Change is inevitable, and increasingly rapid and continuous in healthcare as organizations strive to adapt, improve and innovate. Organizational change challenges healthcare providers because it restructures how and when patient care delivery is provided, changing ways in which nurses must carry out their work. The aim of this doctoral study was to explore frontline nurses’ experiences of living with rapid and continuous organizational change. A critical hermeneutic approach was utilized. Participants described feeling voiceless, powerless and apolitical amidst rapid and continuous (...) organizational changes which fuelled apathy, cynicism and disengagement from the organization. However, critical analysis of the data showed that nurses actively engaged with power, voice and politics through resistant and transgressive behaviours in micro‐ethical moments of practice. There is a need to reconceptualize the concepts of voice, power and politics in nursing as there is dissonance between nurses’ beliefs about these concepts and what they are enacting in practice. Recognizing their enactment of power, voice and political agency at the micro‐level may empower nurses. Empowerment would mitigate the high levels of reports of powerlessness experienced in practice during organizational changes. (shrink)

In this paper, I discuss nurses' ongoing difficulty in engaging with politics and address the persistent belief that political positioning is antithetical to quality nursing care. I suggest that nurses are not faced with choosing either caring for their patients or engaging with politics. I base my discussion on the assumption that such dichotomy is meaningless and that engaging with issues of relationships firmly grounds nursing in the realm of politics. I argue that the ethical merit of nursing care relies (...) instead on positioning nurses squarely at the centre of care activities, experiences, and functions. Such positioning makes possible what Foucault called ‘practices of self‐formation’, that is, micro‐level processes that balance out the ubiquitous economic, cultural, legal, and scientific technologies that steadily constitute subjects in this era of modernity. Nurses, then, become not a group that needs to be controlled and governed, but individuals who must care for their self before they may care for anyone else. (shrink)

The debate surrounding the issue of collective moral responsibility is often steeped in metaphysical issues of agency and personhood. I suggest that we can approach the metaphysical problems surrounding the issue of collective responsibility in a roundabout manner. My approach is reminiscent of that taken by P.F. Strawson in "Freedom and Resentment" (1968). Strawson argues that the participant reactive attitudes - attitudes like resentment, gratitude, forgiveness and so on - provide the justification for holding individuals morally responsible. I argue that (...) the framework of the reactive attitudes extends to collectives and provides the justification for holding collectives morally responsible. (shrink)

In this paper, we embark on the complicated discussion about the nature of vice in Virtue Ethics through a twofold approach: first, by taking seriously the claim that virtues (and certain flavours of vices) are genuinely dispositional features possessed by agents, and secondly, by employing a pluralistic attitude borrowed from Battaly’s pluralism (2008). Through these lenses, we identify three varieties of viciousness: incontinence, indifference, and malevolence. The upshot is that the notion of vice is not as categorically homogeneous as that (...) of virtue: some states of viciousness consist in interference of present virtuous dispositions, or mimicking of absent vicious ones, whereas others can be considered genuine dispositions themselves. Furthermore, this set-up can provide an interesting, albeit highly idealized story as to how, through the interference in one’s environment, one gets acquainted with vice in various degrees. Finally, this approach can be illuminating vis-à-vis Virtue Ethics in general; e.g. we can employ it to discuss more productively Johnston’s (2003) objection to Hursthouse’s (1999) account of moral conduct. Finally, this approach can be illuminating vis-a-vis Virtue Ethics in general; e.g. we can employ it to discuss more productively Johnston’s (2003) objection to Hursthouse’s (1999) account of moral conduct. (shrink)

This essay seeks to give a contractarian foundation to the concept of Corporate Social Responsibility, meant as an extended model of corporate governance of the firm. It focuses on justification according to the contractarian point of view. It begins by providing a definition of CSR as an extended model of corporate governance, based on the fiduciary duties owed to all the firm's stakeholders. Then, by establishing the basic context of incompleteness of contracts and abuse of authority, it analyses how the (...) extended view of corporate governance arises directly from criticism of the contemporary neo-institutional economic theory of the firm. Thereafter, an application of the theory of bargaining games is used to deduce the structure of a multi-stakeholder firm, on the basis of the idea of a constitutional contract, which satisfies basic requirements of impartial justification and accordance with intuitions of social justice. This is a sequential model of constitutional bargaining, whereby a constitution is first chosen, and then a post-constitutional coalition game is played. On the basis of the unique solution given to each step in the bargaining model, the quest for a prescriptive theory of governance and strategic management is accomplished, so that I am able to define an objective-function for the firm consistent with the idea of CSR. Finally, a contractarian potential explanation for the emergence of the multi-fiduciary firm is provided. (shrink)

