Physicists regularly invoke universal laws, such as those of motion and electromagnetism, to explain events. Biological and medical scientists have no such laws. How then do they acquire a reliable body of knowledge about biological organisms and human disease? One way is by repeatedly returning to, manipulating, observing, interpreting, and reinterpreting certain subjects—such as flies, mice, worms, or microbes—or, as they are known in biology, “model systems.” Across the natural and social sciences, other disciplinary fields have developed canonical examples that (...) have played a role comparable to that of biology’s model systems, serving not only as points of reference and illustrations of general principles or values but also as sites of continued investigation and reinterpretation. The essays in this collection assess the scope and function of model objects in domains as diverse as biology, geology, and history, attending to differences between fields as well as to epistemological commonalities. Contributors examine the role of the fruit fly Drosophila and nematode worms in biology, troops of baboons in primatology, box and digital simulations of the movement of the earth’s crust in geology, and meteorological models in climatology. They analyze the intensive study of the prisoner’s dilemma in game theory, ritual in anthropology, the individual case in psychoanalytic research, and Athenian democracy in political theory. The contributors illuminate the processes through which particular organisms, cases, materials, or narratives become foundational to their fields, and they examine how these foundational exemplars—from the fruit fly to Freud’s Dora—shape the knowledge produced within their disciplines. Contributors Rachel A. Ankeny Angela N. H. Creager Amy Dahan Dalmedico John Forrester Clifford Geertz Carlo Ginzburg E. Jane Albert Hubbard Elizabeth Lunbeck Mary S. Morgan Josiah Ober Naomi Oreskes Susan Sperling Marcel Weber M. Norton Wise. (shrink)

