Although many regulators of skeletogenesis have been functionally characterized, one current challenge is to integrate this information into regulatory networks. Here, we discuss how the canonical Wnt and Smad‐dependent BMP pathways interact together and play antagonistic or cooperative roles at different steps of osteogenesis, in the context of the developing vertebrate embryo. Early on, BMP signaling specifies multipotent mesenchymal cells into osteochondroprogenitors. In turn, the function of Wnt signaling is to drive these osteochondroprogenitors towards an osteoblastic fate. Subsequently, both pathways (...) promote osteoblast differentiation, albeit with notable mechanistic differences. In osteocytes, the ultimate stage of osteogenic differentiation, the Wnt and BMP pathways exert opposite effects on the control of bone resorption by osteoclasts. We describe how the dynamic molecular wiring of the canonical Wnt and Smad‐dependent BMP signaling into the skeletal cell genetic programme is critical for the generation of bone‐specific cell types during development. (shrink)

This book seeks to explain long-term economic development and institutional change in terms of the cognitive features of human learning and communication processes. Martens links individual cognitive processes to macroeconomic growth theories, including economies of scale and scope, and to theories of institutional development based on asymmetric information in production processes and economies of scale in enforcement technology. With considerable flair, Bertin Martens has applied the hot new area of psychological and behavioural economics to notions of growth and development (...) and has created a unique and impressive volume. (shrink)

Recently, due in part to the research of Angela Duckworth, the cultivation of dispositions in education, grit in particular, has gained the attention of educational policymakers and the educational research community. While much of the research has focused on how to detect grit, there has been little discussion regarding how grit came to be valued as a noncognitive disposition and what its recent prominence might tell us about current social conditions. In this essay, Ariana Gonzalez Stokas attempts to illuminate (...) grit as a concept that has undergone a number of conceptual transformations in American culture. She seeks to show how grit developed as a way to justify social and economic inequality and how this history is bound up in its conceptual structure. Through conducting a genealogical excavation, Stokas reveals the relationship of grit to a cluster of cultural events that occurred at the turn of the twentieth century in the confluence of boxing, cowboys, and Theodore Roosevelt, and aims to illuminate how grit has served as a tool for convincing society that achievement occurs through heroic individual effort despite inadequate social supports. This historical understanding of grit, Stokas concludes, may help us to recognize that the energy and resources currently spent on cultivating grit in children would be better spent on ameliorating the problems of social and economic inequality. (shrink)

The foundations of Islam: Islamic doctrine -- Fundamental practices and institutions -- Islamic theology -- Islamic philosophy -- Islamic social and ethical principles.

En este trabajo nos proponemos rastrear la manera en que dos teóricos provenientes de campos disciplinares en apariencia distintos, interpretan en términos comunes la tragedia de la modernidad. Se trata de la tragedia que viene a mostrarnos que el orden del mundo ya no está predeterminado por ninguna voluntad divina y que su construcción deviene objeto de la acción humana. Para ilustrar esto nos referiremos al modo en que Thomas Hobbes y Sigmund Freud indagan el carácter contingente de lo humano (...) en las respectivas representaciones del estado de naturaleza y de la horda primitiva. Al mismo tiempo veremos cómo se articula en ambos planteos la idea de orden como producción social necesaria pero al mismo tiempo imposible. en el caso de Freud esta operación se asocia a la figura de la Kultur y en Hobbes a la del Leviathan. De este modo mostraremos que el estado y la Cultura se constituyen en el artificio para dar un orden —institucional y simbólico— al desorden constitutivo de la sociedad. (shrink)

Comme ailleurs dans le monde, les courants évangéliques et pentecôtistes ont tenté dès les années 1980 de s’imposer dans l’espace public de l’Afrique de l’Ouest. Bien qu’apparus au début du XX e siècle, ce n’est que dans la deuxième moitié du siècle que l’on observe un changement dans l’engagement évangélique vis-à-vis de la société : d’un retrait du monde à une « ouverture vers l’activité politique », marquée par le thème du combat spirituel pour les territoires. En Afrique de l’Ouest, (...) cette nouvelle visibilité dans l’espace public s’est concrétisée par l’élection de présidents évangéliques, comme Matthieu Kérékou au Bénin en 1996, ou Laurent Gbagbo en Côte d’Ivoire en 2000. Mais au sein d’une même société, les relations entre évangélismes et politique peuvent ainsi être multiples. Pour les saisir, il est nécessaire d’adopter différents points de vue, depuis les instances de pouvoir jusqu’aux relations interpersonnelles de la vie quotidienne. (shrink)

Review of Moshe Idel, Mircea Eliade. De la magie la mit (Mircea Eliade. From Magic to Myth), translation by Maria‑Magdalena Anghelescu (Iași: Polirom, 2014).