Despite recent essentialist approaches to Kant’s laws of nature, it is unclear whether Kant’s critical philosophy is compatible with core tenets of essentialism. In this paper, I first reconstruct Kant’s position by identifying the key metaphysical and epistemological features of his notion of ‘nature’ or ‘essence’. Two theses about natures can be found in the literature, namely that they are noumenal in character (noumenal thesis) and that they guide scientific investigation as regulative ideas of reason (regulative thesis). I argue that (...) Kant’s notion of nature does not entail the noumenal thesis and, based on his model of causal explanation, I propose a novel, phenomenal thesis, that allows for a better understanding of the function of natures as regulative ideas. In the last part of the paper, I show that Kant’s ‘essentialism’ is a genuine form of essentialism committed to de re modality, although it differs in several respects from major contemporary essentialist accounts. I conclude by suggesting that Kant’s essentialism (if appropriately updated) can be relevant to the contemporary debate, which has so far been dominated by Humean and Aristotelian proposals. (shrink)

This essay seeks to give a contractarian foundation to the concept of Corporate Social Responsibility, meant as an extended model of corporate governance of the firm. Whereas, justificatory issues have been discussed in a related paper, in this essay I focus on the implementation of and compliance with this normative model. The theory of reputation games, with reference to the basic game of trust, is introduced in order to make sense of self-regulation as a way to implement the social contract (...) on the multi-fiduciary model of corporate governance. This affords understanding of why self-regulation, meant as mere recourse to a long-run strategy in a repeated trust game, fails. Two basic problems for the functioning of the reputation mechanism are examined: the cognitive fragility problem, and the motivational problem. As regards the cognitive fragilities of reputation, the paper develops the logic and the structure that self-regulatory norms must satisfy if they are to serve as gap-filling tools with which to remedy cognitive limitations in the reputation mechanism. The motivation problem then arises from the possibility of sophisticated abuse by the firm. Developed in this case is an entirely new application of the theory of conformism-and-reciprocity-based preferences, the result of which is that the stakeholders refuse to acquiesce to sophisticated abuse on the part of the firm. (shrink)

Inner speech has been shown to vary in form along several dimensions. Along condensation, condensed inner speech forms have been described, that are supposed to be deprived of acoustic, phonological and even syntactic qualities. Expanded forms, on the other extreme, display articulatory and auditory properties. Along dialogality, inner speech can be monologal, when we engage in internal soliloquy, or dialogal, when we recall past conversations or imagine future dialogues involving our own voice as well as that of others addressing us. (...) Along intentionality, it can be intentional (when we deliberately rehearse material in short-term memory) or it can arise unintentionally (during mind wandering). We introduce the ConDialInt model, a neurocognitive predictive control model of inner speech that accounts for its varieties along these three dimensions. ConDialInt spells out the condensation dimension by including inhibitory control at the conceptualization, formulation or articulatory planning stage. It accounts for dialogality, by assuming internal model adaptations and by speculating on neural processes underlying perspective switching. It explains the differences between intentional and spontaneous varieties in terms of monitoring. We present an fMRI study in which we probed varieties of inner speech along dialogality and intentionality, to examine the validity of the neuroanatomical correlates posited in ConDialInt. Condensation was also informally tackled. Our data support the hypothesis that expanded inner speech recruits speech production processes down to articulatory planning, resulting in a predicted signal, the inner voice, with auditory qualities. Along dialogality, covertly using an avatar’s voice resulted in the activation of right hemisphere homologues of the regions involved in internal own-voice soliloquy and in cerebellar deactivation, consistent with internal model adaptation. Switching from first-person to third-person perspective resulted in activations in precuneus and parietal lobules. Along intentionality, compared with intentional inner speech, mind wandering with inner speech episodes was associated with greater bilateral inferior frontal activation and decreased activation in left temporal regions. This is consistent with the reported subjective evanescence and presumably reflects condensation processes. Our results provide neuroanatomical evidence compatible with predictive control and in favor of the assumptions made in the ConDialInt model. (shrink)

