The genes involved in methionine biosynthesis are scattered throughout the Escherichia coli chromosome and are controlled in a similar but not coordinated manner. The product of the metJ gene and S‐adenosylmethionine are involved in the repression of this ‘regulon’.

Auf den Ersten Weltkrieg folgte in Mitteleuropa ein grundlegender politischer Umbruch. Albert Dikovich arbeitet die Folgen dieser demokratischen Zeitenwende für die deutschsprachige Philosophie umfassend auf. Dabei untersucht er zum einen, wie nach dem katastrophalen Gewaltereignis des Krieges und angesichts der akuten Eskalation im Inneren die Grenzen der moralisch legitimen Mittel politischer Konfliktaustragung neu gezogen wurden. Zum anderen beleuchtet er den Zusammenhang zwischen rechts- und erkenntnistheoretischen Annahmen und Positionierungen innerhalb eines Spannungsfeldes konkurrierender politischer Neuordnungsentwürfe. Dabei zeigt sich, dass die damals (...) geführten philosophischen Kämpfe um die Demokratie mit unserer Gegenwart mehr zu tun haben, als es der geschichtliche Abstand vermuten lässt. (shrink)

Is socialism desirable? Is it even possible? In this concise book, one of the world's leading political philosophers presents with clarity and wit a compelling moral case for socialism and argues that the obstacles in its way are exaggerated. There are times, G. A. Cohen notes, when we all behave like socialists. On a camping trip, for example, campers wouldn't dream of charging each other to use a soccer ball or for fish that they happened to catch. Campers do (...) not give merely to get, but relate to each other in a spirit of equality and community. Would such socialist norms be desirable across society as a whole? Why not? Whole societies may differ from camping trips, but it is still attractive when people treat each other with the equal regard that such trips exhibit. But, however desirable it may be, many claim that socialism is impossible. Cohen writes that the biggest obstacle to socialism isn't, as often argued, intractable human selfishness--it's rather the lack of obvious means to harness the human generosity that is there. Lacking those means, we rely on the market. But there are many ways of confining the sway of the market: there are desirable changes that can move us toward a socialist society in which, to quote Albert Einstein, humanity has "overcome and advanced beyond the predatory stage of human development.". (shrink)

An important obstacle to lawhood in the special sciences is the worry that such laws would require metaphysically extravagant conspiracies among fundamental particles. How, short of conspiracy, is this possible? In this paper we'll review a number of strategies that allow for the projectibility of special science generalizations without positing outlandish conspiracies: non-Humean pluralism, classical MRL theories of laws, and Albert and Loewer's theory. After arguing that none of the above fully succeed, we consider the conspiracy problem through the (...) lens of our preferred view of laws, an elaboration of the MRL view that we call the Better Best System (BBS) theory. BBS offers a picture on which, although all events supervene on a fundamental level, there is no one unique locus of projectibility; rather there are a large number of loci corresponding to the different areas (ecology, economics, solid-state chemistry, etc.) in which there are simple and strong generalizations to be made. While we expect that some amount of conspiracy-fear-inducing special science projectibility is inevitable given BBS, we'll argue that this is unobjectionable. It follows from BBS that the laws of any particular special or fundamental science amount to a proper subset of the laws. From this vantage point, the existence of projectible special science generalizations not guaranteed by the fundamental laws is not an occasion for conspiracy fantasies, but a predictable fact of life in a complex world. (shrink)

Albert Ellis is widely recognized as one of the most influential psychologists in the history of psychology. However, his importance as a pioneer of applied philosophy is not as widely acknowledged. This paper, in memoriam, pays tribute to Ellis’s contributions to applied philosophy. In particular it discusses his revolutionarily important applications of philosophy to the field of psychology and briefly discusses his influence on the emerging field of philosophical counseling.

Albert Ellis is widely recognized as one of the most influential psychologists in the history of psychology. However, his importance as a pioneer of applied philosophy is not as widely acknowledged. This paper, in memoriam, pays tribute to Ellis’s contributions to applied philosophy. In particular it discusses his revolutionarily important applications of philosophy to the field of psychology and briefly discusses his influence on the emerging field of philosophical counseling.

