Despite its widespread existence, the adaptive role of aneuploidy (the abnormal state of having an unequal number of different chromosomes) has been a subject of debate. Cellular aneuploidy has been associated with enhanced resistance to stress, whereas on the organismal level it is detrimental to multicellular species. Certain aneuploid karyotypes are deleterious for specific environments, but karyotype diversity in a population potentiates adaptive evolution. To reconcile these paradoxical observations, this review distinguishes the role of aneuploidy in cellular versus organismal evolution. (...) Further, it proposes a population genetics perspective to examine the behavior of aneuploidy on a populational versus individual level. By altering the copy number of a significant portion of the genome, aneuploidy introduces large phenotypic leaps that enable small cell populations to explore a wide phenotypic landscape, from which adaptive traits can be selected. The production of chromosome number variation can be further increased by stress‐ or mutation‐induced chromosomal instability, fueling rapid cellular adaptation. (shrink)

This paper is an examination of some modelling problems regarding imperfect recall within the model of extensive games. It is argued that, if the assumption of perfect recall is violated, care must be taken in interpreting the main elements of the model. Interpretations that are inconsequential under perfect recall have important implications in the analysis of games with imperfect recall.

Im 2009 erschienenen Buch "Philosophie des Leidens" versucht Boris Wandruszka, jene immanente Lebensstruktur und Lebensdynamik aufzudecken, die zu den einfachsten und fundamentalen Strukturmomenten des Leidens vorstosst; diese erste "Wissenschaft vom Leiden" transzendierte daher nicht die Grenzen der Anschaubarkeit, sondern verblieb in der "Immanenz des 'inneren Lebens' bzw. des Erlebens". Im aktuellen Buch "Metaphysik des Leidens" werden die "realen Bedingungen der Moglichkeit von Leiden" ermittelt: Wie muss eine Welt beschaffen sein, damit darin ein leidendes Wesen erscheinen konne? Welche Rolle hat (...) das Leiden in Bezug zum fundamentalen Widerfahrnis-, Resonanz- und Responsivitatscharakter des Lebens? Es wird gezeigt, dass menschliches Leben, das einer plural-agonalen Welt ausgesetzt ist, nicht leidfrei moglich ist, dass aber andererseits das Leid nicht das letzte Wort sein kann, sondern notwendig auf Ganzheit, Reifung, Erlosung und Harmonie bezogen ist. Nur auf dem Hintergrund der Spannung zwischen absoluter Seins-, Sinn- und Lebensfulle und der stets problematischen und fragilen Teilhabe von Menschen am "absoluten und leiduberwindenden Urleben" kann Leiden entstehen, durchlitten, verstanden, aber auch uberwunden werden. Hier erreicht der "Opfergedanke", in dem das unvermeidliche Leid frei angenommen und dadurch transformiert wird, seine reinste und hochste Ausformung. Erst nach Klarung dieser Verhaltnisse wird die "Theodizeefrage" als "das Problem der Probleme" angegangen und am Leitfaden der Hiob-Erzahlung diskutiert. Letztlich erweist sich, dass trotz allem Schmerz, Mangel, Unrecht und Unsinn ein "Potential des Unendlichen" im Leiden verborgen liegt, das auf seine Uberwindung durch Sein-, Sinn- und Werterfullung, durch Tat, Erkenntnis und Liebe verweist und dass diese drei "Machte" der Leidensherausforderung bedurfen, um ihre Weite, Tiefe und Hohe auszuloten. (shrink)

We argue that in extensive decision problems (extensive games with a single player) with imperfect recall care must be taken in interpreting information sets and strategies. Alternative interpretations allow for different kinds of analysis. We address the following issues: 1. randomization at information sets; 2. consistent beliefs; 3. time consistency of optimal plans; 4. the multiselves approach to decision making. We illustrate our discussion through an example that we call the ‘‘paradox of the absentminded driver.’’ Journal of Economic Literature Classification (...) Numbers: C7, D0. 1997 Academic Press. (shrink)

In this handbook, I put into practice my philosophical views on children's mathematics. The handbook contains brief instructions and examples of mathematical activities. In the INSTRUCTIONS section, instructions are given on how, and in part why that way, to help preschool children in their mathematical development. In the ACTIVITIES section, there are examples of activities through which the child develops her mathematical abilities.