Philosophers have debated at length the epistemological status of scientific thought experiments. I contend that the literature on this topic still lacks a common conceptual framework, a lacuna that produces radical disagreement among the participants in this debate. To remedy this problem, I suggest focusing on the distinction between the internal and the external validity of an experiment, which is also crucial for thought experiments. I then develop an account of both kinds of validity in the context of thought experiments. (...) I show that we can naturally conceptualise internal validity in terms of games of make-believe. Then, I argue that external validity is best defined as accurate representation of a target system. Finally, I turn back to the current debate on thought experiments and show that my diarchic account provides a general framework that can be shared by the competing philosophical views, as well as a fruitful guide for their reconciliation. (shrink)

RACINE L and PERRON A. Nursing Inquiry 2012; 19: 190–201 Unmasking the predicament of cultural voyeurism: a postcolonial analysis of international nursing placementsThe growing interest in international nursing placements cannot be left unnoticed. After 11 years into this twenty‐first century, violations of human rights and freedom of speech, environmental disasters, and armed conflicts still create dire living conditions for men and women around the world. Nurses have an ethical duty to address issues of social justice and global health as a (...) means to fulfil nursing’s social mandate. However, international placements raise some concerns. Drawing on the works of postcolonial theorists in nursing and social sciences, we examine the risk of replicating colonialist practices and discourses of health in international clinical placements. Referring to Bakhtin’s notions of dialogism and unfinalizability, we envision a culturally safe nursing practice arising from dialogical encounters between the Self as an Other and with the Other as an Other. We suggest that exploring the intricacies of cultural and race relations in everyday nursing practice are the premises upon which nurses can understand the broader historic, racial, gendered, political and economic contexts of global health issues. Finally, we make suggestions for developing culturally safe learning opportunities at the international level without minimizing the impact of dialogical cultural encounters occurring at the local and community levels. (shrink)

This paper attempts a reconstruction of reason’s contribution to empirical truth in connection with Kant’s definition of truth as the agreement of cognition with its object. I argue that Kant’s treatment of truth in the Transcendental Analytic gets completed in the Appendix to the Transcendental Dialectic with an often neglected but compelling argument (what I shall call the Variety Argument). This argument postulates such a variety in the appearances as to undermine any attempt at formulating empirical truths. Crucially, I argue (...) that this variety does not depict an extreme-case scenario, but our own epistemic situation without reason. Reason completes Kant’s theory of truth by allowing the understanding (i.) to form empirical concepts and (ii.) approximate to empirical truth. (shrink)

Many important concepts of the calculus are difficult to grasp, and they may appear epistemologically unjustified. For example, how does a real function appear in “small” neighborhoods of its points? How does it appear at infinity? Diagrams allow us to overcome the difficulty in constructing representations of mathematical critical situations and objects. For example, they actually reveal the behavior of a real function not “close to” a point but “in” the point. We are interested in our research in the diagrams (...) which play an optical role –microscopes and “microscopes within microscopes”, telescopes, windows, a mirror role, and an unveiling role. In this paper we describe some examples of optical diagrams as a particular kind of epistemic mediator able to perform the explanatory abductive task of providing a better understanding of the calculus, through a non-standard model of analysis. We also maintain they can be used in many other different epistemological and cognitive situations. (shrink)

In today's world, the corporate image of the largest companies is closely linked to their performance in the field of corporate social responsibility and the disclosure of information on that topic, specifically, on climate change. Since the Board of Directors is the body responsible for this process, the aim of this article is to show the role that companies' Boards of Directors play in the accountability process vis-à-vis stakeholders in relation to one specific aspect which has enormous significance in environmental (...) information: practices used to monitor greenhouse gas emissions. In order to achieve this, we shall verify certain business characteristics, in addition to the size and activity of the Board of Directors, and we shall take different dependence models into consideration. These models will include variables related to the level of independence and diversity of the Board of Directors, which interact with dummy variables representing the company's litigation risks regarding environmental behavior and the institutional macro-context of the organization's country of origin. The results make it clear that Boards of Directors are basically focused on the traditional responsibility of creating economic value, instead of dealing with today's broader business world concepts, which include social responsibility. This focus, therefore, does not favor the accountability process before other stakeholders, if this makes it more difficult to protect the interests of shareholders. (shrink)