Data from the World Values Survey shows that generalized trust in Mainland China—trust in out-group members—is very low, but generalized trust in Taiwan is much higher. The present article argues that positive interactions with out-group members in the context of Taiwan’s export-oriented economy fostered generalized trust—and so explains this difference. This line of argument provides evidence for Albert O. Hirschman’s doux commerce thesis, that market interaction can improve persons and even stabilize the social order. The present article defends this (...) point by separating two theses that Hirschman combines under that label, a countervailing forces thesis and a doux commerce thesis narrowly understood. These theses offer different explanations (or mechanisms) for how commerce could have those positive effects. The data about Taiwanese trust practices provides evidence for the latter. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Future Directions for Human Cloning by Embryo Splitting:After the HullabalooCynthia B. Cohen (bio)In October 1993, a paper entitled, "Experimental Cloning of Human Polyploid Embryos Using an Artificial Zona Pellucida," was presented at a joint meeting of the American Fertility Society and the Canadian Fertility and Andrology Society. Although it was awarded a prize, its authors, who are affiliated with George Washington University, decided against calling a press conference (...) to announce their findings. Word of their experiment soon leaked out, however, and the New York Times blazoned on its front page that human embryo cloning had been achieved. The story was accompanied by a diagram of cloning by nuclear transplantation.Newspapers and television networks around the world picked up the story and embellished it. The idea of unlimited, xeroxed copies of human beings gripped the public imagination. Wild scenarios of hundreds of Hitlers plotting to take over the world and of clones giving birth to their own twins enlivened media reports. Only gradually did it become clear that the term "polyploid" in the title of the paper referred to abnormal embryos that could never develop into living human beings and that "cloning" referred to embryo splitting or twinning, not to nuclear transplantation or the transfer of a donor nucleus into an enucleated egg. Once this sank into public consciousness, the "hullabaloo," as Dr. Howard W Jones, Jr., called it, died down.It left in its wake unanswered questions about the ethics of splitting embryos. During the height of the publicity given to the George Washington experiment, newspaper and TV stories had not delved in any depth into the ethical issues it raised. Ethicists, given limited time to discuss the ethical questions at stake, had been quoted in quick, simplistic responses. Some had offered little analysis of the rights and wrongs of embryo splitting, but, revealing tremendous creative talent, had spun out [End Page 187] imaginary and frightening applications of the procedure. This was a story essentially about ethics in which ethics was never really discussed.The National Advisory Board on Ethics in Reproduction* (NABER), an independent, multidisciplinary group that addresses ethical issues in modern reproductive science, technology, and care, became concerned about the sparsity of reflective ethical debate about embryo splitting. NABER's chair, Albert Jonsen, observed that "reporters phoning ethicists for comment and ethicists appearing on talk shows do not a debate make. Debate requires face to face (or at least essay to essay) argument among persons sharing the same information. This has yet to take place." Consequently, NABER decided to convene a workshop on human cloning by embryo splitting at the National Academy of Sciences in February 1994. The board invited participants who would provide a broad range of opinion about the ethical and public policy issues entailed by human embryo splitting. Embryologists, ethicists, reproductive biologists, public policy experts, staff from the National Institutes of Health (NIH), legal scholars, journalists, and infertility specialists were among those who participated. The feature articles in this issue of the Kennedy Institute of Ethics Journal derive from that workshop. Their authors were given free rein to take whatever stance they deemed ethically supportable.The first article is designed to provide some understanding of the science of human cloning as a basis for exploring the ethical issues raised by this set of techniques. Jacques Cohen, a leading reproductive embryologist, and Giles Tomkin, a science writer, both of Cornell University Medical School, explain, in a way that is clear to laypersons and biologists alike, the meaning, nature, and function of cloning. They discuss recent: advances in this area and offer an assessment of feasible uses of human cloning procedures, hoping to dispel what they view as mistaken fears about its future applications. Dr. Howard W Jones, Jr., a pioneer infertility specialist, briefly comments on Cohen and Tomkin's paper, pointing out that embryo splitting may not improve pregnancy results if genetic heterogeneity is required for successful embryo transfer and implantation.In the next article, three major ethical arguments against human cloning by embryo splitting are analyzed and rejected by Ruth Macklin, an expert in reproductive ethics from Albert Einstein College of Medicine. She finds the first argument, that the worth of individuals... (shrink)

A translation of one section of Hermann Cohen's introduction to Friedrich Albert Lange's History of Materialism.

