In medical research, the ethical principle of respect for persons is operationalized into the process of informed consent. The consent tools should be contextualized and adapted to the different socio-cultural environment, especially when research crosses the traditional boundaries and reaches poor communities. We look at the challenges experienced in the malaria Quinact trial, conducted in the Democratic Republic of Congo, and describe some lessons learned, related to the definition of acceptable representative, the role of independent witness and the impact of (...) socio-economic vulnerability. To ensure children's protection, consent is required by the parents or, in their absence, by a legally mandated representative. In our setting, children's responsibility is often entrusted permanently or temporarily to relatives or friends without a tribunal mandate. Hence, a notion of ‘culturally acceptable representative’ under supervision of the local Ethics Committee may be more suitable. To ensure protection of illiterate subjects, an independent witness is required to confirm that the consent was freely given. However, in low-literacy contexts, potential witnesses often don't have any previous relationship with patient and there may be power-unbalance in their relationship, rather than genuine dialogue. In poor communities, trial participation may be seen as an opportunity to secure access to healthcare. Poverty may also lead to ‘competition’ to access the research-related benefits, with a risk of disturbance at societal or household level. Adjusting consent procedures to sociocultural and socioeconomic realities is essential for fulfilling the underlying ethical principles. This requires a collaborative dialogue between researchers, regulators and ethics committees. (shrink)

Pascal was a scientist and man of the world who came to be a passionately devout Christian. The fragments of his great defense of Christianity, left unfinished at his death in 1662, survive in the form of the Pensees. This series of brief, dramatic notes on his religious convictions are here translated into English. These thoughts expose Pascal's vision of the world and display powerful reasoning and a profound faith.

"I know of no religious writer more pertinent to our time."—T. S. Eliot, Introduction to Pensees Intended to prove that religion is not contrary to reason, Pascal's Pensees rank among the liveliest and most eloquent defenses of Christianity. Motivated by the seventeenth-century view of the supremacy of human reason, Pascal (1623–1662) had intended to write an ambitious apologia for Christianity in which he argued the inability of reason to address metaphysical problems. His untimely death prevented the work's completion, but the (...) fragments published posthumously in 1670 as Pensees remain a vital part of religious and philosophical literature. W. F. Trotter translation. Introduction by T. S. Eliot. (shrink)

Journal Name: Semiotica Issue: Ahead of print.

Nineteenth Century Collections Online: European Literature, 1790-1840: The Corvey Collection includes the full-text of more than 9,500 English, French and German titles. The collection is sourced from the remarkable library of Victor Amadeus, whose Castle Corvey collection was one of the most spectacular discoveries of the late 1970s. The Corvey Collection comprises one of the most important collections of Romantic era writing in existence anywhere -- including fiction, short prose, dramatic works, poetry, and more -- with a focus on especially (...) difficult-to-find works by lesser-known, historically neglected writers. The Corvey library was built during the last half of the 19th century by Victor and his wife Elise, both bibliophiles with varied interests. The collection thus contains everything from novels and short stories to belles lettres and more populist works, and includes many exceedingly rare works not available in any other collection from the period. These invaluable, sometimes previously unknown works are of particular interest to scholars and researchers. European Literature, 1790-1840: The Corvey Collection includes: * Novels and Gothic Novels * Short Stories * Belles-Lettres * Short Prose Forms * Dramatic Works * Poetry * Anthologies * And more Selected with the guidance of an international team of expert advisors, these primary sources are invaluable for a wide range of academic disciplines and areas of study, providing never before possible research opportunities for one of the most studied historical periods. Additional Metadata Primary Id: B0545300 PSM Id: NCCOF0063-C00000-B0545300 DVI Collection Id: NCCOC0062 Bibliographic Id: NCCO006452 Reel: 4262 MCODE: 4UVC Original Publisher: Chez Lefevre, libraire Original Publication Year: 1819 Original Publication Place: Paris Original Imprint Manufacturer: ľimprimerie de Crapelet Subjects French fiction -- Early works to 1800. (shrink)

For much of his life Pascal (1623-62) worked on a magnum opus which was never published in its intended form. Instead, he left a mass of fragments, some of them meant as notes for the Apologie. These were to become known as the Pensées, and they occupy a crucial place in Western philosophy and religious writing. Pascal's general intention was to confound scepticism about metaphysical questions. Some of the Pensées are fully developed literary reflections on the human condition,, some contradict (...) others, and some remain jottings whose meaning will never be clear. The most important are among the most powerful aphorisms about human experience and behaviour ever written in any language. This translation is the only one based on the Pensées as Pascal left them. It includes the principal dossiers classified by Pascal, as well as the essential portion of the important Writings on Grace. A detailed thematic index gives access to Pascal's areas of concern, while the selection of texts and the introduction help to show why Pascal changed the plan of his projected work before abandoning the book he might have written. (shrink)

Afin de clarifier la réalité elle-même, Nietzsche rapporte généalogiquement le « conatus » spinoziste à une volonté de statisme à laquelle il oppose la dynamique expansive de la volonté de puissance. Pourtant, on peut montrer que Nietzsche rejette moins la conservation qu’il ne la réinterprète dans l’ordre d’une grandeur à produire, indissociable du tragique.

