To put it in Peirce's words, philosophy is an act of semiosis. Interpretation, communication, and mediation are at the core of the philosophical enterprise. Mediation in a wide sense is indeed a constitutive character of human experience. If, at the core of our philosophical research, we focus on the so-called issue of cross-cultural and intercultural thought, in which the necessity of translation springs immediately up from the necessity to understand different languages and different systems of signs, the question of mediation (...) reveals itself to be a crucial one. Immediacy itself, whenever it is thought, reveals itself to be something mediated by our language: but what separates and requires mediation is also what connects, and binds together different elements in order to allow them communicate. (shrink)

Surrogacy is an encouraging management for many childless couples and can hypothetically resolve many unbearable pain that they are confronted. Initially surrogacy treatment was frowned upon, however, surrogacy is more popularly accepted now a day. Though, surrogacy has not yet recognized by 199 country in the globe. Different country has different regulations on surrogacy. However, “there are some indication of the degree of divergence between official discourse and actual practice of surrogacy throughout world”. There are positive changes in attitude toward (...) surrogacy has been seen in some countries. This special issue of Bangladesh Journal of Bioethics has been organized on surrogacy to see the current thinking of surrogacy around the world and how people come out from the social, religious and political framework. (shrink)

This collection of essays turnings around aesthetic and ethical questions, and intertwining them, is intended to foster and elaborate the notion of intercultural philosophy. Without idealizing any single way of thinking or tradition, without idolizing any lazy relativism, the author wants to show how interculturality is neither a comprehensive, ultimate system of thoughts, nor a disconnected plurality of opinions. Surmounting monism without fading into dualism, he moves on leads to deal with the philosophical character of symbols, analogies, and comparisons, through (...) which we can grasp the links and relations between identity and difference. (shrink)

Entre phénoménologie et neurologie. Merleau-Ponty, Goldstein, SacksLa phénoménologie de Merleau-Ponty a traité des matériaux et des éléments de réflexion importants de diverses études sur des pathologies psychiques et physiques. La confrontation et l’entrelacement entre la pensée du philosophe français et certaines recherches de neuropsychologie, comme Kurt Goldstein ou Oliver Sacks, font émerger la possibilité de nouvelles approches de la dimension de la maladie, entre narration, spéculation et recherche scientifique. Un dialogue fécond entre disciplines et champs de recherche différents met en (...) lumière comment toute modalité perceptive, même quand elle se présente comme déficitaire ou déviante, constitue de fait une vraie recréation ou re-constitution du monde et non pas seulement un enregistrement. Ce processus de création continue est lié à une des questions de fond soulevée par l’expérience de la maladie: celle des modes et des conditions de la singularité, de l’identité d’un soi, à la recherche de reconnaissance et d’acceptation de la part d’un regard ou d’un geste que nous savons contribuer de manière inédite à la relation entre sujets humains.Between Phenomenology and Neurology. Merleau-Ponty, Goldstein, SacksMerleau-Ponty’s phenomenology deals with materials and elements of important reflections in diverse studies on psychological and physical pathologies. The confrontation and the connections between French philosophical thought and certain research in neuropsychology, such as that of Kurt Goldstein or Oliver Sacks, allow the possibility of new approaches to the dimension of sickness to emerge, approaches between narration, speculation, and scientific research. A fertile dialogue between disciplines and fields of different research brings to light how every perceptual modality, even when it presents itself as deficient or deviant, constitutes in fact a true re-creation or reconstitution of the world and not only a recording. This process of continuous creation is linked to one of the basic questions raised by the experience of sickness: the question of the modes and conditions of singularity, of the identity of a self in pursuit of recognition or acceptance from another’s gaze or gesture, a gaze or gesture that, in the relation between human subjects, we have the ability to contribute ever in a unique manner. (shrink)