Pourquoi croyons-nous? D’où vient que nous croyons? Pour aborder cette interrogation, qui touche à l’origine du sentiment religieux, Albert Piette se tourne en premier lieu vers les sciences de la préhistoire, défrichant la littérature scientifique pour tenter de déceler à quel moment émerge, en ses origines préhistoriques, la capacité du « croire ». Contre la tradition de l’évolutionnisme culturel du tournant du 20e siècle, Piette refuse de réduire la croyance à la crédulité, ou à une irra...

Logic-Based Therapy, a mode of philosophical counseling I invented beginning in the mid 1980s, under the auspices of Cognitive Behavior Therapy founder Albert Ellis, takes metaphysical security as a sin qua non for human happiness. The goal of LBT is to help people overcome irrational thinking that leads to metaphysical insecurity and to help build constructive, philosophical thinking that promotes metaphysical security. However, the advent of augmented and digital reality are beginning to present new challenges to obtaining metaphysical security. (...) Applying the tenets of LBT, this paper examines the implications for attaining metaphysical security in this brave new world of advancing technologies. (shrink)

The traditional ludomotor activities (LA) are recognized by UNESCO as an intangible piece of cultural heritage. The ethnomotricity analyzes LA in its sociocultural context, taking into account the proprieties of rules or motor conditions (internal logic) and the link with local culture (external logic). The aim of this research was to identify and reveal the distinctive ethnomotor features of LA in order to understand the adaptations that occurred in the social scenario of the Spanish Civil War (1936–1939) in Lleida. The (...) corpus of the research was constituted by 101 LA which were collected from the analysis of 20 semi-structured interviews. An “ad hoc” tool was designed and agreed upon by expert observers. It was comprised of a total of 27 ethnomotor variables related to LA. The experts achieved high reliability [Cohen’s kappa coefficient (κ) and Spearman’s correlation coefficient = 1] when the classification of LA was carried out on two different occasions. Descriptive statistics, cross-tabulations (Pearson’s chi-squared) effect sizes, and two-step clusters were performed by external and internal logic variables. The presence or absence of motor interaction (X2= 9.029;df= 1;p< 0.003;ES= 0.298) was enlightening when comparing LA with and without a war connotation. On the other hand, the hierarchy of variables rested primarily on IL-Domain (Psycho-Coop-Oppo-Coop/Oppo) (PI = 1). Among other singularities, while two-step cluster analysis revealed a corresponding ethnomotor silhouette with cluster 1, with the warlike connotation (n= 48; 96.0%), its homologous structure was expressed (Cluster 2) in the absence of the warlike character (n= 26; 50%). (shrink)

Résumé Confronté à l’orientation tendanciellement matérialiste des sciences de la nature dans le dernier tiers du xix e siècle, Hermann Cohen s’efforça d’offrir une fondation idéaliste de ces sciences en recourant à la philosophie transcendantale kantienne. Il fut en accord avec Friedrich Albert Lange dans le refus de toute métaphysique dogmatique, mais il ne partagea pas son naturalisme, et l’idéalisme poético-fictif qui le complétait. Alors que Lange, dans son Histoire du matérialisme, avait eu pour but de décrire l’autodissolution (...) de la métaphysique matérialiste, Cohen voulut montrer comment le matérialisme débouchait dans un idéalisme méthodique, de provenance kantienne. En fin de compte, la distance dans le temps par rapport à Lange s’accroissant, il en vint à prêter un tel idéalisme à Lange lui-même ; ce qui est problématique. (shrink)

Friedrich Albert Lange (1828-1875) author of a famous History of Materialism and Critique of Its Present Significance (1866, English transI. 1877-79, repr. 1925 with introduction by Bertrand Russell), was also interested in the epistemological foundations of formal logic. Part I of his intended two-volume Logische Studien was published posthumously in 1877 by Hermann Cohen, head of the Marburg school of neo-Kantianism. Lange, departing from Kant, claims that spatial intuition is the source of the apodeictic character not only of (...) the truths of mathematics, but also of the truths of logic. He aims at showing this by basing validity and invalidity of syllogistic inferences on an interpretation of the standard forms (of proposition in assertoric syllogistic) with the help of the five kinds of possible relations (in fact what is known today as the Gergonne-Euler relations) between extensions of concepts given to us as areas in a plane, i.e.in space. Generality is achieved by considering all possible variations within each type of spatial relation, exhibiting a connection between concept and intuition reminding Lange of the Kantian "schema". Lange is well aware of the contemporary English "algebraic" logic, but he considers its approach as the appropriate one for a logic of content (Inhaltslogik) and not for a logic of extension (Umfangslogik). Lange did not live to enjoy the recognition by some leading logicians (amongst them John Venn, to whose reference in 1881 to Lange's "admirable Logische Studien" the present paper owes it title), nor could he respond to the many critics of his proposed foundation of logic. Its radicality as well as its broad reception (and discussion up to at least 1959) seem to entitle Lange's Logische Studien to an, if modest, place in the history of logic in the 19th century. (shrink)