Review of Alberto Castaldini, Il Dio Nascosto e la possibilità di Auschwitz. Prospettive filosofiche e teologiche sull’Ollocausto,, 370 pag.

The proteins encoded by early region 1 A (E1A) of human adenoviruses (Ad) modulate the expression of both adenovirus genes and various host cell genes. With these transcription‐regulating properties the E1A proteins redirect the cell's metabolism, which enables them to induce oncogenic transformation in rodent cells. The E1A proteins modulate transcription by interacting both with gene‐specific and general cellular transcription factors. Various members of the AP‐1 and ATF/CREB families of transcription factors are targets for E1A‐dependent regulation, including cJun, the protein (...) product of the c‐jun proto‐oncogene. The E1A proteins modulate cJun‐dependent transcription both positively and negatively, and affect the activity as well as the expression levels of cJun. By increasing the phosphorylation status of cJun, E1A can stimulate transcription regulated by cJun/ATF2 heterodimers. In contrast, E1A inhibits the expression of various metalloproteases by interfering with the DNA‐binding capacity of cJun/cJun and cJun/cFos dimers, which might involve the association of E1A with the putative transcriptional coactivator p300. Since the ability of E1A to alter cJun‐dependent transcription correlates with its transforming capacity, interference with cJundependent transcription may be an essential step in E1A‐induced transformation. (shrink)

In Algerian Kabyle families, the intersection of tradition and modernity creates a dilemma for family-based eldercare. As daughters-in-law choose to live independently from their in-laws’ home, some unmarried daughters may be left to fill the care gap. Given the shift from traditional to modern caregiving arrangements, how can elders and the members of their family survive and thrive? Choosing an empirical case study that is analyzed using key concepts from care ethics and gender justice, we develop a notion of “caring (...) with the heart” for aging family members in need of long-term care. We offer seven possible solutions and policy options for the modern Kabyle context. (shrink)

Este trabajo aborda la experiencia de reflexión ideológico-política realizada por un grupo de intelectuales de izquierda —denominados “gramscianos argentinos”— en torno al concepto de hegemonía durante la transición democrática. El corpus de trabajos sobre el que centraremos nuestro análisis está conformado por los artículos publicados en la revista Controversia para el examen de la realidad argentina (México, 1979-1981) y los trabajos presentados en el seminario sobre “Hegemonía y alternativas políticas en América Latina” (UNAM, México, 1980).Nuestra hipótesis es que en los (...) debates del exilio de estos intelectuales el concepto de hegemonía se convierte en una herramienta analítica fundamental para repensar la relación entre democracia y socialismo por vía de un ejercicio de revisión conceptual sobre el sentido de la democracia. Esto supuso disputar un sentido liberal racionalista del concepto y rescatar la productividad política de la tensión entre las dimensiones formal y sustantiva de la democracia. Asimismo, analizaremos cómo la noción de hegemonía aparece en el marco de la polémica entre socialismo y peronismo, especialmente en la crítica teórico-política que hacen del populismo.Inspirados en una estrategia metodológica que combina los aportes de la teoría política contemporánea con los de la nueva historia intelectual, intentaremos demostrar nuestra hipótesis analizando los usos del concepto de hegemonía en el debate intelectual, entendiendo que dichos usos son índice y factor de una revisión conceptual más amplia y compleja de la relación entre democracia y socialismo. (shrink)

Despite myths of color-blindness in the Netherlands, Black women are marginalized by mainstream expectations of racial and cultural homogeneity. I use Amsterdam Black Women as a case study to illustrate the lived experiences of women affected by this exclusion. In this space, women freely critique Dutch society through mundane moments of truth-telling, venting, and joking, which enable individual problems to rise to a community level. I explore how subtle configurations of Black feminist organizing can be key sites of healing, experimentation, (...) and political engagement. This research complicates how we understand experiences of misogynoir when race consciousness is blended in a transnational context and how Amsterdam Black Women has made possible the refusal of Dutch norms that require members to accept their oppression silently and support false narratives of progressiveness and color-blindness. (shrink)

