The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

My aim here is (1) to argue that the usual argument for thinking dysfunction has no place in a dispositionalist approach to functions is deeply flawed and (2) to develop a positive account of the explanatory role dysfunction attributions play in dispositionalist-style functional analysis. I will also argue that while my account undermines one common motivation for preferring an etiological over a dispositionalist approach, perhaps more interestingly, it also blurs the boundary between the two and opens a path to unifying (...) them. (shrink)

A sample of 44 psychologists who practice in the Caribbean completed a web-based survey containing 73 behavioral items related to ethical issues in professional practice. The aim of this exploratory study was to learn about perceptions regarding ethical behaviors that create ethical dilemmas and the level of agreement to their responses and to identify how demographic variables influenced their perceptions of ethical behaviors. Findings suggest that there was approximately an equal level of agreement on behaviors such as being an advocate (...) for your client and being sexually involved with a current client rated as ethical and unethical, respectively. Several demographic variables and ethical behaviors such as level of degree and confidentiality issues were statistically significant. Finally, psychologists prefer the presence of a professional psychological association with an ethics committee. (shrink)

Research on animal behavior is typically organized according to a combination of two influential frameworks: Ernst Mayr’s distinction between proximate and ultimate causes, and Niko Tinbergen’s “four questions”. My aim is to debunk two common interpretive misconceptions about Mayr’s proximate–ultimate distinction and its relationship to Tinbergen’s four questions, and to offer a new interpretation that avoids both. The first misconception is that the proximate–ultimate distinction maps cleanly onto Tinbergen’s four questions, marking a boundary between Tinbergen’s evolutionary and survival value questions (...) versus developmental and mechanistic questions. The second is that Mayr’s proximate–ultimate distinction is meant to rule out the relevance of proximate causes to evolutionary explanations. I argue that neither is plausible given the text and Mayr’s philosophical aims, namely, to argue that evolutionary biology cannot be reduced to either the physical sciences or to other areas of biology. Through a reconstruction of Mayr’s anti-reductionist argument, I develop an interpretation according to which the proximate–ultimate distinction marks two ways that teleological reasoning can be naturalistically grounded in biology, corresponding to Mayr’s distinction between teleonomic and adapted systems. Mayr distinguishes reduction, which the proximate–ultimate distinction is meant to block, from analysis, through which he allows that proximate causes, causes that are neither proximate nor ultimate, and chance can all contribute to evolutionary explanations. I conclude by suggesting some ways in which the interpretation defended here reframes our understanding of Mayr’s disagreements with some evolutionary-developmental biologists. (shrink)

Research on animal behavior is typically organized according to a combination of two influential frameworks: Ernst Mayr’s distinction between proximate and ultimate causes, and Niko Tinbergen’s “four questions”. My aim is to debunk two common interpretive misconceptions about Mayr’s proximate–ultimate distinction and its relationship to Tinbergen’s four questions, and to offer a new interpretation that avoids both. The first misconception is that the proximate–ultimate distinction maps cleanly onto Tinbergen’s four questions, marking a boundary between Tinbergen’s evolutionary and survival value questions (...) versus developmental and mechanistic questions. The second is that Mayr’s proximate–ultimate distinction is meant to rule out the relevance of proximate causes to evolutionary explanations. I argue that neither is plausible given the text and Mayr’s philosophical aims, namely, to argue that evolutionary biology cannot be reduced to either the physical sciences or to other areas of biology. Through a reconstruction of Mayr’s anti-reductionist argument, I develop an interpretation according to which the proximate–ultimate distinction marks two ways that teleological reasoning can be naturalistically grounded in biology, corresponding to Mayr’s distinction between teleonomic and adapted systems. Mayr distinguishes reduction, which the proximate–ultimate distinction is meant to block, from analysis, through which he allows that proximate causes, causes that are neither proximate nor ultimate, and chance can all contribute to evolutionary explanations. I conclude by suggesting some ways in which the interpretation defended here reframes our understanding of Mayr’s disagreements with some evolutionary-developmental biologists. (shrink)

Debates about the concept of disease have traditionally been framed as a competition between two conflicting approaches: naturalism, on the one hand, and normativism or social constructivism, on the other. In this article, we lay the groundwork for a naturalistic form of social constructivism by dissociating the presumed link between value-free conceptions of disease and a broadly naturalistic approach; offering a naturalistic argument for a form of social constructivism; and suggesting avenues that strike us as especially promising for filling in (...) the details of an alternative approach and addressing the most obvious objections. (shrink)