Friedrich Albert Lange author of a famous History of Materialism and Critique of Its Present Significance, was also interested in the epistemological foundations of formal logic.Part I of his intended two‐volume Logische Studienwas published posthumously in 1877 by Hermann Cohen“head”of the Marburg school of neo‐Kantianism.Lange, departing from Kant, claims that spatial intuition is the source of the apodeictic character not only of the truths of mathematics, but also of the truths of logic.He aims at showing this by basing (...) validity and invalidity of syllogistic inferences on an interpretation of the standard forms with the help of the five kinds of possible relations between extensions of concepts given to us as areas in a plane, i.e.in space.Generality is achieved by considering all possible variations within each type of spatial relation, exhibiting a connection between concept and intuition reminding Lange of the Kantian “schema”. Lange is well aware of the contemporary English “algebraic” logic, but he considers its approach as the appropriate one for a logic of content and not for a logic of extension Lange did not live to enjoy the recognition by some leading logicians, nor could he respond to the many critics of his proposed foundation of logic.Its radicality as well as its broad reception seem to entitle Lange’s Logische Studiento an, if modest, place in the history of logic in the 19th century. (shrink)

Friedrich Adolf Trendelenburg war einer der akademischen Lehrer Hermann Cohens und die Debatte zwischen Trendelenburg und Kuno Fischer über die Interpretation der transzendentalen Ästhetik gilt gemeinhin als Anlass für Cohens Kantstudien und seine Abwendung von der Völkerpsychologie und damit als Geburtsstunde des Marburger Neukantianismus. Über die nähere persönliche Beziehung Cohens zu Trendelenburg ist allerdings wenig bekannt und auch die Frage, ob und inwiefern Cohen als „Schüler“ Trendelenburgs bezeichnet werden kann ist nicht eindeutig zu beantworten, zumindest scheint Cohens Verhältnis zu (...) Trendelenburg eher distanziert gewesen zu sein und es ist nicht klar, ob nicht Cohens Trendelenburg gegenüber teilweise auch kritische Haltung in seiner Stellungnahme zur Kontroverse zwischen Trendelenburg und Fischer auch zum Scheitern seiner Habilitationsversuche in Berlin beigetragen hat. Andererseits wurde darauf hingewiesen, dass sich Cohen durch die von Trendelenburg aufgeworfene Frage, ob Kant die ausschließliche Subjektivität von Raum und Zeit bewiesen habe, vor das für seine Philosophie und Kantkritik zentrale Problem einer nicht bloß „subjektiven“ Begründung des Idealismus gestellt sah und diesbezüglich (in Abgrenzung von Kuno Fischer und Friedrich Albert Lange) im wesentlichen Trendelenburgs Absicht, „das Ideale im Realen zu befestigen“, weiterverfolgte (Klaus Christian Köhnke). Kurt Walter Zeidler hat diese These vor kurzem insofern zugespitzt, als er zu dem Schluss kommt, dass Cohen „seine eigene systematische Position – und damit die Grunddoktrin der Marburger Schule – an dem Leitfaden einer Kantinterpretation entwickelt, die Trendelenburgs latenten Platonismus, seine Lehre von der ursprünglichen Tätigkeit und konstruktiven Bewegung sowie den wissenschaftstheoretischen Ansatz seiner Logischen Untersuchungen gleichsam als Hebel einsetzt, um Kants Lehre von allen Anmutungen eines empirischen oder subjektiven Idealismus zu befreien.“ Diese These wird mit Blick auf Cohens frühe Kant- und Platon-Interpretation überprüft und der historische und biographische Kontext von Cohens Berliner Studienzeit skizziert. (shrink)