Depuis la fin des années 1990, la « complexité » a le vent en poupe. Ce texte présente une réflexion menée à l’Institut rhône-alpin des systèmes complexes sur le rôle que peuvent avoir les instituts pour promouvoir une étude réflexive des systèmes complexes. Il s’appuie également sur une étude empirique du domaine des systèmes complexes perçu à travers le prisme d’une base d’articles de sciences dures. Nous concluons sur la nécessité de permettre la maturation de projets interdisciplinaires.Since the late 1990s, (...) the "complexity" has the wind in its sails. This paper presents a discussion conducted at the Institute Rhône-Alpes complex systems on the role that institutions may have to promote a reflexive study of complex systems. It is also based on an empirical study of the field of complex systems seen through the prism of a base articles sciences. We conclude on the need to allow the maturation of interdisciplinary projects. (shrink)

ABSTRACT This paper aims to illustrate the contribution of Acquisition Linguistics combined with the dialogic view driven by Bakhtin’s ideas, in order to describe morpho-syntactic acquisitions. According to the first approach, interaction is the main driver of syntactic acquisition processes, especially adults’ adjustments to the morpho-syntactic attempts of children and children’s repetitions of adults’ speech. In parallel, a dialogic approach to language acquisition focuses on how the two speakers’ co-construction of discourse leads children to use and acquire the linguistic ability (...) to share and construct meaning in discourse. We analyse conversations between adults and children aged between 2 and 4 years old, with typical and atypical developments. Our results show how inter-discursive facts in dialogue and repetition in interaction are major contributors of language acquisition processes. (shrink)

Residency selection is a challenging process for medical students, one further complicated in the USA by the recentDobbs v Jackson Women’s Health Organization(Dobbs) decision over-ruling the federal right to abortion. We surveyed medical students to examine howDobbsis influencing the ideological, personal and professional factors they must reconcile when choosing where and how to complete residency.Between 6 August and 22 October 2022, third-year and fourth-year US medical students applying to US residency programmes were surveyed through social media and direct outreach to (...) medical schools. Analysis of quantitative and qualitative data from 494 responses was performed to assess downstream effects ofDobbson residency applicants’ family, health and career choices.Most respondents said changes in abortion access would likely or very likely influence their decision regarding location of considered residency programme (76.9%), where to start a family (72.2%) and contraceptive planning for them or their partner (57.9%). Cis-gender females were more influenced byDobbsregarding where (5 (4, 5) p<0.001) and when (3 (3, 5) p<0.001) to start a family. In qualitative responses, medical trainees highlighted the importance of abortion access for their patients, themselves and their loved ones.Medical trainees are incorporating state abortion access into their residency programme choices. Future physicians care about both the quality of care they will be able to provide and their own health. For personal and professional reasons, reproductive healthcare access is now a key factor in residency match decisions. (shrink)

ABSTRACTWe trace Susan Moller Okin’s reception of Mary Wollstonecraft with respect to the relationship between religion and feminist liberalism, by way of manuscripts housed at Somerville College, Oxford and Harvard University. These unpublished documents – dated from 1967 to 1998 – include her Somerville advising file, with papers dated from 1967 to 1979; her 1970 Oxford B.Phil. thesis on the feminist political theory of Wollstonecraft, William Thompson, and J.S. Mill; her teaching notes on Wollstonecraft originating in 1978, for her course (...) ‘Gender and Political Theory’ held at Brandeis and Stanford in the 1980s and 1990s; and her correspondence with John Rawls, dated from 1985 to 1998. A consistently secular feminist liberal, Okin had a blind spot with regard to religion, which led her to misinterpret Wollstonecraft’s theology as contradictory to her consequentialist arguments for women’s rights. Wollstonecraft virtually disappeared from Okin’s published corpus, overshadowed by the secular utilitarian feminist liberal J.S. Mill. Wollstonecraft nevertheless remained a deep philosophical source for both the method and the principle behind Okin’s distinctive brand of feminist liberalism. Okin’s reception of Wollstonecraft suggests that the fissures caused by religious conflict in modern politics have not only generated multiple liberalisms, as Rawls argued, but also multiple feminist liberalisms. (shrink)

