Once anesthetized, patients are inherently “compliant” with surgical interventions because they can no longer intervene on their own behalf. In their target article, Minkoff et al. (2024) reasonabl...

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This is a new volume of original essays on the metaphysics of quantum mechanics. The essays address questions such as: What fundamental metaphysics is best motivated by quantum mechanics? What is the ontological status of the wave function? Does quantum mechanics support the existence of any other fundamental entities, e.g. particles? What is the nature of the fundamental space of quantum mechanics? What is the relationship between the fundamental ontology of quantum mechanics and ordinary, macroscopic objects like tables, chairs, and (...) persons? This collection includes a comprehensive introduction with a history of quantum mechanics and the debate over its metaphysical interpretation focusing especially on the main realist alternatives. (shrink)

This paper introduces a new, expanded range of relevant cognitive psychological research on collaborative recall and social memory to the philosophical debate on extended and distributed cognition. We start by examining the case for extended cognition based on the complementarity of inner and outer resources, by which neural, bodily, social, and environmental resources with disparate but complementary properties are integrated into hybrid cognitive systems, transforming or augmenting the nature of remembering or decision-making. Adams and Aizawa, noting this distinctive complementarity argument, (...) say that they agree with it completely: but they describe it as “a non-revolutionary approach” which leaves “the cognitive psychology of memory as the study of processes that take place, essentially without exception, within nervous systems.” In response, we carve out, on distinct conceptual and empirical grounds, a rich middle ground between internalist forms of cognitivism and radical anti-cognitivism. Drawing both on extended cognition literature and on Sterelny’s account of the “scaffolded mind” (this issue), we develop a multidimensional framework for understanding varying relations between agents and external resources, both technological and social. On this basis we argue that, independent of any more “revolutionary” metaphysical claims about the partial constitution of cognitive processes by external resources, a thesis of scaffolded or distributed cognition can substantially influence or transform explanatory practice in cognitive science. Critics also cite various empirical results as evidence against the idea that remembering can extend beyond skull and skin. We respond with a more principled, representative survey of the scientific psychology of memory, focussing in particular on robust recent empirical traditions for the study of collaborative recall and transactive social memory. We describe our own empirical research on socially distributed remembering, aimed at identifying conditions for mnemonic emergence in collaborative groups. Philosophical debates about extended, embedded, and distributed cognition can thus make richer, mutually beneficial contact with independently motivated research programs in the cognitive psychology of memory. (shrink)

Jaegwon Kim has argued that unless mental events are reducible to subvening physical events, they are at best overdeterminers of their effects. Recently, nonreductive physicalists have endorsed this consequence claiming that the relationship between mental events and their physical bases is tight enough to render any such overdetermination nonredundant, and hence benign. I focus on instances of this strategy that appeal to the notion of constitution. Ultimately, I argue that there is no way to understand the relationship between irreducible mental (...) events and their physical bases such as to both eliminate causal redundancy and preserve the efficacy of mental events. (shrink)

Fundamental physics makes no clear use of causal notions; it uses laws that operate in relevant respects in both temporal directions and that relate whole systems across times. But by relating causation to evidence, we can explain how causation fits in to a physical picture of the world and explain its temporal asymmetry. This paper takes up a deliberative approach to causation, according to which causal relations correspond to the evidential relations we need when we decide on one thing in (...) order to achieve another. Tamsin's taking her umbrella is a cause of her staying dry, for example, if and only if her deciding to take her umbrella for the sake of staying dry is adequate grounds for believing she'll stay dry. This correspondence explains why causation matters: knowledge of causal structure helps us make decisions that are evidence of outcomes we seek. The account also explains why we can control the future and not the past, and why causes come before their effects. When agents properly deliberate, their decisions can never count as evidence for any outcomes they may seek in the past. From this it follows that causal relations don't run backwards. This deliberative asymmetry is itself traced back to asymmetries of evidence and entropy, providing a new way of deriving causal asymmetry from temporally symmetric laws. (shrink)