If well-designed, the results of a Randomised Clinical Trial can justify a causal claim between treatment and effect in the study population; however, additional information might be needed to carry over this result to another population. RCTs have been criticized exactly on grounds of failing to provide this sort of information Evidence, inference and enquiry. Oxford University Press, New York, 2011), as well as to black-box important details regarding the mechanisms underpinning the causal law instantiated by the RCT result. On (...) the other side, so-called In Silico Clinical Trials face the same criticisms addressed against standard modelling and simulation techniques, and cannot be equated to experiments Philosophy of molecular medicine: foundational issues in research and practice, Routledge, New York, 2017; Parker in Synthese 169:483–496, 2009; Parke in Philos Sci 81:516–536, 2014; Diez Roux in Am J Epidemiol 181:100–102, 2015 and related discussions in Frigg and Reiss in Synthese 169:593–613, 2009; Winsberg in Synthese 169:575–592, 2009; Beisbart and Norton in Int Stud Philos Sci 26:403–422, 2012). We undertake a formal analysis of both methods in order to identify their distinct contribution to causal inference in the clinical setting. Britton et al.’s study :E2098–E2105, 2013) on the impact of ion current variability on cardiac electrophysiology is used for illustrative purposes. We deduce that, by predicting variability through interpolation, ISCTs aid with problems regarding extrapolation of RCTs results, and therefore in assessing their external validity. Furthermore, ISCTs can be said to encode “thick” causal knowledge —as opposed to “thin” difference-making information inferred from RCTs. Hence, ISCTs and RCTs cannot replace one another but rather, they are complementary in that the former provide information about the determinants of variability of causal effects, while the latter can, under certain conditions, establish causality in the first place. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Unknowing BarbaraLee Edelman (bio)There's something you should know about Barbara Johnson. Something you don't know. Something you can't know. Something that's hidden in plain sight. And Johnson, though never possessing that knowledge, indicates, time and time again, both its utter impossibility and the impossibility of ceasing to utter it—the impossibility that generates time as always already time again, as allegorical temporality, as the compulsion (implicit in the phrase (...) "you should know") to repeat our failure to know it and to call that failure knowledge itself. There's something you should know about Barbara Johnson, and it's something I'm here not to tell you. For telling, as Johnson allows us to see, obscures the unmasterable relation between what's told and the act of telling it. It distracts our attention, in other words, from something else always at work in its words to complicate or confound it, something we've come to identify as the rhetorical, the performative, or the literary, but something to which Johnson, by way of reference to Freud, gives another name as well: "Freud called this something the death instinct, but this death instinct is to be understood as what ceaselessly escapes the mastery of understanding and the binary logic of opposition by exhibiting some 'other' logic one can neither totally comprehend nor exclude." To which she then goes on to add: "Any statement that affirms, while using a logic different from the logic of binary opposition, will necessarily not conform to binary notions of 'clarity'" ["Nothing Fails Like Success" 13].Now consider the opening sentences of the headnote to the Norton Anthology of Criticism's selection from Barbara Johnson's work, a headnote that situates Johnson with the anonymous authority of a knowledge from on high, of the sujet supposé savoir, though that subject here, like its object, is Barbara Johnson, who wrote it herself: "Barbara Johnson is known as a translator in various senses of the word. She is the celebrated translator of Jacques Derrida's Dissemination; and she is also one of the earliest and most interesting translators of structuralist and poststructuralist theory into literary insights. Often praised for her 'lucidity' and 'clarity,' she has nevertheless emphasized, again and again, the unavoidability and necessity of linguistic complexity and difficulty in formulating intractable problems."1 Though this seems, on the face of it, clear enough, don't let that obscure its obscurity. For Johnson acknowledges—or confesses, or laments—that she's "often praised" for a "clarity" to which, as the earlier passage makes clear, the statements in deconstructive texts "will necessarily not conform." Are Johnson's texts not deconstructive then? Is her logic really binary? Or is some "other" logic operative here when she clearly affirms that deconstructive affirmations necessarily won't seem clear?To see this obscurity more clearly—to see it more clearly, that is, as obscurity—let me translate Johnson's comments into the logical pattern of a syllogism, although Johnson herself reminds us that "what is most radical in deconstruction" is precisely its incompatibility with familiar structures of binary logic ["Nothing" 12]. Describing that incompatibility, she writes, "while traditionalists say that a thing cannot be both A and not-A, deconstructors open up ways in which A is necessarily but unpredictably [End Page 89] already different from A" [14]. Let me frame this account of deconstruction as the major premise of a syllogism: "All deconstructive statements or texts affirm through a logic different from that of binary opposition.'" Johnson, in discussing the death instinct, has already provided our minor premise: "All statements or texts that affirm through a logic not that of binary opposition 'will necessarily not conform to binary notions of "clarity."'" Syllogistic logic, then, clearly affirms an inevitable conclusion: "All deconstructive statements or texts 'will necessarily not conform to binary notions of "clarity."'" But if this is so, why is Johnson herself "often praised" for being clear? Just what does she have in common with the logical clarity of a syllogism despite her repeated insistence on "linguistic complexity and difficulty"?Well, for one thing, she shares a name. My syllogism belongs to the type that's been known, since... (shrink)

Some of the series' finest lectures have been lost for many years, unavailable to the public in any form -- until now.

Spacetime substantivalism leads to a radical form of indeterminism within a very broad class of spacetime theories which include our best spacetime theory, general relativity. Extending an argument from Einstein, we show that spacetime substantivalists are committed to very many more distinct physical states than these theories' equations can determine, even with the most extensive boundary conditions.

Is there progress in philosophy? If so, how much? Philosophers have recently argued for a wide range of answers to these questions, from the view that there is no progress whatsoever to the view that philosophy has provided answers to all the big philosophical questions. However, these views are difficult to compare and evaluate, because they rest on very different assumptions about the conditions under which philosophy would make progress. This paper looks to the comparatively mature debate about scientific progress (...) for inspiration on how to formulate four distinct accounts of philosophical progress, in terms of truthlikeness, problem-solving, knowledge, and understanding. Equally importantly, the paper outlines a common framework for how to understand and evaluate these accounts. We distill a series of lessons from this exercise, to help pave the way for a more fruitful discussion about philosophical progress in the future. (shrink)

This collection addresses a post-WWII shift in the hierarchy of scientific explanations, where the highest goal moves from reductionism towards some ...

