The paper proposes a minimal definition of dreaming in terms of immersive spatiotemporal hallucination (ISTH) occurring in sleep or during sleep–wake transitions and under the assumption of reportability. I take these conditions to be both necessary and sufficient for dreaming to arise. While empirical research results may, in the future, allow for an extension of the concept of dreaming beyond sleep and possibly even independently of reportability, ISTH is part of any possible extension of this definition and thus is (...) a constitutive condition of dreaming. I also argue that the proposed ISTH model of dreaming, in conjunction with considerations on the epistemic relationship between dreaming and dream reports, raises important questions about the extent to which dreams typically involve a detailed body representation—an assumption that plays an important role in philosophical work on dreaming. As a commonly accepted definition of dreaming is lacking in current dream research, the ISTH model, which integrates conceptual analysis and epistemological considerations with results from empirical research, is an important contribution to this field. By linking dreaming to felt presence, full-body illusions, and autoscopic phenomena such as out-of-body experiences in wakefulness and in the hypnagogic state, the ISTH model of dreaming also helps integrate dream research, both theoretically and experimentally, with the study of other altered states of consciousness involving hallucinations. It makes straightforward and investigable predictions by claiming that all of these experiences have amodal spatiotemporal hallucinations as their common denominator. Finally, it is theoretically relevant for the philosophical discussion on minimal phenomenal selfhood. (shrink)

The integration of event-related potential and functional magnetic resonance imaging helps to obtain and study neural networks with high temporal and spatial resolution. EEG/fMRI data proves that in the visual tristimulus oddball paradigm, two P300 potentials induced by target stimulation and novel stimulation are detected at the frontal-middle, center, and mid-apical electrodes. Previous studies have shown that P3a and P3b have different spatial distributions of brain activation, but it is unclear whether they have the same neural mechanism. The purpose (...) of this study is to determine the neuropsychological mechanisms of P3a and P3b, as well as the spatiotemporal differences in neurodynamics between the two ERP subcomponents. In a group of 25 subjects, P300 ERP induced by target stimulation and novel stimulation can be detected at the Fz, Cz, and Pz electrodes. At Cz and Fz, compared with P3b related to the target stimulus, the P3a related to the novel stimulus has a higher amplitude and the waveform declines more slowly. But at Pz, P3b has a higher amplitude than P3a. P3a appeared earlier than P3b at Cz and Fz, but the opposite phenomenon was observed at the Pz electrode. The activated brain regions of P3a included the left frontal-parietal lobe region, left anterior wedge lobe region, and right insula, while the target-driven P3b was significantly associated with BOLD changes in the bilateral fusiform gyrus, the left frontal region, and the bilateral insula. The results showed that the integration of the spatial and temporal information of the two imaging modes, namely, ERP and fMRI, proves the existence of the different brain function processes of the two P300 subcomponents. Through the analysis of the composition of P300, the results further proved that the top-down and bottom-up processing processes have played a role in the occurrence of attention capture. It is just that the modulation effects of the two processing mechanisms are different in different tasks. Therefore, it should be noted that the captured neural mechanism is not a single top-down or bottom-up processing process but should be the result of the interaction between the two. (shrink)

Naturalistic stimuli, including movie, music, and speech, have been increasingly applied in the research of neuroimaging. Relative to a resting-state or single-task state, naturalistic stimuli can evoke more intense brain activities and have been proved to possess higher test–retest reliability, suggesting greater potential to study adaptive human brain function. In the current research, naturalistic functional magnetic resonance imaging (N-fMRI) has been a powerful tool to record brain states under naturalistic stimuli, and many efforts have been devoted to study the high-level (...) semantic features from spatial or temporal representations via N-fMRI. However, integrating both spatial and temporal characteristics of brain activities for better interpreting the patterns under naturalistic stimuli is still underexplored. In this work, a novel hybrid learning framework that comprehensively investigates both the spatial (via Predictive Model) and the temporal [via convolutional neural network (CNN) model] characteristics of the brain is proposed. Specifically, to focus on certain relevant regions from the whole brain, regions of significance (ROS), which contain common spatial activation characteristics across individuals, are selected via the Predictive Model. Further, voxels of significance (VOS), whose signals contain significant temporal characteristics under naturalistic stimuli, are interpreted via one-dimensional CNN (1D-CNN) model. In this article, our proposed framework is applied onto the N-fMRI data during naturalistic classical/pop/speech audios stimuli. The promising performance is achieved via the Predictive Model to differentiate the different audio categories. Especially for distinguishing the classic and speech audios, the accuracy of classification is up to 92%. Moreover, spatial ROS and VOS are effectively obtained. Besides, temporal characteristics of the high-level semantic features are investigated on the frequency domain via convolution kernels of 1D-CNN model, and we effectively bridge the “semantic gap” between high-level semantic features of N-fMRI and low-level acoustic features of naturalistic audios in the frequency domain. Our results provide novel insights on characterizing spatiotemporal patterns of brain activities via N-fMRI and effectively explore the high-level semantic features under naturalistic stimuli, which will further benefit the understanding of the brain working mechanism and the advance of naturalistic stimuli clinical application. (shrink)

Road link speed is one of the important indicators for traffic states. In order to incorporate the spatiotemporal dynamics and correlation characteristics of road links into speed prediction, this paper proposes a method based on LDA and GCN. First, we construct a trajectory dataset from map-matched GPS location data of taxis. Then, we use the LDA algorithm to extract the semantic function vectors of urban zones and quantify the spatial dynamic characteristics of road links based on taxi trajectories. Finally, (...) we add semantic function vectors to the dataset and train a graph convolutional network to learn the spatial and temporal dependencies of road links. The learned model is used to predict the future speed of road links. The proposed method is compared with six baseline models on the same dataset generated by GPS equipped on taxis in Shenzhen, China, and the results show that our method has better prediction performance when semantic zoning information is added. Both composite and single-valued semantic zoning information can improve the performance of graph convolutional networks by 6.46% and 8.35%, respectively, while the baseline machine learning models work only for single-valued semantic zoning information on the experimental dataset. (shrink)