Philosophers have studied geometry since ancient times. Geometrical knowledge has often played the role of a laboratory for the philosopher's conceptual experiments dedicated to the ideation of powerful theories of knowledge. Lorenzo Magnani's new book Philosophy and Geometry illustrates the rich intrigue of this fascinating story of human knowledge, providing a new analysis of the ideas of many scholars (including Plato, Proclus, Kant, and Poincaré), and discussing conventionalist and neopositivist perspectives and the problem of the origins of geometry. The (...) book also ties together the concerns of philosophers of science and cognitive scientists, showing, for example, the connections between geometrical reasoning and cognition as well as the results of recent logical and computational models of geometrical reasoning. All the topics are dealt with using a novel combination of both historical and contemporary perspectives. Philosophy and Geometry is a valuable contribution to the renaissance of research in the field. (shrink)

This book aims to develop the tradition of philosophical hermeneutics, the theoretical account of interpretive (as opposed to explanatory) understanding--the account of meanings and contexts rather than causes and predictions--usually restricted to the domain of literary and textual analysis, in new directions by exploiting its potential as an instrument of critique. It refutes commonly held claims that hermeneutic analyses are necessarily relativistic, Eurocentric, or critically impotent and demonstrates how hermeneutic procedures can inform analyses of urgent current and cross-cultural issues such (...) as the biology of race, female genital excision, and the so-called "culture of poverty" thesis. Lorenzo Simpson demonstrates that a robust methodology of philosophical hermeneutics is well positioned to intervene in critical political and social issues in global ethics and justice in concert with critical theory's emancipatory aims. (shrink)

The purpose of this text is to tell the story of the implementation of the _Act Respecting End-of-Life Care,_ referred to hereafter as _Law 2_ (Gouvernement du Québec, 2014) with an emphasis on the ambiguous role of ethics in the Interdisciplinary Support Groups (ISGs), created by Quebec's _Ministère de la santé et des services sociaux_ (MSSS). As established, ISGs provide “clinical, administrative and ethical support to health care professionals responding to a request for Medical aid in dying (MAiD)” (Gouvernement du (...) Québec, 2015). It is suggested that their composition includes the participation of a person with an expertise in ethics. These ISGs represent an important innovation for stakeholders involved in MAiD. To date, no scientific research has specifically addressed ISGs and little research has been conducted in other jurisdictions on the roles, operations and practices of MAiD support structures, especially the implication of ethics. Several ISGs have certainly developed promising practices that could benefit all stakeholders in the wider field of ethics and end of life. We will explore the development of ISGs in Quebec as a support structure for MAiD by highlighting the role that ethics has played (and should play) in these morally and humanly challenging situations. (shrink)

PERRON A and HOLMES D. Nursing Inquiry 2011; 18: 191–204Constructing mentally ill inmates: nurses’ discursive practices in correctionsThe concepts of discourse, subjectivity and power allow for innovative explorations in nursing research. Discourse take many different forms and may be maintained, transmitted, even imposed, in various ways. Nursing practice makes possible many discursive spaces where discourses intersect. Using a Foucauldian perspective, were explored the ways in which forensic psychiatric nurses construct the subjectivity of mentally ill inmates. Progress notes and individual interviews (...) constitute discursive spaces within which nurses construct patients’ subjectivities. Progress notes provide a written (and permanent) form of discourse, while interviews set the space for a more fluid and contextual form of discourse. We identified five types of subjectivities – the (in)visible patient, the patient as risk, the deviant patient, the disturbed patient and the disciplined patient. These subjectivities were rooted in various types of discourses circulating in the selected setting. Despite the multiple discursive dimensions of forensic psychiatric nursing, progress notes remain the main formal source of information regarding nursing care even though it is not representative of the care provided nor is it representative of nurses’ complex discursive practices in corrections. (shrink)