Entre phénoménologie et neurologie. Merleau-Ponty, Goldstein, SacksLa phénoménologie de Merleau-Ponty a traité des matériaux et des éléments de réflexion importants de diverses études sur des pathologies psychiques et physiques. La confrontation et l’entrelacement entre la pensée du philosophe français et certaines recherches de neuropsychologie, comme Kurt Goldstein ou Oliver Sacks, font émerger la possibilité de nouvelles approches de la dimension de la maladie, entre narration, spéculation et recherche scientifique. Un dialogue fécond entre disciplines et champs de recherche différents met en (...) lumière comment toute modalité perceptive, même quand elle se présente comme déficitaire ou déviante, constitue de fait une vraie recréation ou re-constitution du monde et non pas seulement un enregistrement. Ce processus de création continue est lié à une des questions de fond soulevée par l’expérience de la maladie: celle des modes et des conditions de la singularité, de l’identité d’un soi, à la recherche de reconnaissance et d’acceptation de la part d’un regard ou d’un geste que nous savons contribuer de manière inédite à la relation entre sujets humains.Between Phenomenology and Neurology. Merleau-Ponty, Goldstein, SacksMerleau-Ponty’s phenomenology deals with materials and elements of important reflections in diverse studies on psychological and physical pathologies. The confrontation and the connections between French philosophical thought and certain research in neuropsychology, such as that of Kurt Goldstein or Oliver Sacks, allow the possibility of new approaches to the dimension of sickness to emerge, approaches between narration, speculation, and scientific research. A fertile dialogue between disciplines and fields of different research brings to light how every perceptual modality, even when it presents itself as deficient or deviant, constitutes in fact a true re-creation or reconstitution of the world and not only a recording. This process of continuous creation is linked to one of the basic questions raised by the experience of sickness: the question of the modes and conditions of singularity, of the identity of a self in pursuit of recognition or acceptance from another’s gaze or gesture, a gaze or gesture that, in the relation between human subjects, we have the ability to contribute ever in a unique manner. (shrink)

This article deals with the Chinese ink painting tradition, as a paradigm in which art and life are coupled and intertwined. In fact, in Chinese classical aesthetics, art and life do not produce a dramatic tension, but are inscribed in a common process of naturalness or spontaneity. The painter has to learn how the breath, or vital energy, that flows in every single image-phenomenon, can be enlivened by the brush strokes. Moreover, the paper builds a dialogue between the European and (...) the Chinese main patterns. Showing alternately the continuity or the discontinuity between art and life, both traditions of thought display the possibility to learn a sort of “art of living”, through – and not despite – the dynamic de-coincidence that appears in the folds of human experience. (shrink)

A specific interest and attention to translation and to the relation between signs, natural languages, and thought spread out not only from the so called “linguistic turn” in the 20th century, but also from the cross-cultural dimension that gained prominency in the last decades. Interlinguistic translation can thus be considered and analyzed as a particular and fruitful field of study for philosophy, because in that experience we have to face the intimate relationship that intertwine form and content, the contingency of (...) expression and the ideal aspiration to a shared, universal truth. The case of Chinese language and thought provide further material to explore, in order to raise more questions about the links among grammar, morphology, system of writing, and the meanings that those structures intrinsecally brings and convey. Re-considering Hegel’s ideas about alphabetical and non-alphabetical writing, and through a peculiar case study of a poem by Wang Wei, we can learn to appreciate in a new way the alterity of Chinese characters and language. Finally, the act of translation can be seen as a model of ethical understanding, in order take into account the Other, without enclosing it into the frames that have been shaped with our own categories. (shrink)

The article deals with Chinese ink painting and some aesthetic notions, in particular those of xiang 象 and shanshui 山水 (literally: “mountains-waters”, i.e. landscape...

Taking into account my personal path as a philosopher and as a painter, I try to sketch the perspective on aesthetics that was opened to me by a cross-cultural encounter. The European tradition, on one side, and the Sino-Japanese tradition, on the other side, are the two mirroring currents along which I moved in order to trace a sort of “deconstruction” and a “restructuring” of artistic and philosophical vision. In my painting, I aim for a confluence of different streams of (...) thought by thinking about European informal art and landscape ink-painting of China and Japan. This confluence continues to produce a fertile dialogue, enlivening the deep resources that constitute the core of a subjectivity in process. Aesthetics converts itself into ethics: an ethical move, beyond the opposition of visible and invisible as dull substances, beyond the opposition of immanence and transcendence, is one of the inner goals of this pathway between art and philosophy. (shrink)