The cognitive unbinding paradigm suggests that the synthesis of neural information is attenuated by general anesthesia. Here, we analyzed the functional organization of brain activities in the conscious and anesthetized states, based on functional segregation and integration. Electroencephalography recordings were obtained from 14 subjects undergoing induction of general anesthesia with propofol. We quantified changes in mean information integration capacity in each band of the EEG. After induction with propofol, mean information integration capacity was reduced most prominently in (...) the γ band of the EEG . Furthermore, we demonstrate that loss of consciousness is reflected by the breakdown of the spatiotemporal organization of γ waves. We conclude that induction of general anesthesia with propofol reduces the capacity for information integration in the brain. These data directly support the information integration theory of consciousness and the cognitive unbinding paradigm of general anesthesia. (shrink)

The progress of the molecular biosciences has been so enormous that a discipline studying how cellular functioning emerges out of the behaviors of their molecular constituents has become reality. Systems biology studies cells as spatiotemporal networks of interacting molecules using an integrative approach of theory , experimental biology , and quantitative network-wide analytical measurement . Its aim is to understand how molecules jointly bring about life. Systems biology is rapidly discovering principles governing the functioning of molecular networks and methods (...) to model and measure them. The application of the conceptual strength of systems sciences such as physics and engineering are opening up new ways of experimentally studying the design and functioning of molecular networks. Typically, in such studies models are used to highlight principles, design experiments, or to act in a predictive mode to specifically modify cellular behavior. In this trend article, theoretical approaches being applied in systems biology will be discussed. A number of books have recently appeared that deal with theoretical aspects of systems biology. In this article they are highlighted to facilitate the communication of systems biology to a broader audience. (shrink)

Neural organization: Structure, function, and dynamics shows how theory and experiment can supplement each other in an integrated, evolving account of the brain's structure, function, and dynamics. Structure: Studies of brain function and dynamics build on and contribute to an understanding of many brain regions, the neural circuits that constitute them, and their spatial relations. We emphasize Szentágothai's modular architectonics principle, but also stress the importance of the microcomplexes of cerebellar circuitry and the lamellae of hippocampus. Function: Control of eye (...) movements, reaching and grasping, cognitive maps, and the roles of vision receive a functional decomposition in terms of schemas. Hypotheses as to how each schema is implemented through the interaction of specific brain regions provide the basis for modeling the overall function by neural networks constrained by neural data. Synthetic PET integrates modeling of primate circuitry with data from human brain imaging. Dynamics: Dynamic system theory analyzes spatiotemporal neural phenomena, such as oscillatory and chaotic activity in both single neurons and neural networks, the self-organizing development and plasticity of ordered neural structures, and learning and memory phenomena associated with synaptic modification. Rhythm generation involves multiple levels of analysis, from intrinsic cellular processes to loops involving multiple brain regions. A variety of rhythms are related to memory functions. The Précis presents a multifaceted case study of the hippocampus. We conclude with the claim that language and other cognitive processes can be fruitfully studied within the framework of neural organization that the authors have charted with John Szentágothai. (shrink)

What are the ethics of child genital cutting? In a recent issue of the journal, Duivenbode and Padela (2019) called for a renewed discussion of this question. Noting that modern health care systems...

En el presente artículo se busca exponer sintéticamente el meta-modelo de la Psicología integral de la persona. A partir de seis preguntas fundamentales se intenta mostrar sus principales planteamientos: (1) qué es la Psicología clínica, (2) qué es la salud psíquica, (3) qué es el desorden psíquico, (4) en qué consiste el diagnóstico clínico, (5) en qué consiste el proceso de sanar psíquicamente y (6) cuál es el rol del terapeuta.

Although much evidence indicates that young infants perceive unitary objects by analyzing patterns of motion, infantsÕ abilities to perceive object unity by analyzing Gestalt properties and by integrating distinct views of an object over time are in dispute. To address these controversies, four experiments investigated adultsÕ and infantsÕ perception of the unity of a center-occluded, moving rod with misaligned visible edges. Both alignment information and depth information affected adultsÕ and infantsÕ perception of object unity in similar ways, and infants perceived (...) object unity by integrating information about object features over time. However, infants perceived a moving, misaligned, three-dimensional object as indeterminate in its connectedness, whereas adults perceived it as connected behind the occluder. These findings indicate that the effectiveness of common motion in specifying unified surfaces across an occluder is reduced by misalignment of edges. Alignment information enhances perception of object unity either by serving directly as information for unity or by optimizing the detectability of motion-carried information for unity. In addition, young infants are able to retain information about edge orientation over short intervals in determining connectedness via a process of spatiotemporal integration. Ó 2003 Elsevier Science (USA). All rights reserved. (shrink)

This is the editors' Introduction to a special issue of the journal, Multisensory Research. European philosophers of the modern period found multisensory perception to be impossible because they thought that perceptual ideas are defined by how they are experienced. Under this conception, the individual modalities are determinables of ideas—just as colour is a determinable that embraces red and blue, so also the visual is a determinable that embraces colour and (visually experienced) shape. Since no idea is experienced as, for example, (...) both visual and auditory, there can be no such thing as audiovisual perception. This conception of modality is not directly contested, but a variety of perceptual phenomena are listed that could raise interesting questions if treated as multimodal in origin. (shrink)

A unifing theory of spatiotemporal brain dynamics should incorporate multiple spatial and temporal scales. Between the microscopic (local) and macroscopic (global) components proposed by Nunez, mesoscopic (intermediate-range) elements should be integral parts of models. The corresponding mathematical formalism requires tools of nonlinear dynamics and the use of aperiodic (chaotic) attractors. Some relations between local-mesoscopic and mesoscopic-global components are outlined.