Cooperative child care among humans, where individuals other than the biological mother (allomothers) provide care, may increase a mother’s fertility and the survivorship of her children. Although the potential benefits to the mother are clear, the motivations for allomothers to provide care are less clear. Here, we evaluate the kin selection allomothering hypothesis using observations on Hadza hunter-gatherers collected in ten camps over 17 months. Our results indicate that related allomothers spend the largest percentage of time holding children. The higher (...) the degree of relatedness among kin, the more time they spend holding, supporting the hypothesis of nepotism as the strongest motivation for providing allomaternal care. Unrelated helpers of all ages also provide a substantial amount of investment, which may be motivated by learning to mother, reciprocity, or coercion. (shrink)

This semester-long research project examined the use of social studies trade books to thematically teach about six individuals who served as change agents in the United States during the late 19th century and early 20th century. Three of the individuals were African American men, Robert Smalls, Frederick Douglass, and John Roy Lynch, who took civic action to address racial discrimination faced by the Black community in the half century following the U.S. Civil War. The other three indivduals were women women, (...) Ida B. Wells, Clara Lemlich, and Jane Addams, who challenged social inequities and injustices within their communities. Over the course of the semester-long research project, sixth-grade U.S. history students read selected trade books, examined primary sources, completed graphic organizers, and crafted writing assessments about each of the six individuals. Students demonstrated complex historical thinking, integrated economic and civic thinking, and communicated thematic ideas of systemic oppression of minorities, women, and the poor. They struggled to make connections between examples of historic oppression and contemporary examples of societal oppression. (shrink)

Cross-cultural sex differences in mobility and harm avoidance have been widely reported, often emphasizing fitness benefits of long-distance travel for males and high costs for females. Data emerging from adults in small-scale societies, however, are challenging the assumption that female mobility is restricted during reproduction. Such findings warrant further exploration of the ontogeny of mobility. Here, using a combination of machine-learning, mixed-effects linear regression, and GIS mapping, we analyze range size, daily distance traveled, and harm avoidance among Hadza foragers during (...) middle childhood and adolescence. Distance traveled increased with age and, while male adolescents had the longest daily ranges, average daily distance traveled by each sex was similar. We found few age- or sex-related patterns in harm-avoidant responses and a high degree of individual variation. When queried on the same issues, children and their parents were often in alignment as to expectations pertaining to harm avoidance, and siblings tended to behave in similar ways. To the extent that sex differences in mobility did emerge, they were associated with ecological differences in physical threats associated with sex-specific foraging behaviors. Further, we found no strong association between harm avoidance and mobility. Young Hadza foragers of both sexes are highly mobile, regardless of how harm avoidant they are. Taken together, our findings indicate that the causal arrows between harm avoidance and mobility must be evaluated in ecologically specific frameworks where cultural expectations of juvenile mobility can be contextualized. (shrink)

This is a new volume of original essays on the metaphysics of quantum mechanics. The essays address questions such as: What fundamental metaphysics is best motivated by quantum mechanics? What is the ontological status of the wave function? What is the nature of the fundamental space (or space-time manifold) of quantum mechanics?

"What are the ontological implications of quantum theories, that is, what do they tell us about the fundamental objects that make up our world? How should quantum theories make us reevaluate our classical conceptions of the basic constitution of material objects and ourselves? Is there fundamental quantum nonlocality? This book articulates several rival approaches to answering these questions, ultimately defending the wave function realist approach. It is a way of interpreting quantum theories so that the central object they describe is (...) the quantum wave function, interpreted as a field, and that the nonseparability and nonlocality we seem to find in quantum mechanics are ultimately manifestations of a more intuitive, separable and local picture in higher dimensions. quantum mechanics, quantum field theory, wave function, wave function realism, measurement problem, macro-object problem, primitive ontology, quantum entanglement, quantum nonlocality, quantum ontology"--. (shrink)