For anyone working in aesthetics interested in understanding the richness of the Chinese aesthetic tradition this handbook is the place to start. Comprised of general introductory overviews, critical reflections and contextual analysis, it covers everything from the origins of aesthetics in China to the role of aesthetics in philosophy today. Beginning in early China (1st millennium BCE), it traces the Chinese aesthetic tradition, exploring the import of the term aesthetics into Chinese thought via Japan around the end of the 19th (...) century. It looks back to early practices of art and craftsmanship, showing how the history of Chinese thought provides a multitude of artifacts and texts that give rise to a wide range of aesthetic creations and notions. Introducing various perspectives on traditional arts in China, including painting, ceramics, calligraphy, poetry, music and theatre, it explores those aesthetic traditions not included in "canonic" art forms, such as martial arts, rock gardening, and ritual performance. Written by Chinese, European, and American theoreticians and practitioners, this authoritative research resource enhances contemporary aesthetics by revealing the possibilities of a Chinese philosophy of art. (shrink)

The traditional arts may possibly constitute that aspect of Japanese culture that has the most literature dedicated to it, and the new book by the Italian scholar Marcello Ghilardi, Arte e pensiero in Giappone: Corpo, immagine, gesto, should have a deservedly high place among the works in this genre.

The genetic code appeared on Earth with the first cells. The codes of cultural evolution arrived almost four billion years later. These are the only codes that are recognized by modern biology. In this book, however, Marcello Barbieri explains that there are many more organic codes in nature, and their appearance not only took place throughout the history of life but marked the major steps of that history. A code establishes a correspondence between two independent 'worlds', and the codemaker (...) is a third party between those 'worlds'. Therefore the cell can be thought of as a trinity of genotype, phenotype and ribotype. The ancestral ribotypes were the agents which gave rise to the first cells. The book goes on to explain how organic codes and organic memories can be used to shed new light on the problems encountered in cell signalling, epigenesis, embryonic development, and the evolution of language. (shrink)

Rapid advancements in human neuroscience and neurotechnology open unprecedented possibilities for accessing, collecting, sharing and manipulating information from the human brain. Such applications raise important challenges to human rights principles that need to be addressed to prevent unintended consequences. This paper assesses the implications of emerging neurotechnology applications in the context of the human rights framework and suggests that existing human rights may not be sufficient to respond to these emerging issues. After analysing the relationship between neuroscience and human rights, (...) we identify four new rights that may become of great relevance in the coming decades: the right to cognitive liberty, the right to mental privacy, the right to mental integrity, and the right to psychological continuity. (shrink)

When subjects view stimulation of a rubber hand while feeling congruent stimulation of their own hand, they may come to feel that the rubber hand is part of their own body. This illusion of body ownership is termed ‘Rubber Hand Illusion’ . We investigated sensitivity of RHI to spatial mismatches between visual and somatic experience. We compared the effects of spatial mismatch between the stimulation of the two hands, and equivalent mismatches between the postures of the two hands. We created (...) the mismatch either by adjusting stimulation or posture of the subject’s hand, or, in a separate group of subjects, by adjusting stimulation or posture of the rubber hand. The matching processes underlying body ownership were asymmetrical. The illusion survived small changes in the subject’s hand posture, but disappeared when the same posture transformations were applied to the rubber hand. Mismatch between the stimulation delivered to the subject’s hand and the rubber hand abolished the illusion. The combination of these two situations is of particular interest. When the subject’s hand posture was slightly different from the rubber hand posture, the RHI remained as long as stimulation of the two hands was congruent in a hand-centred spatial reference frame, even though the altered posture of the subject’s hand meant that stimulation was incongruent in external space. Conversely, the RHI was reduced when the stimulation was incongruent in hand-centred space but congruent in external space. We conclude that the visual–tactile correlation that causes the RHI is computed within a hand-centred frame of reference, which is updated with changes in body posture. Current sensory evidence about what is ‘me’ is interpreted with respect to a prior mental body representation. (shrink)

The increasing availability of brain data within and outside the biomedical field, combined with the application of artificial intelligence (AI) to brain data analysis, poses a challenge for ethics and governance. We identify distinctive ethical implications of brain data acquisition and processing, and outline a multi-level governance framework. This framework is aimed at maximizing the benefits of facilitated brain data collection and further processing for science and medicine whilst minimizing risks and preventing harmful use. The framework consists of four primary (...) areas of regulatory intervention: binding regulation, ethics and soft law, responsible innovation, and human rights. (shrink)

Unification was originally introduced in automated deduction and term rewriting, but has recently also found applications in other fields. In this article, we give a survey of the results on unification obtained in two closely related, yet different, application areas of unification: description logics and modal logics.