Plant and animal species are information-processing entities of such complexity, integration, and adaptive competence that it may be scientifically fruitful to consider them intelligent. The possibility arises from the analogy between learning and evolution, and from recent developments in evolutionary science, psychology and cognitive science. Species are now described as spatiotemporally localized individuals in an expanded hierarchy of biological entities. Intentional and cognitive abilities are now ascribed to animal, human, and artificial intelligence systems that process information adaptively, and that (...) manifest problem-solving abilities. The structural and functional similarities between such systems and species are extensive, although they “are usually obscured by population-genetic metaphors that have nonetheless contributed much to our understanding of evolution.In this target article, I use Sewall Wright's notion of the “adaptive landscape” to compare the performances of evolving species to those of intelligent organisms. With regard to their adaptive achievements and the kinds of processes by which they are achieved, biological species compare very favorably to intelligent animals by virtue of interactions between populations and their environments, between ontogeny and phylogeny, and between natural, interdemic, organic, and species selection. Addressing the question of whether species are intelligent could help to refine our ideas about species, evolution, and intelligence, and could open new lines of empirical and theoretical inquiry in many disciplines. (shrink)

Molyneux's Question (MQ) concerns whether a newly sighted man would recognize/distinguish a sphere and a cube by vision, assuming he could previously do this by touch. We argue that (MQ) splits into questions about (a) shared representations of space in different perceptual systems, and about (b) shared ways of constructing higher dimensional spatiotemporal features from information about lower dimensional ones, most of the technical difficulty centring on (b). So understood, MQ resists any monolithic answer: everything depends on the constraints (...) faced by particular perceptual systems in extracting features of higher dimensionality from those of lower. Each individual question of this type is empirical and must be investigated separately. We present several variations on MQ based on different levels of dimensional integration—some of these are familiar, some novel adaptations of problems known elsewhere, and some completely novel. Organizing these cases in this way is useful because it unifies a set of disparate questions about intermodal transfer that have held philosophical and psychological interest, suggests a new range of questions of the same type, sheds light on similarities and differences between members of the family, and allows us to formulate a much-augmented set of principles and questions concerning the intermodal transfer of spatiotemporal organization. (shrink)

We review some of the main implications of the free-energy principle (FEP) for the study of the self-organization of living systems – and how the FEP can help us to understand (and model) biotic self-organization across the many temporal and spatial scales over which life exists. In order to maintain its integrity as a bounded system, any biological system - from single cells to complex organisms and societies - has to limit the disorder or dispersion (i.e., the long-run entropy) of (...) its constituent states. We review how this can be achieved by living systems that minimize their variational free energy. Variational free energy is an information theoretic construct, originally introduced into theoretical neuroscience and biology to explain perception, action, and learning. It has since been extended to explain the evolution, development, form, and function of entire organisms, providing a principled model of biotic self-organization and autopoiesis. It has provided insights into biological systems across spatiotemporal scales, ranging from microscales (e.g., sub- and multicellular dynamics), to intermediate scales (e.g., groups of interacting animals and culture), through to macroscale phenomena (the evolution of entire species). A crucial corollary of the FEP is that an organism just is (i.e., embodies or entails) an implicit model of its environment. As such, organisms come to embody causal relationships of their ecological niche, which, in turn, is influenced by their resulting behaviors. Crucially, free-energy minimization can be shown to be equivalent to the maximization of Bayesian model evidence. This allows us to cast natural selection in terms of Bayesian model selection, providing a robust theoretical account of how organisms come to match or accommodate the spatiotemporal complexity of their surrounding niche. In line with the theme of this volume; namely, biological complexity and self-organization, this chapter will examine a variational approach to self-organization across multiple dynamical scales. (shrink)

It remains controversial whether touch is a truly spatial sense or not. Many philosophers suggest that, if touch is indeed spatial, it is only through its alliances with exploratory movement, and with proprioception. Here we develop the notion that a minimal yet important form of spatial perception may occur in purely passive touch. We do this by showing that the array of tactile receptive fields in the skin, and appropriately relayed to the cortex, may contain the same basic informational building (...) blocks that a creature navigating around its environment uses to build up a perception of space. We illustrate this point with preliminary evidence that perception of spatiotemporal patterns on the human skin shows some of the same features as spatial navigation in animals. We argue (a) that the receptor array defines a ‘tactile field’, (b) that this field exists in a minimal form in ‘skin space’, logically prior to any transformation into bodily or external spatial coordinates, and (c) that this field supports tactile perception without integration of concurrent proprioceptive or motor information. The basic cognitive elements of space perception may begin at lower levels of neural and perceptual organisation than previously thought. (shrink)

This article summarizes a variety of current as well as previous research in support of a new theory of consciousness. Evidence has been steadily accumulating that information about a stimulus complex is distributed to many neuronal populations dispersed throughout the brain and is represented by the departure from randomness of the temporal pattern of neural discharges within these large ensembles. Zero phase lag synchronization occurs between discharges of neurons in different brain regions and is enhanced by presentation of stimuli. This (...) evidence further suggests that spatiotemporal patterns of coherence, which have been identified by spatial principal component analysis, may encode a multidimensional representation of a present or past event. How such distributed information is integrated into a holistic percept constitutes the binding problem. How a percept defined by a spatial distribution of nonrandomness can be subjectively experienced constitutes the problem of consciousness. Explanations based on a discrete connectionistic network cannot be reconciled with the relevant facts. Evidence is presented herein of invariant features of brain electrical activity found to change reversibly with loss and return of consciousness in a study of 176 patients anesthetized during surgical procedures. A review of relevant research areas, as well as the anesthesia data, leads to a postulation that consciousness is a property of quantumlike processes, within a brain field resonating within a core of structures, which may be the neural substrate of consciousness. This core includes regions of the prefrontal cortex, the frontal cortex, the pre- and paracentral cortex, thalamus, limbic system, and basal ganglia. (shrink)

We investigated whether the inferior parietal lobule (IPL) responds in real-time to multisensory inconsistency during movement. The IPL is thought to be involved in both the detection of inconsistencies in multisensory information obtained during movement and that obtained during self-other discrimination. However, because of the limited temporal resolution of conventional neuroimaging techniques, it is difficult to distinguish IPL activity during movement from that during self-other discrimination. We simultaneously conducted electroencephalography (EEG) and near-infrared spectroscopy (NIRS) with the goal of examining IPL (...) activity with a high spatiotemporal resolution during single reaching movements. Under a visual feedback-delay condition, gamma event-related synchronization (γ-ERS), i.e., an increase in gamma (31–47 Hz) EEG power, occurred during reaching movements. This γ-ERS is considered to reflect processing of information about prediction errors. To integrate this temporal information with spatial information from the NIRS signals, we developed a new analysis technique that enabled estimation of the regions that show a hemodynamic response characterized by EEG fluctuation present in the visual feedback-delay condition. As a result, IPL activity was explained by γ-ERS specific to visual feedback delay during movements. Thus, we succeeded in demonstrating real-time activation of the IPL in response to multisensory inconsistency. However, we did not find any correlation between either IPL activity or γ-ERS with the sense of agency. Therefore, our results suggest that while the IPL is influenced by prediction error signals, it does not engage in direct processing underlying the conscious experience of making a movement, which is the foundation of self-other discrimination. (shrink)