This article aims at commenting in a novel way on the concept of political correctness, by showing that, even if adopting a politically-correct behavior aims at promoting a precise moral outcome, violence can be still perpetrated, despite good intentions. To afford in a novel way the problem of political correctness, I will adopt a theoretical strategy that adheres to moral stoicism, the problem of “silence”, the “fascist state of the mind” and the concept of “overmorality”, which I have introduced in (...) my book Understanding Violence. The Intertwining of Morality, Religion, and Violence: A Philosophical Stance. I will demonstrate that political correctness certainly obeys the stoic moral rule, which teaches us that we have to diminish conflicts and, so, the potential for derived violence, by avoiding to pronounce words and expressions that can be offensive and so conflict making. Unfortunately, political correctness often increases the so-called already widespread overmorality, typical of our era, and postulates too many minor moral values to be attributed to individuals and groups, which must be respected. Therefore, engaging in political correctness obscures more serious issues regarding social, political and economic life, committing a sin of abstractness and idealization. At the same time, by discouraging the use of words and expressions, the intrinsic overmoralization at work creates potential new conflicts and potential derived violence. (shrink)

This article aims to justify the positive role in the empirical investigation of nature that Kant attributes to the idea of God in the Critique of Pure Reason. In particular, I propose to read the Transcendental Ideal section and the Appendix to the Transcendental Dialectic together to see whether they can reciprocally illuminate each other. I argue that it is only by looking at the transcendental deduction of the ideas of reason and the resulting analogical conception of God that a (...) fully legitimate positive use of the idea of God can be vindicated. (shrink)

The evolution of the concept of subjectivity in the works of Jacques Lacan.

As humanity becomes increasingly interconnected through globalization, the question of whether community is possible within culturally diverse societies has returned as a principal concern for contemporary thought. Lorenzo Simpson charges that the current discussion is stuck at an impasse-between postmodernism's fragmented notions of cultural difference and humanism's homogeneous versions of community. Simpson proposes an alternative-one that bridges cultural differences without erasing them. He argues that we must establish common aesthetic and ethical standards incorporating sensitivity to difference if we are (...) to achieve cross-cultural understanding. (shrink)

According to most interpreters, Aristotle explains death as the result of material processes of the body going against the nature of the living being. Yet, this description is incomplete, for it does not clarify the relationship between the process of decay and the teleological system in which it occurs: this makes it impossible to distinguish between natural and violent death. In this paper, I try to fill this gap by looking at his so-called ‘biological works’ and mainly at the De (...) Juventute. I first introduce the specific concept of life at play in this treatise and prove its complementarity with the framework of the De Anima. Then, I illustrate in detail the process of dying and the reasons why a merely material description is insufficient to account for the distinction between natural and violent death. Finally, I show that for Aristotle natural death is a by-product of teleologically directed life activities: only against the background of this teleological structure is natural death fully explained in terms of essence and causes. To support this claim, I compare death to two analogous cases in Aristotle’s biology, namely dreams and the features of GA V. (shrink)

The sentences employed in semantic paradoxes display a wide range of semantic behaviours. However, the main theories of truth currently available either fail to provide a theory of paradox altogether, or can only account for some paradoxical phenomena by resorting to multiple interpretations of the language. In this paper, I explore the wide range of semantic behaviours displayed by paradoxical sentences, and I develop a unified theory of truth and paradox, that is a theory of truth that also provides a (...) unified account of paradoxical sentences. The theory I propose here yields a threefold classification of paradoxical sentences – liar-like sentences, truth-teller-like sentences, and revenge sentences. Unlike existing treatments of semantic paradox, the theory put forward in this paper yields a way of interpreting all three kinds of paradoxical sentences, as well as unparadoxical sentences, within a single model. (shrink)

Scientific models typically contain idealizations, or assumptions that are known not to be true. Philosophers have long questioned the nature of idealizations: Are they heuristic tools that will be abandoned? Or rather fictional representations of reality? And how can we reconcile them with realism about knowledge of nature? Immanuel Kant developed an account of scientific investigation that can inspire a new approach to the contemporary debate. Kant argued that scientific investigation is possible only if guided by ideal assumptions—what he calls (...) “regulative ideas”. These ideas are not true of objects of nature, and yet they are not heuristic tools or fictional represen- tations. They are necessary rules governing the construction and assessment of scientific explanations. In this paper, I suggest that some idealizations can be interpreted as having necessary regulative value and as being compatible with scientific realism. I first analyze the puzzle of the nature of idealization and present the main approaches to this topic in the literature. Second, I reconsider the puzzle vis-a-vis a restricted, Kantian definition of idealization and a novel characterization of the relation between idealization and truth. Finally, I discuss in detail an example of idealization (the Hardy-Weinberg equilibrium) along the suggested Kantian lines. (shrink)