The use of Intelligent Assistive Technology in dementia care opens the prospects of reducing the global burden of dementia and enabling novel opportunities to improve the lives of dementia patients. However, with current adoption rates being reportedly low, the potential of IATs might remain under-expressed as long as the reasons for suboptimal adoption remain unaddressed. Among these, ethical and social considerations are critical. This article reviews the spectrum of IATs for dementia and investigates the prevalence of ethical considerations in the (...) design of current IATs. Our screening shows that a significant portion of current IATs is designed in the absence of explicit ethical considerations. These results suggest that the lack of ethical consideration might be a codeterminant of current structural limitations in the translation of IATs from designing labs to bedside. Based on these data, we call for a coordinated effort to proactively incorporate ethical considerations early in the design and development of new products. (shrink)

Brain–computer interfacing technologies are used as assistive technologies for patients as well as healthy subjects to control devices solely by brain activity. Yet the risks associated with the misuse of these technologies remain largely unexplored. Recent findings have shown that BCIs are potentially vulnerable to cybercriminality. This opens the prospect of “neurocrime”: extending the range of computer-crime to neural devices. This paper explores a type of neurocrime that we call brain-hacking as it aims at the illicit access to and manipulation (...) of neural information and computation. As neural computation underlies cognition, behavior and our self-determination as persons, a careful analysis of the emerging risks of malicious brain-hacking is paramount, and ethical safeguards against these risks should be considered early in design and regulation. This contribution is aimed at raising awareness of the emerging risk of malicious brain-hacking and takes a first step in developing an ethical and legal reflection on those risks. (shrink)

The genetic code appeared on Earth at the origin of life, and the codes of culture arrived almost four billion years later. For a long time it has been assumed that these are the only codes that exist in Nature, and if that were true we would have to conclude that codes are extraordinary exceptions that appeared only at the beginning and at the end of the history of life. In reality, various other organic codes have been discovered in the (...) past few decades and it is likely that more will come to light in the future. The existence of many organic codes in Nature is therefore an experimental fact, but also more than that. It is one of those facts that have extraordinary implications. In this book it is shown that the genetic code was a precondition for the origin of the first cells, the signal transduction codes divided the first cells into three primary kingdoms (Archaea, Bacteria and Eukarya), the splicing codes were instrumental to the origin of the eukaryotic nucleus, the histone code provided a new regulation system in eukaryotic genomes, and the cytoskeleton codes allowed the Eukarya to perform internal movements, including those of mitosis and meiosis. It is shown, furthermore, that organic codes had a key role in multicellular life, in particular in the origin of animals, the origin of mind and the origin of language. The great events of macroevolution, in other words, were associated with the appearance of new organic codes, and we can easily understand why. The reason is that a new code brings into existence something that has never existed before because it creates arbitrary associations, relationships that are not determined by physical necessity. Another outstanding implication is the fact that codes involve meaning and we need therefore to introduce in biology, with the standard methods of science, not only the concept of biological information but also that of biological meaning. The research on biological codes, in conclusion, is bringing to light new mechanisms in evolution and new fundamental concepts in science. This research is the field of Code Biology, the study of all codes of life, from the genetic code to the codes of culture, from the origin of life to the origin of man. (shrink)

Thomas Sebeok and Noam Chomsky are the acknowledged founding fathers of two research fields which are known respectively as Biosemiotics and Biolinguistics and which have been developed in parallel during the past 50 years. Both fields claim that language has biological roots and must be studied as a natural phenomenon, thus bringing to an end the old divide between nature and culture. In addition to this common goal, there are many other important similarities between them. Their definitions of language, for (...) example, have much in common, despite the use of different terminologies. They both regard language as a faculty, or a modelling system, that appeared rapidly in the history of life and probably evolved as an exaptation from previous animal systems. Both accept that the fundamental characteristic of language is recursion, the ability to generate an unlimited number of structures from a finite set of elements (the property of ‘discrete infinity’). Both accept that human beings are born with a predisposition to acquire language in a few years and without apparent efforts (the innate component of language). In addition to similarities, however, there are also substantial differences between the two fields, and it is an historical fact that Sebeok and Chomsky made no attempt at resolving them. Biosemiotics and Biolinguistics have become two separate disciplines, and yet in the case of language they are studying the same phenomenon, so it should be possible to bring them together. Here it is shown that this is indeed the case. A convergence of the two fields does require a few basic readjustments in each of them, but leads to a unified framework that keeps the best of both disciplines and is in agreement with the experimental evidence. What is particularly important is that such a framework suggests immediately a new approach to the origin of language. More precisely, it suggests that the brain wiring processes that take place in all phases of human ontogenesis (embryonic, foetal, infant and child development) are based on organic codes, and it is the step-by-step appearance of these brain-wiring codes, in a condition that is referred to as cerebra bifida, that holds the key to the origin of language. (shrink)