Roots presents articles on major discoveries that laid the basis for contemporary molecular and cellular biology. In this article, Norton D. Zinder reviews the first findings about the single‐stranded DNA‐containing bacteriophages and what is known today about the genetics and molecular biology of these phages.

Responding to a major pandemic and planning for allocation of scarce resources under crisis standards of care requires coordination and cooperation across federal, state and local governments in tandem with the larger societal infrastructure. Maryland remains one of the few states with no state-endorsed ASR plan, despite having a plan published in 2017 that was informed by public forums across the state. In this article, we review strengths and weaknesses of Maryland’s response to COVID-19 and the role of the Maryland (...) Healthcare Ethics Committee Network in bridging gaps in the state’s response to prepare health care facilities for potential implementation of ASR plans. Identified “lessons learned” include: Deliberative Democracy Provided a Strong Foundation for Maryland’s ASR Framework; Community Consensus is Informative, Not Normative; Hearing Community Voices Has Inherent Value; Lack of Transparency & Political Leadership Gaps Generate a Fragmented Response; Pandemic Politics Requires Diplomacy & Persistence; Strong Leadership is Needed to Avoid Implementing ASR … And to Plan for ASR; An Effective Pandemic Response Requires Coordination and Information-Sharing Beyond the Acute Care Hospital; and The Ability to Correct Course is Crucial: Reconsidering No-visitor Policies. (shrink)

The standard theory of computation excludes computations whose completion requires an infinite number of steps. Malament-Hogarth spacetimes admit observers whose pasts contain entire future-directed, timelike half-curves of infinite proper length. We investigate the physical properties of these spacetimes and ask whether they and other spacetimes allow the observer to know the outcome of a computation with infinitely many steps.

In this first part of a two-part paper, we describe efforts in the early decades of this century to restrict the extent of violations of the Second Law of thermodynamics that were brought to light by the rise of the kinetic theory and the identification of fluctuation phenomena. We show how these efforts mutated into Szilard’s proposal that Maxwell’s Demon is exorcised by proper attention to the entropy costs associated with the Demon’s memory and information acquisition. In the second part (...) we will argue that the information theoretic exorcisms of the Demon provide largely illusory benefits. According to the case, they either return a presupposition that can be had without information theoretic consideration or they postulate a broader connection between information and entropy than can be sustained. (shrink)

In this second part of our two-part paper we review and analyse attempts since 1950 to use information theoretic notions to exorcise Maxwell’s Demon. We argue through a simple dilemma that these attempted exorcisms are ineffective, whether they follow Szilard in seeking a compensating entropy cost in information acquisition or Landauer in seeking that cost in memory erasure. In so far as the Demon is a thermodynamic system already governed by the Second Law, no further supposition about information and entropy (...) is needed to save the Second Law. In so far as the Demon fails to be such a system, no supposition about the entropy cost of information acquisition and processing can save the Second Law from the Demon. (shrink)

Individual objects have potentials: paper has the potential to burn, an acorn has the potential to turn into a tree, some people have the potential to run a mile in less than four minutes. Barbara Vetter provides a systematic investigation into the metaphysics of such potentials, and an account of metaphysical modality based on them. -/- In contemporary philosophy, potentials have been recognized mostly in the form of so-called dispositions: solubility, fragility, and so on. Vetter takes dispositions as her (...) starting point, but argues for and develops a more comprehensive conception of potentiality. She shows how, with this more comprehensive conception, an account of metaphysical modality can be given that meets three crucial requirements: Extensional correctness: providing the right truth-values for statements of possibility and necessity; formal adequacy: providing the right logic for metaphysical modality; and semantic utility: providing a semantics that links ordinary modal language to the metaphysics of modality. -/- The resulting view of modality is a version of dispositionalism about modality: it takes modality to be a matter of the dispositions of individual objects. This approach has a long philosophical tradition going back to Aristotle, but has been largely neglected in contemporary philosophy. In recent years, it has become a live option again due to the rise of anti-Humean, powers-based metaphysics. The aim of Potentiality is to develop the dispositionalist view in a way that takes account of contemporary developments in metaphysics, logic, and semantics. (shrink)