In this paper, I offer a systematic account of Kant’s view on ‘phenomenal substance’. Several studies have recently analyzed Kant’s notion of substance. However, I submit that more needs to be said about how this notion is reconceptualized within the critical framework to vindicate a genuine and legitimate sense of substance in the phenomenal realm. More specifically, I show that Kant’s transcendental idealism does not commit him to a rejection of substantiality in phenomena. Rather, Kant isolates a general notion of (...) substance (as ultimate subject) and argues that (i) the relationality of phenomena is compatible with this notion; and that (ii) matter and all its parts are the ultimate subjects of everything existing in space (as what is independently movable in space). I suggest that vindicating a genuine and legitimate notion of phenomenal substance has far-ranging consequences for the interpretation of Kant’s empirical realism. (shrink)

This article outlines the struggle between the power of the health care professional and the rights of the individual to choose freely a modality of treatment. Nurses are instrumental in assisting patients in making the best decision for a therapy they will have to assume for the rest of their lives. In guiding patients' decision, nurses must take into account these unavoidable contingencies: changes in lifestyle, nutritional restrictions, level of acceptance, compliance issues, ease of training and availability of support/facilities. Ensuring (...) that the patient makes an informed decision is therefore an ongoing challenge for nurses as they are taking part in a delicate balancing act between not directly influencing the patient's decision while making sure the patient is accurately informed. (shrink)

The idea of agency has long been used in the nursing literature in the study of nurses' roles regarding the patients they take care of, but it has not often been used to study its relationship with nurses themselves and their status in the healthcare system. The purpose of this article is to analyze how the idea of agency is used in nursing research to better understand how we might advance our thinking around nurses' agency to shape nursing and healthcare (...) with an emancipatory intent. Based on the results of a literature review focused on the study of conceptions, treatments, and applications of the concept of agency in nursing, we present a critical discussion to reflect on the need to consistently define the idea of nurses' agency, to guide research concerned with this topic in theoretical frameworks with emancipatory and social change tenets, and to make a call to develop the idea of agency as a central one to rework nurses' relationship with themselves. The idea of agency provides a valuable analytical framework for the study of a wide range of issues around nurses' status in healthcare organizations and in the healthcare system while offering a means for nurses' emancipation. (shrink)

There are those who would argue that, recently, the profession of nursing has made a radical shift, while others believe that a schism has been created among both scholars and clinicians as a result of the emerging dominance of the evidence‐based nursing movement. This paper offers a philosophical critique of this movement using Gilles Deleuze and Felix Guattari’s concept of schizoanalysis. As a conclusion, the authors posit that nursing professionals maintain a stance of academic freedom of thought and scientific integrity (...) through the acceptance of multiplicity, diversity, and polyvocality, and by challenging with politically charged concepts the totalizing perspectives that often spread through the profession/discipline of nursing. (shrink)

According to the most common interpretation of the simulation argument, we are very likely to live in an ancestor simulation. It is interesting to ask if some families of simulations are more likely than others inside the space of all simulations. We argue that a natural probability measure is given by computational complexity: easier simulations are more likely to be run. Remarkably this allows us to extract experimental predictions from the fact that we live in a simulation. For instance we (...) show that it is very likely that humanity will not achieve interstellar travel and that humanity will not meet other intelligent species in the universe, in turn explaining the Fermi's Paradox. On the opposite side, experimental falsification of any of these predictions would constitute evidence against our reality being a simulation. (shrink)

This article analyses a sceptical challenge resulting from metaphysical approaches to the problem of the necessity of empirical laws of nature in Kant’s critical philosophy (what I shall call ‘essentialist’ readings). I argue that this challenge may jeopardize the purpose of empirical enquiry (and therefore the plausibility of essentialist readings), but that Kant has internal resources to address it in the Dialectic of the Critique of Pure Reason. I show that reading this problem through the lens of the Dialectic allows (...) us to reconcile the metaphysical question of necessitation of laws with a robust sense of empirical cognition. (shrink)

