This paper reviews the fate of the central ideas behind the complementary learning systems (CLS) framework as originally articulated in McClelland, McNaughton, and O’Reilly (1995). This framework explains why the brain requires two differentially specialized learning and memory systems, and it nicely specifies their central properties (i.e., the hippocampus as a sparse, pattern-separated system for rapidly learning episodic memories, and the neocortex as a distributed, overlapping system for gradually integrating across episodes to extract latent semantic structure). We review the application (...) of the CLS framework to a range of important topics, including the following: the basic neural processes of hippocampal memory encoding and recall, conjunctive encoding, human recognition memory, consolidation of initial hippocampal learning in cortex, dynamic modulation of encoding versus recall, and the synergistic interactions between hippocampus and neocortex. Overall, the CLS framework remains a vital theoretical force in the field, with the empirical data over the past 15 years generally confirming its key principles. (shrink)

The posterior cortex, hippocampus, and prefrontal cortex in the Leabra architecture are specialized in terms of various neural parameters, and thus are predilections for learning and processing, but domain-general in terms of cognitive functions such as face recognition. Also, these areas are not encapsulated and violate Fodorian criteria for modularity. Anderson's terminology obscures these important points, but we applaud his overall message.

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)

The prefrontal cortex is widely believed to play an important role in facilitating people's ability to switch performance between different tasks. We present a biologically‐based computational model of prefrontal cortex (PFC) that explains its role in task switching in terms of the greater flexibility conferred by activation‐based working memory representations in PFC, as compared with more slowly adapting weight‐based memory mechanisms. Specifically we show that PFC representations can be rapidly updated when a task switches via a dynamic gating mechanism based (...) on a temporal‐differences reward‐prediction learning mechanism. Unlike prior models of this type, the present model develops all of its internal representations via learning mechanisms as shaped by the demands of continuous periodic task switching. This advance opens up a new domain of research into the interactions between working memory task demands and the representations that develop to meet them. Results on a version of the Wisconsin card sorting task are presented for the full model and a number of comparison networks that test the importance of various model features. Furthermore, we show that a lesioned model produces perseverative errors like those seen in frontal patients. (shrink)

The prefrontal cortex is widely believed to play an important role in facilitating people's ability to switch performance between different tasks. We present a biologically‐based computational model of prefrontal cortex (PFC) that explains its role in task switching in terms of the greater flexibility conferred by activation‐based working memory representations in PFC, as compared with more slowly adapting weight‐based memory mechanisms. Specifically we show that PFC representations can be rapidly updated when a task switches via a dynamic gating mechanism based (...) on a temporal‐differences reward‐prediction learning mechanism. Unlike prior models of this type, the present model develops all of its internal representations via learning mechanisms as shaped by the demands of continuous periodic task switching. This advance opens up a new domain of research into the interactions between working memory task demands and the representations that develop to meet them. Results on a version of the Wisconsin card sorting task are presented for the full model and a number of comparison networks that test the importance of various model features. Furthermore, we show that a lesioned model produces perseverative errors like those seen in frontal patients. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

ABSTRACT There is limited guidance about whether and how to provide psychological assessment results to research participants. This paper considers several ethical challenges associated with offering individual research results in psychological assessment research. Additionally, the process used to return individual results within a study examining neurodevelopmental effects of anesthesia exposure in children and adolescents is described. Almost all participants requested to know if results were concerning; however, only around a third of those with concerning findings sought additional feedback. Ongoing research (...) and guidance are necessary to establish evidence-based practices and manage challenges that may emerge when disclosing such results. (shrink)