In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often‐ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. (...) SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk‐benefit profile. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Persuasion and RhetoricThomas M. ConleyPersuasion and Rhetoric. Carlo Michelstaedter. Translated with an introduction and commentary by Russell Scott Valentino, Cinzia Sartini Blum, and David J. Depew : New Haven: Yale University Press, 2004. Pp. 178. $32.50, hardcover.Readers of this book will not find much in it about the "persuasion" and "rhetoric" they might expect to read about in this journal. Nor will they find in it the Appendici (...) Critiche that appear in the original text, Michelstaedter's thesis entitled I concetti di persuasione e rettorica [sic] in Platone e Aristotele, which he submitted to the Faculty of Letters in Florence in 1910. But the version printed here by the editors (hereafter "VBD," as there is no indication of who did what) will no doubt appeal to those who dislike Plato and Aristotle, have the idea that something better can be found in the Presocratics, and claim allegiance to such philosophers as Schopenhauer, Nietzsche, and the Heidegger of Being and Time; for this is a book about the problem of attaining a sort of existential "authenticity" and not, in my view, "one of the most trenchant and influential studies in modern rhetoric," as the liner notes claim. To be sure, Persuasione e rettorica has been the subject of decades of contentious scholarship in Italy. But most of that scholarship (and that displayed in the headnotes provided by VBD) concerns the sources of Michelstaedter's ideas and his true debt to the likes of Parmenides and Heraclitus, both of whom figure significantly in his worldview."Persuasione"—and I use the Italian here to avoid confusion—might best be understood to mean a sort of self-possession, being at one with oneself and with the world, or what I called before "authenticity." Michelstaedter himself never makes an effort to define it, for to do that would be to turn it into the sort of abstraction that Michelstaedter opposes. Defining things, as we learn from the Appendici, is the sort of thing philosophers like Aristotle and Hegel do in an act of bad faith or delusion. "Persuasione" is, by contrast, something lived, not understood—or, more precisely, it is a state to which true philosophers (Parmenides and Socrates, for instance) aspire with the full understanding that, like the limit approached asymptotically by an hyperbola (see 48, 109), it can never be attained. That understanding was replaced by the false consciousness represented by the "rettorica" taught by the Sophists and Plato (along with his disciple, Aristotle), and continues to the present day. This account is hinted at in the "Historical Example" allegory of the present text (77–84); but is more fully "documented" in a section of the long Appendix 2, "Note alla triste historia" (107–56 in the 1972 Raschini edition), entitled "La decadenza" (129–35). [End Page 170]"Rettorica," then, is the name Michelstaedter gives to the whole range of ingenious linguistic devices we use to convince ourselves that we are satisfied, fulfilled, secure in our selves and in the world—i.e., "persuaded"—when we are only suffering from a delusion created by language itself. It is rettorica that gives rise to "commonplaces" that masquerade as true understanding, to the impostures of "science" in the name of "objectivity" (see 89–95), to technology and machines, to "education" (110–11, 148–52), and indeed to every manifestation of bourgeois ideology (see the "dialogue" at 104–6, for instance). Rettorica is a kind of hypocrisy, deception, and (self-) flattery; an instrument of "the community of the wicked" (100, 143), a collection of "ornaments of the darkness" (e.g., 137, 139).The problem we face in acknowledging all this is, of course, that the attempt to articulate it has to be done in language; and language, by its very nature in all its semantic and syntactic elements (the point of Appendix 1, Raschini, 103–6), subverts true "persuasione." How can one "speak truth to authenticity," so to speak, when one begins by "giving a name to" its contrary, "rettorica"?"Trenchant," in any event, is hardly the right term to describe Persuasion and Rhetoric. "Mordant" or "plangent" might be closer to the mark. And as for its influence on "modern rhetoric... (shrink)

Advances in genomics have led to calls for developing population-based preventive genomic sequencing programs with the goal of identifying genetic health risks in adults without known risk factors. One critical issue for minimizing the harms and maximizing the benefits of PGS is determining the kind and degree of control individuals should have over the generation, use, and handling of their genomic information. In this article we examine whether PGS programs should offer individuals the opportunity to selectively opt out of the (...) sequencing or analysis of specific genomic conditions or whether PGS should be implemented using an all-or-nothing panel approach. We conclude that any responsible scale-up of PGS will require a menu approach that may seem impractical to some, but that draws its justification from a rich mix of normative, legal, and practical considerations. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

This paper analyses the activities of five organizations shaping the debate over the global governance of genome editing in order to assess current approaches to public engagement (PE). We compare the recommendations of each group with its own practices. All recommend broad engagement with the general public, but their practices vary from expert-driven models dominated by scientists, experts, and civil society groups to citizen deliberation-driven models that feature bidirectional consultation with local citizens, as well as hybrid models that combine elements (...) of both approaches. Only one group practices PE that seeks community perspectives to advance equity. In most cases, PE does little more than record already well-known views held by the most vocal groups, and thus is unlikely to produce more just or equitable processes or policy outcomes. Our exploration of the strengths, weaknesses, and possibilities of current forms of PE suggests a need to rethink both “public” and “engagement.”. (shrink)

'The Anthem Handbook of Screen Theory' offers readers a unique survey of the new horizons of film and media theory, focusing on the applicability of screen theories and updating the field for new social, cultural and geopolitical contexts.