Boris Kment takes a new approach to the study of modality that emphasises the origin of modal notions in everyday thought. He argues that the concepts of necessity and possibility originate in counterfactual reasoning, which allows us to investigate explanatory connections. Contrary to accepted views, explanation is more fundamental than modality.

According to the aspect theory of instantiation, a particular A instantiates a universal B if and only if an aspect of A is cross-count identical with an aspect of B. This involves the assumption that both particulars and universals have aspects, and that aspects can mediate between different ways of counting things. I will ask what is new about this account of instantiation and, more importantly, whether it is an improvement on its older relatives. It will turn out that the (...) part of it that is new is the notion of cross-count identity among aspects. As I will show, this notion is both dubious and unnecessary. I will end by presenting a simplified aspect theory of instantiation that does not involve cross-count identity. (shrink)

I propose a general alethic theory of epistemic risk according to which the riskiness of an agent’s credence function encodes her relative sensitivity to different types of graded error. After motivating and mathematically developing this approach, I show that the epistemic risk function is a scaled reflection of expected inaccuracy. This duality between risk and information enables us to explore the relationship between attitudes to epistemic risk, the choice of scoring rules in epistemic utility theory, and the selection of priors (...) in Bayesian epistemology more generally. (shrink)

Analysing several characteristic mathematical models: natural and real numbers, Euclidean geometry, group theory, and set theory, I argue that a mathematical model in its final form is a junction of a set of axioms and an internal partial interpretation of the corresponding language. It follows from the analysis that (i) mathematical objects do not exist in the external world: they are our internally imagined objects, some of which, at least approximately, we can realize or represent; (ii) mathematical truths are not (...) truths about the external world but specifications (formulations) of mathematical conceptions; (iii) mathematics is first and foremost our imagined tool by which, with certain assumptions about its applicability, we explore nature and synthesize our rational cognition of it. (shrink)

In this paper we develop a general theory of algorithmic fairness. Drawing on Johnson King and Babic’s work on moral encroachment, on Gary Becker’s work on labor market discrimination, and on Strawson’s idea of resentment and indignation as responses to violations of the demand for goodwill toward oneself and others, we locate attitudes to fairness in an agent’s utility function. In particular, we first argue that fairness is a matter of a decision-maker’s relative concern for the plight of people from (...) different groups, rather than of the outcomes produced for different groups. We then show how an agent’s preferences, including in particular their attitudes to error, give rise to their decision thresholds. Tying these points together, we argue that the agent’s relative degrees of concern for different groups manifest in a difference in decision thresholds applied to these groups. (shrink)

While there are satisfactory answers to the question “How should we teach children mathematics?”, there are no satisfactory answers to the question “What mathematics should we teach children?”. This paper provides an answer to the last question for preschool children (early childhood), although the answer is also applicable to older children. This answer, together with an appropriate methodology on how to teach mathematics, gives a clear conception of the place of mathematics in the children’s world and our role in helping (...) children develop their mathematical abilities. Briefly, children’s mathematics consists of the world of children’s internal activities that they eventually purposefully organize in order to understand and control the outside world and organize their overall activities in it. We need to support a child in mathematical activities that she does spontaneously and in which she shows interest, and we need to teach her mathematics that she is interested in developing through these activities. In doing so, we must be fully aware that the child’s mathematics is part of the child’s world of internal activities and is not outside of it. We help the child develop mathematical abilities by developing them in the context of her world and not outside of it. From the point of view of this conception, the standards established today are limiting and too focused on numbers and geometric figures: these topics are too prominent and elaborated, and other mathematical contents are subordinated to them. Adhering to the standards, we drastically limit the mathematics of the child’s world, hamper the correct mathematical development of a child, and we can turn her away from mathematics. (shrink)

