We investigated people's ability to infer others’ mental states from their emotional reactions, manipulating whether agents wanted, expected, and caused an outcome. Participants recovered agents’ desires throughout. When the agent observed, but did not cause the outcome, participants’ ability to recover the agent's beliefs depended on the evidence they got. When the agent caused the event, participants’ judgments also depended on the probability of the action ; when actions were improbable given the mental states, people failed to recover the agent's (...) beliefs even when they saw her react to both the anticipated and actual outcomes. A Bayesian model captured human performance throughout, consistent with the proposal that people rationally integrate information about others’ actions and emotional reactions to infer their unobservable mental states. (shrink)

Human vision supports social perception by efficiently detecting agents and extracting rich information about their actions, goals, and intentions. Here, we explore the cognitive architecture of perceived animacy by constructing Bayesian models that integrate domain‐specific hypotheses of social agency with domain‐general cognitive constraints on sensory, memory, and attentional processing. Our model posits that perceived animacy combines a bottom–up, feature‐based, parallel search for goal‐directed movements with a top–down selection process for intent inference. The interaction of these architecturally distinct processes makes perceived (...) animacy fast, flexible, and yet cognitively efficient. In the context of chasing, in which a predator (the “wolf”) pursues a prey (the “sheep”), our model addresses the computational challenge of identifying target agents among varying numbers of distractor objects, despite a quadratic increase in the number of possible interactions as more objects appear in a scene. By comparing modeling results with human psychophysics in several studies, we show that the effectiveness and efficiency of human perceived animacy can be explained by a Bayesian ideal observer model with realistic cognitive constraints. These results provide an understanding of perceived animacy at the algorithmic level—how it is achieved by cognitive mechanisms such as attention and working memory, and how it can be integrated with higher‐level reasoning about social agency. (shrink)

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

Williams Syndrome is a developmental disorder that is characterized by cardiovascular problems, particular facial features and several typical behavioral and neurological abnormalities. In Williams Syndrome patients, a heterozygous deletion is present of a region on chromosome 7q11.23 (the Williams Syndrome critical region), which spans approximately 20 genes. Two of these genes encode proteins that regulate dynamic aspects of the cytoskeleton of the cell, either via the actin filament system (LIM kinase 1, or LIMK1), or through the microtubule network (cytoplasmic linker (...) protein of 115 kDa, or CLIP‐115). The recent findings that knockout mice lacking LIMK1 or CLIP‐115 have distinct neurological and behavioural phenotypes, indicates that cytoskeletal defects might play a role in the development of neurological symptoms in Williams Syndrome patients. In this review, we discuss the properties of LIMK and CLIP family proteins, their function in the regulation of the actin and microtubule cytoskeletal systems, respectively, and the relationship with neurodevelopmental aspects of Williams Syndrome. BioEssays 26:141–150, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The self-interaction spin-2 approach to GR has been extremely influential in the particle physics community. Leaving no doubt regarding its heuristic value, we argue that any view of the metric field of GR as nothing but a stand-in for a self-coupling field in at spacetime runs into a dilemma: either the view is physically incomplete in so far as it requires recourse to GR after all, or it leads to an absurd multiplication of alternative viewpoints on GR rendering any understanding (...) of the metric field as nothing but a spin-2 field in at spacetime unjustified. (shrink)

This book examines the hypothesis of "direct compositionality", which requires that semantic interpretation proceed in tandem with syntactic combination. Although associated with the dominant view in formal semantics of the 1970s and 1980s, the feasibility of direct compositionality remained unsettled, and more recently the discussion as to whether or not this view can be maintained has receded. The syntax-semantics interaction is now often seen as a process in which the syntax builds representations which, at the abstract level of logical form, (...) are sent for interpretation to the semantics component of the language faculty. In the first extended discussion of the hypothesis of direct compositionality for twenty years, this book considers whether its abandonment might have been premature and whether in fact direct compositionality is not after all a simpler and more effective conception of the grammar than the conventional account of the syntax-semantics interface in generative grammar. It contains contributions from both sides of the debate, locates the debate in the setting of a variety of formal theories, and draws on examples from a range of languages and a range of empirical phenomena. (shrink)