The German tradition of considering species, and higher taxonomic entities, as individuals begins with the temporalization of natural history, thus pre-dating Darwin’s ‘Origin’ of 1859. In the tradition of German Naturphilosophie as developed by Friedrich Schelling, species came to be seen as parts of a complex whole that encompasses all (living) nature. Species were comprehended as dynamic entities that earn individuality by virtue of their irreversible passage through time. Species individuality was conceived in terms of species taxa forming a spatiotemporally (...) located relational system (complex whole), a conception of species that was easily assimilated to an evolutionary world view. However, the dynamics of an evolutionary process driven by variation and natural selection created a tension between continuity in nature as opposed to the discreteness and relative stasis of species. As a consequence, some authors such as Ernst Haeckel and Karl August Möbius denied the reality of species, while others explicitly linked the reality and individuality of species to their temporal duration. The mature conception of species as individuals, as formulated by Ludwig von Bertalanffy and adopted by Willi Hennig, is one of an historically conditioned, spatiotemporally located, causally integrated, dynamic yet transiently homeostatically stabilized relational system. (shrink)

Plant and animal species are information-processing entities of such complexity, integration, and adaptive competence that it may be scientifically fruitful to consider them intelligent. The possibility arises from the analogy between learning and evolution, and from recent developments in evolutionary science, psychology and cognitive science. Species are now described as spatiotemporally localized individuals in an expanded hierarchy of biological entities. Intentional and cognitive abilities are now ascribed to animal, human, and artificial intelligence systems that process information adaptively, and that (...) manifest problem-solving abilities. The structural and functional similarities between such systems and species are extensive, although they “are usually obscured by population-genetic metaphors that have nonetheless contributed much to our understanding of evolution.In this target article, I use Sewall Wright's notion of the “adaptive landscape” to compare the performances of evolving species to those of intelligent organisms. With regard to their adaptive achievements and the kinds of processes by which they are achieved, biological species compare very favorably to intelligent animals by virtue of interactions between populations and their environments, between ontogeny and phylogeny, and between natural, interdemic, organic, and species selection. Addressing the question of whether species are intelligent could help to refine our ideas about species, evolution, and intelligence, and could open new lines of empirical and theoretical inquiry in many disciplines. (shrink)

The information contained within the linear sequence of bases (the genome) must be faithfully replicated in each cell cycle, with a balance of constancy and variation taking place over the course of evolution. Recently, it has become clear that additional information important for genetic regulation is contained within the chromatin proteins associated with DNA (the epigenome). Epigenetic information also must be faithfully duplicated in each cell cycle, with a balance of constancy and variation taking place during the course of development (...) to achieve differentiation while maintaining identity within cell lineages. Both the genome and the epigenome are synthesized at the replication fork, so the events occurring during S‐phase provide a critical window of opportunity for eliciting change or maintaining existing genetic states. Cells discriminate between different states of chromatin through the activities of proteins that selectively modify the structure of chromatin. Several recent studies report the localization of certain chromatin modifying proteins to replication forks at specific times during S‐phase. Since transcriptionally active and inactive chromosome domains generally replicate at different times during S‐phase, this spatiotemporal regulation of chromatin assembly proteins may be an integral part of epigenetic inheritance. BioEssays 25:647–656, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The article focuses on Enoch Powell’s “Rivers of Blood” speech and its recontextualisation 50 years later in view of the rising anti-immigration sentiment and Brexit campaign. Having discussed the dynamics of the threat construction process and its role in shaping public attitudes to migration and policies related to it across time and space, we proceed to analyse Powell’s speech in terms of lexical, grammatical, and discursive fear-inciting devices and strategies. While doing so we draw on the insights from neuroscientific research (...) on the role of lexis in fear stimulation and functional-cognitive models of grammatical structure. The second part of our analysis is meant to demonstrate how the semiotic potential of cyberspace and social media, along with multimodal integration of various forms, intertextuality, and interdiscursivity they enable, endow fear-inciting discourse with new spatiotemporal and affective qualities. To this end we examine one of the most popular YouTube videos making “Rivers of Blood” speech part of its anti-immigration stance. (shrink)

Research is starting to identify correlations between consciousness and some of the spatiotemporal patterns in the physical brain. For theoretical and practical reasons, the results of experiments on the correlates of consciousness have ambiguous interpretations. At any point in time a number of hypotheses co-exist about and the correlates of consciousness in the brain, which are all compatible with the current experimental results. This paper argues that consciousness should be attributed to any system that exhibits spatiotemporal physical patterns (...) that match the hypotheses about the correlates of consciousness that are compatible with the current experimental results. Some computers running some programs should be attributed consciousness because they produce spatiotemporal patterns in the physical world that match those that are potentially linked with consciousness in the human brain. (shrink)

An increasing number of users have been attracted by location-based social networks in recent years. Meanwhile, user-generated content in online LBSNs like spatial, temporal, and social information provides an ever-increasing chance to study the human behavior movement from their spatiotemporal mobility patterns and spawns a large number of location-based applications. For instance, one of such applications is to produce personalized point of interest recommendations that users are interested in. Different from traditional recommendation methods, the recommendations in LBSNs come with (...) two vital dimensions, namely, geographical and temporal. However, previously proposed methods do not adequately explore geographical influence and temporal influence. Therefore, fusing geographical and temporal influences for better recommendation accuracy in LBSNs remains potential. In this work, our aim is to generate a top recommendation list of POIs for a target user. Specially, we explore how to produce the POI recommendation by leveraging spatiotemporal information. In order to exploit both geographical and temporal influences, we first design a probabilistic method to initially detect users’ spatial orientation by analyzing visibility weights of POIs which are visited by them. Second, we perform collaborative filtering by detecting users’ temporal preferences. At last, for making the POI recommendation, we combine the aforementioned two approaches, that is, integrating the spatial and temporal influences, to construct a unified framework. Our experimental results on two real-world datasets indicate that our proposed method outperforms the current state-of-the-art POI recommendation approaches. (shrink)

