However, the complex morphology and life cycles inherent to these parasites present obstacles for the efficient application of CRISPR/Cas9‐targeted mutagenesis. This is especially true with the trematode flukes where only modest levels of gene mutation efficiency have been achieved. Current major challenges in the application of CRISPR/Cas9 for study of parasitic worms thus lie in enhancing gene mutation efficiency and overcoming issues (...) involved in host passage so that mutated parasites survive. Strategies developed for CRISPR/Cas9 studies on Caenorhabditis elegans, protozoa and mammalian cells, including novel delivery methods, the choice of selectable markers, and refining mutation precision represent novel tactics whereby these impediments can be overcome. Furthermore, employing CRISPR/Cas9‐mediated gene drive to interfere with vector transmission represents a novel approach for the control of parasitic worms that is worthy of further exploration. (shrink)

Online crowdsourcing platforms have rapidly become a popular source of data collection. Despite the various advantages these platforms offer, there are substantial concerns regarding not only data validity issues, but also the ethical, societal, and global ramifications arising from the prevalent use of online crowdsourcing platforms. This paper seeks to expand the dialogue by examining both the “internal” aspects of crowdsourcing research practices, such as data quality issues, reporting transparency, and fair compensation, and the “external” aspects, in terms of how (...) the widespread use of crowdsourcing data collection shapes the nature of scientific communities and our society in general. Online participants in research studies are informal workers who provide labor in exchange for remuneration. The paper thus highlights the need for researchers to consider the markedly different political, economic, and socio-cultural characteristics of the Global North and the Global South when undertaking crowdsourcing research involving an international sample; such consideration is crucial for both increasing research validity and mitigating societal inequities. We encourage researchers to scrutinize the value systems underlying this popular data collection research method and its associated ethical, societal, and global ramifications, as well as provide a set of recommendations regarding the use of crowdsourcing platforms. (shrink)

The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing the (...) 5'-flanking region of the human APOE gene . Sequence analysis of this region suggests the presence of two potential NF-B elements. To demonstrate promoter activity, the region was cloned upstream of a promoterless luciferase gene. This segment was able to drive expression of luciferase in transient transfections of human fetal glial cells. Promoter activity was stimulated twofold by A treatment. Pretreatment with double-stranded DNA decoy oligonucleotides against NF-B reduced A stimulation. Deletion and mutagenetic analyses demonstrated that the distal NF-B element was functional and showed a strong DNA-protein complex band in gel shift analysis, similar to that from control NF-B consensus element. An anti-inflammatory and anti-NF-B drug, sodium salicylate, significantly blocked A-induced APOE promoter function. Our data provide evidence that upregulation of APOE by A in astroglial cells is mediated by an NF-B-element present in the 5'-flanking region of the APOE gene. (shrink)

ABSTRACTPeople high in social anxiety experience fear of social situations due to the likelihood of social evaluation. Whereas happy faces are generally processed very quickly, this effect is impaired by high social anxiety. Mouth regions are implicated during emotional face processing, therefore differences in mouth salience might affect how social anxiety relates to emotional face discrimination. We designed an emotional facial expression recognition task to reveal how varying levels of sub-clinical social anxiety related to the discrimination of happy and fearful (...) faces, and of happy and angry faces. We also categorised the facial expressions by the salience of the mouth region. In a sample of 90 participants higher social anxiety was associated with a reduced happy face reaction time advantage. However, this effect was mainly driven by the faces with less salient closed mouths. Our results are... (shrink)

The parables of Jesus have historically been attributed with a plethora of interpretations. The first hearers of the parables of Jesus had native (emic) knowledge of the social realities embedded in the parables told by Jesus, that is, cultural scripts present in the parables that might not be apparent to modern readers. Because of this, the modern reader of a parable might not be aware of all the different cultural scripts in a given parable, especially if these scripts are not (...) specifically mentioned or explained by the gospel narrators. Using the parable of the Prodigal Son as an example, this study argues that there are voices in the parable most probably heard by its first hearers that modern hearers might not be aware of. These ‘muted’ voices not heard by modern readers of the parables often include the voices of women and other minority figures. In this study, a case is made for the possible value that a ‘realistic reading’ of familial parables could bring to the interpretation of the parables.Contribution: It is suggested that this reading can contribute to feminist biblical scholarship’s deconstruction and reconstruction of gender paradigms of Christian theology if the voices of women are ‘exhumed’ from or ‘unhidden’ within, patriarchal and androcentric texts. (shrink)