Next SectionIn this remark, I first show that a Lewis–Kratzer–von Fintel style semantics of conditionals and modals (Lewis 1973; Kratzer 1991a, b; von Fintel 1994; a.o.) together with the downward-entailing-based (DE-based) approach to the licensing of negative polarity items (NPIs) incorrectly predicts that NPIs are ungrammatical in the if-clause of a conditional with a possibility modal in the main clause (i.e., a conditional of the form if p, ◊q; henceforth, CPM; e.g., If John has ever been to Paris, he might (...) become a good chef). I then list three possible solutions to this problem to be explored in future work. (shrink)

The Neo-Moorean Deduction (I have a hand, so I am not a brain-in-a-vat) and the Zebra Deduction (the creature is a zebra, so isn’t a cleverly disguised mule) are notorious. Crispin Wright, Martin Davies, Fred Dretske, and Brian McLaughlin, among others, argue that these deductions are instances of transmission failure. That is, they argue that these deductions cannot transmit justification to their conclusions. I contend, however, that the notoriety of these deductions is undeserved. My strategy is to clarify, attack, defend, (...) and apply. I clarify what transmission and transmission failure really are, thereby exposing two questionable but quotidian assumptions. I attack existing views of transmission failure, especially those of Crispin Wright. I defend a permissive view of transmission failure, one which holds that deductions of a certain kind fail to transmit only because of premise circularity. Finally, I apply this account to the Neo-Moorean and Zebra Deductions and show that, given my permissive view, these deductions transmit in an intuitively acceptable way—at least if either a certain type of circularity is benign or a certain view of perceptual justification is false. (shrink)

It is well established that single crystals of B2-structured Fe-Al change from paramagnetic to ferromagnetic upon plastic deformation. This strain-induced ferromagnetism arises mostly from Fe atoms which have three or more like nearest neighbours in antiphase-boundary tubes. Such Fe atoms carry magnetic moments according to their local environment. In this study, the saturation magnetizations, M S , of cold-rolled Fe-34 at.% Al, Fe-40 at.% Al and Fe-43 at.% Al single crystals were measured in a vibrating-sample magnetometer from 77 K to (...) room temperature and transmission electron microscopy was used to confirm the presence of APB tubes. After magnetic measurements, rolled single crystals were heated in a differential scanning calorimeter at 20 K min m 1 to 973 K and the enthalpy associated with the removal of the APB tubes measured. From the enthalpy measurement, the APB tube density and the number of Fe NNs were estimated. Hence, the M S values at 0 K were calculated. These were in good agreement with the experimentally determined values. (shrink)

Looking out the window, I see that it's raining outside. Do I know that it’s raining outside? According to proponents of the Entailment Thesis, I do. If I see that p, I know that p. In general, the Entailment Thesis is the thesis that if S perceives that p, S knows that p. But recently, some philosophers (McDowell 2002, Turri 2010, Pritchard 2011, 2012) have argued that the Entailment Thesis is false. On their view, we can see p and not (...) know that p. In this paper, I argue that their arguments are unsuccessful. (shrink)

Seminal work in moral neuroscience by Joshua Greene and colleagues employed variants of the well-known trolley problems to identify two brain networks which compete with each other to determine moral judgments. Greene interprets the tension between these brain networks using a dual process account which pits deliberative reason against automatic emotion-driven intuitions: reason versus passion. Recent neuroscientific evidence suggests, however, that the critical tension that Greene identifies as playing a role in moral judgment is not so much a tension between (...) reason and passion, but a tension between distinct forms of deliberative reasoning: analytic versus empathetic. In this paper we present results from several new studies supporting this alternative hypothesis. (shrink)