In this paper we evaluate how to effectively use the crowdsourcing service, Amazon’s Mechanical Turk (MTurk), to content analyze textual data for use in psychological research. MTurk is a marketplace for discrete tasks completed by workers, typically for small amounts of money. MTurk has been used to aid psychological research in general, and content analysis in particular. In the current study, MTurk workers content analyzed personally-written textual data using coding categories previously developed and validated in psychological research. These codes were (...) evaluated for reliability, accuracy, completion time, and cost. Results indicate that MTurk workers categorized textual data with comparable reliability and accuracy to both previously published studies and expert raters. Further, the coding tasks were performed quickly and cheaply. These data suggest that crowdsourced content analysis can help advance psychological research. (shrink)

Participants in clinical studies are frequently unable to remember study information for the duration of their participation in the research. Along with a nine-member work group and a seven-member advisory group, we determined that six elements of consent are necessary to uphold the validity of consent over time: awareness of ongoing participation; understanding the right to withdraw; understanding that withdrawal will not influence other treatment options; knowledge of the general purpose of the research; knowledge of potential risks of participation; and (...) understanding of the differences between traditional, individualized clinical care and standardized treatment during research participation. Based on these important elements, we developed an Assessment of Sustained Informed Consent as a tool to periodically review a protocol’s essential elements with its participants. We hope this will be a useful means of confirming research participants’ continued knowledge of the critical elements of consent, and of identifying those subjects who need reminding. (shrink)

The growing practice of returning individual results to research participants has revealed a variety of interpretations of the multiple and sometimes conflicting duties that researchers may owe to participants. One particularly difficult question is the nature and extent of a researcher’s duty to facilitate a participant’s follow-up clinical care by placing research results in the participant’s medical record. The question is especially difficult in the context of genomic research. Some recent genomic research studies — enrolling patients as participants — boldly (...) address the question with protocols dictating that researchers place research results directly into study participants’ existing medical records, without participant consent. Such privileging of researcher judgment over participant choice may be motivated by a desire to discharge a duty that researchers perceive themselves as owing to participants. However, the underlying ethical, professional, legal, and regulatory duties that would compel or justify this action have not been fully explored. (shrink)

This paper presents an experimental approach for engaging undergraduate STEM students in anticipatory ethical reasoning, or ethical reasoning applied to the analysis of potential mid- to long-term implications and outcomes of technological innovation. The authors implemented two variations of an approach that integrates three key components—scenario analysis, design fiction, and ethical frameworks—into five sections of an introductory course on the social contexts of science and technology that is required of STEM majors. The authors dub this approach Creative Anticipatory Ethical Reasoning, (...) or CAER. Scenario analysis is a strategy emerging from business consulting for grounded analysis of plausible future trajectories to inform planning. Design fiction is a creative hands-on activity that blends science fiction and design prototyping to facilitate critical thinking with respect to the societal dimensions of a plausible future technology. The authors present the following findings: in each of the variations, students demonstrated significant engagement with CAER and a substantive shift in their conception of what constitutes responsible innovation and ethical conduct in science and technology. Specifically, their integration of ethical reasoning with stakeholder perspectives and scenario analysis reframed technologies, from unproblematic solutions for societal problems to socially-embedded forms of life that might diverge from designers’ intentions. This suggests that CAER could be a useful pedagogical intervention for expanding students’ ethical engagement to consider the potential unintended consequences of technological innovation. (shrink)