Monetary intelligence theory asserts that individuals apply their money attitude to frame critical concerns in the context and strategically select certain options to achieve financial goals and ultimate happiness. This study explores the dark side of monetary Intelligence and behavioral economics—dishonesty. Dishonesty, a risky prospect, involves cost–benefit analysis of self-interest. We frame good or bad barrels in the environmental context as a proxy of high or low probability of getting caught for dishonesty, respectively. We theorize: The magnitude and intensity of (...) the relationship between love of money and dishonest prospect may reveal how individuals frame dishonesty in the context of two levels of subjective norm—perceived corporate ethical values at the micro-level and Corruption Perceptions Index at the macro-level, collected from multiple sources. Based on 6382 managers in 31 geopolitical entities across six continents, our cross-level three-way interaction effect illustrates: As expected, managers in good barrels, mixed barrels, and bad barrels display low, medium, and high magnitude of dishonesty, respectively. With high CEV, the intensity is the same across cultures. With low CEV, the intensity of dishonesty is the highest in high CPI entities —the Enron Effect, but the lowest in low CPI entities. CPI has a strong impact on the magnitude of dishonesty, whereas CEV has a strong impact on the intensity of dishonesty. We demonstrate dishonesty in light of monetary values and two frames of social norm, revealing critical implications to the field of behavioral economics and business ethics. (shrink)

Monetary Intelligence theory asserts that individuals apply their money attitude to frame critical concerns in the context and strategically select certain options to achieve financial goals and ultimate happiness. This study explores the bright side of Monetary Intelligence and behavioral economics, frames money attitude in the context of pay and life satisfaction, and controls money at the macro-level and micro-level. We theorize: Managers with low love of money motive but high stewardship behavior will have high subjective well-being: pay satisfaction and (...) quality of life. Data collected from 6586 managers in 32 cultures across six continents support our theory. Interestingly, GDP per capita is related to life satisfaction, but not to pay satisfaction. Individual income is related to both life and pay satisfaction. Neither GDP nor income is related to Happiness. Our theoretical model across three GDP groups offers new discoveries: In high GDP entities, “high income” not only reduces aspirations—“Rich, Motivator, and Power,” but also promotes stewardship behavior—“Budget, Give/Donate, and Contribute” and appreciation of “Achievement.” After controlling income, we demonstrate the bright side of Monetary Intelligence: Low love of money motive but high stewardship behavior define Monetary Intelligence. “Good apples enjoy good quality of life in good barrels.” This notion adds another explanation to managers’ low magnitude of dishonesty in entities with high Corruption Perceptions Index. In low GDP entities, high income is related to poor Budgeting skills and escalated Happiness. These managers experience equal satisfaction with pay and life. We add a new vocabulary to the conversation of monetary intelligence, income, GDP, happiness, subjective well-being, good and bad apples and barrels, corruption, and behavioral ethics. (shrink)

Jannie Pretorius and Michael Von Maltitz have identified some of the most pressing problems in South African education.1 They have argued that the education system is still suffering from the fragmented effects of apartheid and that the postapartheid government is struggling to set schools in motion to provide learners with authentic perspectives on the realities of their existence in a postapartheid South Africa. Naledi Pandor, the country's previous minister of education, painted a rather somber picture of the situation in the (...) Eastern Cape, one of South Africa's nine provinces:In a context in which there is ineffective system response on core obligations, it is very important to isolate those attributes that are .. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