This paper argues for the concept of a decolonial humanism at the heart of C.L.R. James’s theoretical and political engagements. In exploring the concept of decolonial humanism, the paper moves through three major sections dealing with some of the definitive epistemic and political aspects of James’s work: a critique of Enlightenment Humanism and European Marxism without disavowing the aspirations of universal human emancipation; James’s work with the Johnson-Forest Tendency, the Pan-Africanist movement, and his attempts at labor organizing in Trinidad first (...) alongside Eric Williams in the People’s National Movement and later in his own Workers and Farmer’s Party ; and the practicality of decolonial humanism in terms of its adoption by Tim Hector and the Antigua Caribbean Liberation Movement. (shrink)

The COVID-19 pandemic introduced many restrictions to in-person interactions, and remote social interactions may be especially important for managing loneliness when such restrictions are in place. However, it is unclear how social interactions are related to loneliness when in-person interactions are limited. Data were collected between February 2021 and March 2022 from a sample of 581 university students. Participants reported their loneliness and participation in positive in-person or remote social interactions each day for 14 days. Results from dynamic structural equation (...) models showed that participants felt less lonely than they usually felt on the days they engaged in positive remote interactions at the within-person level. Moreover, participants generally felt less lonely when engaging more frequently in remote interactions, but only when in-person interactions were restricted (between-person level). Some of these results varied by changing COVID-19 restrictions. Finally, for participants who felt lonelier in general, the effect of positive in-person and remote interactions on loneliness was less strong. These findings suggest that social interactions may buffer loneliness but are not as impactful for those who experience greater loneliness. (shrink)

Over the past several years, the human rights implications of climate change have become more evident. While extreme weather events and slow onset changes caused by climate change affect the exercise of human rights, the implementation of climate change policies - in relation to both mitigation and adaptation - may also lead to the infringement of the rights of indigenous peoples and local communities. Despite this recognition by the UN Human Rights Council and other bodies, the international climate change regime (...) has failed to address these implications, recognizing only in 2010 the importance for parties to respect human rights in the implementation of the Framework Convention. The adoption of the Durban Platform for Enhanced Action (ADP), together with the reform of existing mechanisms and the operationalization of new institutions, offers several opportunities to ensure the adequate fulfillment of human rights obligations under the Convention. In this commentary, we highlight four concrete options available to the parties in the upcoming negotiations to guarantee the respect of substantial and procedural rights of all the stakeholders and to offer a redress mechanism in the case of loss and damages caused by climate change. (shrink)

Ecological concern has recently prompted efforts to assess the economic value of ecological functions: the “work of nature” must no longer be taken for granted as a free amenity, but priced and accounted for as “natural capital.” Critiques of this approach tend to defend nature’s intrinsic value against intrusions of economic logic, but fail to articulate a compelling politics in response. I here argue that nature ought indeed to be brought in to the realm of political economy, but question the (...) category of natural capital: instead, extending the insights of feminist theorists regarding undervalued forms of production, I articulate an expanded idea of hybrid labor that understands the “work of nature” as a collective, distributed undertaking of humans and nonhumans acting to reproduce, regenerate, and renew a common world. This approach poses the value of nature as inherently political and suggests the potential for new forms of more-than-human politics. (shrink)

Realists wanting to capture the facts of quantum entanglement in a metaphysical interpretation find themselves faced with several options: to grant some species of fundamental nonseparability, adopt holism, or to view localized spacetime systems as ultimately reducible to a higher-dimensional entity, the quantum state or wave function. Those adopting the latter approach and hoping to view the macroscopic world as grounded in the quantum wave function face the macro-object problem. The challenge is to articulate the metaphysical relation obtaining between three-dimensional (...) macro-objects and the wave function so that the latter may be seen in some sense as constituting the former. This paper distinguishes several strategies for doing so and defends one based on a notion of partial instantiation. (shrink)