To explore the realm of creativity, we will make use of the concept of instauration as articulated in the work of Étienne Souriau. Although infrequently used, the word remains extant in English, with agreement among dictionaries that the primary definition is the action of restoring or renewing, with a secondary meaning of instituting or founding. While both senses are at play in Souriau’s thought, it is perhaps the tension between the two that is predominantly in question, akin to what we (...) describe as open containment. We think instauration, as institutive renewal, in dialogue with Merleau-Ponty’s late use of the term aesthesiology to further elaborate the process of creating as a return to the wonder that is aesthesis, the affectively and sensually apprehended opening onto and entanglement with what is. Merleau-Ponty extends aesthesiology as the science of the sense organs themselves into a philosophical organology for ontology. His use of aesthesiology and Souriau’s use of instauration constitute efforts to offer sufficient conceptual containment to be able to say the contingent and ambiguous open of ongoing originating, even while both thinkers strive not to institute any final closure by this very act of naming. This is the inevitable tension of writing philosophic creation.Pour explorer le royaume de la créativité, nous utilisons ici le concept d’instauration tel qu’il a été articulé dans l’oeuvre d’Étienne Souriau. Quoique utilisé rarement, ce terme est attesté dans la langue anglaise. Les dictionnaires anglais accordent que sa définition principale désigne une action de rétablissement ou de renouvellement, avec un sens secondaire d’institution ou fondation. Si les deux sens sont à l’oeuvre chez Souriau, c’est peut-être la tension entre eux qui y est surtout patente. Nous pensons ici l’instauration, entendue comme renouvellement instituant, en dialogue avec l’idée d’esthésiologie telle que Merleau-Ponty la comprend à la fin de son oeuvre. Il utilise cette notion pour développer sa conception du processus de création comme retour à l’étonnement que produit l’áisthesis. L’áisthesis est en effet l’ouverture, affective et sensible, et l’entrelacs, affectif et sensible, à ce qui est. Merleau-Ponty prolonge ainsi l’esthésiologie entendue comme science des organes sensibles, vers une organologie philosophique à visée ontologique. L’usage de l’esthésiologie chez Merleau-Ponty et l’usage de l’instauration chez Souriau constituent des efforts vers une maîtrise conceptuelle suffisante pour pouvoir dire l’ouverture continue, contingente et ambiguë de l’originaire – bien que les deux penseurs ne visent pas à instaurer une clôture finale à partir de l’acte nominatif. Telle est la tension inévitable qu’on rencontre lorsqu’on cherche à écrire la création philosophique.Utilizzeremo in queste pagine per esplorare il regno della creatività il concetto di “instaurazione” così come si trova articolato nell’opera di Étienne Souriau. Benché impiegato raramente, questo termine è attestato anche nella lingua inglese. I dizionari inglesi danno come significato principale quello di un’azione di ristabilimento o rinnovamento, a cui si aggiunge un significato secondario di istituzione o fondazione. Se è vero che entrambi i significati sono all’opera in Souriau, è d’altra parte ancor più evidente la loro tensione. Proporremo qui di pensare l’instaurazione, intesa come rinnovamento istituente, in dialogo con l’idea di estesiologia così come la intende Merleau-Ponty alla fine del suo percorso. Egli usa questa nozione per sviluppare la sua concezione del processo creativo come ritorno allo stupore dell’áisthesis, cioè dell’apertura affettiva e sensibile, e dell’intreccio affettivo e sensibile, a ciò che è. Merleau-Ponty prolunga così l’estesiologia come scienza degli organi di senso in direzione di un’organologia filosofica orientata ontologicamente. L’indagine sull’estesiologia condotta da Merleau-Ponty e l’uso del concetto di instaurazione in Souriau costituiscono così altrettanti sforzi di dire concettualmente l’apertura continua, contingente e ambigua dell’originario – benché sia chiaro che i due pensatori non intendono raggiungere in alcun modo, con questo dire concettuale e con questa scelta lessicale, una qualsiasi “chiusura” della questione. Tale è infatti la tensione inevitabile cui ci si ritrova esposti quando si tenta di scrivere la creazione. (shrink)

Provides an ideology-critique of Whitehead's and Hartshorne's metaphysics and demonstrates how their metaphysical principles reflect their personal commitments to the values and norms of the modern liberal political ideology.

John Calvin claims that the foundation of Scripture is the oracles and visions revealed to the patriarchs, transmitted through countless generations by an oral tradition that faithfully preserved these oracles. The oral tradition of the patriarchs also contains practices not found in written Scripture that are applicable to the church of Calvin day.

This paper examines the investigations carried out between 1798 and 1834 to determine whether, and how, magnetism affected the rate at which marine chronometers gained or lost time. There were persistent claims that chronometers systematically altered rate between those determined on land and those at sea, and magnetism was thought by some to be the most likely cause. Others disputed any rate difference at all. The experiments carried out to determine the influence of magnetism and those carried out to determine (...) if there was a difference between land and sea rates of chronometers will be considered. The data will be re-analysed in an attempt to extract additional information to clarify the answers to these questions. The influence these experiments had on certain navigational practices will be discussed briefly. (shrink)

In orthodox quantum mechanics, it has virtually become the custom to identify properties of a physical system with operationally testable propositions about the system. The causes and consequences of this practice are explored mathematically in this paper. Among other things, it is found that such an identification imposes severe constraints on the admissible states of the physical system.

A comprehensive formal system is developed that amalgamates the operational and the realistic approaches to quantum mechanics. In this formalism, for example, a sharp distinction is made between events, operational propositions, and the properties of physical systems.

Overshadowed by Kant and Hegel, the intervening figures have received comparatively little attention from American scholars. Whatever the reasons, they do not dispel the irony of this state of affairs, for the relationship between the philosophies of Kant and Hegel cannot be fully understood apart from considering these figures, chief among them being Fichte and Schelling. Whatever shortcomings may be identified by “specialists” in German idealism or nonspecialists “interested in the intellectual transition from Kant to Kierkegaard to Marx”—the work reviewed (...) here is intended for both groups—it unquestionably makes a valuable contribution toward remedying this oversight. (shrink)

Overshadowed by Kant and Hegel, the intervening figures have received comparatively little attention from American scholars. Whatever the reasons, they do not dispel the irony of this state of affairs, for the relationship between the philosophies of Kant and Hegel cannot be fully understood apart from considering these figures, chief among them being Fichte and Schelling. Whatever shortcomings may be identified by “specialists” in German idealism or nonspecialists “interested in the intellectual transition from Kant to Kierkegaard to Marx”—the work reviewed (...) here is intended for both groups—it unquestionably makes a valuable contribution toward remedying this oversight. (shrink)