In this essay the authors provide arguments that teaching is an art and that teachers can learn much about their trade from a careful study of the performances of other artists. Artists and teachers have the same basic challenge: in order to be successful, both groups have to obtain and retain peoples’ attention. This also holds for popular music artists. Ten female student teachers specializing in the Pre-school and Foundation phases of schooling (four-to-six-year olds), and six lecturers from the Faculty (...) of Education at the University of the Free State, Bloemfontein, South Africa, participated in a workshop at a local game lodge. During the workshop, videos of ABBA songs and Mamma Mia! The Movie were analyzed and discussed. The theme of the workshop was “Being an Excellent Teacher: Appreciating ABBA.” The 4D-cycle of Appreciative Inquiry– Discover, Dream, Design and Destiny–was used as a methodological framework to identify numerous positive themes with possible classroom applications from the songs and the film. These themes were then connected to educational theory and embedded in the insights of Benny Andersson, Björn Ulvaeus, Judy Cramer and other people involved with ABBA. A reflective report by one student teacher about the impact the workshop had on her views of teaching and an excellent class that she presented is also included. (shrink)

" En écrivant son Traité de l'Interprétation, Aristote a trempé sa plume à l'encre de son esprit! " L'antique remarque de Cassiodore vaut encore aujourd'hui tant la matière étudiée est complexe et le style ramassé. Aristote démonte les mécanismes du langage philosophique, aux confins de la linguistique et de la métaphysique. Il offre à cette occasion des développements fondateurs sur la formulation de la vérité, les règles de mise en contradiction, les propositions universelles, la contingence des jugements sur le futur, (...) ou encore les redoutables énonciations modales. S'appuyant sur ses prédécesseurs, Thomas d'Aquin en rédige un commentaire hautement structuré, reconnu comme l'un des plus explicites. Demeuré cependant inachevé, il est complété par Thomas de Vio, dit Cajetan, un des premiers grands thomistes et maître logicien. C'est de l'ensemble de ces deux parties de commentaires que nous proposons la traduction ; la seconde pour la première fois en langue française. (shrink)

Le P. D. M. De Petter, o.p., fondateur de cette revue dont il assuma la direction jusqu'à sa mort, survenue le 6 avril 1971, publia pendant sa vie divers articles qui ont suscité, à bon droit, l'intérêt du public philosophique. Ces études demeurent cependant fragmentaires par rapport à sa vision philosophique globale, telle qu'elle est exprimée dans ses cours non publiés. Elles ne reçoivent d'ailleurs leur pleine signification qu'à partir de cette vue d'ensemble. Le présent exposé a pour objectif d'initier (...) les lecteurs aux idées maîtresses de cette œuvre. Il n'a par conséquent d'autre prétention que de rendre fidèlement la pensée du P. De Petter. Il s'agit surtout de deux cours, qui sont étroitement liés : l'un d'anthropologie, l'autre de métaphysique. Le premier constitue le fondement du deuxième lequel, à son tour, complète le premier, en sorte que les deux forment une parfaite unité. De Petter révèle à travers ses cours une ligne de pensée très personnelle et originale. Sans doute en était-il conscient et il n'hésita pas à remettre en question toute la philosophie occidentale. Il y décelait une double erreur : d'une part une vision défectueuse et unilatérale de l'unité complexe de l'homme, d'autre part une interprétation insuffisante de l'ouverture humaine sur la réalité en soi et indépendante. En ce qui concerne le premier point, De Petter insiste sur le dualisme qui domine, quasiment sans contestation, toute la philosophie occidentale, et qui n'est contredit que par l'antidualisme des phénoménologues ; d'autre part il souligne les déficiences de cet antidualisme. Le dualisme n'a pas su rendre compte de l'unité humaine, tandis que l'antidualisme l'exagérait au point d'oublier la complexité de l'homme. En ce qui concerne le second point – l'ouverture humaine sur la réalité en soi – De Petter insiste sur le conceptualisme de toute la philosophie jusqu'à Kant. L'erreur de celui-ci consistait à considérer les concepts comme l'expression adéquate de la réalité elle-même, qu'ils tendaient à supplanter. Ensuite, il signale la réduction de l'être à l'être-pour-moi, prônée depuis Kant. Sur ce point également, la position de De Petter consiste à refuser les deux erreurs mentionnées. Aux phénoménologues, il imprunta tous les facteurs qui relativisent la connaissance humaine, mais à son avis l'affirmation de tout relativisme reste en deça de sa propre implication. Cette affirmation, en effet, prouve l'intentionalité foncière de la conscience sur la réalité même. C'est par cette intentionalité que la métaphysique devient possible. Celle-ci pourtant devra s'accorder au réalisme tel que De Petter le conçoit. Par ce réalisme il faut comprendre que la conscience humaine, à travers toutes les formes de relativité, vise l'absolu sans pouvoir y accéder. Dans cette ligne de pensée, la métaphysique ne fera que se rapprocher du mystère de la réalité toujours inaccessible. Sera-t-elle pour autant une métaphysique du silence ? Non pas. De Petter estime que le mystère de Dieu se montre – en tant que profondeur insondable – à travers l'insuffisance, la contingence ou le vide intérieur de notre monde. Signalons, pour terminer, que De Petter avance dans ses cours, une critique perspicace et profonde des thèses principales de l'anthropologie et de la métaphysique scolastiques. (shrink)