Machine generated contents note: Prelude -- Introduction -- Part I: A Cabinet of Diversity -- 1. Object 1: Diversity Doesn't Work? -- 2. Object 2: Dominance -- 3. Object 3: From Wunderkammner to the Majors -- 4. Object 4: Patrol/Willy -- 5. Object 5: Accumulation/Difference that Makes No Difference -- 6. Object 6: Colorblindness/Federalist Paper no.6 -- 7. Object 7: Partition/No. 76-811: A Grievance Not of Their Making -- 8. Object 8: The Morrill Acts: "The Land Grab University" -- 9. (...) Afterthoughts -- Part II: The Constellation of Reparation -- 10. Star 1: Attempted Remedies -- 11. Star 2: Outlines of Epistemic Reparation -- 12. Star 3: How is a University like a Light Switch? -- 13. Afterthoughts -- Part III: Reparative Endeavors -- 14. Thread 1: Why Poetics? -- 15. Thread 2: Breath-Taking Landscapes: Place based interventions -- 16. Thread 3: Counter-space as the dramatization of a poetics of refusal -- 17. Thread 4: Gates/Gatekeeping -- 18. Thread 5: Unraveling Patrol -- 19. Thread 6: From Rank to Rhizome -- 20. Afterthoughts -- Acknowledgements -- Bibliography -- Notes -- Index. (shrink)

To better prepare students for active and thoughtful participation in a democratic society, civic education should foster an array of civic competencies. Cultivating student civic agency—an under-studied civic competency—is of particular importance to equip students to authentically use their voice in their communities. But what does it look like to foster student civic agency in a classroom setting? This article leverages a social and emotional learning (SEL) framework to uncover the active curricular ingredients and educational mechanisms through which a student-led (...) civics curriculum has fostered civic agency. In this multi-site case study, we analyze the implementation of an eighth grade student-led civics curriculum in a northeastern U.S. state. We outline how implicit SEL processes in these classrooms, stemming from a pedagogical focus on “changemakers,” supported development of civic agency. We found that the changemakers theme facilitated student exploration of their own civic identity and values, while prompting students to critically examine political power structures. Notably, the theme also helped students to develop a narrative of self as changemakers and to envision themselves actively engaged in civic spaces. This study adds insights to growing evidence on the multi-faceted benefits that civically-oriented SEL may offer to preparing young people to engage in democracy. (shrink)

Singles are an understudied yet growing segment of the adult population. The current study aims to expand the lens of relationship science by examining the well-being of unpartnered, single adults using latent profile analysis. We recruited singles closely matched to the United States census for an exploratory cross-sectional survey using five variables that strongly predict well-being. All five variables significantly predicted life satisfaction for the full sample. Latent profile analyses detected 10 groups of singles. Half of the profiles were happy (...) and half of the profiles were unhappy. Each profile had its own unique patterns relating to personal relationships, self-esteem, and personality traits. The happiest profile had the best relationships, self-esteem, and personality, while the unhappiest profile had the worst relationships, self-esteem, and personality. The profiles in between these two extremes had more nuanced patterns. For example, one relatively happy profile in the middle had high friendship satisfaction but low family satisfaction, while an adjacent profile showed the opposite pattern. Overall, singles who had positive relationships—both with themselves and others—were happiest. (shrink)

We study the case of a Chinese industrial policy, implemented in Shanghai that makes it mandatory for car manufacturers to share electro-mechanical performance and real time navigation data from their entire fleet of electric and hybrid vehicles with local and central government authorities. This policy seeks to prevent fraud in state subsidies, reduce emissions, assess the performance of New Energy Vehicles and strengthen the competitiveness of Chinese manufacturers of these vehicles. We argue that economies of scope in data aggregation may (...) provide traditional market failure arguments in favor of government intervention and mandatory data pooling. Our paper illustrates how data access regimes could be used for economic competition. The EU and China pursue similar data sharing and pooling policy goals that hinge on economies of scope in data aggregation. However, they follow very different political processes to achieve these goals. (shrink)

On June 28, 1993, the United States Supreme Court ruled on the admissibility of expert scientific opinion and evidence in federal court cases. The importance of the case can be measured by the interest it stimulated. The scientific community turned out in particular force to register its views. At the heart of the controversy was a debate over the nature of scientific knowledge and its relation to law. More than any other Supreme Court case in recent memory, the amici seemed (...) to view the Daubert case both as posing a potential challenge to basic scientific premises and as an opportunity to reclaim a lost prerogative to determine how science is applied in courts. (shrink)