What should we do when faced with powerful theoretical arguments that support a severe change in our personal beliefs and commitments? For example, what should new parents do when confronted by unanswered anti-natalist arguments, or two lovers vexed by social theory that apparently undermines love? On the one hand, it would be irrational to ignore theory just because it’s theory; good theory is evidence, after all. On the other hand, factoring in theory can be objectifying, or risks unraveling one's life, (...) fracturing one's identity or social relations. Sometimes, then, following the evidence where it apparently leads would mean not merely changing what we think but who we are. Some might say that there’s something right about the thought that theory can bear on what we ought to believe, it’s just that when we work with full beliefs, only then do we seriously risk having to substantially alter our doxastic economy when pressed by exceptional theoretical arguments. When we work with partial beliefs, however, this risk is greatly diminished. Others will say that we can advocate or champion revisionary positions whilst rationally retaining our pre-theoretical personal convictions. Still others will argue that we should adopt a Moorean posture towards the revisionary arguments. I argue that each response is inadequate, and argue instead that we are permitted to bracket certain kinds of theoretical evidence against our beliefs because of the personal and ethical risks born out of giving them serious consideration. In turn, some of philosophy's doxastic influence is constrained by its attendant ethical risks: the personal enjoys a partial insulation from the theoretical. I close by addressing what this means for practicing philosophers. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

Patient safety has only recently been subjected to wide-spread systematic study. Healthcare differs from other high risk industries in being more diverse and multi-contextual, and less certain and regulated. Also many patient safety problems are low-frequency events associated with many, varied contributing factors. The subject of this paper is the epistemology of patient safety (the science of the method of finding out about patient safety). Patient safety research is considered here on the background of a risk management framework which requires (...) researchers to: • Understand the context - as a subset of healthcare quality, services and systems research, with technical and human behavioural (cultural) components and a range of external and internal organisational influences, a wide range of research disciplines is necessary • Identify the risks - identify the things that go wrong and the frequency and nature of different types of incidents from sources such as medical record review, observational studies, audit, incident and medico-legal reports • Analyse the risks - deconstruct the things that go wrong, identifying contributing factors and trying to detect trends and patterns in contributing factors, detection, mitigation factors, ameliorating factors and actions taken to reduce risk • Evaluate the risks - decide on priorities, identifying preventive and corrective strategies and judging the risk- and cost-benefit of potential corrective strategies such as standardisation or simplification of a process or device • Manage the risk - evaluate and scope preventive and/or corrective strategies and then implement these, or place the problem on a risk register pending solution, or accept that what is needed is unaffordable • Communicate and consult - use interactive sessions, audit, on-going feedback, reminders and patient mediated prompts • Monitor and review the state of the problem - get baseline trends and patterns so that changes can be tracked and properly attributed to an intervention A hierarchy of levels of evidence has been proposed for clinical research and we argue that insufficient weighting has been given to lower ranked levels of research and to qualitative research, although critical interpretive synthesis is now gaining acceptance in mainstream thinking (e.g. by the Cochrane Collaboration). Fundamental challenges remain including how to grasp the elusive concept of patient safety, how to quantify, characterise and cost the problems, how to judge the extent to which harm can be attributed to errors, violations or system failures, how to identify contributing factors and the extent to which they can be implicated, how to judge whether incidents or their precursors are preventable, how to generate strong evidence to make healthcare safer and how to translate research into practice. Future directions include addressing the mundane as well as rare, dramatic events, and developing further research in non-hospital settings and in developing countries. In summary, a mixture of qualitative and quantitative methods, using information from all available data sources and combining retrospective, real time and prospective study designs, is necessary to address some of the more difficult patient safety problems. (shrink)

The desire to minimize the number of individual new entities postulated is often referred to as quantitative parsimony. Its influence on the default hypotheses formulated by scientists seems undeniable. I argue that there is a wide class of cases for which the preference for quantitatively parsimonious hypotheses is demonstrably rational. The justification, in a nutshell, is that such hypotheses have greater explanatory power than less parsimonious alternatives. My analysis is restricted to a class of cases I shall refer to as (...) additive. Such cases involve the postulation of a collection of qualitatively identical individual objects which collectively explain some particular observed phenomenon. Especially clear examples of this sort occur in particle physics. 1 Introduction 2 Particle physics: a case study 3 Three kinds of simplicity 4 Explanatory power 5 Explanation and non-observation 6 Parsimony and scientific methodology 7 Conclusions. (shrink)