The current ethical norms of genomic biobanking creating and maintaining large repositories of human DNA and/or associated data for biomedical research have generated criticism from every angle, at both the practical and theoretical levels. The traditional research model has involved investigators seeking biospecimens for specific purposes that they can describe and disclose to prospective subjects, from whom they can then seek informed consent. In the case of many biobanks, however, the institution that collects and maintains the biospecimens may not itself (...) be directly involved in research, instead banking the biospecimens and associated data for other researchers. Moreover, the future uses of biospecimens may be unknown, if not unknowable, at the time of collection. Biobanking may thus stretch the meanings of inform and consent to their breaking point: if you cannot inform subjects about what their biospecimens will be used for, what can they consent to? Given that informed consent by individual subjects is the ethical gold standard, the seeming dilution of the concept in the context of biobanking is a profound problem. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Boundaries: Writing and DrawingTom ConleyBoundaries: Writing and Drawing, edited by Martine Reid; Yale French Studies, iv & 268 pp. New Haven: Yale University Press, 1994, $15.95 paper.The fifteen articles of this issue of Yale French Studies discern the limits of meaning and legibility wherever writing and drawing become coextensive. In pondering the origins of writing Henry-Jean Martin (in Le pouvoir et l’histoire de l’écrit) has recently asked if (...) script and print have evolved from pictographic or hieroglyphic writing. If so, he implies, to what degree does visual force animate all writing? How does meaning, otherwise conveyed through writing, get complicated or subverted by the shape or motion of its form? When does the writer engage the illegible to call into question communication in general? Citing Michel Foucault, for whom calligraphy and drawing offer a glimpse of an “immense and unavowable teratology” (p. 12), the editor argues that the visible matter of discourse becomes its repressed or irrecuperable—hence supremely literary—worth.She organizes the contributions under three rubrics. Part one studies the history of the relation of writing to drawing through emphasis on psychogenesis. For Serge Tisseron an “inscriptive gesture” (p. 29), a memory of a manual pleasure, is relayed through the artist’s or writer’s labors. The written trace recalls originary separation, the page becoming a “metaphoric container of one’s own body and the mother’s body” (p. 41). Georges Roque shows how postcartesian ideology associates line with philosophy and relegates color to a lower order of sensation. In a Derridean turn he notes, “color is to drawing as [End Page 410] writing is to speech” (p. 57). Jean-Gérard Lapacherie argues that we are taught to exclude reading from the act of looking at a text, and that contemporary literature forcibly erodes that division.Part two is devoted to close analysis of writers who draw. Jacques Leenhardt brilliantly analyzes visual and aural displacements, even condensations, what he calls “monograms of sensation,” in the sketches and notes in Stendhal’s Journal de Paris. Alain Buisine traces the appeal that drawings of Rimbaud’s face had for the poet’s milieu. Claude Gandelman studies Proust’s manuscript drawings in light of the broader process of dreamwork in A la recherche du temps perdu. Looking at the Cahiers, 1894–1914, Serge Bourjea contends that for Paul Valéry the labors of intellection and writing are a “matter of sketching” (p. 137), or of perpetually “rough” drafting. Jacques Derrida’s “Maddening the Subjectile,” Mary Ann Caws’s limpid translation of an essay on Artaud’s textual drawings (“Forcener le subjectile”), defines a pictogram as what moves ceaselessly and inseparably between painting, drawing, and verbal expression.Part three moves toward artists who write. Bernard Vouilloux rehearses Derrida’s arguments about the “supplement” and the pictogram to themes of painting and painters in Rousseau’s early and later works. Michel Thévoz gives a dazzling reading of Jean Dubuffet’s art brut dans l’écriture, the explosive sketching of discourse that fractures the icons of elegance and control that project the myth of clear and classical French. Jan Baetens calls “latent violence” the marvelous areas where image, geometrical form, typography, and enunciation abut each other in M. C. Escher’s drawings, Régis Franc’s comic strips, and Martin Vaughn-James’s La Cage. Renée Riese Hubert sums up the volume with a study of the double binds that Derrida and Adami project in their collaborations of drawing and writing.This issue of Yale French Studies holds to the theme of writing as drawing. Martine Reid’s introduction and her two interviews with Michel Butor and Yves Bonnefoy map out an overall itinerary of vicious circularity. Literature is a continuing regression, fraught with pleasure and risk, that takes place when language, writing, and drawing are conflated. All of the essays are of high quality. Tisseron, Leenhardt, Derrida, and Thévoz set a standard to which the others conform. All adepts of art and literature will welcome this fabulous volume.Tom ConleyHarvard UniversityCopyright © 1995 The Johns Hopkins University Press... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Heuretics: The Logic of InventionTom ConleyHeuretics: The Logic of Invention, by Gregory L. Ulmer; xiv & 267 pp. Baltimore: Johns Hopkins University Press, 1994, $40.00 cloth, $13.95 paper.Heuretics designates areas of logic devoted to discovery and invention. This book sets out to reconfigure the metaphors that have dominated investigation since the advent of print-culture and the Columbian voyages. Adventure, quest, risk, discovery: Francis Bacon’s analogy of scientific research (...) to oceanic travel established the stereotypes that Ulmer strives to dismantle. In 1962 Claude Lévi-Strauss noted in The Raw and the Cooked that in our time: “It is no longer a question of sailing toward other lands: only the voyage is real, not the earth, and the routes have been replaced by the rules of navigation.” With the advent of hypermedia, creation becomes an art of selection and combination. Truth gives way to discovery. Creation is likened to a programmed mélange of material ordered by negotiation, intuition, and strategy.Ulmer performs his proof—and proves his performance—by constructing a virtual staging of a multilayered commemoration he fashions from cinema, architecture, Jacques Derrida’s oeuvre, American history, and autobiography. The result is a collage of signifiers that apposes literary theory, memory-arts, Gary Cooper’s persona in Beau Geste (dir. William Wellman, 1939), Columbian voyages, Platonic dialogues, and a canon of postmodern writings. Ulmer divides the book into four parts, the first of which crafts the overall method from Cartesian reason and Surrealist practices of juxtaposition and automatism. Part two offers a dynamic definition of choreography, the study of local, inherited, and originary areas in which subjectivity is born. In part three Ulmer [End Page 147] sets forth textual rehearsals, based on Lee Strasner’s Method (via Stanislavsky), that mobilize the space and time of his chosen materials. Part four, “Yellowstone Desert,” bring together the strands of the narrative embroidery into a gag-joke (a “puncept” on Custer and custard) that explodes in the author’s face.A good deal of the work turns on Ulmer’s treatment of chora. Exploiting its signifying potential (chora, corps, choral, chorus, coral) he discovers that the myth of the world’s creation recounted in the Timaeus begins when the demiurge makes an X from two strands of plasma. The chi is folded as colures of a sphere that becomes the globe. Nonetheless the presence of the self as an unknown (x) is inferred (in I, or ich). Ulmer shows that “in subordinating mystery to memory, and arguments to paradigms,” choreography will “engage the users’ premises in the process of learning, opening a mutually transforming circuit between judgment and theory, and hence affect not only (...) institutional practices (...) but human subjectivation as well” (p. 202). Patterned constructions replace the creation and resolution of enigmas. Hypermedia becomes the technology of new creation, while choreography comprises “the institutional practice for augmenting the intuitions of inference, for writing with the logic of the unconscious” (p. 224).Heuretics extends the field of play staked out in Ulmer’s Teletheory. Here is offered a scheme for creating multileveled texts that are both creative and critical and infinitely generative, and that invite readers to connect electronic media to the unconscious. Most readers will not fail to appreciate the wit of the exposition and the clarity of the creative method. Others will pause over some of its assumptions. Certain critical paradigms, such as the antithetical ontologies of Lacan and Derrida, appear easily reconciled. The unnameable traumas of history (genocide) and psychogenesis (the birth and growth of subjectivity) are glossed with an effortless art of citation (pp. 114, 233). The unconscious is assimilated into an easily “accessed” logic, the latter effortlessly “logging in” to the former. The redesign of the Columbian quincentenary indirectly ratifies some of the modes of control that flexible capitalism seeks to impose upon the unconscious. These four points require greater space of exchange in the rich and problematic dialogue that informs Ulmer’s stunning performance of theory.Tom ConleyUniversity of MinnesotaCopyright © 1995 The Johns Hopkins University Press... (shrink)