This eloquent and philosophically astute translation is the first complete English translation based on the Sellier edition of Pascal's manuscript, widely accepted as the manuscript that is closest to the version Pascal left behind on his death in 1662. A brief history of the text, a select bibliography of primary and secondary sources, a chronology of Pascal’s life and works, concordances between the Sellier and Lafuma editions of the original, and an index are provided.

Cet ouvrage rassemble les textes des interventions prononcées lors du colloque Cornelius Castoriadis. Réinventer l'autonomie qui s'est déroulé aux universités de Paris-VIII et de Cergy-Pontoise en mars 2007.

AESTHETICS OF “PURE SIGN” ADORNO, MERLEAU-PONTY AND ART AS AN ENDLESS REINVENTION OF REALITY Contemporary painting has often dealt with signs, graffiti, calligraphy, and more precisely with aesthetic objects that take the form and appearance of signs, but which do not belong to any existing alphabet. These are forms that imitate signs but are what we might call “pure signs”, i.e. signifiers without a signified. This form of artistic experimentation has elicited parallel and convergent analyses by Merleau-Ponty and Adorno. These (...) authors show the ways in which this kind of artistic experimentation at once renews reflection on language and reflection on art, through a more fundamental reflection on the cognitive actions that they necessarily share, namely deciphering and interpretation. By asking how signs that have no conventional meaning can still be identified as signs–the “decryption” of which is therefore impossible–we re-actualize a question that goes back to Plato and Augustine. How can we begin to investigate and understand what we do not know yet? How does the decryption and interpretation process arise for one who does not yet know if there is something to understand? This type of artwork actually has a meaning, but not in the traditional sense. Although they are unreadable and untranslatable, such works clarifying the meaning of interpretation for us, they free us from a naive and simplistic conception of the process of understanding. They show us that interpretation is always a process of inventing and producing a new meaning, but never of actually finding a pre-existing meaning. In doing so, these kinds of artwork are inseparable from ontological and political issues. Against a conservative view of our relationship to reality, they make us aware that the sense of reality is never simply given nor definitive, and that our relationship to reality contains much more potential than we commonly believe. (shrink)

On associe habituellement Rousseau à la tradition républicaine, opposée schématiquement à la tradition libérale. Sans remettre en cause globalement cette thèse, il peut être intéressant de déplacer les termes de la problématique, en présentant la critique rousseauiste du libéralisme comme une critique menée de l’intérieur, plutôt que de l’extérieur. On peut en effet, à l’exemple de John Pocock, identifier un tronc commun aux pensées républicaine et libérale ou, à l’exemple de Charles Larmore, voir dans le républicanisme « une formulation plus (...) lucide de la théorie libérale ». Cela se traduit chez Rousseau par une stratégie consistant à se réapproprier les promesses contenues dans les prémisses du libéralisme, pour mieux en dénoncer les conséquences dogmatiques. De fait, on trouve chez Rousseau une défense des droits individuels, un souci de l’indépendance individuelle dans les relations économiques et plus généralement dans les rapports sociaux, une justification jusnaturaliste de la propriété privée, et même des emprunts à l’idée selon laquelle la mise en concurrence permettrait de définir les conditions d’un choix optimal. Cependant l’analyse de certains textes de l’Émile montre que Rousseau vise en définitive à dissiper l’illusion d’une autorégulation optimale des rapports sociaux et économiques : l’opacité et les distorsions des rapports économiques ainsi que l’usage spontanément irrationnel de la liberté individuelle impliquent la nécessité de gouverner la liberté, par l’éducation et par la législation. (shrink)

La notion de libéralisme crée un sentiment trompeur de familiarité : sa présence envahissante dans le débat public brouille le plus souvent sa compréhension.

Le but de cet ouvrage est d'éclairer la façon dont Rousseau fait de la philosophie. Il s'organise autour des notions de dispositions, de sensibilité, et de relations sous lesquelles Rousseau pense le devenir humain de la nature. Leur rôle transversal et cardinal dans sa philosophie permet d'en appréhender l'unité.

L’Émile met en scène deux leçons de choses visant à initier l’élève à la science économique : l’une concernant le fondement du droit de propriété, l’autre concernant l’échange marchand et la division sociale du travail. Ces deux moments éducatifs donnent un précieux éclairage sur la pensée économique de Rousseau, pensée plus complexe et informée qu’on ne le considère communément. Mais c’est également dans les décisions existentielles d’émile que sont abordées philosophiquement les conditions d’un choix rationnel, la maximisation de la satisfaction (...) et les vertus supposées de la concurrence. Par ces différents biais, Rousseau met à l’épreuve et critique les thèses de la science économique, annonciatrices du libéralisme, qui s’ébauchent à son époque.Two practical lessons, in Émile, aim to introduce the pupil to economics. The first one concerns the foundation of the right to property ; the second one concerns trade and the social division of work. Both of these educational moments show Rousseau’s economic thought to be more complex and informed than we often believe. But Émile’s existential decisions are also occasions for philosophical investigations on the conditions of rational choice, the maximization of satisfaction and the supposed benefits of competition between bids. Through these differents issues, Rousseau puts to the test and critically examines the free market principles which are starting to take shape just then. (shrink)

Do you believe it to be impossible that God is infinite, without parts?-Yes. I wish therefore to show you an infinite and indivisible thing. It is a point moving everywhere with an infinite velocity; for it is one in all places, and is all totality in every place. Let this effect of nature, which previously seemed to you impossible, make you know that there may be others of which you are still ignorant. Do not draw this conclusion from your experiment, (...) that there remains nothing for you to know; but rather that there remains an infinity for you to know. (shrink)

Cet article est disponible en texte intégral en format PDF.