Is radical skepticism ethically problematic? This paper argues that it is. Radical skepticism’s strong regulation of our doxastic economy results in us having to forego doxastic commitments that we owe to others. Whatever skepticism’s epistemic defects, it is ethically defective. In turn, I defend Moralism, the view that the kind of extreme doubt characteristic of radical skepticism is a serious moral and eudaimonic weakness of radical skeptical epistemology. Whether this means that skepticism is false or incorrect, however, is a further (...) claim that Moralists may or may not accept. I distinguish between an encroachment and abrogation version of the view, and show how each one bears on radical skepticism. In either case, Moralism makes our beliefs less vulnerable to radical revision. The paper concludes with some exploratory reflections on whether the argument can be extended to show that radical skepticism is politically problematic, even risking injustice. (shrink)

"This book is a comprehensive attack on several of the views that have been most influential in the philosophy of psychology during the last two decades. Professor Baker argues that mentalistic notions should not be eliminated, and need not be explained in terms of other notions, in cognitive science.' The book is interesting and shows an honest concern for clear argumentation. It deserves a wide readership." --Tyler Burge, University of California at Los Angeles"This book is a provocative and relentlessly argued (...) treatment of a deep and important topic: the fate of intentionality. Baker's arguments oblige those who wish to defend the current conception of cognitive science to rethink the discipline. She has put the ball squarely in the physicalists' court. ... Despite the technical character of the topic, the book is wonderfully readable."--John Heil, Visiting Fellow, University of California, BerkeleyThis stimulating book critically examines a wide range of physicalistic conceptions of mind in the works of Jerry A. Fodor, Stephen P. Stich, Paul M. Churchland, Daniel C. Dennett, and others. Part I argues that intentional concepts cannot be reduced to nonintentional (and nonsemantic) concepts; Part II argues that intentional concepts are nevertheless indispensable to our cognitive enterprises and thus need no foundation in physicalism.As a sustained challenge to the prevailing interpretation of cognitive science, this timely book fills a large gap in the philosophical literature. It is sure to spark controversy, yet its clarity makes it attractive as a text in upper-level undergraduate and graduate courses in philosophy of mind and cognitive science. Saving Belief should be read byphilosophers, psychologists, and others interested in the philosophy of language, philosophy of mind, and cognitive science. (shrink)

Bioethics and human rights were conceived in the aftermath of the Holocaust, when moral outrage reenergized the outmoded concepts of and renaming them and to give them new purpose. Originally, the principles of bioethics were a means for protecting human rights, but through a historical accident, bioethical principles came to be considered as fundamental. In this paper I reflect on the parallel development and accidental divorce of bioethics and human rights to urge their reconciliation.

My aim is twofold: first, to root out the metaphysical assumptions that generate the problem of mental causation and to show that they preclude its solution; second, to dissolve the problem of mental causation by motivating rejection of one of the metaphysical assumptions that give rise to it. There are three features of this metaphysical background picture that are important for our purposes. The first concerns the nature of reality: all reality depends on physical reality, where physical reality consists of (...) a network of events.1 The second concerns the nature of causation, and the third concerns the conception of behavior. I try to vindicate a robust idea of mental causation. (shrink)

This article argues for a revised best system account of laws of nature. David Lewis’s original BSA has two main elements. On the one hand, there is the Humean base, which is the totality of particular matters of fact that obtain in the history of the universe. On the other hand, there is what I call the ‘nomic formula’, which is a particular operation that gets applied to the Humean base in order to output the laws of nature. My revised (...) account focuses on this latter element of the view. Lewis conceives of the nomic formula as a balance of simplicity and strength, but I argue that this is a mistake. Instead, I motivate and develop a different proposal for the standards that figure into the nomic formula, and I suggest a rationale for why these should be the correct standards. Specifically, I argue that the nomic formula should be conceived as a collection of desiderata designed to generate principles that are predictively useful to creatures like us. The resulting view—which I call the ‘best predictive system’ account of laws—is thus able to explain why scientists are interested in discovering the laws, and it also gives rise to laws with the sorts of features that we find in actual scientific practice 1Introduction2The LOPP3A Problem with Lewis's Formula4A Pragmatic Account of the Nomic Formula 4.1Informative dynamics4.2Wide applicability4.3Spatial locality4.4Temporal locality4.5Spatial, temporal, and rotational symmetries4.6Predictively useful properties4.7Simplicity4.8Recap5 Conclusion. (shrink)