Genomic biobanks present ethical challenges that are qualitatively unique and quantitatively unprecedented. Many critics have questioned whether the current system of informed consent can be meaningfully applied to genomic biobanking. Proposals for reform have come from many directions, but have tended to involve incremental change in current informed consent practice. This paper reports on our efforts to seek new ideas and approaches from those whom informed consent is designed to protect: research subjects. Our model emerged from semi-structured interviews with healthy (...) volunteers who had been recruited to join either of two biobanks , and whom we encouraged to explain their concerns and how they understood the relationship between specimen contributors and biobanks. These subjects spoke about their DNA and the information it contains in ways that were strikingly evocative of the legal concept of the trade secret. They then described the terms and conditions under which they might let others study their DNA, and there was a compelling analogy to the commonplace practice of trade secret licensing. We propose a novel biobanking model based on this trade secret concept, and argue that it would be a practical, legal, and ethical improvement on the status quo. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along chromosome arms (...) was nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long arms. Duplications of group 1 ESTs in other homoeologous groups occurred at a rate of 35.5%. Seventy-five percent of wheat chromosome 1 ESTs had significant matches with rice sequences, where large regions of conservation occurred between wheat consensus chromosome 1 and rice chromosome 5 and between the proximal portion of the long arm of wheat consensus chromosome 1 and rice chromosome 10. Only 9.5% of group 1 ESTs showed significant matches to Arabidopsis genome sequences. The results presented are useful for gene mapping and evolutionary and comparative genomics of grasses. (shrink)

This commentary builds on Haico te Kulve and Arie Rip’s ( 2011 ) notion of “engagement agents,” individuals that must be able to move between multiple dimensions, or “levels” of research, innovation, and policy processes. The commentary compares and contrasts the role of the engagement agent within the Constructive Technology Assessment and integration approaches, and suggests that on-site integration research represents one way to transform both social and natural scientists into competent and informed “engagement agents,” a new generation of researchers (...) that possess the knowledge and capacities to forge “novel linkages” between the oftentimes disparate terrains of science, politics, and policy. (shrink)