De unione Verbi incarnati est sans doute celle des Questions disputees qui a suscite parmi les disciples de saint Thomas d'Aquin les plus apres controverses. Seule en effet, elle mentionne, a cote de l'unique esse personnel du Christ, un autre etre de ce suppot, correspondant a la nature humaine. Comment concilier cette affirmation avec la doctrine thomasienne de l'unite d'etre substantiel? Et ne risque-t-elle pas de remettre en cause l'unite ontologique du Christ, et par la de detruire Jesus? Mais au-dela (...) de ces controverses, notre QuAestio revele l'emerveillement d'un contemplatif fascine par la nouveaute ineffable de l'Incarnation. 2000 ans apres la naissance du Christ, cette oeuvre puissante, publiee pour la premiere fois en edition latin-francais, ne pourra manquer de susciter un ardent interet. (shrink)

New foreword written by HeritageMom, Amber O'Neal Johnston. "During a time when the United States needed to be reminded of the contributions Black people have made to its democracy, freedom, music, literature, and more, W.E.B. Du Bois took on the task of enumerating the gifts that we've provided to our country. "When I began reading The Gift of Black Folk...the story that unfolded was one that I had never anticipated. We the People of the United States, all of us, have (...) left our indelible mark on America the Beautiful." -Amber O'Neal Johnston In 1924, William Edward Burghardt (W.E.B.) Du Bois (1868-1963) penned The Gift of Black Folk in response to systemic racism in the United States, showing that "...the American spirit is a new and interesting result of diverse threads of thought and feeling coming not only from America but from Europe and Asia and indeed from Africa." Du Bois was the first African American to earn a Ph.D. from Harvard University, and later became a professor of history, sociology, and economics at Atlanta University. In 1909 he co-founded the NAACP. Du Bois was a lifelong leader and proponent of civil rights. Amber O'Neal Johnston is a writer, speaker, and home educator who blends life-giving books with a culturally-rich environment for her four children and others. She's the author of A Place to Belong, a guide for families of all backgrounds to celebrate cultural heritage and embrace inclusivity in the home and beyond, and she's known for sharing literary "mirrors and windows" on HeritageMom.com. (shrink)

Nous nous intéressons dans cet article à la façon dont Ernst Cassirer renforce et réinvestit la méthode critique de Kant en replaçant l’imagination productrice non seulement au cœur de la théorie de la connaissance – désormais étendue au cosmos de la culture –, mais aussi au cœur d’une métaphysique renouvelée. La valorisation de la spontanéité – inséparable de ses objectivations, les formes symboliques –, traduit et sert les enjeux corrélatifs de l’idéalisme critique de Cassirer : d’une part, son combat mené (...) à travers les déductions transcendantales contre les métaphysiques dogmatiques marchandes d’illusions dualistes au sein du savoir, d’autre part, la recherche d’un sens d’ordre métaphysique-anthropologique inspirant l’alliance de la forme et de la liberté pour la totalité systématique de la culture.In the present article, we contemplated the way Ernst Cassirer reinforces and rethinks the Kant’s critical method by replacing the productive imagination not only in the heart of the epistemology – henceforth extended to culture’s cosmos – but also in the heart of a renewed metaphysics. The highlighting of the spontaneity – inseparable of the symbolic form – rejoins the interrelated issues of the critical idealism of Ernst Cassirer: on the one hand, his opposition against dogmatic metaphysics generating dualism in knowledge, and on the other hand, the study of an anthropological-metaphysical sense inspiring the connection between form and freedom for the culture’s systematic totality. (shrink)