The standard representation of the Central Dogma (CD) of Molecular Biology conspicuously ignores metabolism. However, both the metabolites and the biochemical fluxes behind any biological phenomenon are encrypted in the DNA sequence. Metabolism constrains and even changes the information flow when the DNA‐encoded instructions conflict with the homeostasis of the biochemical network. Inspection of adaptive virulence programs and emergence of xenobiotic‐biodegradation pathways in environmental bacteria suggest that their main evolutionary drive is the expansion of their metabolic networks towards new chemical (...) landscapes rather than perpetuation and spreading of their DNA sequences. Faulty enzymatic reactions on suboptimal substrates often produce reactive oxygen species (ROS), a process that fosters DNA diversification and ultimately couples catabolism of the new chemicals to growth. All this calls for a revision of the CD in which metabolism (rather than DNA) has the leading role. (shrink)

The present article argues for the non-authenticity of l. 38 in the first Horatian Epistle. Together with the allusions to avarice and pride at ll. 33 and 36, it contains a reference to the cardinal sins, a concept that did not yet exist at the time of Horace. In particular, the sins listed in the line at issue appear to coincide with those discussed by Gregory the Great in his Moralia in Iob (31.45) and eventually adopted by medieval thought. The (...) metrical pattern and a check of the main medieval commentaries support the suspected spuriousness of the line. (shrink)

This book deals with one of the most important issues of philosophy of law and constitutional thought: how to understand clashes of fundamental rights, such as the conflict between free speech and privacy. The main argument of this book is that much can be learned about the nature of fundamental legal rights by examining them through the lens of conflicts among such rights, and criticizing the views of scholars and jurists who have discussed both fundamental legal rights and the nature (...) of conflicts among them. -/- Theories of rights are necessarily abstract, aiming at providing the best possible answers to pressing social problems. Yet such theories must also respond to the real and changing dilemmas of the day.Taking up the problem of conflicting rights, Zucca seeks a theory of rights that can guide us to a richer, more responsive approach to rights discourse. -/- The idea of constitutional rights is one of the most powerful tools to advance justice in the Western tradition. But as this book demonstrates, even the most ambitious theory of rights cannot satisfactorily address questions of conflicting rights. How, for instance, can we fully secure privacy when it clashes with free speech? To what extent can our societies assist people in dying without compromising the protection of life? Exploring the limitations of the rights discourse in these areas, Zucca questions the role of law in settling ethical dilemmas helping to clarify thinking about the limitations of rights discourse. (shrink)

Nell'ultima decade la letteratura sugli effetti dei movimenti sociali ha conosciuto una notevole espansione. Questo sviluppo ha generato una domanda di miglioramento dei nostri approcci alla materia sia a livello teorico sia metodologico. Nonostante tutto questo, nel cercare di misurare l'impatto dei movimenti sociali, legando questi agli obiettivi che alcune componenti di un movimento dichiarano di avere, la ricerca scientifica sulla materia ha prodotto scarsi risultati. L'articolo suggerisce che per conoscere come i movimenti sociali producono cambiamento sociale bisogna guardare all'interrelazione (...) delle conseguenze e non limitarsi a studiare le conseguenze nel breve periodo ma estendere le analisi al lungo periodo. L'articolo vuole provocare una discussione sulla materia e identificare una nuova opportunitÀ d'investigazione empirica. (shrink)

The aim of this paper is to propose a novel reading of the critical legitimacy of the regulative use of reason in the Transcendental Dialectic of Kant's Critique of Pure Reason. After introducing some key terminology of the Dialectic, I analyse the shortcomings of two influential accounts of the regulative use of reason and identify their common problem in their commitment to the descriptivity of the ideas of reason. I then offer my rule‐based account of the regulative use of reason (...) by clarifying how Kant transforms reason's metaphysical inclinations into prescriptive rules of bottom‐up empirical research. Finally, I explain why such interpretation of reason is metaphysically innocent and thereby a promising approach to understand its role in Kant's scientific project. (shrink)