_Parages_ brings together four essays by Derrida on the fictions of Maurice Blanchot. Three of the essays—"Living On," "Title To Be Specified," and "The Law of Genre," are by now canonical. The fourth, "_Pa_ce Not" as well as Derrida's 1986 introduction to the French edition of the book, appear here in English for the first time. This was a breakthrough publication in the analysis of Blanchot, a notoriously difficult writer. It is safe to say Derrida contributed much to that writer's (...) reputation in both French and English, always insisting on the philosophical pertinence of Blanchot's work to any discussion of the relationship between literature and critical thought. Through patient citation, and an ample collocation and readings of Blanchot's various motifs, Derrida explores a variety of questions, including the limits of genre, the procedure of crossing out, and the evocation of a non-dialectical and non-privative negativity. The book marks a crucial stage in Derrida's itinerary and provides a context for his later writings on apophatics in such works as _On the Name_ and his response to Heidegger on death in _Aporias_. (shrink)

In his monograph, Ryan Patrick Hanley offers a revisionist interpretation of the political philosophy of François de Salignac de la Mothe-Fénelon, archbishop of Cambrai. A series of Enlightenment commentators and their progeny have hailed Fénelon as a political subversive who boldly attacked the injustices of the reign of Louis XIV and who prepared the arrival of an egalitarian society with socialist and pacifist traits. Hanley, however, argues that Fénelon actually defended a more moderate and realistic model of political society than (...) his Enlightenment exegetes have suggested. Like earlier commentators, Hanley attempts to prove his argument primarily through an analysis of... (shrink)

The growing practice of returning individual results to research participants has revealed a variety of interpretations of the multiple and sometimes conflicting duties that researchers may owe to participants. One particularly difficult question is the nature and extent of a researcher’s duty to facilitate a participant’s follow-up clinical care by placing research results in the participant’s medical record. The question is especially difficult in the context of genomic research. Some recent genomic research studies — enrolling patients as participants — boldly (...) address the question with protocols dictating that researchers place research results directly into study participants’ existing medical records, without participant consent. Such privileging of researcher judgment over participant choice may be motivated by a desire to discharge a duty that researchers perceive themselves as owing to participants. However, the underlying ethical, professional, legal, and regulatory duties that would compel or justify this action have not been fully explored. (shrink)

From high school cafeterias to the floor of Congress, insult is a truly universal and ubiquitous cultural practice with a long and earthy history. And yet, this most human of human behaviors has rarely been the subject of organized and comprehensive attention—until _Toward a Rhetoric of Insult_. Viewed through the lens of the study of rhetoric, insult, Thomas M. Conley argues, is revealed as at once antisocial and crucial for human relations, both divisive and unifying. Explaining how this works (...) and what exactly makes up a rhetoric of insult prompts Conley to range across the vast and splendidly colorful history of offense. Taking in Monty Python, Shakespeare, Eminem, Cicero, Henry Ford, and the Latin poet Martial, Conley breaks down various types of insults, examines the importance of audience, and explores the benign side of abuse. In doing so, Conley initiates readers into the world of insult appreciation, enabling us to regard insults not solely as means of expressing enmity or disdain, but as fascinating aspects of human interaction. (shrink)