Obstacles to achieving a global climate treaty include disagreements about questions of justice raised by the UNFCCC's principle that countries should respond to climate change by taking cooperative action "in accordance with their common but differentiated responsibilities and respective capabilities and their social and economic conditions". Aiming to circumvent such disagreements, Climate Change Justice authors Eric Posner and David Weisbach argue against shaping treaty proposals according to requirements of either distributive or corrective justice. The USA's climate envoy, Todd Stern, takes (...) a similar position. In this article I explain the practical and theoretical drawbacks of Posner & Weisbach's welfarist perspective and propose an alternative. I show that their arguments fail to rule out John Rawls' non-utilitarian, political conception of international justice and human rights, the Law of Peoples. On this basis I develop a conception of climate justice that highlights implications of some of Rawls' principles and adds a principle for determining fair shares of climate -treaty-related benefits and burdens. I propose this conception as a moral framework for negotiating a treaty that would promote human welfare consistently with requirements of justice, and I argue that a treaty proposal satisfying these requirements could best satisfy Posner & Weisbach's own feasibility criteria. (shrink)

Incidental findings in research with human participants may have implications for a person’s present health or future health outcomes. Current guidelines focus on methods for handling and reporting incidental findings from biological test data but incidental findings might also arise from non-biological tests. This article presents three examples in which the results from non-biological test data can be predictive of future disease and should be disclosed to research participants. It is intended to increase awareness and facilitate further discussion about the (...) reporting of incidental findings from non-biological data. (shrink)

This paper defends wave function realism against the charge that the view is empirically incoherent because our evidence for quantum theory involves facts about objects in three-dimensional space or space-time . It also criticizes previous attempts to defend wave function realism against this charge by claiming that the wave function is capable of grounding local beables as elements of a derivative ontology.

There are now several, realist versions of quantum mechanics on offer. On their most straightforward, ontological interpretation, these theories require the existence of an object, the wavefunction, which inhabits an extremely high-dimensional space known as configuration space. This raises the question of how the ordinary three-dimensional space of our acquaintance fits into the ontology of quantum mechanics. Recently, two strategies to address this question have emerged. First, Tim Maudlin, Valia Allori, and her collaborators argue that what I have just called (...) the ‘most straightforward’ interpretation of quantum mechanics is not the correct one. Rather, the correct interpretation of realist quantum mechanics has it describing the world as containing objects that inhabit the ordinary three-dimensional space of our manifest image. By contrast, David Albert and Barry Loewer maintain the straightforward, wavefunction ontology of quantum mechanics, but attempt to show how ordinary, three-dimensional space may in a sense be contained within the high-dimensional configuration space the wavefunction inhabits. This paper critically examines these attempts to locate the ordinary, three-dimensional space of our manifest image “within” the ontology of quantum mechanics. I argue that we can recover most of our manifest image, even if we cannot recover our familiar three-dimensional space. (shrink)

Why is it that despite having many of the same concerns on how ethics may be included in undergraduate medical curriculums, I write to state my concerns on Cowley’s formulation and conclusions.1I think my main problem is with an argument that starts from a position of criticising “universalising”, but offers as a substitute the idealising of another universality—“their own healthy intuitions and vocabulary”. What is it that can help in promoting an appreciation of what may be a “healthy”, as opposed (...) to an “unhealthy”, intuition? At the risk of immediately undermining my argument by indulging in psychoanalytical …. (shrink)

Some philosophers argue that many contemporary debates in metaphysics are “illegitimate,” “shallow,” or “trivial,” and that “contemporary analytic metaphysics, a professional activity engaged in by some extremely intelligent and morally serious people, fails to qualify as part of the enlightened pursuit of objective truth, and should be discontinued” (Ladyman and Ross, Every thing must go: Metaphysics naturalized , 2007 ). Many of these critics are explicit about their sympathies with Rudolf Carnap and his circle, calling themselves ‘neo-positivists’ or ‘neo-Carnapians.’ Yet (...) despite the fact that one of the main conclusions of logical positivism was that metaphysical statements are meaningless, many of these neo-positivists are themselves engaged in metaphysical projects. This paper aims to clarify how we may see a neo-positivist metaphysics as proceeding in good faith, one that starts with serious engagement with the findings of science, particularly fundamental physics, but also has room for traditional, armchair methods. (shrink)

This is a commentary on Mathias Frisch's book Causal Reasoning in Physics (Cambridge 2014). This commentary was presented at the 2016 Pacific Division Meeting of the American Philosophical Association in a session sponsored by the Society for the Metaphysics of Science.