The aim of this paper is to give a sharp definition of Bell's notion of local causality. To this end, first we unfold a framework, called local physical theory, integrating probabilistic and spatiotemporal concepts. Formulating local causality within this framework and classifying local physical theories by whether they obey local primitive causality---a property rendering the dynamics of the theory causal, we then investigate what is needed for a local physical theory, with or without local primitive causality, to be locally (...) causal. Finally, comparing Bell's local causality with the Common Cause Principles and relating both to the Bell inequalities we find a nice parallelism: Bell inequalities cannot be derived neither from local causality nor from a common cause unless the local physical theory is classical or the common cause is commuting, respectively. (shrink)

Phosphatidylinositol 5‐phosphate (PtdIns5P), the least characterized among the three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in the control of several cellular functions. Similar to PtdIns3P, it is present in low amounts in mammalian cells, and can be detected at the plasma membrane and endomembranes as well as in the nucleus. Changes in PtdIns5P levels are observed in mammalian cells following specific stimuli or stresses, and in human diseases. Recently, the contribution of several enzymes such as PIKfyve, myotubularins, (...) and type II PtdInsP‐kinases to PtdIns5P metabolism has gained a strong experimental support. Here, we provide a picture emerging from recent studies showing how this lipid can be generated and act as a regulator of membrane and cytoskeleton dynamics, and as a modulator of gene expression. We briefly summarize the current methods and tools for studying PtdIns5P, and discuss how PtdIns5P can integrate and coordinate different functions in a spatiotemporal manner. (shrink)

This paper is the philosopher-friendly version of our more technical work. It aims to give a clear-cut definition of Bell's notion of local causality. Having provided a framework, called local physical theory, which integrates probabilistic and spatiotemporal concepts, we formulate the notion of local causality and relate it to other locality and causality concepts. Then we compare Bell's local causality with Reichenbach's Common Cause Principle and relate both to the Bell inequalities. We find a nice parallelism: both local causality (...) and the Common Cause Principle are more general notions than captured by the Bell inequalities. Namely, Bell inequalities cannot be derived neither from local causality nor from a common cause unless the local physical theory is classical or the common cause is commuting, respectively. (shrink)

I present an exemplary Humean modal epistemology. My version takes inspiration from but incurs no commitment to both Hume’s historical position and Lewis’s Humeanism. Modal epistemology should meet two challenges: the Integration challenge of integrating metaphysics and epistemology and the Reliability challenge of giving an account of how our epistemic capacities can be reliable in detecting modal truth. According to Lewis, modal reasoning starts from certain Humean principles: there is only the vast mosaic of spatiotemporally distributed local matters of (...) fact. The facts can be arbitarily recombined. These principles cannot be taken for granted. I suggest a bottom-up approach instead: Humean principles of recombining the mosaic of facts can be retrieved from the evolutionarily instilled and empirically informed use of imagination in exploring everyday circumstantial possibilities. This use of imagination conforms to a primitive conception of matter as freely recombinable. The modal beliefs that can be obtained from generalizing the more elementary exercise of imagination have to be corrected. Recombination is limited by sortal criteria of identity. Moreover, the overall picture of a recombinable spatiotemporal mosaic must be weighed against the results of science. (shrink)

O'Shea concludes that Sellars's attempts to preserve the core truths in Kant's theory of experience and to integrate them with an overall scientific naturalist outlook can and should survive the rejection of several central components of Sellars's proposed adaptation of Kant's transcendental idealism: ABSTRACT: "Sellars’ career-long engagement with Kant’s philosophy involved both readings of Kant and appropriations of Kant that are nuanced, original, and related in complex ways to Sellars’ own philosophical views. In some ways similar to Strawson’s classic reading, (...) Sellars defended Kant’s theory of experience and his analysis of human knowledge as essentially correct. This includes various views on the nature of conceptual cognition, the thinking self, practical reason, perceptual experience, and the lawfulness of nature. On the other hand, and again like Strawson, Sellars regarded Kant’s transcendental idealism as involving a strong ontological commitment to unknowable but thinkable (and non-spatiotemporal) ‘things in themselves’. However, whereas Strawson regarded such a position as deeply incoherent, Sellars argues that Kant’s theological conception of things in themselves can coherently be replaced with a scientific realist conception of things in themselves as theoretically postulated imperceptible processes, which play a structurally similar role for Sellars in grounding the Kantian-phenomenal ‘appearances’ in the ‘manifest image’ of the world. Sellars’ highly complex but sophisticated reading of Kant on sensibility and intuition, when combined with Sellars’ own idiosyncratic views on sensory qualia, render it even more difficult to come to terms with Sellars’ engagements with Kant’s idealism. This chapter attempts to provide a concise presentation and evaluation of certain central themes in Sellars’ complex philosophical dialogue with Kant.". (shrink)

As postcolonial approaches in the studies of religion have challenged liberal-secular presuppositions in addressing non-Western forms of life, there has been a growing concern to examine the normative presuppositions of postcolonial approaches in the field of religious ethics. This paper addresses how Charles Taylor, Talal Asad, and Homi Bhabha show their normative concerns for addressing the interstitial existence of ethnic-religious minorities, negoriating between their subaltern religions and the inclusive-but-exclusive potential of the liberal secular frame of integration. These thinkers raise (...) normative critiques of the spatiotemporal and moral frameworks of liberal, secular integration while suggesting thgeir own normative visions for transforming the existing form of liberal secular democracy. They reveal different models in their normative critiques and visions: Taylor suggests a postsecular and dialogical model, while Asad sets forth an antisecular traditionalist model and Bhabha a pro-secular and vernacular one. (shrink)