Deliberation often begins with the question ‘What do I want to do?’ rather than the question of what one ought to do. This paper takes that question at face value, as a question about which of one’s desires is strongest, which sometimes guides action. The paper aims to explain which properties of a desire make that desire strong, in the sense of ‘strength’ relevant to this deliberative question. Both motivational force and phenomenological intensity seem relevant to a desire’s strength; however, (...) accounting for the strength of a desire in these terms opens up significant indeterminacy about what we want. The paper argues that this indeterminacy is often resolved simply by posing the question ‘What do I want to do?’ to oneself: there is reason to believe that one’s answer will play a verdictive role, partially determining what the agent most wants. Self-reflective beliefs can play a self-fulfilling role, and surprisingly this seems to follow from basic platitudes about the belief-desire model. (shrink)

What is the nature of deep disagreement? In this paper, I consider two similar albeit seemingly rival answers to this question: the Wittgensteinian theory, according to which deep disagreements are disagreements over hinge propositions, and the fundamental epistemic principle theory, according to which deep disagreements are disagreements over fundamental epistemic principles. I assess these theories against a set of desiderata for a satisfactory theory of deep disagreement, and argue that while the fundamental epistemic principle theory does better than the Wittgensteinian (...) theory on this score, the fundamental epistemic principle theory nevertheless struggles to explain the variety of deep disagreement. (shrink)

Users of psychedelic drugs often report that their sense of being a self or ‘I’ distinct from the rest of the world has diminished or altogether dissolved. Neuroscientific study of such ‘ego dissolution’ experiences offers a window onto the nature of self-awareness. We argue that ego dissolution is best explained by an account that explains self-awareness as resulting from the integrated functioning of hierarchical predictive models which posit the existence of a stable and unchanging entity to which representations are bound. (...) Combining recent work on the ‘integrative self' and the phenomenon of self-binding with predictive processing principles yields an explanation of ego dissolution according to which self-representation is a useful Cartesian fiction: an ultimately false representation of a simple and enduring substance to which attributes are bound which serves to integrate and unify cognitive processing across levels and domains. The self-model is not a mere narrative posit, as some have suggested; it has a more robust and ubiquitous cognitive function than that. But this does not mean, as others have claimed, that the self-model has the right attributes to qualify as a self. It performs some of the right kinds of functions, but it is not the right kind of entity. Ego dissolution experiences reveal that the self-model plays an important binding function in cognitive processing, but the self does not exist. (shrink)

Various questions arise in semantic analysis concerning the nature of types. These questions include whether we need types in a semantic theory, and if so, whether some version of simple type theory (STT, Church 1940) is adequate or whether a richer more flexible theory is required to capture our semantic intuitions. Propositions and propositional attitudes can be represented in an essentially untyped first-order language, provided a sufficiently rich language of terms is adopted. In the absence of rigid typing, care needs (...) to be taken to avoid the paradoxes, for example by constraining what kinds of expressions are to be interpreted as propositions (Turner 1992). But the notion of type is ontologically appealing. In some respects, STT seems overly restrictive for natural language semantics. For this reason it is appropriate to consider a system of types that is more flexible than STT, such as a Curry-style typing (Curry & Feys 1958). Care then has to be taken to avoid the logical paradoxes. Here we show how such an account, based on the Property Theory with Curry Types (PTCT, Fox & Lappin 2005), can be formalised within Typed Predicate Logic (TPL, Turner 2009). This presentation provides a clear distinction between the classes of types that are being used to (i) avoid paradoxes (ii) allow predicative polymorphic types. TPL itself provides a means of expressing PTCT in a uniform language. (shrink)