Die MISCELLANEA MEDIAEVALIA präsentieren seit ihrer Gründung durch Paul Wilpert im Jahre 1962 Arbeiten des Thomas-Instituts der Universität zu Köln. Das Kernstück der Publikationsreihe bilden die Akten der im zweijährigen Rhythmus stattfindenden Kölner Mediaevistentagungen, die vor über 50 Jahren von Josef Koch, dem Gründungsdirektor des Instituts, ins Leben gerufen wurden. Der interdisziplinäre Charakter dieser Kongresse prägt auch die Tagungsakten: Die MISCELLANEA MEDIAEVALIA versammeln Beiträge aus allen mediävistischen Disziplinen - die mittelalterliche Geschichte, die Philosophie, die Theologie sowie die Kunst- und Literaturwissenschaften (...) sind Teile einer Gesamtbetrachtung des Mittelalters. (shrink)

This paper argues that the ‘scientific dispute’ between Hermann Cohen and Rudolf Stammler is symptomatic of a philosophical movement of left-wing Kant interpretations at the turn of the twentieth century. By outlining influential predecessors that shaped Cohen’s and Stammler’s thinking, I show that their Kantian justifications of socialism differ regarding their conception of law, history, and the political implications that follow from their practical philosophies. Against scholars who suggest that the Marburg School’s view on socialism was a coherent (...) school of thought, I introduce the concept of ‘left-Kantianism’ as an open term that includes a wide variety of novel socialist approaches to Kant at the time. (shrink)

Die MISCELLANEA MEDIAEVALIA präsentieren seit ihrer Gründung durch Paul Wilpert im Jahre 1962 Arbeiten des Thomas-Instituts der Universität zu Köln. Das Kernstück der Publikationsreihe bilden die Akten der im zweijährigen Rhythmus stattfindenden Kölner Mediaevistentagungen, die vor über 50 Jahren von Josef Koch, dem Gründungsdirektor des Instituts, ins Leben gerufen wurden. Der interdisziplinäre Charakter dieser Kongresse prägt auch die Tagungsakten: Die MISCELLANEA MEDIAEVALIA versammeln Beiträge aus allen mediävistischen Disziplinen - die mittelalterliche Geschichte, die Philosophie, die Theologie sowie die Kunst- und Literaturwissenschaften (...) sind Teile einer Gesamtbetrachtung des Mittelalters. (shrink)

In Mindblindness, Simon Baron-Cohen presents a model of the evolution and development of "mindreading." He argues that we mindread all the time, effortlessly, automatically, and mostly unconsciously. It is the natural way in which we interpret, predict, and participate in social behavior and communication. We ascribe mental states to people: states such as thoughts, desires, knowledge, and intentions. Building on many years of research, Baron-Cohen concludes that children with autism, suffer from "mindblindness" as a result of a selective (...) impairment in mindreading. For these children, the world is essentially devoid of mental things. Baron-Cohen develops a theory that draws on data from comparative psychology, from developmental, and from neuropsychology. He argues that specific neurocognitive mechanisms have evolved that allow us to mindread, to make sense of actions, to interpret gazes as meaningful, and to decode "the language of the eyes." A Bradford Book. (shrink)

We use a new model of metarepresentational development to predict a cognitive deficit which could explain a crucial component of the social impairment in childhood autism. One of the manifestations of a basic metarepresentational capacity is a ‘ theory of mind ’. We have reason to believe that autistic children lack such a ‘ theory ’. If this were so, then they would be unable to impute beliefs to others and to predict their behaviour. This hypothesis was tested using Wimmer (...) and Perner’s puppet play paradigm. Normal children and those with Down’s syndrome were used as controls for a group of autistic children. Even though the mental age of the autistic children was higher than that of the controls, they alone failed to impute beliefs to others. Thus the dysfunction we have postulated and demonstrated is independent of mental retardation and specific to autism. (shrink)

This book provides an analytical and critical appraisal of Rousseau's political thought that, while frank about its limits, also explains its enduring power.

From the author of Quantum Mechanics and Experience, a hugely influential book that challenged key assertions by Niels Bohr and other founders of quantum mechanics, A Guess at the Riddle provides a major metaphysical overhaul of one of physics' most intractable problems-the quest to bridge quantum and classical physics in order to understand the nature of reality.

An examination of the controversial "theory of mind" hypothesis, which states that children with autism are unable to comprehend other people's mental states. The theory relates to the most fundamental questions of normal development as well as to autism i.