It is widely noted that physicalism, taken as the doctrine that the world contains just what physics says it contains, faces a dilemma which, some like Tim Crane and D.H. Mellor have argued, shows that “physicalism is the wrong answer to an essentially trivial question”. I argue that both problematic horns of this dilemma drop out if one takes physicalism not to be a doctrine of the kind that might be true, false, or trivial, but instead an attitude or oath (...) one takes to formulate one’s ontology solely according to the current posits of physics. (shrink)

This article discusses recent disagreements over the correct formulation of physicalism. Although there appears to be a consensus outside those who discuss the issue that physicalists believe that what exists is what is countenanced by physics, as we will see, this orthodoxy faces an important puzzle now frequently referred to as 'Hempel's Dilemma'. After surveying the historical trajectory from Enlightenment-era materialism to contemporary physicalism, I examine several mainstream approaches that respond to Hempel's dilemma, and the benefits and drawbacks of each.

Integrative and naturalistic philosophy of mind can both learn from and contribute to the contemporary cognitive sciences of dreaming. Two related phenomena concerning self-representation in dreams demonstrate the need to bring disparate fields together. In most dreams, the protagonist or dream self who experiences and actively participates in dream events is or represents the dreamer: but in an intriguing minority of cases, self-representation in dreams is displaced, disrupted, or even absent. Working from dream reports in established databanks, we examine two (...) key forms of polymorphism of self-representation: dreams in which I take an external visuospatial perspective on myself, and those in which I take someone else's perspective on events. In remembering my past experiences or imagining future or possible experiences when awake, I sometimes see myself from an external or 'observer' perspective. By relating the issue of perspective in dreams to established research traditions in the study of memory and imagery, and noting the flexibility of perspective in dreams, we identify new lines of enquiry. In other dreams, the dreamer does not appear to figure at all, and the first person perspective on dream events is occupied by someone else, some other person or character. We call these puzzling cases 'vicarious dreams' and assess some potential ways to make sense of them. Questions about self-representation and perspectives in dreams are intriguing in their own right and pose empirical and conceptual problems about the nature of self-representation with implications beyond the case of dreaming. (shrink)

This paper examines the relationship between physical theories of causation and theories of difference-making. It is plausible to think that such theories are compatible with one another as they are aimed at different targets: the former, an empirical account of actual causal relations; the latter, an account that will capture the truth of most of our ordinary causal claims. The question then becomes: what is the relationship between physical causation and difference-making? Is one kind of causal fact more fundamental than (...) the other? This paper defends causal foundationalism: the view that facts about difference-making are dependent on the obtaining of facts about physical causation. However, the paper's main goal is to clarify the structure of the debate. At the end of the paper, it is shown how settling the issue about the relationship between physical theories of causation and theories of difference-making has more than mere intrinsic interest in unifying the very different pursuits that have been undertaken in the philosophy of causation. It can help to break a stalemate that has arisen in the current debate about mental causation. (shrink)

Pauline Kleingeld and Marcus Willaschek, in a co-authored article, declare that their purportedly new interpretation of Immanuel Kant's writings on autonomy reveals that his moral philosophy is neither realist nor constructivist. However, as I explain here, John Rawls already occupies the area of intellectual territory to which Kleingeld and Willaschek attempt to lay claim: Rawls interprets Kant's moral philosophy as neither realist, as Kleingeld and Willaschek evidently construe this term, nor constructivist, as they evidently construe this term. Contra Kleingeld and (...) Willaschek, the moral constructivism attributed to Kant by Rawls is not voluntarist, and Rawls's account of Kant's concept of autonomy is not paradoxical. In order to understand autonomy, it is necessary to understand Kant's complex conception of the will, which structures his moral philosophy (as Rawls, unlike Kleingeld and Willaschek, explains). Rawls, like Kant, but unlike Kleingeld and Willaschek, clearly distinguishes between certain importantly different questions about normativity and obligation. Kant's moral philosophy, according to Rawls's insightful interpretation, is a form of objective moral constructivism. (shrink)