Some understand Stein’s “Yes, but…” as an entry in the realism—instrumentalism debate (RID) itself, albeit one dissatisfied with then-extant positions. In this paper, however, I argue the opposite: Stein’s conception of science and his approach to its history and philosophy actually preclude the RID. First, I characterize Stein as persistently attending to his own historical and philosophical methods. I then describe his conception of science as both a dialectic and an enterprise, and I draw from this conception several conclusions about (...) the relations between science and its history and philosophy. Finally, I provide a reading of “Yes, but…” that follows from Stein’s conception of science. On this reading, the RID is either irrelevant to or wrong of science and, moreover, distracts from a legitimate inquiry. I conclude by interpreting Stein’s remark that there is ``no difference that makes a difference’’ between a cogent and enlightened realism and a sophisticated instrumentalism. (shrink)

This paper explores the application of hinge epistemology to deep disagreement. Hinge epistemology holds that there is a class of commitments—hinge commitments—which play a fundamental role in the structure of belief and rational evaluation: they are the most basic general ‘presuppositions’ of our world views which make it possible for us to evaluate certain beliefs or doubts as rational. Deep disagreements seem to crucially involve disagreements over such fundamental commitments. In this paper, I consider pessimism about deep disagreement, the thesis (...) that such disagreements are rationally irresolvable, and ask whether the Wittgensteinian account of deep disagreement—according to which such disagreements are disagreements over hinge commitments—provides adequate support for pessimism. I argue that the answer to this question depends on what hinge commitments are and what our epistemic relation to them is supposed to be. I argue for two core claims. First, that non-epistemic theories of hinge commitments provide adequate support for pessimism. Nevertheless, such theories have highly implausible consequences in the context of deep disagreement. Secondly, at least one epistemic theory of hinge commitments, the entitlement theory, permits optimism about such disagreements. As such, while hinge epistemology is mainly pessimistic about deep disagreement, it doesn’t have to be. (shrink)

This paper explores the application of hinge epistemology to deep disagreement. Hinge epistemology holds that there is a class of commitments—hinge commitments—which play a fundamental role in the structure of belief and rational evaluation: they are the most basic general ‘presuppositions’ of our world views which make it possible for us to evaluate certain beliefs or doubts as rational. Deep disagreements seem to crucially involve disagreements over such fundamental commitments. In this paper, I consider pessimism about deep disagreement, the thesis (...) that such disagreements are rationally irresolvable, and ask whether the Wittgensteinian account of deep disagreement—according to which such disagreements are disagreements over hinge commitments—provides adequate support for pessimism. I argue that the answer to this question depends on what hinge commitments are and what our epistemic relation to them is supposed to be. I argue for two core claims. First, that non-epistemic theories of hinge commitments provide adequate support for pessimism. Nevertheless, such theories have highly implausible consequences in the context of deep disagreement. Secondly, at least one epistemic theory of hinge commitments, the entitlement theory, permits optimism about such disagreements. As such, while hinge epistemology is mainly pessimistic about deep disagreement, it doesn’t have to be. (shrink)

One of the main challenges confronting Humean accounts of natural law is that Humean laws appear to be unable to play the explanatory role of laws in scientific practice. The worry is roughly that if the laws are just regularities in the particular matters of fact (as the Humean would have it), then they cannot also explain the particular matters of fact, on pain of circularity. Loewer (2012) has defended Humeanism, arguing that this worry only arises if we fail to (...) distinguish between scientific and metaphysical explanations. However, Lange (2013, 2018) has argued that scientific and metaphysical explanations are linked by a transitivity principle, which would undercut Loewer's defense and re-ignite the circularity worry for the Humean. I argue here that the Humean has antecedent reasons to doubt that there are any systematic connections between scientific and metaphysical explanations. The reason is that the Humean should think that scientific and metaphysical explanation have disparate aims, and therefore that neither form of explanation is beholden to the other in its pronouncements about what explains what. Consequently, the Humean has every reason to doubt that Lange's transitivity principle obtains. (shrink)