Use of the word "Counter-Enlightenment" has become increasingly frequent in scholarly and journalistic writing. The word was almost certainly invented by the late Sir Isaiah Berlin, and it is owing to his enormous prestige and on-going influence that it has gained its current familiarity. In Berlin's view, two of the most important sources of the supposed Counter-Enlightenment are J. G. Hamann and J. G. Herder. But as I show, Berlin's numerous accounts of their thought are profoundly flawed and reflect not (...) Herder's or Hamann's own thought, but rather that of late nineteenth- and early twentieth-century German historians, who wished to legitimate their own anti-democratic, and hence anti-Enlightenment, ideology through the construction of a false historical genealogy. (shrink)

Religious Pluralism Religious pluralism, broadly construed, is a response to the diversity of religious beliefs, practices, and traditions that exist both in the contemporary world and throughout history. The terms “pluralism” and “pluralist” can, depending on context or intended use, signify anything from the mere fact of religious diversity to a particular kind of philosophical … Continue reading Pluralism, Religious →.

Seeing Wittgenstein Anew is a collection which examines Ludwig Wittgenstein's remarks on the concept of aspect-seeing, showing that it was not simply one more topic of investigation in Wittgenstein's later writings but rather a pervasive and guiding concept in his efforts to turn philosophy's attention to the actual conditions of our common life in language. The essays in this 2010 volume open up novel paths across familiar fields of thought: the objectivity of interpretation, the fixity of the past, the acquisition (...) of language, and the nature of human consciousness. Significantly, they exemplify how continuing consideration of the interrelated phenomena of aspect-seeing might produce a fruitful way of doing philosophy in a new century. (shrink)

This book presents the most important problems of reference and considers their solution. It presupposes no technical knowledge, presents analyses from first principles, illustrates every stage with examples, and is written with verve and clarity. This is the ideal introduction to reference for students of linguistics and philosophy of language.

David and Mary Norton present the definitive scholarly edition of Hume's Treatise, one of the greatest philosophical works ever written. This set comprises the two volumes of texts and editorial material, which are also available for purchase separately. -/- David Hume (1711 - 1776) is one of the greatest of philosophers. Today he probably ranks highest of all British philosophers in terms of influence and philosophical standing. His philosophical work ranges across morals, the mind, metaphysics, epistemology, religion, and aesthetics; (...) he had broad interests not only in philosophy as it is now conceived but in history, politics, economics, religion, and the arts. He was a master of English prose. -/- The Clarendon Hume Edition will include all of his works except his History of England and minor historical writings. It is the only thorough critical edition, and will provide a far more extensive scholarly treatment than any previous editions. This edition (which has been in preparation since the 1970s) offers authoritative annotation, bibliographical information, and indexes, and draws upon the major advances in textual scholarship that have been made since the publication of earlier editions - advances both in the understanding of editorial principle and practice and in knowledge of the history of Hume's own texts. (shrink)

David Hume is, arguably, the most important philosopher ever to have written in English. Although best known for his contributions to epistemology, metaphysics, and the philosophy of religion, Hume also made substantial and influential contributions to psychology and the philosophy of mind, ethics, the philosophy of science, political and economic theory, political and social history, and, to a lesser extent, aesthetic and literary theory. All facets of Hume's output are discussed in this volume, the first genuinely comprehensive overview of his (...) work. The picture that emerges is of a thinker who, though critical to the point of scepticism, was nonetheless able to build on that scepticism a profoundly important, and still viable, constructive philosophy. (shrink)