In this paper, we aim to show that the framework of embedded, distributed, or extended cognition offers new perspectives on social cognition by applying it to one specific domain: the psychology of memory. In making our case, first we specify some key social dimensions of cognitive distribution and some basic distinctions between memory cases, and then describe stronger and weaker versions of distributed remembering in the general distributed cognition framework. Next, we examine studies of social influences on memory in cognitive (...) psychology, and identify the valuable concepts and methods to be extended and embedded in our framework; we focus in particular on three related paradigms: transactive memory, collaborative recall, and social contagion. Finally, we sketch our own early studies of individual and group memory developed within our framework of distributed cognition, on social contagion of autobiographical memories, collaborative flashbulb memories, and memories of high school at a high school reunion. We see two reciprocal benefits of this conceptual and empirical framework to social memory phenomena: that ideas about distributed cognition can be honed against and tested with the help of sophisticated methods in the social cognitive psychology of memory; and conversely, that a range of social memory phenomena that are as yet poorly understood can be approached afresh with theoretically motivated extensions of existing empirical paradigms. (shrink)

Physicalism is sometimes portrayed by its critics as a dogma, but there is an empirical argument for the position, one based on the accumulation of diverse microphysical causal explanations in physics, chemistry, and physiology. The canonical statement of this argument was presented in 2001 by David Papineau. The goal of this paper is to demonstrate a tension that arises between this way of understanding the empirical case for physicalism and a view that is becoming practically a received position in philosophy (...) of physics: that microphysics does not support the existence of causal facts (and so does not support causal explanations). Indeed this is a conclusion embraced in recent work by Papineau himself. This paper examines a range of natural ways of avoiding this tension and reconciling the empirical case for physicalism with the rejection of microphysical causation. (shrink)

The urgent importance of dealing with the climate crisis has led some influential theorists to argue that at least some demands for justice must give way to pragmatic and strategic considerations. These theorists (Cass Sunstein, Eric Posner, and David Weisbach, all academic lawyers, and John Broome, an academic philosopher) contend that the failures of international negotiations and other efforts to change economic policies and practices have shown that moral exhortations are worse than ineffective. Although Broome's position is similar in these (...) respects to that of Sunstein, Posner and Weisbach, it differs in other important respects, including his understanding of the idea of justice, his disagreement with the policy approach (which he calls "efficiency with sacrifice") favored by the economists Nicholas Stern and William Nordhaus, and his proposal for establishing a new international financial institution, a World Climate Bank, in addition to putting a price on carbon. Elsewhere I offer a critical analysis of the position taken by Posner and Weisbach in their book, Climate Change Justice. Their arguments against allowing principles of distributive justice (narrowly understood) to constrain treaty negotiations fail to rule out the principles of John Rawls' Law of Peoples (which is a conception of the moral basis of a just international order, including states' obligations to secure basic human rights for all). Therefore their arguments against shaping climate treaties to reflect any principles of justice do not succeed in supporting their position. Here I offer a critical analysis of Broome's position. I raise and discuss objections to Broome's proposal for a WCB, and I argue that the continued relevance of these objections is contingent on how the proposal for a WCB may get developed. (shrink)

As awareness of global warming has spread during the past couple of decades and developed into the realization that humanity faces an existential threat, a number of more or less Kantian liberal or cosmopolitan moral and political theorists have attempted to address questions of justice raised by the climate crisis. David Held was among the most prolific and influential of them. Here I discuss Held's cosmopolitan perspective on climate governance and consider its bearing on certain recent proposals for new institutions, (...) including in particular a proposal offered by John Broome and Duncan Foley for establishing a World Climate Bank. I argue that such a WCB may be endorsable from Held's perspective, depending how the initial proposal may get further developed. Held's approach to politics is similar to Kant's in certain significant respects, including the role of hope. Both approaches are valuable and important in relation to the climate crisis. (shrink)

This chapter contains section titled: Basic Human Rights Public Reason Sovereignty and Self‐determination The DNSL Argument and the Minimum Respect‐for‐Justice Condition Adequate Justification Rights of Political Participation Post‐war Nation Building Promoting Political Reform Conclusion Acknowledgments Notes.