The existence of different types of semiosis has been recognized, so far, in two ways. It has been pointed out that different semiotic features exist in different taxa and this has led to the distinction between zoosemiosis, phytosemiosis, mycosemiosis, bacterial semiosis and the like. Another type of diversity is due to the existence of different types of signs and has led to the distinction between iconic, indexical and symbolic semiosis. In all these cases, however, semiosis has been defined by the (...) Peirce model, i.e., by the idea that the basic structure is a triad of ‘sign, object and interpretant’, and that interpretation is an essential component of semiosis. This model is undoubtedly applicable to animals, since it was precisely the discovery that animals are capable of interpretation that allowed Thomas Sebeok to conclude that they are also capable of semiosis. Unfortunately, however, it is not clear how far the Peirce model can be extended beyond the animal kingdom, and we already know that we cannot apply it to the cell. The rules of the genetic code have been virtually the same in all living systems and in all environments ever since the origin of life, which clearly shows that they do not depend on interpretation. Luckily, it has been pointed out that semiosis is not necessarily based on interpretation and can be defined exclusively in terms of coding. According to the ‘code model’, a semiotic system is made of signs, meanings and coding rules, all produced by the same codemaker, and in this form it is immediately applicable to the cell. The code model, furthermore, allows us to recognize the existence of many organic codes in living systems, and to divide them into two main types that here are referred to as manufacturing semiosis and signalling semiosis. The genetic code and the splicing codes, for example, take part in processes that actually manufacture biological objects, whereas signal transduction codes and compartment codes organize existing objects into functioning supramolecular structures. The organic codes of single cells appeared in the first three billion years of the history of life and were involved either in manufacturing semiosis or in signalling semiosis. With the origin of animals, however, a third type of semiosis came into being, a type that can be referred to as interpretive semiosis because it became closely involved with interpretation. We realize in this way that the contribution of semiosis to life was far greater than that predicted by the Peirce model, where semiosis is always a means of interpreting the world. Life is essentially about three things: (1) it is about manufacturing objects, (2) it is about organizing objects into functioning systems, and (3) it is about interpreting the world. The idea that these are all semiotic processes, tells us that life depends on semiosis much more deeply and extensively than we thought. We realize in this way that there are three distinct types of semiosis in Nature, and that they gave very different contributions to the origin and the evolution of life. (shrink)

Biosemiotics is the synthesis of biology and semiotics, and its main purpose is to show that semiosis is a fundamental component of life, i.e., that signs and meaning exist in all living systems. This idea started circulating in the 1960s and was proposed independently from enquires taking place at both ends of the Scala Naturae. At the molecular end it was expressed by Howard Pattee’s analysis of the genetic code, whereas at the human end it took the form of Thomas (...) Sebeok’s investigation into the biological roots of culture. Other proposals appeared in the years that followed and gave origin to different theoretical frameworks, or different schools, of biosemiotics. They are: (1) the physical biosemiotics of Howard Pattee and its extension in Darwinian biosemiotics by Howard Pattee and by Terrence Deacon, (2) the zoosemiotics proposed by Thomas Sebeok and its extension in sign biosemiotics developed by Thomas Sebeok and by Jesper Hoffmeyer, (3) the code biosemiotics of Marcello Barbieri and (4) the hermeneutic biosemiotics of Anton Markoš. The differences that exist between the schools are a consequence of their different models of semiosis, but that is only the tip of the iceberg. In reality they go much deeper and concern the very nature of the new discipline. Is biosemiotics only a new way of looking at the known facts of biology or does it predict new facts? Does biosemiotics consist of testable hypotheses? Does it add anything to the history of life and to our understanding of evolution? These are the major issues of the young discipline, and the purpose of the present paper is to illustrate them by describing the origin and the historical development of its main schools. (shrink)

Predicate extensions of the intermediate logic of the weak excluded middle and of the modal logic S4.2 are introduced and investigated. In particular it is shown that some of them are characterized by subclasses of the class of directed frames with either constant or nested domains.