As illiberal and authoritarian trends are on the rise--both in fragile and seemingly robust democracies--there is growing concern about the longevity of liberalism and democracy. The purpose of this volume is to draw on the analytical resources of various disciplines and public policy approaches to reflect on the current standing of liberal democracy. Leading social scientists from different disciplinary backgrounds aim to examine the ideological and structural roots of the current crisis of liberal democracies, in the West and beyond, conceptually (...) and empirically. The volume is divided into two main parts: Part I explores tensions between liberalism and democracy in a longer-term, historical perspective to explain immanent vulnerabilities of liberal democracy. Authors examine the conceptual foundations of Western liberal democracy that have shaped its standing in the contemporary world. What lies at the core of illiberal tendencies? Part II explores case studies from the North Atlantic, Eastern Europe, Turkey, India, Japan, and Brazil, raising questions whether democratic crises, manifested in the rise of populist movements in and beyond the Western context, differ in kind or only in degree. How can we explain the current popular appeal of authoritarian governments and illiberal ideas? The Emergence of Illiberalism will be of great interest to teachers and students of politics, sociology, political theory and comparative government. (shrink)

First published in 2005. Routledge is an imprint of Taylor & Francis, an informa company.

We further investigate a divisibility relation on the set of BN ultrafilters on the set of natural numbers. We single out prime ultrafilters (divisible only by 1 and themselves) and establish a hierarchy in which a position of every ultrafilter depends on the set of prime ultrafilters it is divisible by. We also construct ultrafilters with many immediate successors in this hierarchy and find positions of products of ultrafilters.

The essential role of language in rational cognition is analysed. The approach is functional: only the results of the connection between language, reality, and thinking are considered. Scientific language is analysed as an extension and improvement of everyday language. The analysis gives a uniform view of language and rational cognition. The consequences for the nature of ontology, truth, logic, thinking, scientific theories, and mathematics are derived.

Neuroeconomics is examined critically using data on the response times of subjects who were asked to express their preferences in the context of the Allais Paradox. Different patterns of choice are found among the fast and slow responders. This suggests that we try to identify types of economic agents by the time they take to make their choices. Nevertheless, it is argued that it is far from clear if and how neuroeconomics will change economics.

Many philosophers have argued that statistical evidence regarding group characteristics (particularly stereotypical ones) can create normative conflicts between the requirements of epistemic rationality and our moral obligations to each other. In a recent article, Johnson-King and Babic argue that such conflicts can usually be avoided: what ordinary morality requires, they argue, epistemic rationality permits. In this article, we show that as data get large, Johnson-King and Babic’s approach becomes less plausible. More constructively, we build on their project and develop a (...) generalized model of reasoning about stereotypes under which one can indeed avoid normative conflicts, even in a big data world, when data contain some noise. In doing so, we also articulate a general approach to rational belief updating for noisy data. (shrink)

In this paper, we reflect on the connection between the notions of organism and organisation, with a specific interest in how this bears upon the issue of the reality of the organism. We do this by presenting the case of Buffon, who developed complex views about the relation between the notions of “organised” and “organic” matter. We argue that, contrary to what some interpreters have suggested, these notions are not orthogonal in his thought. Also, we argue that Buffon has a (...) view in which organisation is not just ubiquitous, but basic and fundamental in nature, and hence also fully natural. We suggest that he can hold this view because of his anti-mathematicism. Buffon’s case is interesting, in our view, because he can regard organisation, and organisms, as perfectly natural, and can admit their reality without invoking problematic supernaturalist views, and because he allows organisation and the organismal to come in kinds and degrees. Thus, his view tries to do justice to two cautionary notes for the debate on the reality of the organism: the need for a commitment to a broadly naturalist perspective, and the need to acknowledge the interesting features of organisms through which we make sense of them. (shrink)

We continue the research of an extension of the divisibility relation to the Stone‐Čech compactification. First we prove that ultrafilters we call prime actually possess the algebraic property of primality. Several questions concerning the connection between divisibilities in and nonstandard extensions of are answered, providing a few more equivalent conditions for divisibility in. Results on uncountable chains in are proved and used in a construction of a well‐ordered chain of maximal cardinality. Probably the most interesting result is the existence of (...) a chain of type in. Finally, we consider ultrafilters without divisors in and among them find the greatest class. (shrink)