What is the epistemological significance of deep disagreement? Part I explored the nature of deep disagreement, while Part II considers its epistemological significance. It focuses on two core problems: the incommensurability and the rational resolvability problems. We critically survey key responses to these challenges, before raising worries for a variety of responses to them, including skeptical, relativist, and absolutist responses to the incommensurability problem, and to certain steadfast and conciliatory responses to the rational resolvability problem. We then pivot to the (...) ethical and political dimensions of deep disagreement. We focus on whether an unwillingness to engage with positions one considers to be immoral or repugnant might be good, and conclude with some reflections on the moral risks of engagement. (shrink)

Conflicting accounts of the role of mathematics in our physical theories can be traced to two principles. Mathematics appears to be both (1) theoretically indispensable, as we have no acceptable non-mathematical versions of our theories, and (2) metaphysically dispensable, as mathematical entities, if they existed, would lack a relevant causal role in the physical world. I offer a new account of a role for mathematics in the physical sciences that emphasizes the epistemic benefits of having mathematics around when we do (...) science. This account successfully reconciles theoretical indispensability and metaphysical dispensability and has important consequences for both advocates and critics of indispensability arguments for platonism about mathematics. (shrink)

The moral enhancement of humans by biological or genetic means has recently been urged as a response to the pressing concerns facing human civilization. In this paper, I argue that proponents of biological moral enhancement have misrepresented the facts of human moral psychology. As a result, the likely effectiveness of traditional methods of moral enhancement has been underestimated, relative to biological or genetic means. I review arguments in favor of biological moral enhancement and argue that the complexity of moral psychology (...) raises serious problems for such interventions. I offer a programmatic sketch of the ways in which our improved understanding of moral psychology can help facilitate more traditional methods of moral enhancement. I conclude that the best response to the dangers faced by human civilization is the continued use of traditional methods of moral enhancement and the use of our improved understanding of moral psychology to further refine and develop these methods. (shrink)

Anabaptists have long been thought to have been ‘biblicists’ and shunned reading patristic literature. But a close analysis of the debates Anabaptists had with Magisterial Reformers shows that the Anabaptists developed an extensive history of baptism using church fathers. They attempted to show that adult baptism was the norm in the earliest centuries of the church and that infant baptism was the innovation away from the Bible. This debate was about who had inherited the biblical faith around baptism.

relation between, say, a lump of clay and a statue that it makes up, or between a red and white piece of metal and a stop sign, or between a person and her body? Assuming that there is a single relation between members of each of these pairs, is the relation “strict” identity, “contingent” identity or something else?1 Although this question has generated substantial controversy recently,2 I believe that there is philo- sophical gain to be had from thinking through the (...) issues from scratch. Many of the charges and countercharges are based on the following dichotomy: For any x and y that are related as the lump of clay is to the statue that it makes up, either x is identical to y, or x and y are separate entities, independent of each other. By giving up this dichotomy, we will be able to begin to make sense, I hope, of an intermediate unity relation that holds promise for solving a raft of philosophical problems, including the problem of how persons are related to their bodies.3 And if I am correct, then this relation—constitution without identity—is ubiquitous and interesting in its own right, apart from the light that it sheds on human persons. (shrink)

The desire-satisfaction theory of well-being says, in its simplest form, that a person’s level of welfare is determined by the extent to which their desires are satisfied. A question faced by anyone attracted to such a view is, *Which desires*? This paper proposes a new answer to this question by characterizing a distinction among desires that isn’t much discussed in the well-being literature. This is the distinction between what a person wants in a merely behavioral sense, in that the person (...) is, for some reason or other, disposed to act so as to try to get it, and what a person wants in a more robust sense, the sense of being *genuinely attracted* to the thing. I try to make this distinction more clear, and I argue for its axiological relevance by putting it to work in solving four problem cases for desire satisfactionism. The theory defended holds that only desires in the latter, genuine-attraction sense are relevant to welfare. (shrink)