Modern biology has not yet come to terms with the presence of many organic codes in Nature, despite the fact that we can prove their existence. As a result, it has not yet accepted the idea that the great events of macroevolution were associated with the origin of new organic codes, despite the fact that this is the most parsimonious and logical explanation of those events. This is probably due to the fact that the existence of organic codes in all (...) fundamental processes of life, and in all major transitions in the history of life, has enormous theoretical implications. It requires nothing less than a new theoretical framework, and that kind of change is inevitably slow. There are too many facts to reconsider, too many bits of history to weave together in a new mosaic. But this is what science is about, and the purpose of the present paper is to show that it can be done. More precisely, it is shown that the whole natural history of the brain can be revisited in the light of the organic codes. What is described here is only a bird’s-eye view of brain macroevolution, but it is hoped that the extraordinary potential of the organic codes can nevertheless come through. The paper contains also another message. The organic codes prove that life is based on semiosis, and are in fact the components of organic semiosis, the first and the most diffused form of semiosis on Earth, but not the only one. It will be shown that the evolution of the brain was accompanied by the development of two new types of sign processes. More precisely, it gave origin first to interpretive semiosis, mostly in vertebrates, and then to cultural semiosis, in our species. (shrink)

Systems Biology and the Modern Synthesis are recent versions of two classical biological paradigms that are known as structuralism and functionalism, or internalism and externalism. According to functionalism (or externalism), living matter is a fundamentally passive entity that owes its organization to external forces (functions that shape organs) or to an external organizing agent (natural selection). Structuralism (or internalism), is the view that living matter is an intrinsically active entity that is capable of organizing itself from within, with purely internal (...) processes that are based on mathematical principles and physical laws. At the molecular level, the basic mechanism of the Modern Synthesis is molecular copying, the process that leads in the short run to heredity and in the long run to natural selection. The basic mechanism of Systems Biology, instead, is self-assembly, the process by which many supramolecular structures are formed by the spontaneous aggregation of their components. In addition to molecular copying and self-assembly, however, molecular biology has uncovered also a third great mechanism at the heart of life. The existence of the genetic code and of many other organic codes in Nature tells us that molecular coding is a biological reality and we need therefore a framework that accounts for it. This framework is Code biology, the study of the codes of life, a new field of research that brings to light an entirely new dimension of the living world and gives us a completely new understanding of the origin and the evolution of life. (shrink)

This book explores how we can measure consciousness. It clarifies what consciousness is, how it can be generated from a physical system, and how it can be measured. It also shows how conscious states can be expressed mathematically and how precise predictions can be made using data from neurophysiological studies.

The discovery of the genetic code has shown that the origin of life has also been the origin of semiosis, and the discovery of many other organic codes has indicated that organic semiosis has been the sole form of semiosis present on Earth in the first three thousand million years of evolution. With the origin of animals and the evolution of the brain, however, a new type of semiosis came into existence, a semiosis that is based on interpretation and is (...) commonly referred to as interpretive, or Peircean semiosis. This suggests that there are two distinct types of semiosis in Nature, one based on coding and one based on interpretation, and all the experimental evidence that we have does support this conclusion. Both in principle and in practice, therefore, there is no conflict between organic semiosis and Peircean semiosis, and yet they have been the object of a fierce controversy because it has been claimed that semiosis is always based on interpretation, even at the cellular level. Such a claim has recently been reproposed in a number of papers and it has become necessary therefore to reexamine it in the light of the proposed arguments. (shrink)

The past few years have witnessed several media-covered cases involving citizens actively engaging in the pursuit of experimental treatments for their medical conditions—or those of their loved ones—in the absence of established standards of therapy. This phenomenon is particularly observable in patients with rare genetic diseases, as the development of effective therapies for these disorders is hindered by the limited profitability and market value of pharmaceutical research. Sociotechnical trends at the cross-section of medicine and society are facilitating the involvement of (...) patients and creating the digital infrastructure necessary to its sustainment. Such participant-led research has the potential to promote the autonomy of research participants as drivers of discovery and to open novel non-canonical avenues of scientific research. At the same time, however, the extra-institutional, self-appointed, and, often, oversight-free nature of PLR raises ethical concern. This paper explores the complex ethical entanglement of PLR by critically appraising case studies and discussing the conditions for its moral justification. Furthermore, we propose a path forward to ensure the safe and effective implementation of PLR within the current research ecosystem in a manner that maximizes the benefits for both individual participants and society at large, while minimizing the risks. (shrink)