Background: A growing literature has raised—skeptically—the question of whether cutting-edge scientific research can identify and address broader ethical and policy considerations in real time. In genomics, the question is: Can ELSI contribute to genomics in real time, or will it be relegated to its historical role of after-the-fact outsider critique? We address this question against the background of a genomic screening project where we participated as embedded, real-time ELSI researchers and observers, from its initial design through its conclusion.Methods: As part (...) of the ELSI study design, the project included an ongoing reflexive ethnography in which the authors studied the process of its design and implementation. The authors were true participant observers, serving as members of various task-oriented groups while recording meetings and other events for ongoing qualitative analysis. We also conducted and analyzed interviews of multiple participants at the conclusion of the project.Results: Our real-time ELSI initiative had a mixed record of successes and challenges. If we define success as ELSI researchers having had an opportunity to participate fully in the project and to make the ELSI perspective heard, then our assessment is largely positive. If, however, we define successes as instances where real-time ELSI contributions changed the direction of the genomic or public health aspects of the GeneScreen project or, after careful deliberation, confirmed the appropriateness of the status quo, then we can identify only a few examples. While we had a seat at the table, we were, for the most part, tolerated guests.Conclusions: We conclude that there are significant barriers to real-time ELSI influence. The difficulty does not reside in any intended exclusion of an ELSI perspective, but in factors endemic to genomic research, including knowledge disparities, epistemological biases, and the pressures of time and money. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Writing of Space:On French Critical Theory in 1973 and its AftermathTom Conley (bio)Je rempliz d'un beau nom ce grand espace vide(I fill with a handsome name this great empty space)—Joachim Du Bellay, Les regrets[...] l'unique mot ESPACE, indéfiniment répété, isolé, d'une ligne à l'autre; clos sur lui-même par la recurrence du e (espace), brisé pourtant par l'adjonction interne du s (espace), qui se réfléchit en trompe l'oeil (...) phonétique (espace); avec un centre immuable—espace—, où peut se lire l'amorce de la paix ou du tombeau—mais susceptible de faire cap de tout côté, comme on fait eau. L'espace est « découvert », « brisé » ou « vécu »—à droite, où poussent les épithètes ; l'espace est objet de « découverte », de « promenade » ou d' « odyssée », à gauche où s'alignent les substantifs qui commandent les clichés dont l'espace serait le complément obligé. Génitif d'un côté, ou pour le moin complétif, générateur de l'autre, ou en tout cas substance à qualités variables. Dans l'arbre à syntagmes ainsi érigé, l'espace est inventé par l'écriture qui fait alterner, sans jamais les combiner sur une même ligne, un espace donné comme objet stable d'exploration. [...]([...] the unique word ESPACE can be placed, indefinitely repeated, isolated, from one line to another ; closed upon itself by the recurrence of the e (espace), yet broken by the inner adjunction of the s (espace) reflected in a phonetic trompe-l'œil (espace) ; with an immutable center—espace—, in which can be read the first letters of peace or of tomb—but liable to go everywhere, like water in the sea. Space is « discovered, » « broken, » or « lived »—on the right where epithets come forward; space is the object of « discovery », of a « walk » or an « odyssey », on the left where are aligned the substantives that order the clichés for [End Page 189] which space would be the required object. Genitive on one side, or at least objective, generative of the other, or in every event a substance with variable traits. In the tree of syntagms erected above space is invented by writing that causes to alternate—without ever combining them on the same line—a given space as a stable object of exploration. [...]—Marie-Claire Ropars-Wuilleumier, Écrire l'espaceIn 1974 Henri Lefebvre published La production de l'espace (The Production of Space), a study said to have changed the course of critical reflection on the world around us. In his copious work Lefebvre locates the gaps and rifts between spatial practices or representational spaces and representations of space in order to mark the brute nature of social contradiction. Over history, he shows, those individuals who practice and represent space generally own control over those who do not or cannot. The very history of the reception of Lefebvre's work has been so rich that it cannot be disentangled from debates concerning the nature of the postmodern condition. It has brought forward an element, something akin to Lacan's "real," that cannot be contained or discerned by language, the arena of life itself. The impact of La production de l'espace cannot be underestimated.1 Yet, at the same time, the work remains a legacy or a point of reference for a concurrent labor born at the same moment and of a different texture than Lefebvre's: an activity that I would like to call a writing of space, a labor by which authors of different formation engage and invent alternative or other spaces within the texture of their own reflections on space. Like Lefebvre, they respond to a anxiety about the condition of space in which they live, but unlike him, they embody, in the gist of their own writing, spaces alternative to those in which they live. What follows is thus aimed at discerning why and how space emerged in the field of critical theory when it did and, in turn, at showing how the reflections remain crucial for critical practice here and now.The first of the two epigraphs above is... (shrink)

Ecopolitics is a study of environmental awareness--or non-awareness--in contemporary French theory. Arguing that it is now impossible not to think in an ecological way, Verena Andermatt Conley traces the roots of today's concern for the environment back to the intellectual climate of the late '50s and '60s. Major thinkers of 1968, the author argues, changed the way we think the world; this owes much to an ecological awareness that remains at the heart of issues concerning cultural theory in general. (...) The book points to critiques of ecology in the work of Luc Ferry and Jean Baudrillard before turning to more complicated ecological awareness primarily in French thought. The author considers key texts by influential figures such as Michael Serres, Paul Virilio, Gilles Deleuze and Felix Guattari, Michel de Certeau, Helene Cixous and Luce Irigaray. (shrink)

Highlighting the importance of historical methods for Christian ethics, this essay begins with a general overview of recent trends in historiography that culminate in the ideologically attuned and textually based work of Elizabeth Clark. Clark's work provides the basis in the second part of the essay that identifies Constantinianism as a dominant master narrative in the work of Stanley Hauerwas through which he rereads Tertullian's concept of patience and undergirds his call for pacifism. The final section explores the dangers of (...) such master narratives for Christian ethical analysis and calls instead for a critical, collaborative, and self-reflexive approach to history more capable of reconciling power, privilege, and marginalization. (shrink)