An examination of the ways human movement can be represented as a formal language and how this language can be mediated technologically. In Motion and Representation, Nicolás Salazar Sutil considers the representation of human motion through languages of movement and technological mediation. He argues that technology transforms the representation of movement and that representation in turn transforms the way we move and what we understand to be movement. Humans communicate through movement, physically and mentally. To record and capture integrated movement (...) (both bodily and mental), by means of formal language and technological media, produces a material record and cultural expression of our evolving kinetic minds and identities. Salazar Sutil considers three forms of movement inscription: a written record (notation), a visual record (animation), and a computational record (motion capture). He focuses on what he calls kinetic formalism—formalized movement in such pursuits as dance, sports, live animation, and kinetic art, as well as abstract definitions of movement in mathematics and computer science. He explores the representation of kinetic space and spatiotemporality; the representation of mental plans of movement; movement notation, including stave notation (Labanotation) and such contemporary forms of notation as Choreographic Language Agent; and the impact of digital technology on contemporary representations of movement—in particular motion capture technology and Internet transfer protocols. Motion and Representation offers a unique cultural theory of movement and of the ever-changing ways of representing movement. (shrink)

Introduction: Advantageous effects of biological motion detection, a low-perceptual mechanism that allows the rapid recognition and understanding of spatiotemporal characteristics of movement via salient kinematics information, can be amplified when combined with motor imagery, i.e., the mental simulation of motor acts. According to Jeannerod’s neurostimulation theory, asynchronous firing and reduction of mu and beta rhythm oscillations, referred to as suppression over the sensorimotor area, are sensitive to both MI and action observation of BM. Yet, not many studies investigated the (...) use of BM stimuli using combined AO-MI tasks. In this study, we assessed the neural response in the form of event-related synchronization and desynchronization patterns following the observation of point-light-walkers and concordant MI, as compared to MI alone.Methods: Twenty right-handed healthy participants accomplished the experimental task by observing BM stimuli and subsequently performing the same movement using kinesthetic MI. We recorded an electroencephalogram with 32 channels and performed time-frequency analysis on alpha and beta frequency bands during the MI task. A two-way repeated-measures ANOVA was performed to test statistical significance among conditions and electrodes of interest.Results: The results revealed significant ERD/S patterns in the alpha frequency band between conditions and electrode positions. Post hoc comparisons showed significant differences between condition 1 and condition 3 over the left primary motor cortex. For the beta band, a significantly less difference in ERD patterns was detected only between condition 3 and condition 4.Discussion: Our results confirmed that the observation of BM combined with MI elicits a neural suppression, although just in the case of jumping. This is in line with previous findings of AO and MI eliciting a neural suppression for simulated whole-body movements. In the last years, increasing evidence started to support the integration of AOMI training as an adjuvant neurorehabilitation tool in Parkinson’s disease.Conclusion: We concluded that using BM stimuli in AOMI training could be promising, as it promotes attention to kinematic features and imitative motor learning. (shrink)

Mathematical modeling can ground communication and reciprocal enrichment among fields of knowledge whose domains are very different. We propose a new mathematical model applicable in biology, specified into ecology and evolutionary biology, and in cultural transmission studies, considered as a branch of economics. Main inspiration for the model are some biological concepts we call “eco-phenotypic” such as development, plasticity, reaction norm, phenotypic heritability, epigenetics, and niche construction. “Physiology” is a core concept we introduce and translate differently in the biological and (...) cultural domains. The model is ecological in that it aims at describing and studying organisms and populations that perform living, intended as a thermodynamic, matter-energy process concerning resources gathering, usage, and depletion in a spatiotemporal context with given characteristics, as well as with multiplication and space occupation. The model also supports evolution, intended as a dynamics including cumulative change in the features of unique organisms that are connected into breeding populations. The model is then applicable to the economics of cultural transmission in which individuals form their attitudes and patterns of behavior under a complex system of influences derived from their “cultural parents”, other members of the society, and the environment. On the side of biology, an innovative goal is to integrate in a single model all the eco-phenotypic concepts as well as both evolution and ecology. On the side of cultural transmission, eco-phenotypic modeling seems more appropriate in capturing some aspects of cultural systems which are modeled away in the earlier framework based on Mendelian population genetics. (shrink)

Constructing an all-directional, multilevel, and composite interconnection network, accelerating the free flow of producer services elements across regions, and further improving the efficiency of resource integration demand to conduct a comprehensive and systematic analysis of producer services trade. Thus, using bilateral trade data, this paper builds producer services trade network composed of 61 major countries and innovatively combines the methods of social network and economic geography to explore its spatiotemporal evolution and system properties. The results show that, firstly, (...) the producer services trade network has spatial heterogeneity, which is characterized by high-value agglomerations in Western Europe and East Asia, and low-value agglomerations in Southern Europe and Southeast Asia. Secondly, most countries tend to choose trading partners with close geographical locations or common cultures to establish a cohesive subgroup. Thirdly, the producer services trade network has a significant core-periphery structure, the “spaghetti bowl” effect, which leads to a downward trend in the number of core and semi-peripheral countries. Finally, the trade agreement relations, language relations, and differences in economy, geography, institution, and technology all have a significant impact on the evolution of producer services trade network, but this change has little relationship with the population size divergences of different countries. (shrink)

This 4000 word essay was selected for a special issue of 'Image & Narrative' (Issue 18, September 2007), on 'Thinking Pictures', guest edited by Hanneke Grootenboer, author of 'The Rhetoric of Perspective' (University of Chicago Press, 2005). 'Image & Narrative' is a peer-reviewed e-journal on visual narratology, with essays reviewed by at least two members of the editorial board. The essay addresses contemporary arguments on spectatorship within the philosophy of art. It examines different ways by which internal and external spectators (...) negotiate painting's two perspectives: the absent scene represented by the picture's marked surface and the external point of view of a beholder, standing in real space. The essay argues that if the imaginative engagement provided by an internal spectator (see Wollheim) renders the picture plane transparent, so that we might enter the virtual space of the painting, then in paintings integrated into their architectural contexts the surface plays a semantic role in both connecting and separating different realms. If the picture surface disappears for the internal spectator, then for works integrated into their architectural settings its status is heightened and negated as a threshold separating spatiotemporal realms. The essay challenges semiotic accounts of painting. While linguistic derived semiotic accounts negate a spatial engagement, in Hubert Damisch's proposal that painting is a form of thinking, structure emerges from within the loop of the perspective paradigm. The essay argues, however, that if certain paintings 'think', they do so only in the sense that thought permeates a phenomenological whole where perception and imagination merge. The essay is a development of 'A spatiality of situation', published by Art In-sight, Filmwaves magazine (no. 31, 2006), guest edited with Adam Kossoff. A related paper, 'Levels of Reality', was given at the 'Real Things: matter, materiality, representation' conference at the University of York, 5-8 July 2007. (shrink)