Some presuppositions seem to be weaker than others in the sense that they can be more easily neutralized in some contexts. For example some factive verbs, most notably epistemic factives like know, be aware, and discover, are known to shed their factivity fairly easily in contexts such as are found in (1). (1) a. …if anyone discovers that the method is also wombat-proof, I’d really like to know! b. Mrs. London is not aware that there have ever been signs erected (...) to stop use of the route… c. Perhaps God knows that we will never reach the stars…. (The examples in (1) are all naturally occurring ones, discovered by David Beaver with the aid of Google; cf. Beaver 2002, exx. 32, 43, and 51, respectively.) On the other hand some other factives, e.g. regret, matter, and be surprised, do not exhibit the same type of behavior: (2) a. If any of the students regrets behaving badly, they’ll let us know. b. It doesn’t matter that the chimpanzees escaped. c. Was Bill surprised that spinach was included? Unlike the examples in (1), those in (2) could not be used appropriately in contexts where the speaker was not assuming that the complement clause was true. Our main concern will be trying to find the cause of this difference. However, before we get to that, we will look more closely at the concept “presupposition” itself, as well as its close neighbor in the linguistic literature, “conventional implicature” (section 2), and also at various ways of getting rid of presuppositions (section 3). In section 4 we will investigate two possible explanations for differences in presupposition triggering – the “lexical alternative” approach of Abusch (2002, 2005), and a suggestion of Ladusaw’s involving detachability of presuppositions. The final section contains concluding remarks. (shrink)

The prototypes of definiteness and indefiniteness in English are the definite article the and the indefinite article a/an, and singular noun phrases (NPs)1 determined by them. That being the case it is not to be predicted that the concepts, whatever their content, will extend satisfactorily to other determiners or NP types. However it has become standard to extend these notions. Of the two categories definites have received rather more attention, and more than one researcher has characterized the category of definite (...) NPs by enumerating NP types. Westerståhl (1985), who is concerned only with determiners in the paper cited, gives a very short list: demonstrative NPs, possessive NPs, and definite descriptions. Prince (1992) lists proper names and personal pronouns, as well as NPs with the, a demonstrative, or a possessive NP as determiner. She notes, in addition, that “certain quantifiers (e.g. all, every) have been argued to be definite” (Prince 1992: 299). This list, with the quantifiers added, agrees with that given by Birner & Ward (1998, 114). Ariel (1988, 1990) adds null anaphoric NPs. (shrink)

Reply to Steven Lestition's article, "Countering, Transposing, or Negating the Enlightenment? A Response to Robert Norton," published in the Journal of the History of Ideas(2007), pp. 659-81.

Introduction -- Membership -- Employment -- Property disputes -- The family -- Goods and services -- Conclusion.

This book considers the context of the colonial policies of Britain, Locke's contribution to them, and the importance of these ideas in his theory of property. It also reconsiders the debate about John Locke's influence in America. The book argues that Locke's theory of property must be understood in connection with the philosopher's political concerns, as part of his endeavour to justify the colonialist policies of Lord Shaftesbury's cabinet, with which he was personally associated. The author maintains that traditional scholarship (...) has failed to do justice to Locke by ignoring the implications of contemporary British imperial policy for the interpretation of his political thought. (shrink)

Dispositions are modal properties. The standard conception of dispositions holds that each disposition is individuated by its stimulus condition(s) and its manifestation(s), and that their modality is best captured by some conditional construction that relates stimulus to manifestation as antecedent to consequent. I propose an alternative conception of dispositions: each disposition is individuated by its manifestation alone, and its modality is closest to that of possibility — a fragile vase, for instance, is one that can break easily. The view is (...) expounded in some detail and defended against the major objections. (shrink)

Norton’s and Myrvold’s recent analyses of fluctuations and Landauer’s principle are compatible.

Abilities are in many ways central to what being an agent means, and they are appealed to in philosophical accounts of a great many different phenomena. It is often assumed that abilities are some kind of dispositional property, but it is rarely made explicit exactly which dispositional properties are our abilities. Two recent debates provide two different answers to that question: the new dispositionalism in the debate about free will, and virtue reliabilism in epistemology. This paper argues that both answers (...) fail as general accounts of abilities, and discusses the ramifications of this result. (shrink)