We hypothesize that life began not with the first self‐reproducing molecule or metabolic network, but as a prebiotic ecology of co‐evolving populations of macromolecular aggregates (composomes). Each composome species had a particular molecular composition resulting from molecular complementarity among environmentally available prebiotic compounds. Natural selection acted on composomal species that varied in properties and functions such as stability, catalysis, fission, fusion and selective accumulation of molecules from solution. Fission permitted molecular replication based on composition rather than linear structure, while fusion (...) created composomal variability. Catalytic functions provided additional chemical novelty resulting eventually in autocatalytic and mutually catalytic networks within composomal species. Composomal autocatalysis and interdependence allowed the Darwinian co‐evolution of content and control (metabolism). The existence of chemical interfaces within complex composomes created linear templates upon which self‐reproducing molecules (such as RNA) could be synthesized, permitting the evolution of informational replication by molecular templating. Mathematical and experimental tests are proposed. BioEssays 28: 399–412, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

We largely agree with Grimwade et al ’s1 conclusion that challenge trial participants may ethically be paid, including for risk. Here, we add further arguments, clarify some points from the perspective of economics and indicate areas where economists can support the development of a framework for ethically justifiable payment. Our arguments apply to carefully constructed and monitored controlled human infection model trials that have been appropriately reviewed and approved. Participants in medical studies perform a service. Outside the domain of research (...) participation, there is nearly universal agreement that workers providing a service should be compensated fairly, and that work involving more discomfort and risk should be compensated more generously. Accordingly, labour regulations impose floors, not caps on compensation. Caps, even if intended to protect against undue inducement, also raise concerns about illegal price-fixing that disadvantages workers. Such limits on payment for egg donors have successfully been challenged in court.i Moreover, caps on compensation may harm everyone at risk of infection, not just potential participants. Insufficient compensation may impede the recruitment of enough suitable subjects, for example, when representativeness of the subject sample is required. Delays in vaccine development not only prolong disruption of social, educational and economic activity but also lead to excess infections and deaths. Unlike paid CHIM participants, individuals exposed to such infection do not accept it voluntarily, are not compensated for it, and are unlikely to receive the level of medical supervision afforded to closely monitored CHIM participants. Payment caps can lead to attempts to circumvent the regulation. For example, many countries …. (shrink)

Despite being very common in both public and private argumentation, accusations of selective application of general premises, also known as “whataboutisms”, have been mostly overlooked in argumentation studies, where they are, at most, taken as accusations of inconsistency. Here I will defend an account according to which allegations of this sort can express the suspicion that the argumentation put forward by one party does not reflect his or her actual standpoint and reasons. Distinguishing this kind of argumentative moves is important (...) for evaluating its appropriateness in critical discussions where knowing the honest opinion of arguers is relevant, as in political controversies or interpersonal communication. (shrink)

What exactly is it to be a social constructivist in Metaphysics? In this brief note I try to introduce a few acclamatory distinctions that I have identified as having generated a lot of confusion in recent literature as well as serving to better frame current debates within metaphysical social constructivism. I also illustrate it with an example from the ontology of disability/.

This paper critically examines I.I. Rubin's Essays on Marx's Theory of Value and argues that two different approaches to value theory can be found in that book: a more 'production-centred' value-form theory uneasily co-exists with a 'circulationist' perspective. This unresolved tension, the authors claim, reflects a more general theoretical shortcoming in Rubin's work, namely, a problematic conceptualisation of the inner connection between materiality and social form that eventually leads to a formalist perspective on the value-form. Furthermore, the paper argues that (...) all those antinomies are an expression of the historical and political context underlying Rubin's work, in which Marxism was being codified as state ideology. The political implications of Rubin's formalism are explored through the critical examination of its consequences for the comprehension of the social determinations of the revolutionary subjectivity of the working class. (shrink)

Under what conditions would it be paradoxical to consider the possibility of false judgment? Here we claim that in the initial puzzle of Theaetetus 187e5–188c9, where Plato investigates the question of what could psychologically cause a false judgment, the paradoxical nature of this question derives from certain constraints and restrictions about causal explanation, in particular, from the metaphysical principle that opposites cannot cause opposites. Contrary to all previous interpretations, this metaphysical approach does not attribute to Plato any controversial epistemological assumptions (...) and fits better with the text and its role within the dialectic of the dialogue. (shrink)

Is there a notion of domain specificity which affords genuine insight in the context of the highly modular mind, i.e. a mind which has not only input modules, but also central ‘conceptual’ modules? Our answer to this question is no. The main argument is simple enough: we lay out some constraints that a theoretically useful notion of domain specificity, in the context of the highly modular mind, would need to meet. We then survey a host of accounts of what domain (...) specificity is, based on the intuitive idea that a domain specific mechanism is restricted in the kind of information that it processes, and show that each fails at least one of those constraints. (shrink)

Cognitive Gadgetsoffers a new, convincing perspective on the origins of our distinctive cognitive faculties, coupled with a clear, innovative research program. Although we broadly endorse Heyes’ ideas, we raise some concerns about her characterisation of evolutionary psychology and the relationship between biology and culture, before discussing the potential fruits of examining cognitive gadgets through the lens of active inference.

I argue that an ontological pluralist strategy that relies on category-relative properties is immune to all the particular criticisms Beall wields in his book against other strategies for recovering the consistency of the immutability of the incarnated god.

Mit diesem Handbuch wird auf wissenschaftlicher Grundlage eine Gesamtdarstellung vor allem der privatrechtlichen Medienprozesse vorgelegt, die im Zusammenhang mit der Produktion und Vermarktung bzw. Nutzung von Zeichen, Bildern, T nen und anderen Informationen (Medienprodukten) entstehen. Dabei werden auch die europarechtlichen Aspekte der Entwicklung des Medienrechts dargestellt. Das Handbuch enth lt Richtlinien, Gesetzestexte und Vertragsmuster, um dem Nutzer einen schnellen Zugriff zu erleichtern.