En esta ponencia nos proponemos mostrar que ciertas tesis o consensos recibidos sobre pseudoprocesos causales , procesos cuya característica prominente parece ser superar la velocidad de la luz, deben ser cuestionados o seriamente modificados. Dos de dichos consensos son, primero, que los PSP deberían ser tratados simplemente como "basura espacio-temporal" y, segundo, que ellos no cumplen, aparte de permitir aislar procesos causales genuinos, ninguna función epistémica o metodológica en la descripción de cualquier estado físico, en particular, al interior de la (...) relatividad especial . Para ello, apelaremos a procedimientos de medición física bien conocidos tanto en física clásica como en RE. Como consecuencia de lo anterior, argumentamos que, una vez que los PSP son integrados en toda la escena física, se revela que ellos juegan un rol fundamental y más complejo en la física experimental de lo que hasta ahora se ha pensado. In this paper we show that some received contentions about causal pseudo processes , processes of which the most salient aspect seems to be travelling faster than the speed of light, must be rejected o seriously modified. Two of such contentions are, first, that PSPs should be considered just "spatiotemporal junk" and, second, that they do not meet, besides allowing us to isolate proper genuine causal processes, any other epistemic or methodological role in the description of a physical state of affair, in particular, in a special relativity setting. In order to do that, we are going to appeal to physical measure procedures, well known both in classic and relativistic physics. As a consequence of that, we contend that, once PSPs are integrated into the whole physical scenario, a fundamental and more complex role for them in experimental physics is revealed. (shrink)

One of the outstanding problems in the cognitive sciences is to understand how ongoing conscious experience is related to the workings of the brain and nervous system. Neurodynamics offers a powerful approach to this problem because it provides a coherent framework for investigating change, variability, complex spatiotemporal patterns of activity, and multiscale processes (among others). In this chapter, we advocate a neurodynamical approach to consciousness that integrates mathematical tools of analysis and modeling, sophisticated physiological data recordings, and detailed phenomenological (...) descriptions. We begin by stating the basic intuition: Consciousness is an intrinsically dynamic phenomenon and must therefore be studied within a framework that is capable of rendering its dynamics intelligible. We then discuss some of the formal, analytical features of dynamical systems theory, with particular reference to neurodynamics. We then review several neuroscientific proposals that make use of dynamical systems theory in characterizing the neurophysiologi-. (shrink)

This essay argues that it is a matter of vital concern to develop a theoretical apparatus that is adequate to the inherent spatiotemporal dynamics of capital accumulation and the changing practices developed to manage the crisis tendencies of those dynamics. This requires integrating the a-spatial theory of capital accumulation and its internal contradictions with the spatial/geographical theory of imperialism that invokes geopolitical and geo-economic struggles between nation-states. I argue that the two are linked by the way capital deals with (...) the problem of absorbing capital surpluses, namely through geographical fixes. The geographical fix requires imperialist expansionism and the battering down of all barriers to the spatial movement of capital. Such a conception provides the necessary clarity in formulating the relations between capital and state that are sometimes missing from Ellen M. Wood's arguments in Empire of Capital. (shrink)

Human perception has long been a critical subject of design thinking. While various studies have stressed the link between thinking and acting, particularly in spatial experience, the term “design thinking” seems to disconnect conceptual thinking from physical expression or process. Spatial perception is multimodal and fundamentally bound to the body that is not a mere receptor of sensory stimuli but an active agent engaged with the perceivable environment. The body apprehends the experience in which one’s kinesthetic engagement and knowledge play (...) an essential role. Although design disciplines have integrated the abstract, metaphoric, and visual aspects of the body and its movement into conceptual thinking, studies have pointed out that design disciplines have emphasized visuality above the other sensory domains and heavily engaged with the perception of visual configurations, relying on the Gestalt principles. Gestalt psychology must be valued for its attention to a whole. However, the theories of design elements and principles over-empathizing such visuality posit the aesthetics of design mainly as visual value and understate other sensorial and perceptual aspects. Although the visual approach may provide a practical means to represent and communicate ideas, a design process heavily driven by visuality can exhibit weaknesses undermining certain aspects of spatial experience despite the complexity. Grounded in Merleau-Ponty’s notion of multisensory perception, this article discusses the relationship between body awareness and spatial perception and its implication for design disciplines concerning built environments. Special attention is given to the concepts of kinesthetic and synesthetic phenomena known as multisensory and cross-sensory, respectively. This discussion integrates the corporeal and spatiotemporal realms of human experience into the discourse of kinesthetic and synesthetic perceptions. Based on the conceptual, theoretical, and precedent analyses, this article proposes three models for design thinking: Synesthetic Translation, Kinesthetic Resonance, and Kinesthetic Engagement. To discuss the concepts rooted in action-based perception and embodied cognition, this study borrows the neurological interpretation of haptic perception, interoception, and proprioception of space. This article suggests how consideration of the kinesthetic or synesthetic body can deepen and challenge the existing models of the perceptual aspects of environmental psychology adopted in design disciplines. (shrink)

The aim of the paper is to relate Bell’s notion of local causality to the Causal Markov Condition. To this end, first a framework, called local physical theory, will be introduced integrating spatiotemporal and probabilistic entities and the notions of local causality and Markovity will be defined. Then, illustrated in a simple stochastic model, it will be shown how a discrete local physical theory transforms into a Bayesian network and how the Causal Markov Condition arises as a special case (...) of Bell’s local causality and Markovity. (shrink)

This essay argues that it is a matter of vital concern to develop a theoretical apparatus that is adequate to the inherent spatiotemporal dynamics of capital accumulation and the changing practices developed to manage the crisis tendencies of those dynamics. This requires integrating the a-spatial theory of capital accumulation and its internal contradictions with the spatial/geographical theory of imperialism that invokes geopolitical and geo-economic struggles between nation-states. I argue that the two are linked by the way capital deals with (...) the problem of absorbing capital surpluses, namely through geographical fixes. The geographical fix requires imperialist expansionism and the battering down of all barriers to the spatial movement of capital. Such a conception provides the necessary clarity in formulating the relations between capital and state that are sometimes missing from Ellen M. Wood's arguments in Empire of Capital. (shrink)