Approximate coherentism suggests that imperfectly rational agents should hold approximately coherent credences. This norm is intended as a generalization of ordinary coherence. I argue that it may be unable to play this role by considering its application under learning experiences. While it is unclear how imperfect agents should revise their beliefs, I suggest a plausible route is through Bayesian updating. However, Bayesian updating can take an incoherent agent from relatively more coherent credences to relatively less coherent credences, depending on the (...) data observed. Thus, comparative rationality judgments among incoherent agents are unduly sensitive to luck. (shrink)

We continue the exploration of various aspects of divisibility of ultrafilters, adding one more relation to the picture: multiplicative finite embeddability. We show that it lies between divisibility relations \ and \. The set of its minimal elements proves to be very rich, and the \-hierarchy is used to get a better intuition of this richness. We find the place of the set of \-maximal ultrafilters among some known families of ultrafilters. Finally, we introduce new notions of largeness of subsets (...) of \, and compare it to other such notions, important for infinite combinatorics and topological dynamics. (shrink)

Mit dem Erscheinen der ersten Untersuchung der Autorin zu diesem Thema im Jahre 1984 (Φ.Εὐαγγελάτου-Νοταϱᾶ, Συλλογὴ χϱονολογημένων „σημειωμάτων“ ἑλληνιϰως ϰωδίϰων. 13ος αἰ. Athen) wurde seinerzeit ein Nachschlagewerk geschaffen, das für die Erforschung der spätbyzantinischen Handschriftenkunde unentbehrliche Dienste leistet. In dem vorliegenden Buch sind nunmehr erneut die Notizen und Einträge spätbyzantinischer Handschriften zum Gegenstand gewählt. Dabei wurde der chronologische Rahmen der Arbeit erheblich erweitert, doch bleibt die Auswahl der erörterten und edierten Texte auf jene eingeschränkt, die eben von den Auftraggebern, Besitzern (...) und Schenkern der Handschriften handeln. (shrink)

We construct and study structures imitating the field of complex numbers with exponentiation. We give a natural, albeit non first-order, axiomatisation for the corresponding class of structures and prove that the class has a unique model in every uncountable cardinality. This gives grounds to conjecture that the unique model of cardinality continuum is isomorphic to the field of complex numbers with exponentiation.

This paper analyzes the historical context and systematic importance of Kant's hypothetical use of reason. It does so by investigating the role of hypotheses in Kant's philosophy of science. We first situate Kant’s account of hypotheses in the context of eighteenth-century German philosophy of science, focusing on the works of Wolff, Meier, and Crusius. We contrast different conceptions of hypotheses of these authors and elucidate the different theories of probability informing them. We then adopt a more systematic perspective to discuss (...) Kant's idea that scientific hypotheses must articulate real possibilities. We argue that Kant's views on the intelligibility of scientific hypotheses constitute a valuable perspective on scientific understanding and the constraints it imposes on scientific rationality. (shrink)

Evidential decision theory (EDT) says that the choiceworthiness of an option depends on its evidential connections to possible outcomes. Causal decision theory (CDT) holds that it depends on your beliefs about its causal connections. While Newcomb cases support CDT, Arif Ahmed has described examples that support EDT. A new account is needed to get all cases right. I argue that an option A's choiceworthiness is determined by the probability that a good outcome ensues at possible A‐worlds that match actuality in (...) the facts causally unaffected by your decision (the “unaffected facts”). Moreover, you should evaluate A on the assumption that A is compossible with the unaffected facts. This view entails that you should use EDT when evaluating A on the assumption that the unaffected facts determine your action, but use CDT when assessing A on the opposite assumption. A's choiceworthiness equals a weighted average of these conditional assessments. The weights are determined by your beliefs about whether the unaffected fact determine your action. This account gets both Newcomb and Ahmed cases right. According to an influential view, whether you take the unaffected facts to determine your action can make a difference to whether you can regard yourself as free and the action as being under your control. While my account is neutral on this issue, it entails that whether you take the unaffected facts to determine your action is important in a different way: it matters to whether you should follow EDT or CDT. (shrink)