"I know of no religious writer more pertinent to our time." — T. S. Eliot, Introduction to Pensées "Men despise religion. They hate it and are afraid it may be true," declared Pascal in his Pensées. "The cure for this," he explained, "is first to show that religion is not contrary to reason, but worthy of reverence and respect. Next make it attractive, make good men wish it were true, and then show that it is." Motivated by the 17th-century view (...) of the supremacy of human reason, Pascal (1623-62) had intended to write an ambitious apologia for Christianity, in which he argued the inability of reason to address metaphysical problems. His untimely death prevented his completion of the work, but the fragments published posthumously in 1670 form a vital part of religious and philosophical literature. Essential reading for students of history, philosophy, and theology, the Pensées remain among the liveliest and most eloquent defenses of Christianity ever written. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This article defines the Nietzsche's philosophy as a Versuch (test, attempt, trial) and not as a set of articulated theses in a fixed manner. The Nietzsche's readers work is itself constrained to approach the texts of this thinker in a groping way: if at first the reading seems impossible to comprehend, the second part of the contribution resembles that a methodical reading can be considered, reading that, however, intends to fully absorb the difficulties posed through the Nietzsche's thought. The Nietzschean (...) Versuch leads, therefore, to build a Versuch reader in a way that, more broadly, invites us to consider the work of Nietzsche as a problem ("als Problem"). (shrink)

Cette étude considére le § 301 du Gai Savoir, à partir du § 98 même ouvrage. Dans le sillage de la «nouvelle justice» brièvement présentée dans le § 289, ce § 301 remaine en profondeur l'opposition traditionelle entre l'actif et le contemplatif; suivre pas à pas ect aphorisme permet ainsi de constituer «l'homme juste» en problime qui est cet «homme juste»? Brutus? Shakespeare? Le «poète»? Et donc: comment appréhender la «nouvelle justice»?Diese Untersuchung befasst sich mit dem § 301 der Fröhlichen (...) Wissenschaft, gestützt auf § 98 desselben Werks. Im Zuge der "neuen Gerechtigkrit", die in § 289 kurz dargestellt worden war, formt dieser § 301 den traditionellen Gegensatz zwischen dem Aktiven und dem Contemplativen grundlegend um. Die schrittweise Betrachtung dieses Aphorismus erlaubt dann, den "gerechten Menschen" zum Problem zu machen: wer ist dieser "gerechter Mensch"? Brutus? Shakespeare? Der "Dichter"? Und somit: wie ist die "neue gerechtigkeit" aufzufassen? This articles considers § 301 of The Gay Science in the light of § 98 of the same work. In the wake of the "new justice" briefly presented in § 289, § 301 is an in-depth reconsideration of the traditional opposition between the active and the contemplative; thus a step by step approach to this aphorism allows one to establish "the just man" as a problem: who is that "just man"? Brutus? Shakespeare? The "poet"? Hence, how is the notion of "new justice" to be grasped? (shrink)

Le perspectivisme nietzschéen se situe-t-il « après la vérité »? Si Nietzsche critique le concept même de vérité, il emploie pourtant très régulièrement cette expression, jusque dans Ecce homo et L’Antéchrist. Prendre acte de cette tension est insuffisant : y a-t-il contradiction ou s’agit-il plutôt de polysémie? Cette étude, qui distingue chemin faisant perspectivisme et relativisme, procède à l’examen des différents sens de « vérité » dans l’œuvre de Nietzsche afin de construire une réponse à ce problème.

Resumo: Se Nietzsche critica o próprio conceito de verdade, ele emprega, no entanto, com muita regularidade essa expressão, como em Ecce homo e em O Anticristo. Apontar essa tensão é insuficiente: há uma contradição ou antes uma polissemia? Este estudo, que distingue o perspectivismo e o relativismo, examina os diferentes sentidos de “verdade” na obra de Nietzsche a fim de construir uma resposta a essa questão. Ela mostra que a verdade depende da interpretação em busca de justiça, ainda que essa (...) orientação continue problemática.: Though Nietzsche critiques the very concept of truth, he nonetheless uses the word very regularly, even in such late texts as Ecce Homo or The Antichrist. Merely taking note of this tension is not enough: is it contradictory, or rather a case of polysemy? This study, which distinguishes, along the way, between perspectivism and relativism, examines the different meanings of “truth” in Nietzsche’s work, so as to figure out an answer to this question. It shows that truth is a matter of interpretation in search of justice, even if this movement itself remains something of a problem. (shrink)