This paper aims to implement Bell’s notion of local causality into a framework, called local physical theory, which is general enough to integrate both probabilistic and spatiotemporal concepts and also classical and quantum theories. Bell’s original idea of local causality will then arise as the classical case of our definition. First, we investigate what is needed for a local physical theory to be locally causal. Then we compare local causality with Reichenbach’s common cause principle and relate both to the (...) Bell inequalities. We find a nice parallelism: both local causality and the common cause principle are more general notions than captured by the Bell inequalities. Namely, Bell inequalities cannot be derived neither from local causality nor from a common cause unless the local physical theory is classical or the common cause is commuting, respectively. (shrink)

We all intuitively know what a diagram is, and still it is surprisingly difficult to describe it as a semiotic function or type. In this article, we present four groups of hypotheses in view of a clarification. We hypothesize: (1) That diagrams are signs of a distinct type, unknown to classical semiotics; (2) That the elementary graphs of a diagram are all derived fromlines and pointsintopologicalmental spaces. The mind applies these diagrammatic spaces to referential spaces in many ways, but basically (...) through conceptual integration (blending). The mind blends topology and reference, which makes the topology unnoticeable; (3) That elementary diagrammatic graphs constitute a natural, phenomenological, spatiotemporal, figurative and dynamic but informal geometry in the embodied, thinking mind; (4) That diagrammatic signs are the active components of the abstract mental figuration in working memory that accompany perception and deliver the schematizing ideas which invest and connect our categories and construe proper descriptive, narrative, patterns of inferentialthoughtand programs of sensorimotor and social action. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Objects, Exchanges, DiscourseMonique David-MénardPhilosophy is a reflection for which all unknown material is good, and we would gladly say, for which all good material must be unknown.—George Canguilhem, The Normal and the PathologicalThis paper may be presented in two ways: it is a matter of understanding, locally, how legal institutions or economic discourses, which propose models of exchange between agents in society, can take into account sexuality in the (...) way that it has been explored by psychoanalysis. It is thus a matter of following and transforming the efforts of Freud in Civilization and Its Discontents and of Lacan in his seminar, The Other Side of Psychoanalysis, in order to consider how the field of unconscious sexuality manages or doesn’t manage to develop thanks to these institutions. Inversely, it is a matter of specifying how institutional creations such as the rituals of the gift, the juridical system, or economic laws put “values” into play that implicate sexual desires. But before developing this question, I will first give some clarification about the method I will employ, or rather, offer some remarks concerning the philosophical background that this apparently “local” question presupposes.Philosophical BackgroundThis project could perhaps be said to share the same philosophical approach as that of Michel Foucault: it is not a question of constructing a system in [End Page 88] the name of an idea of truth which would be the unifying foundation (in this case, sexual and political), but rather of intervening at a neurological point in “our” situation, which demands that one determine how this “our” comes into being. The point of departure for any theoretical project is always entangled in a situation that it subsequently problematizes. Instead of masking the situation that forces us to think by the means that are proper to the system’s own constitution, the strategy that I have called “local” allows for the concepts to take into account the very situation from out of which they are produced as a theoretical framework. Deleuze wrote that an event forces us to think that which, at first, can only be felt and, more precisely, felt as a fact impossible to integrate into a ready-made set of concepts. Foucault redefined critique as the diagnosis of a present: the thinker experiences a situation in a way that puts her at a distance and displaces her. This experience is transformed into an occasion to produce knowledge as well as a practice that allows it to be “thought,” not as a subjective experience, but rather as new objects for knowledge of which this experience of distance was not merely the occasion.It has already been a long time (1990) since I showed, using Kant as an example, that the invention of a philosophy is connected to an event at once present in the texts and concealed by its very systematicity; critical and transcendental philosophy was only possible by the ingenious articulation of heterogenous factors. Deleuze called this “a contingent reason” because of the heterogeneity among the concepts that construct a philosophical problematic. For example, here, the critique of the formalism of logic is the conceptual means with which Kant transformed the event, which was for him his fascination-repulsion for a “delirious” [délirant] thinker, namely, Swedenborg, into a new concept of metaphysics, the “science of the limits of human reason” and a transcendental logic of objectivity.Conceptually, the link he would forge was that of the confrontation between the mad system of Swedenborg and the philosophical idealism of Leibniz. The logical instrument of Leibnizian criticism defined a new kind of negation, the “real conflict,” which bears this name since it introduces the determination of a real object (realer Widerstreit), in contrast to three other kinds of negation: contradiction, which, in negating that which forms within thought, negates at the same time that to which it could refer (nihil negativum); “the being of reason” like the Leibnizian god or the spirits of Swedenborg, which are not contradictory concepts, but instead concepts for which one could not find any correlate in spatiotemporal experience, such that one cannot “count them among the possible things” (ens rationis). Finally, there... (shrink)

Is it possible to construct an alternative framework for the description of physical reality that is not based on space and time? According to Kant, because of the incorrigibility of the spatiotemporal scheme, the contents of any such alternative will be beyond our cognitive grasp. Nonetheless, the possibility of constructing such a descriptive scheme poses itself as an intriguing challenge. In this paper, we attempt to answer this challenge by exploiting an analytical tool extensively used by physicists and engineers: (...) the utilisation of multiple representations of the same data using integral transforms – for example, the Fourier transform. According to the “spectral” picture we propose, frequencies and wavelengths, related to time and space by the Fourier transform, form an adequate alternative basis for describing physical systems, and one that is of equal richness to the spatiotemporal picture. Furthermore, the routine use of Fourier analysis applied to familiar physical systems suggests ways in which sense organs might be constructed such that they naturally give rise to a spectral representation of the world. Although we might never be able to imagine perceiving the world in this way, we can nonetheless describe the contents of such a mode of perception and relate them precisely to our own world-view. Hence, we suggest in a Kantian spirit, that the spatiotemporal description of the world is not unique. (shrink)