Stemming from two conferences, held in 1994, and 1996, Prophecy and Diplomacy: The Moral Doctrine of John Paul II explores the general orientations and the specific applications of the moral teaching of Pope John Paul II. The first part of the book places the Pope's moral theory within a broader theological framework, attempting to identify the overarching philosophical and theological attitudes that shape the Pope's fundamental moral perspective. In part two, the work studies the Pope's teaching in the areas of (...) applied ethics. Both the major lecturers and the respondents focus upon those areas of applied ethics that have provoked the greatest tension between the magisterium and the academy and between the Church and the state in the West. The volume concludes by presenting a homily that places the ethics of John Paul II within a spiritual framework of repentance and redemption. The Pope's moral teaching is not an academic survey of ethical themes. Nor is it a Pelagian call to human self-regeneration. The ultimate truth concerning human conduct and moral judgement emerges only with the proclamation of God's grace. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Putting French Studies on the MapTom Conley (bio)A good deal of work accomplished in new historicism over the last decade has opened new perspectives on the relations of literature to cartography. If new historicism tends to be affiliated with Shakespearean scholars who reconstruct the world of the Globe Theatre in the context of London and the Elizabethan world picture, it almost goes without saying that cartography, whose mobilization (...) and rapid growth occur from the beginnings of the printing press to the middle of the seventeenth century, plays a significant role in the analysis of print-culture in general. 1 The convergence of the two disciplines has shown that Renaissance authors, obsessed with the beginnings of writing, valorize both its geographical and spatial virtues and the ways that its pictogrammar constitutes “a grid for comprehension of the world” [Martin 14]. Humanists discovered that it simulated divisions of land in transactions devoted to their negotiation. What early archeologists of writing discovered is comparable today to what we gather about the meaning of the crosshatched rectangles and insignia we admire on the great prehistoric petroglyph of Bedolina standing over its arable valley below [Jacob 41–48; Thrower 4–5]. In the early modern age cartographical issues are central to broader inquiry about the power of writing.New historicists take up early modern cartography not just to assess the impact of Ptolemy on humanism but to develop agendas that concern how a sense of habitus was conceived, projected, and betrayed at a time of tumultuous change. They ask how the “world” could be both imagined and experienced when its boundaries were expanding at exponential rates. Cartographic studies have shown where the unknown, vital for any definition of consciousness or even the drives of life itself, was located and bracketed. 2 The unknown was an integral part of cartography prior to the eighteenth century. But to assert, as many have, that cartography sought to contain the unknown within the terrae incognitae it indicated on its maps does not solve the relation of the discipline with the [End Page 23] unknown. Evidence shows how much in the early modern age the unknown inhabits most written and schematic representations of the world. 3 Unnamed patches that we retrieve on maps printed in the sixteenth century prompt reverie of spaces that can be fancied as unknown by virtue of the maps themselves. The cartographical impulse in early modern studies cannot be dissociated from our own drive to find spots that can remove us from the regnum of nonplaces that define our world, that is, other places, whether heterotopical or “anywhere out of this world,” valorized when the “nonplace” has come to define contemporary human geography [see Augé 1992].Concurrently, the history of cartography remains one of the most immediate modes of access for what we can understand about the imagination of power, control, statecraft, and economy at a time when maps figured with increasing regularity in matters of administration. In broader terms, we can say that the unforeseen growth of map production and the consequent stress laid on fantasies of power that accompanied cartographic representations from the beginning of print culture to the establishment of “state reason” under Louis XIV bore witness to a greater spatialization of knowledge. What in the study of literature goes by the name of discourse is seen through a cartographical lens as patterns of utterances and exchanges that owe much to the influence of Ramism, monocular perspective, and diagrammatical logic. It is a truism to note that when the world became a function of cartographical representations made accessible to a public at large, the ways it was configured bore great impact on communication in general. 4In this issue of Diacritics, where the current plight and uncertain future of French studies is being pondered, it also goes without saying that many teachers and scholars are wondering what can be done to invigorate one of the richest of all literary canons. The assault that American media have led on French culture (among others, articles in the New Times by Roger Cohen and Craig Whitney) would lead us to believe that literature has [End Page 24] become equivalent to freeze-dried croissants, a... (shrink)

We show that any symmetric, Baire measurable function from the complement of $\ezero$ to a finite set is constant on an $\ezero$-nonsmooth square. A simultaneous generalization of Galvin's theorem that Baire measurable colorings admit perfect homogeneous sets and the Kanovei-Zapletal theorem canonizing Borel equivalence relations on $E_0$-nonsmooth sets, this result is proved by relating $\ezero$-nonsmooth sets to embeddings of the complete binary tree into itself and appealing to a version of Hindman's theorem on the complete binary tree. We also establish (...) several canonization theorems which follow from the main result. (shrink)